Oxidative stress induction by narasin augments doxorubicin's efficacy in osteosarcoma
In this study, we show that narasin is active against osteosarcoma cells at the same concentrations that are less toxic to normal cells. This effect is achieved by growth inhibition and apoptosis induction, which is mediated by oxidative stress and damage, and mitochondrial dysfunction. The antioxidant N-acetyl-l-cysteine (NAC) abolishes the anti-osteosarcoma activity. Importantly, narasin significantly augments doxorubicin's efficacy in both osteosarcoma cell culturing system and subcutaneous implantation mouse model. The combination of narasin and doxorubicin at non-toxic doses completely arrests osteosarcoma growth in m...
Source: BMC Pharmacology and Toxicology - October 20, 2023 Category: Drugs & Pharmacology Authors: Zhaoming Han Juguang Yang Ping Wang Feng Bian Jiguang Jia Source Type: research
Correction: Core decompression combined with local DFO administration loaded on polylactic glycolic acid scaffolds for the treatment of osteonecrosis of the femoral head: a pilot study
BMC Pharmacol Toxicol. 2023 Oct 17;24(1):55. doi: 10.1186/s40360-023-00691-w.NO ABSTRACTPMID:37849005 | PMC:PMC10580663 | DOI:10.1186/s40360-023-00691-w (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 18, 2023 Category: Drugs & Pharmacology Authors: Kaveh Gharanizadeh Ali Mohammad Sharifi Hamed Tayyebi Razieh Heidari Shayan Amiri Sajad Noorigaravand Source Type: research
Correction: Core decompression combined with local DFO administration loaded on polylactic glycolic acid scaffolds for the treatment of osteonecrosis of the femoral head: a pilot study
BMC Pharmacol Toxicol. 2023 Oct 17;24(1):55. doi: 10.1186/s40360-023-00691-w.NO ABSTRACTPMID:37849005 | DOI:10.1186/s40360-023-00691-w (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 18, 2023 Category: Drugs & Pharmacology Authors: Kaveh Gharanizadeh Ali Mohammad Sharifi Hamed Tayyebi Razieh Heidari Shayan Amiri Sajad Noorigaravand Source Type: research
Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats
CONCLUSIONS: The aforementioned results suggested that the LD50 of AT-533 is 228.382 mg/kg and the LD50 of AT-533 gel is greater than 5 g/kg. These findings indicated that AT-533 is non-toxic in rats when the dose less than 50 mg/kg and AT-533 gel can be considered a gel with no toxicity at doses less than 5 g/kg.PMID:37833798 | PMC:PMC10576390 | DOI:10.1186/s40360-023-00696-5 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 14, 2023 Category: Drugs & Pharmacology Authors: Lishan Zhong Yanting Wu Chen Huang Kaisheng Liu Cui-Fang Ye Zhe Ren Yifei Wang Source Type: research
Retraction Note: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study
BMC Pharmacol Toxicol. 2023 Oct 13;24(1):53. doi: 10.1186/s40360-023-00697-4.NO ABSTRACTPMID:37833821 | PMC:PMC10571280 | DOI:10.1186/s40360-023-00697-4 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 14, 2023 Category: Drugs & Pharmacology Authors: Omnia I Ismail Eman S Shaltout Nora Z Abdellah Diab F Hetta Wael M A Abd El-Ghani Lobna A Abdelzaher Ahmed Mohamed Mohamed Mahmoud Asmaa M Hasan Noha A Rashed Noha Esmael Ebrahem Source Type: research
Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats
CONCLUSIONS: The aforementioned results suggested that the LD50 of AT-533 is 228.382 mg/kg and the LD50 of AT-533 gel is greater than 5 g/kg. These findings indicated that AT-533 is non-toxic in rats when the dose less than 50 mg/kg and AT-533 gel can be considered a gel with no toxicity at doses less than 5 g/kg.PMID:37833798 | PMC:PMC10576390 | DOI:10.1186/s40360-023-00696-5 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 14, 2023 Category: Drugs & Pharmacology Authors: Lishan Zhong Yanting Wu Chen Huang Kaisheng Liu Cui-Fang Ye Zhe Ren Yifei Wang Source Type: research
