p90RSK pathway inhibition synergizes with cisplatin in TMEM16A overexpressing head and neck cancer
Head and neck squamous cell carcinoma (HNSCC) constitutes one of the most common types of human cancers and often metastasizes to lymph nodes. Platinum-based chemotherapeutic drugs are commonly used for treatm... (Source: BMC Cancer)
Source: BMC Cancer - February 19, 2024 Category: Cancer & Oncology Authors: Abdulkader Yassin-Kassab, Suman Chatterjee, Nayel Khan, Nathaniel Wang, Vlad C. Sandulache, Eric H-B. Huang, Timothy F. Burns and Umamaheswar Duvvuri Tags: Research Source Type: research
Establishment and external validation of prognosis prediction nomogram for patients with distant metastatic intrahepatic cholangiocarcinoma: based on a large population
Most patients with intrahepatic cholangiocarcinoma (ICC) have developed distant metastasis at the time of diagnosis, while there is rear related nomogram to predict the prognosis. (Source: BMC Cancer)
Source: BMC Cancer - February 16, 2024 Category: Cancer & Oncology Authors: Chen Yuan, Shubing Zou, Kai Wang and Zhigang Hu Tags: Research Source Type: research
Central nervous system metastases in breast cancer patients with germline BRCA pathogenic variants compared to non-carriers: a matched-pair analysis
Breast cancer is a common cause for central nervous system (CNS) metastasis, resulting in a significant reduction in overall survival. Germline pathogenic variants (PVs) in BRCA1/2 are the most common genetic ris... (Source: BMC Cancer)
Source: BMC Cancer - February 16, 2024 Category: Cancer & Oncology Authors: Matan Ben-Zion Berliner, Shlomit Yust-Katz, Inbar Lavie, Yael Goldberg, Inbal Kedar and Rinat Yerushalmi Tags: Research Source Type: research
MZ1, a BRD4 inhibitor, exerted its anti-cancer effects by suppressing SDC1 in glioblastoma
Glioblastoma (GBM) is a relatively prevalent primary tumor of the central nervous system in children, characterized by its high malignancy and mortality rates, along with the intricate challenges of achieving ... (Source: BMC Cancer)
Source: BMC Cancer - February 16, 2024 Category: Cancer & Oncology Authors: Gen Li, Liya Ma, Chenxi Feng, Hongli Yin, Jianping Bao, Di Wu, Zimu Zhang, Xiaolu Li, Zhiheng Li, Chun Yang, Hairong Wang, Fang Fang, Xiaohan Hu, Mei Li, Lixiao Xu, Yunyun Xu & hellip; Tags: Research Source Type: research
Translation and validation of a simplified Chinese version of the psychosocial assessment tool
The Psychosocial Assessment Tool (PAT2.0) is widely used to assess psychosocial risk in families of children with cancer. Our study aims to apply PAT2.0 to Chinese patients and assess the reliability, content ... (Source: BMC Cancer)
Source: BMC Cancer - February 16, 2024 Category: Cancer & Oncology Authors: Jun Kou, Ruiqi Wang, Yuxin Tang, Yi Tang and Yang Gao Tags: Research Source Type: research
Distinguishing IDH mutation status in gliomas using FTIR-ATR spectra of peripheral blood plasma indicating clear traces of protein amyloid aggregation
Glioma is a primary brain tumor and the assessment of its molecular profile in a minimally invasive manner is important in determining treatment strategies. Among the molecular abnormalities of gliomas, mutati... (Source: BMC Cancer)
Source: BMC Cancer - February 16, 2024 Category: Cancer & Oncology Authors: Saiko Kino, Masayuki Kanamori, Yoshiteru Shimoda, Kuniyasu Niizuma, Hidenori Endo and Yuji Matsuura Tags: Research Source Type: research
Using a combination of superb microvascular imaging and other auxiliary ultrasound techniques to increase the accuracy of gray-scale ultrasound for breast masses
Breast ultrasound is highly sensitive, but its specificity is not as high for detecting malignant lesions. Auxiliary modalities like elastography, Color and Power Doppler ultrasound are used as adjuncts to yie... (Source: BMC Cancer)
Source: BMC Cancer - February 16, 2024 Category: Cancer & Oncology Authors: Mahboubeh Abedi, Leyla Sahebi, Bita Eslami, Azin Saberi, Marzieh Orouji, Sadaf Alipour and Shirin Shahsavarhaghighi Tags: Research Source Type: research
SIRT7 promotes the proliferation and migration of anaplastic thyroid cancer cells by regulating the desuccinylation of KIF23
This study was designed to investigate the regulatory effects of kinesin family member (KIF) 23 on anaplastic thyroid cancer (ATC) cell viability and migration and the underlying mechanism. (Source: BMC Cancer)
