Synthetic biological neural networks: From current implementations to future perspectives
Biosystems. 2024 Feb 23:105164. doi: 10.1016/j.biosystems.2024.105164. Online ahead of print.ABSTRACTArtificial neural networks, inspired by the biological networks of the human brain, have become game-changing computing models in modern computer science. Inspired by their wide scope of applications, synthetic biology strives to create their biological counterparts, which we denote synthetic biological neural networks (SYNBIONNs). Their use in the fields of medicine, biosensors, biotechnology, and many more shows great potential and presents exciting possibilities. So far, many different synthetic biological networks have ...
Source: Biosystems - February 25, 2024 Category: Biotechnology Authors: Ana Halu žan Vasle Miha Mo škon Source Type: research
An efficient approach for identifying important biomarkers for biomedical diagnosis
Biosystems. 2024 Feb 22:105163. doi: 10.1016/j.biosystems.2024.105163. Online ahead of print.ABSTRACTIn this paper, we explore the challenges associated with biomarker identification for diagnosis purpose in biomedical experiments, and propose a novel approach to handle the above challenging scenario via the generalization of the Dantzig selector. To improve the efficiency of the regularization method, we introduce a transformation from an inherent nonlinear programming due to its nonlinear link function into a linear programming framework under a reasonable assumption on the logistic probability range. We illustrate the u...
Source: Biosystems - February 24, 2024 Category: Biotechnology Authors: Jing-Wen Huang Yan-Hong Chen Frederick Kin Hing Phoa Yan-Han Lin Shau-Ping Lin Source Type: research
Characterisation of the fig-fig wasp holobiont
Biosystems. 2024 Feb 21:105162. doi: 10.1016/j.biosystems.2024.105162. Online ahead of print.ABSTRACTPlants and animals have long been considered distinct kingdoms, yet here a hitherto undefined 'plant-animal' is described. In an extraordinary symbiosis in which neither organism can complete its lifecycle without the other, the fig tree (Ficus species) provides a habitat for its exclusive pollinator, the fig wasp (Agaonidae family). Characterisation of the 'fig-fig wasp holobiont' marks the first acknowledgement of plant-animal symbiogenesis.PMID:38395103 | DOI:10.1016/j.biosystems.2024.105162 (Source: Biosystems)
Source: Biosystems - February 23, 2024 Category: Biotechnology Authors: Praveen Prathapan Source Type: research
Characterisation of the fig-fig wasp holobiont
Biosystems. 2024 Feb 21:105162. doi: 10.1016/j.biosystems.2024.105162. Online ahead of print.ABSTRACTPlants and animals have long been considered distinct kingdoms, yet here a hitherto undefined 'plant-animal' is described. In an extraordinary symbiosis in which neither organism can complete its lifecycle without the other, the fig tree (Ficus species) provides a habitat for its exclusive pollinator, the fig wasp (Agaonidae family). Characterisation of the 'fig-fig wasp holobiont' marks the first acknowledgement of plant-animal symbiogenesis.PMID:38395103 | DOI:10.1016/j.biosystems.2024.105162 (Source: Biosystems)
Source: Biosystems - February 23, 2024 Category: Biotechnology Authors: Praveen Prathapan Source Type: research
Intrinsic growth rate and evolution of the Premnotrypes Vorax population using fuzzy information
In conclusion, given a weekly average temperature, it is possible to know the white potato worm population per unit area oscillating in an interval whose length depends on the degree of inaccuracy of the initial population and the intrinsic growth rate. This study can be relevant for grower decision making in terms of the type and frequency of pest control on his crop.PMID:38387806 | DOI:10.1016/j.biosystems.2024.105161 (Source: Biosystems)
Source: Biosystems - February 22, 2024 Category: Biotechnology Authors: Élder J Villamizar-Roa Leidy V Espitia-Cruz Gilberto Arenas-D íaz Source Type: research
Intrinsic growth rate and evolution of the Premnotrypes Vorax population using fuzzy information
In conclusion, given a weekly average temperature, it is possible to know the white potato worm population per unit area oscillating in an interval whose length depends on the degree of inaccuracy of the initial population and the intrinsic growth rate. This study can be relevant for grower decision making in terms of the type and frequency of pest control on his crop.PMID:38387806 | DOI:10.1016/j.biosystems.2024.105161 (Source: Biosystems)
Source: Biosystems - February 22, 2024 Category: Biotechnology Authors: Élder J Villamizar-Roa Leidy V Espitia-Cruz Gilberto Arenas-D íaz Source Type: research
Life, its definition, origin, evolution, and four-dimensional hierarchical structure
Biosystems. 2024 Feb 19:105158. doi: 10.1016/j.biosystems.2024.105158. Online ahead of print.ABSTRACTThe main unique features of biological systems are reviewed, and four necessary and sufficient attributes of life are formulated, based on the ideas of Ervin Bauer. The possibility of the occurrence of each of these attributes during the origin of life is analyzed. As a result, different scenarios for the origin of life are presented, with all their pros and cons. Next, the mainstream of biological evolution is discussed, considering it as a special case of general complexification, and structuredness is defined as a quanti...
Source: Biosystems - February 21, 2024 Category: Biotechnology Authors: George E Mikhailovsky Source Type: research
A global solution to a hyperbolic problem for blood flow modelling
Biosystems. 2024 Feb 19:105160. doi: 10.1016/j.biosystems.2024.105160. Online ahead of print.ABSTRACTThe paper aims to examine the hyperbolic system of equations governing one-dimensional haemodynamics and its relevance in analysing blood flow under mechanical influences, with particular emphasis on the impact of altering the angle of the leg axis. Methods and approaches for solving hyperbolic equations have been developed in light of their properties and characteristics. The primary objective of this study was to investigate the interplay between vein pressure, pulse wave velocity, and vascular distension. The study revea...
