In vitro evaluation of cell viability and expression profile of growth factors in mouse Sertoli cells exposed to Delta-9-tetrahydrocannabinol: a mechanistic insight into the cannabinoid-induced testicular toxicity
BMC Pharmacol Toxicol. 2023 Nov 9;24(1):61. doi: 10.1186/s40360-023-00704-8.ABSTRACTThe potentially adverse effects of cannabis (marijuana), a common leisure compound, on male reproductive performance are a reason for concern. δ-9-tetrahydrocannabinol (THC), the primary active component of marijuana alters testicular cells' proliferation and function which affects male fertility and causes testicular cells dysfunction and apoptosis. The main objective of this study was to investigate the possible mechanism underlying the toxic effects of THC with a mechanistic insight into Sertoli cell-based reproductive dysfunction. The ...
Source: BMC Pharmacology and Toxicology - November 10, 2023 Category: Drugs & Pharmacology Authors: Shadi Mohammadpour-Asl Shiva Roshan-Milani Amin Abdollahzade Fard Ali Golchin Source Type: research
Sericin alleviates motor dysfunction by modulating inflammation and TrkB/BDNF signaling pathway in the rotenone-induced Parkinson's disease model
CONCLUSION: These results support a protective benefit of sericin therapy in a rotenone-induced PD paradigm by reducing motor impairment, inflammatory response, and disruption of the TrkB/BDNF signaling pathway.PMID:37936189 | PMC:PMC10631121 | DOI:10.1186/s40360-023-00703-9 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 8, 2023 Category: Drugs & Pharmacology Authors: Zahra Salari Ghorbangol Ashabi Ali Fartoosi Ahmad Fartoosi Marjan Shariatpanahi Mehdi Aghsami Hamed Montazeri Afshin Kheradmand Source Type: research
Efficacy of intravenous N acetylcysteine as an adjuvant therapy in the treatment of acute aluminum phosphide Poisoning: a systematic review and meta-analysis
CONCLUSION: Our meta-analysis revealed that IV N-acetylcysteine may be effective in reducing mortality of severe aluminum phosphide poisoning cases.TRIAL REGISTRATION: Registration number in Prospero CRD42022375344 on 25 NOVEMBER 2022, retrospectively registered.PMID:37924139 | PMC:PMC10625249 | DOI:10.1186/s40360-023-00699-2 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 4, 2023 Category: Drugs & Pharmacology Authors: Heba Othman Shaker Omar El Sayed Rageh Maged Alnajar Nesreen Fares Alshamaly Walaa Abdelfattah Abdelmaged Mohamed Abd-ElGawad Source Type: research
Efficacy of intravenous N acetylcysteine as an adjuvant therapy in the treatment of acute aluminum phosphide Poisoning: a systematic review and meta-analysis
CONCLUSION: Our meta-analysis revealed that IV N-acetylcysteine may be effective in reducing mortality of severe aluminum phosphide poisoning cases.TRIAL REGISTRATION: Registration number in Prospero CRD42022375344 on 25 NOVEMBER 2022, retrospectively registered.PMID:37924139 | DOI:10.1186/s40360-023-00699-2 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 4, 2023 Category: Drugs & Pharmacology Authors: Heba Othman Shaker Omar El Sayed Rageh Maged Alnajar Nesreen Fares Alshamaly Walaa Abdelfattah Abdelmaged Mohamed Abd-ElGawad Source Type: research
GHB toxicokinetics and renal monocarboxylate transporter expression are influenced by the estrus cycle in rats
CONCLUSIONS: Our results suggest that females may be less susceptible to GHB-induced toxicity due to decreased exposure resulting from increased renal clearance, as a result of decreased renal MCT1 expression.PMID:37919807 | PMC:PMC10623699 | DOI:10.1186/s40360-023-00700-y (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 3, 2023 Category: Drugs & Pharmacology Authors: Hao Wei Jieyun Cao Tyler Fallert Su Yeo Melanie A Felmlee Source Type: research
GHB toxicokinetics and renal monocarboxylate transporter expression are influenced by the estrus cycle in rats
CONCLUSIONS: Our results suggest that females may be less susceptible to GHB-induced toxicity due to decreased exposure resulting from increased renal clearance, as a result of decreased renal MCT1 expression.PMID:37919807 | DOI:10.1186/s40360-023-00700-y (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 3, 2023 Category: Drugs & Pharmacology Authors: Hao Wei Jieyun Cao Tyler Fallert Su Yeo Melanie A Felmlee Source Type: research
Correction: Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells
BMC Pharmacol Toxicol. 2023 Oct 27;24(1):57. doi: 10.1186/s40360-023-00688-5.NO ABSTRACTPMID:37891698 | PMC:PMC10612259 | DOI:10.1186/s40360-023-00688-5 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 27, 2023 Category: Drugs & Pharmacology Authors: Jui-Ting Chang Yao-Jen Liang Chia-Yu Hsu Chao-Yi Chen Po-Jung Chen Yi-Feng Yang Yen-Lin Chen Dee Pei Jin-Biou Chang Jyh-Gang Leu Source Type: research
Correction: Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells
BMC Pharmacol Toxicol. 2023 Oct 27;24(1):57. doi: 10.1186/s40360-023-00688-5.NO ABSTRACTPMID:37891698 | DOI:10.1186/s40360-023-00688-5 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - October 27, 2023 Category: Drugs & Pharmacology Authors: Jui-Ting Chang Yao-Jen Liang Chia-Yu Hsu Chao-Yi Chen Po-Jung Chen Yi-Feng Yang Yen-Lin Chen Dee Pei Jin-Biou Chang Jyh-Gang Leu Source Type: research
