Economic evaluation of cemiplimab plus chemotherapy regimen for advanced non-small-cell lung cancer
Cemiplimab, a novel PD-1 inhibitor, exhibits significant antitumor activity against advanced non-small cell lung cancer (NSCLC). However, the cost-effectiveness of this drug for the treatment remains unclear. ... (Source: BMC Cancer)
Source: BMC Cancer - February 21, 2024 Category: Cancer & Oncology Authors: Yitian Lang, Yan Lin, Meng Deng and Xiaoyan Liu Tags: Research Source Type: research

USP14 exhibits high expression levels in hepatocellular carcinoma and plays a crucial role in promoting the growth of liver cancer cells through the HK2/AKT/P62 axis
Hepatocellular carcinoma (HCC) is a common malignant tumor with strong invasiveness and poor prognosis. Previous studies have demonstrated the significant role of USP14 in various solid tumors. However, the ro... (Source: BMC Cancer)
Source: BMC Cancer - February 21, 2024 Category: Cancer & Oncology Authors: Nannan Zhang, Hui Zhang, Xiaobing Yang, Qiang Xue, Quhui Wang, Renan Chang, Lirong Zhu, Zhong Chen and Xiancheng Liu Tags: Research Source Type: research

Long noncoding RNA TMPO-AS1 accelerates glycolysis by regulating the miR-1270/PKM2 axis in colorectal cancer
Long noncoding RNA thymopoietin-antisense RNA 1 (TMPO-AS1) is recognized as a participant in cancer progression. Nevertheless, its biological function in colorectal cancer remains obscure and needs further elu... (Source: BMC Cancer)
Source: BMC Cancer - February 21, 2024 Category: Cancer & Oncology Authors: Yingmin Jin, Aimin Jiang, Liying Sun and Yue Lu Tags: Research Source Type: research

PPARG activation promotes the proliferation of colorectal cancer cell lines and enhances the antiproliferative effect of 5-fluorouracil
Peroxisome proliferator-activated receptor gamma (PPARG) is a member of the nuclear receptor family. It is involved in the regulation of adipogenesis, lipid metabolism, insulin sensitivity, vascular homeostasi... (Source: BMC Cancer)
Source: BMC Cancer - February 20, 2024 Category: Cancer & Oncology Authors: Leah Sch öckel, Christine Woischke, Sai Agash Surendran, Marlies Michl, Tobias Schiergens, Andreas Hölscher, Florian Glass, Peter Kreissl, Frederick Klauschen, Michael Günther, Steffen Ormanns and Jens Neumann Tags: Research Source Type: research

Development of a nomogram for prediction of central lymph node metastasis of papillary thyroid microcarcinoma
Papillary thyroid carcinoma (PTC) is the most frequent malignant tumor in thyroid carcinoma. The aim of this study was to explore the risk factors associated with central lymph node metastasis in papillary thy... (Source: BMC Cancer)
Source: BMC Cancer - February 20, 2024 Category: Cancer & Oncology Authors: Pengjun Qiu, Qiaonan Guo, Kelun Pan and Jianqing Lin Tags: Research Source Type: research

The difference between dacomitinib and afatinib in effectiveness and safety in first-line treatment of patients with advanced EGFR-mutant non-small cell lung cancer: a real-world observational study
The irreversible epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) afatinib and dacomitinib are approved for first-line treatment of EGFR mutation-positive non-small cell lung cancer (NSCLC)... (Source: BMC Cancer)
Source: BMC Cancer - February 19, 2024 Category: Cancer & Oncology Authors: Wen-Chien Cheng, Chi-Chien Lin, Wei-Chih Liao, Yu-Chao Lin, Chia-Hung Chen, Hung-Jen Chen, Chih-Yen Tu and Te-Chun Hsia Tags: Research Source Type: research

Transcriptomics analysis revealed that TAZ regulates the proliferation of KIRC cells through mitophagy
Transcriptional Co-Activator with PDZ-Binding Motif (TAZ, also known as WWTR1) is a downstream effector of the Hippo pathway, involved in the regulation of organ regeneration and cell differentiation in proces... (Source: BMC Cancer)
Source: BMC Cancer - February 19, 2024 Category: Cancer & Oncology Authors: Zhen He, Jianxi Shi, Bing Zhu, Zhentao Tian and Zhihong Zhang Tags: Research Source Type: research

