Effect of single intravenous injection of esketamine on postpartum depression after labor analgesia and potential mechanisms: a randomized, double-blinded controlled trial
CONCLUSIONS: Single intravenous injection of esketamine after delivery in participants underwent labor analgesia can decrease the occurrence of postpartum depression for one week and six weeks after delivery, while the side effects were not increased. The antidepressant effects of esketamine may be related to the reduction of stress response and inflammation.TRIAL REGISTRATION: The trial was registered at the Chinese Clinical Trial Registry on 5/30/2022 (CTRI registration number-ChiCTR2200060387). URL of registry: https://www.chictr.org.cn/bin/home .PMID:37996953 | DOI:10.1186/s40360-023-00705-7
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Authors: Bin Ling Yun Zhu Zelin Yan Hao Chen Hua Xu Qi Wang Wanyou Yu Wei Wang Source Type: research
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