Source: Biosystems - February 21, 2024 Category: Biotechnology Authors: Nie Dayong Source Type: research
The time of appearance of the genetic code
Biosystems. 2024 Feb 17:105159. doi: 10.1016/j.biosystems.2024.105159. Online ahead of print.ABSTRACTI support the hypothesis that the origin of the genetic code occurred simultaneously with the evolution of cellularity. That is to say, I favour the hypothesis that the origin of the genetic code is a very, very late event in the history of life on Earth. I corroborate this hypothesis with observations favouring the progenote's stage for the Last Universal Common Ancestor (LUCA), for the ancestor of bacteria and that of archaea. Indeed, these progenotic stages would imply that - at that time - the origin of the genetic code...
Source: Biosystems - February 19, 2024 Category: Biotechnology Authors: Massimo Di Giulio Source Type: research
The time of appearance of the genetic code
Biosystems. 2024 Feb 17:105159. doi: 10.1016/j.biosystems.2024.105159. Online ahead of print.ABSTRACTI support the hypothesis that the origin of the genetic code occurred simultaneously with the evolution of cellularity. That is to say, I favour the hypothesis that the origin of the genetic code is a very, very late event in the history of life on Earth. I corroborate this hypothesis with observations favouring the progenote's stage for the Last Universal Common Ancestor (LUCA), for the ancestor of bacteria and that of archaea. Indeed, these progenotic stages would imply that - at that time - the origin of the genetic code...
Source: Biosystems - February 19, 2024 Category: Biotechnology Authors: Massimo Di Giulio Source Type: research
Collective durotaxis along a self-generated mobile stiffness gradient in vivo
Biosystems. 2024 Feb 15;237:105155. doi: 10.1016/j.biosystems.2024.105155. Online ahead of print.ABSTRACTA crucial aspect of tissue self-organization during morphogenesis, wound healing, and cancer invasion is directed migration of cell collectives. The majority of in vivo directed migration has been guided by chemotaxis, whereby cells follow a chemical gradient. In certain situations, migrating cell collectives can also self-generate the stiffness gradient in the surrounding tissue, which can have a feedback effect on the directionality of the migration. The phenomenon has been observed during collective durotaxis in vivo...
Source: Biosystems - February 17, 2024 Category: Biotechnology Authors: Ivana Pajic-Lijakovic Milan Milivojevic Source Type: research
Dissipative scaling of development and aging in multicellular organisms
Biosystems. 2024 Feb 15:105157. doi: 10.1016/j.biosystems.2024.105157. Online ahead of print.ABSTRACTEvolution, self-replication and ontogenesis are highly dynamic, irreversible and self-organizing processes dissipating energy. While progress has been made to decipher the role of thermodynamics in cellular fission, it is not yet clear how entropic balances shape organism growth and aging. This paper derives a general dissipation theory for the life-history of organisms. It implies a self-regulated entropy production facilitating exponential growth within a hierarchical and entropy lowering self-organization. The theory pre...
Source: Biosystems - February 17, 2024 Category: Biotechnology Authors: Andres Kriete Source Type: research
Collective durotaxis along a self-generated mobile stiffness gradient in vivo
Biosystems. 2024 Feb 15;237:105155. doi: 10.1016/j.biosystems.2024.105155. Online ahead of print.ABSTRACTA crucial aspect of tissue self-organization during morphogenesis, wound healing, and cancer invasion is directed migration of cell collectives. The majority of in vivo directed migration has been guided by chemotaxis, whereby cells follow a chemical gradient. In certain situations, migrating cell collectives can also self-generate the stiffness gradient in the surrounding tissue, which can have a feedback effect on the directionality of the migration. The phenomenon has been observed during collective durotaxis in vivo...
Source: Biosystems - February 17, 2024 Category: Biotechnology Authors: Ivana Pajic-Lijakovic Milan Milivojevic Source Type: research
Dissipative scaling of development and aging in multicellular organisms
Biosystems. 2024 Feb 15:105157. doi: 10.1016/j.biosystems.2024.105157. Online ahead of print.ABSTRACTEvolution, self-replication and ontogenesis are highly dynamic, irreversible and self-organizing processes dissipating energy. While progress has been made to decipher the role of thermodynamics in cellular fission, it is not yet clear how entropic balances shape organism growth and aging. This paper derives a general dissipation theory for the life-history of organisms. It implies a self-regulated entropy production facilitating exponential growth within a hierarchical and entropy lowering self-organization. The theory pre...
Source: Biosystems - February 17, 2024 Category: Biotechnology Authors: Andres Kriete Source Type: research
Fractal calculus in tumor growth simulations: The proof is in the pudding
Biosystems. 2024 Feb 12;237:105141. doi: 10.1016/j.biosystems.2024.105141. Online ahead of print.ABSTRACTMathematical modeling in oncology has a long history. Recently, mathematical models and their predictions have made inroads into prospective clinical trials with encouraging results. The goal of many such modeling efforts is to make predictions, either to clinician's choice therapy or into "optimal" therapy - often for individual patients. The mathematical oncology community rightfully puts great hope into predictive modeling and mechanistic digital twins - but with this great opportunity comes great responsibility. Mat...
Source: Biosystems - February 14, 2024 Category: Biotechnology Authors: Heiko Enderling Source Type: research