A multi-institutional randomized phase III study comparing minimally invasive distal pancreatectomy versus open distal pancreatectomy for pancreatic cancer; Japan Clinical Oncology Group study JCOG2202 (LAPAN study)
Minimally invasive distal pancreatectomy (MIDP), including laparoscopic and robotic distal pancreatectomy, has gained widespread acceptance over the last decade owing to its favorable short-term outcomes. Howe... (Source: BMC Cancer)
Source: BMC Cancer - February 19, 2024 Category: Cancer & Oncology Authors: Naoki Ikenaga, Tadayoshi Hashimoto, Junki Mizusawa, Ryo Kitabayashi, Yusuke Sano, Haruhiko Fukuda, Kohei Nakata, Kazuto Shibuya, Yuji Kitahata, Minoru Takada, Keiko Kamei, Hiroshi Kurahara, Daisuke Ban, Shogo Kobayashi, Hiroaki Nagano, Hajime Imamura & he Tags: Study Protocol Source Type: research

Using administrative registries as a source for population-based cancer incidence and mortality
(Source: BMC Cancer)
Source: BMC Cancer - February 19, 2024 Category: Cancer & Oncology Authors: C. Corredor, M. Pi ñeros, C. Wiesner and E. de Vries Tags: Correspondence Source Type: research

p90RSK pathway inhibition synergizes with cisplatin in TMEM16A overexpressing head and neck cancer
Head and neck squamous cell carcinoma (HNSCC) constitutes one of the most common types of human cancers and often metastasizes to lymph nodes. Platinum-based chemotherapeutic drugs are commonly used for treatm... (Source: BMC Cancer)
Source: BMC Cancer - February 19, 2024 Category: Cancer & Oncology Authors: Abdulkader Yassin-Kassab, Suman Chatterjee, Nayel Khan, Nathaniel Wang, Vlad C. Sandulache, Eric H-B. Huang, Timothy F. Burns and Umamaheswar Duvvuri Tags: Research Source Type: research

Establishment and external validation of prognosis prediction nomogram for patients with distant metastatic intrahepatic cholangiocarcinoma: based on a large population
Most patients with intrahepatic cholangiocarcinoma (ICC) have developed distant metastasis at the time of diagnosis, while there is rear related nomogram to predict the prognosis. (Source: BMC Cancer)
Source: BMC Cancer - February 16, 2024 Category: Cancer & Oncology Authors: Chen Yuan, Shubing Zou, Kai Wang and Zhigang Hu Tags: Research Source Type: research

Central nervous system metastases in breast cancer patients with germline BRCA pathogenic variants compared to non-carriers: a matched-pair analysis
Breast cancer is a common cause for central nervous system (CNS) metastasis, resulting in a significant reduction in overall survival. Germline pathogenic variants (PVs) in BRCA1/2 are the most common genetic ris... (Source: BMC Cancer)
Source: BMC Cancer - February 16, 2024 Category: Cancer & Oncology Authors: Matan Ben-Zion Berliner, Shlomit Yust-Katz, Inbar Lavie, Yael Goldberg, Inbal Kedar and Rinat Yerushalmi Tags: Research Source Type: research

MZ1, a BRD4 inhibitor, exerted its anti-cancer effects by suppressing SDC1 in glioblastoma
Glioblastoma (GBM) is a relatively prevalent primary tumor of the central nervous system in children, characterized by its high malignancy and mortality rates, along with the intricate challenges of achieving ... (Source: BMC Cancer)
Source: BMC Cancer - February 16, 2024 Category: Cancer & Oncology Authors: Gen Li, Liya Ma, Chenxi Feng, Hongli Yin, Jianping Bao, Di Wu, Zimu Zhang, Xiaolu Li, Zhiheng Li, Chun Yang, Hairong Wang, Fang Fang, Xiaohan Hu, Mei Li, Lixiao Xu, Yunyun Xu & hellip; Tags: Research Source Type: research

Translation and validation of a simplified Chinese version of the psychosocial assessment tool
The Psychosocial Assessment Tool (PAT2.0) is widely used to assess psychosocial risk in families of children with cancer. Our study aims to apply PAT2.0 to Chinese patients and assess the reliability, content ... (Source: BMC Cancer)
Source: BMC Cancer - February 16, 2024 Category: Cancer & Oncology Authors: Jun Kou, Ruiqi Wang, Yuxin Tang, Yi Tang and Yang Gao Tags: Research Source Type: research

Distinguishing IDH mutation status in gliomas using FTIR-ATR spectra of peripheral blood plasma indicating clear traces of protein amyloid aggregation
Glioma is a primary brain tumor and the assessment of its molecular profile in a minimally invasive manner is important in determining treatment strategies. Among the molecular abnormalities of gliomas, mutati... (Source: BMC Cancer)
Source: BMC Cancer - February 16, 2024 Category: Cancer & Oncology Authors: Saiko Kino, Masayuki Kanamori, Yoshiteru Shimoda, Kuniyasu Niizuma, Hidenori Endo and Yuji Matsuura Tags: Research Source Type: research