Source: BMC Cancer - February 15, 2024 Category: Cancer & Oncology Authors: Yongkang Wu, Weijie Chen, Huilai Miao and Tuo Xu Tags: Research Source Type: research
The prognostic role of single cell invasion and nuclear diameter in early oral tongue squamous cell carcinoma
The clinical significance of single cell invasion and large nuclear diameter is not well documented in early-stage oral tongue squamous cell carcinoma (OTSCC). (Source: BMC Cancer)
Source: BMC Cancer - February 15, 2024 Category: Cancer & Oncology Authors: Alhadi Almangush, Jaana Hagstr öm, Caj Haglund, Luiz Paulo Kowalski, Ricardo D. Coletta, Antti A. Mäkitie, Tuula Salo and Ilmo Leivo Tags: Research Source Type: research
Adult genitourinary sarcoma: analysis using hospital-based cancer registry data in Japan
Genitourinary sarcomas are rare in adults and few large-scale studies on adult genitourinary sarcoma are reported. We aimed to elucidate the clinical characteristics, survival outcomes, and prognostic factors ... (Source: BMC Cancer)
Source: BMC Cancer - February 15, 2024 Category: Cancer & Oncology Authors: Satoshi Nitta, Shuya Kandori, Kosuke Kojo, Shuhei Suzuki, Kazuki Hamada, Ichiro Chihara, Masanobu Shiga, Shotaro Sakka, Yoshiyuki Nagumo, Tomokazu Kimura, Bryan J. Mathis, Hiromitsu Negoro, Ayako Okuyama, Takahiro Higashi and Hiroyuki Nishiyama Tags: Research Source Type: research
Rate of benign histology after resection of suspected renal cell carcinoma: multicenter comparison between Korea and the United States
In the United States, the rate of benign histology among resected renal tumors suspected to be malignant is increasing. We evaluated the rates in the Republic of Korea and assessed the racial effect using rece... (Source: BMC Cancer)
Source: BMC Cancer - February 15, 2024 Category: Cancer & Oncology Authors: Chang Wook Jeong, Jang Hee Han, Seok Soo Byun, Cheryn Song, Sung-Hoo Hong, Jinsoo Chung, Seong Il Seo, Hong Koo Ha, Eu Chang Hwang, Ill Young Seo, Joseph G. Cheaib, Phillip M. Pierorazio, Misop Han and Cheol Kwak Tags: Research Source Type: research
Treatment for locally resectable stage IIIC1r cervical cancer: surgery or chemoradiotherapy?
The aim of this study was to compare the therapeutic value and treatment-related complications of radical hysterectomy with those of concurrent chemoradiotherapy (CCRT) for locally resectable (T1a2 –T2a1) stage... (Source: BMC Cancer)
Source: BMC Cancer - February 15, 2024 Category: Cancer & Oncology Authors: Mei-ling Zhong, Yin-chuan Liu, Jian-tong Yang, Ya-nan Wang, Mei-hong Ao, Yun Xiao, Si-yuan Zeng and Mei-rong Liang Tags: Research Source Type: research
Analyzing socio-environmental determinants of bone and soft tissue cancer in Indonesia
This study is designed to explore the potential impact of individual and environmental residential factors as risk determinants for bone and soft tissue cancers, with a particular focus on the Indonesian conte... (Source: BMC Cancer)
Source: BMC Cancer - February 14, 2024 Category: Cancer & Oncology Authors: Yusuf Alam Romadhon, Yuni Prastyo Kurniati, Jumadi Jumadi, Ali Asghar Alesheikh and Aynaz Lotfata Tags: Research Source Type: research
Glycosylation-related genes mediated prognostic signature contribute to prognostic prediction and treatment options in ovarian cancer: based on bulk and single ‑cell RNA sequencing data
Ovarian cancer (OC) is a complex disease with significant tumor heterogeneity with the worst prognosis and highest mortality among all gynecological cancers. Glycosylation is a specific post-translational modi... (Source: BMC Cancer)
Source: BMC Cancer - February 14, 2024 Category: Cancer & Oncology Authors: Yue You and Qing Yang Tags: Research Source Type: research
Integrated transcriptomics uncovers an enhanced association between the prion protein gene expression and vesicle dynamics signatures in glioblastomas
Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC) stan... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2024 Category: Cancer & Oncology Authors: Jacqueline Marcia Boccacino, Rafael dos Santos Peixoto, Camila Felix de Lima Fernandes, Giovanni Cangiano, Paula Rodrigues Sola, B árbara Paranhos Coelho, Mariana Brandão Prado, Maria Isabel Melo-Escobar, Breno Pereira de Sousa, Shamini Ayyadhury, Gary Tags: Research Source Type: research