Retraction Note: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study
BMC Pharmacol Toxicol. 2023 Oct 13;24(1):53. doi: 10.1186/s40360-023-00697-4.NO ABSTRACTPMID:37833821 | PMC:PMC10571280 | DOI:10.1186/s40360-023-00697-4 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 14, 2023 Category: Drugs & Pharmacology Authors: Omnia I Ismail Eman S Shaltout Nora Z Abdellah Diab F Hetta Wael M A Abd El-Ghani Lobna A Abdelzaher Ahmed Mohamed Mohamed Mahmoud Asmaa M Hasan Noha A Rashed Noha Esmael Ebrahem Source Type: research
Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats
CONCLUSIONS: The aforementioned results suggested that the LD50 of AT-533 is 228.382 mg/kg and the LD50 of AT-533 gel is greater than 5 g/kg. These findings indicated that AT-533 is non-toxic in rats when the dose less than 50 mg/kg and AT-533 gel can be considered a gel with no toxicity at doses less than 5 g/kg.PMID:37833798 | PMC:PMC10576390 | DOI:10.1186/s40360-023-00696-5 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 14, 2023 Category: Drugs & Pharmacology Authors: Lishan Zhong Yanting Wu Chen Huang Kaisheng Liu Cui-Fang Ye Zhe Ren Yifei Wang Source Type: research
Retraction Note: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study
BMC Pharmacol Toxicol. 2023 Oct 13;24(1):53. doi: 10.1186/s40360-023-00697-4.NO ABSTRACTPMID:37833821 | PMC:PMC10571280 | DOI:10.1186/s40360-023-00697-4 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 14, 2023 Category: Drugs & Pharmacology Authors: Omnia I Ismail Eman S Shaltout Nora Z Abdellah Diab F Hetta Wael M A Abd El-Ghani Lobna A Abdelzaher Ahmed Mohamed Mohamed Mahmoud Asmaa M Hasan Noha A Rashed Noha Esmael Ebrahem Source Type: research
Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats
CONCLUSIONS: The aforementioned results suggested that the LD50 of AT-533 is 228.382 mg/kg and the LD50 of AT-533 gel is greater than 5 g/kg. These findings indicated that AT-533 is non-toxic in rats when the dose less than 50 mg/kg and AT-533 gel can be considered a gel with no toxicity at doses less than 5 g/kg.PMID:37833798 | DOI:10.1186/s40360-023-00696-5 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 14, 2023 Category: Drugs & Pharmacology Authors: Lishan Zhong Yanting Wu Chen Huang Kaisheng Liu Cui-Fang Ye Zhe Ren Yifei Wang Source Type: research
Retraction Note: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study
BMC Pharmacol Toxicol. 2023 Oct 13;24(1):53. doi: 10.1186/s40360-023-00697-4.NO ABSTRACTPMID:37833821 | DOI:10.1186/s40360-023-00697-4 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 14, 2023 Category: Drugs & Pharmacology Authors: Omnia I Ismail Eman S Shaltout Nora Z Abdellah Diab F Hetta Wael M A Abd El-Ghani Lobna A Abdelzaher Ahmed Mohamed Mohamed Mahmoud Asmaa M Hasan Noha A Rashed Noha Esmael Ebrahem Source Type: research
Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers
CONCLUSION: The method described a model for investigations of pharmacokinetics and pharmacodynamics of topical lidocaine/prilocaine cream. Except the plasma drug level indicator, these pharmacodynamics data should also be evaluated in the anesthetic transdermal pharmacokinetics study.CLINICAL TRIAL REGISTRATION: CTR20211544; registered in http://www.chinadrugtrials.org.cn/ at September 2021.PMID:37828535 | PMC:PMC10571248 | DOI:10.1186/s40360-023-00690-x (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 12, 2023 Category: Drugs & Pharmacology Authors: Lingjun Li Baole Cai Hongyang Li Jun Wei Lei Tao Pengcheng Ma Source Type: research
