Efficacy and safety of thrombopoietin receptor agonists in solid tumors with chemotherapy-induced thrombocytopenia: a meta-analysis
CONCLUSIONS: This meta-analysis suggests that TPO-RAs are generally well-tolerated. However, their efficacy in solid tumors with CIT appears limited, as they only demonstrate a reduction in the incidence of grade 3 or 4 thrombocytopenia.PMID:38041150 | PMC:PMC10693054 | DOI:10.1186/s40360-023-00707-5 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - December 2, 2023 Category: Drugs & Pharmacology Authors: Wen Chen Yubingxue Liu Luchun Li Xianghua Zeng Source Type: research
Evaluation of antibody drug delivery efficiency via nebulizer in various airway models and breathing patterns
CONCLUSION: The results suggest that the total inspiration volume, output rate, and particle size should be considered when IgG nebulization is used. We, therefore, propose a method for evaluating the efficiency of nebulizer for predicting antibody drug delivery.PMID:38041207 | PMC:PMC10691028 | DOI:10.1186/s40360-023-00711-9 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - December 2, 2023 Category: Drugs & Pharmacology Authors: Soon Woo Hong Kyung Hwa Chang Chang Jae Woo Ho Chul Kim Bong Seop Kwak Bong Joo Park Ki Chang Nam Source Type: research
Efficacy of pharmacotherapies for bulimia nervosa: a systematic review and meta-analysis
CONCLUSIONS: This meta-analysis indicates that most pharmacotherapies decreased the frequency of binge-eating and vomiting episodes, body weight, and depressive symptoms in BN patients, but the efficacy was not significant. In each drug the efficacy is different, treating different aspects, different symptoms to improve the clinical performance of bulimia nervosa.PMID:38042827 | DOI:10.1186/s40360-023-00713-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - December 2, 2023 Category: Drugs & Pharmacology Authors: Sijie Yu Yuhan Zhang Chongkai Shen Fei Shao Source Type: research
In silico prediction of bioequivalence of atorvastatin tablets based on GastroPlus ™ software
This study aimed to simulate plasma concentrations with different dissolution profiles and run population simulations to evaluate the bioequivalence of test and reference products of atorvastation using GastroPlus software. The dissolution profiles of the reference and test products of atorvastatin (20 mg tablets), and clinical plasma concentration-time data of the reference product were used for the simulations. The results showed that the simulated models were successfully established for atorvastatin tablets. Population simulation results indicated that the test formulation was bioequivalent to the reference formulation...
Source: BMC Pharmacology and Toxicology - November 29, 2023 Category: Drugs & Pharmacology Authors: Lu Wang Jinliang Chen Wenjun Chen Zourong Ruan Honggang Lou Dandan Yang Bo Jiang Source Type: research
Determination of biochemical and histopathological changes on testicular and epididymis tissues induced by exposure to insecticide Imidacloprid during postnatal development in rats
CONCLUSION: It is concluded that sub-chronic exposure to IMD in neonatal male rats may induce histopathological changes in reproductive tissues and damage normal testicular functions via inducing oxidative stress, decrease in body weight, disturbing normal blood lipid profile and testosterone concentration. IMD exposure can induce pathophysiological effects calls for further evaluation of this widely used insecticide.PMID:38012698 | PMC:PMC10680247 | DOI:10.1186/s40360-023-00709-3 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 28, 2023 Category: Drugs & Pharmacology Authors: Amina Sardar Mehwish David Sarwat Jahan Tayyaba Afsar Aneela Ahmad Asad Ullah Ali Almajwal Huma Shafique Suhail Razak Source Type: research
In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme
CONCLUSION: This clearly shows that asiaticoside will be a better drug candidate than asiatic acid in inhibiting the CatS enzyme for the purpose of improving the outcome of atherosclerosis. However, certain modifications need to be made to the structural make-up of asiaticoside A to improve its pharmacokinetics properties.PMID:38007481 | PMC:PMC10676574 | DOI:10.1186/s40360-023-00701-x (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 25, 2023 Category: Drugs & Pharmacology Authors: Temitope Akinwumi Ajani Kenechukwu Obikeze Zandisiwe E Magwebu Samuel Egieyeh Chesa G Chauke Source Type: research
In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme
CONCLUSION: This clearly shows that asiaticoside will be a better drug candidate than asiatic acid in inhibiting the CatS enzyme for the purpose of improving the outcome of atherosclerosis. However, certain modifications need to be made to the structural make-up of asiaticoside A to improve its pharmacokinetics properties.PMID:38007481 | DOI:10.1186/s40360-023-00701-x (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 25, 2023 Category: Drugs & Pharmacology Authors: Temitope Akinwumi Ajani Kenechukwu Obikeze Zandisiwe E Magwebu Samuel Egieyeh Chesa G Chauke Source Type: research
Effect of single intravenous injection of esketamine on postpartum depression after labor analgesia and potential mechanisms: a randomized, double-blinded controlled trial
CONCLUSIONS: Single intravenous injection of esketamine after delivery in participants underwent labor analgesia can decrease the occurrence of postpartum depression for one week and six weeks after delivery, while the side effects were not increased. The antidepressant effects of esketamine may be related to the reduction of stress response and inflammation.TRIAL REGISTRATION: The trial was registered at the Chinese Clinical Trial Registry on 5/30/2022 (CTRI registration number-ChiCTR2200060387). URL of registry: https://www.chictr.org.cn/bin/home .PMID:37996953 | PMC:PMC10668401 | DOI:10.1186/s40360-023-00705-7 (Source: ...
Source: BMC Pharmacology and Toxicology - November 24, 2023 Category: Drugs & Pharmacology Authors: Bin Ling Yun Zhu Zelin Yan Hao Chen Hua Xu Qi Wang Wanyou Yu Wei Wang Source Type: research
Effect of single intravenous injection of esketamine on postpartum depression after labor analgesia and potential mechanisms: a randomized, double-blinded controlled trial
CONCLUSIONS: Single intravenous injection of esketamine after delivery in participants underwent labor analgesia can decrease the occurrence of postpartum depression for one week and six weeks after delivery, while the side effects were not increased. The antidepressant effects of esketamine may be related to the reduction of stress response and inflammation.TRIAL REGISTRATION: The trial was registered at the Chinese Clinical Trial Registry on 5/30/2022 (CTRI registration number-ChiCTR2200060387). URL of registry: https://www.chictr.org.cn/bin/home .PMID:37996953 | DOI:10.1186/s40360-023-00705-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 24, 2023 Category: Drugs & Pharmacology Authors: Bin Ling Yun Zhu Zelin Yan Hao Chen Hua Xu Qi Wang Wanyou Yu Wei Wang Source Type: research
The effect of acarbose on lipid profiles in adults: a systematic review and meta-analysis of randomized clinical trials
CONCLUSION: The findings of this study suggest that acarbose can reduce serum levels of TG and TC. However, no significant effects were observed on LDL or HDL levels.PMID:37990256 | PMC:PMC10664642 | DOI:10.1186/s40360-023-00706-6 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 22, 2023 Category: Drugs & Pharmacology Authors: Mohsen Yousefi Sahand Tehrani Fateh Mahlagha Nikbaf-Shandiz Fatemeh Gholami Samira Rastgoo Reza Bagher Alireza Khadem Farideh Shiraseb Omid Asbaghi Source Type: research
Study on the association between adverse drug reactions to opioids and gene polymorphisms: a case-case-control study
CONCLUSION: Polymorphism of ABCB1 (062rs1045642) is related to ADRs caused by oxycodone, and the incidence of ADRs is higher with the allele T. Polymorphism of ABCB1 is expected to become a clinical predictor of ADRs to oxycodone, and attention should be given to the occurrence of serious ADRs in patients with ABCB1 (062rs1045642) CT and TT genotypes.PMID:37990344 | PMC:PMC10662635 | DOI:10.1186/s40360-023-00708-4 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 22, 2023 Category: Drugs & Pharmacology Authors: Jing Yang Ying-Zi Sun Qun-Fang Li Zheng Fu Yu-Yao Guan Chao Song Lei Zheng Source Type: research
