COVID-19 spatio-temporal forecast in England
This study describes a novel bio-system reliability spatio-temporal approach, that is especially appropriate for multi-regional environmental, biological and health systems and that, when observed for a sufficient amount of time, produces a reliable long-term forecast of the likelihood of an outbreak of a highly pathogenic virus. Conventional statistical approaches do not have the benefit of effectively handling large regional dimensionality and cross-correlation between various regional observations. These methods deal with temporal observations of multi-regional phenomena. The most afflicted districts of England's COVID-...
Source: Biosystems - September 22, 2023 Category: Biotechnology Authors: Oleg Gaidai Vladimir Yakimov Fuxi Zhang Source Type: research
Diving into cancer OXPHOS - The application of metabolic control analysis to cell and tissue research
Biosystems. 2023 Sep 20:105032. doi: 10.1016/j.biosystems.2023.105032. Online ahead of print.ABSTRACTKnowing how the oxidative phosphorylation (OXPHOS) system in cancer cells operates differently from that of normal cells would help find compounds that specifically paralyze the energy metabolism of cancer cells. The first experiments in the study of mitochondrial respiration using the metabolic control analysis (MCA) method were done with isolated liver mitochondria in the early 80s of the last century. Subsequent studies have shown that the regulation of mitochondrial respiration by ADP in isolated mitochondria differs si...
Source: Biosystems - September 22, 2023 Category: Biotechnology Authors: Marju Puurand Kersti Tepp Tuuli K äämbre Source Type: research
How ambiguity codes specify molecular descriptors and information flow in Code Biology
Biosystems. 2023 Sep 20:105034. doi: 10.1016/j.biosystems.2023.105034. Online ahead of print.ABSTRACTThe aritcle presents IUPAC ambiguity codes for incomplete nucleic acid specification, and their use in Code Biology. It is shown how to use this nomenclature in order to extract accurate information on different properties of the biological systems. We investigated the use of ambiguity codes, as mathematical and logical operators and truth table elements, for the encoding of amino acids by means of the Standard Genetic Code. It is explained how to use ambiguity codes and truth functions in order to obtain accurate informati...
Source: Biosystems - September 22, 2023 Category: Biotechnology Authors: Nikola Štambuk Pa ško Konjevoda Albert Štambuk Source Type: research
COVID-19 spatio-temporal forecast in England
This study describes a novel bio-system reliability spatio-temporal approach, that is especially appropriate for multi-regional environmental, biological and health systems and that, when observed for a sufficient amount of time, produces a reliable long-term forecast of the likelihood of an outbreak of a highly pathogenic virus. Conventional statistical approaches do not have the benefit of effectively handling large regional dimensionality and cross-correlation between various regional observations. These methods deal with temporal observations of multi-regional phenomena. The most afflicted districts of England's COVID-...
Source: Biosystems - September 22, 2023 Category: Biotechnology Authors: Oleg Gaidai Vladimir Yakimov Fuxi Zhang Source Type: research
Is Darwinian selection a retrograde driving force of evolution?
Biosystems. 2023 Sep 19:105031. doi: 10.1016/j.biosystems.2023.105031. Online ahead of print.ABSTRACTModern science has still not provided a satisfactory empirical explanation for the increasing complexity of living organisms through evolutionary history. As no agreed-upon definitions of the complexity exist, the working definition of biological complexity has been formulated. There is no theoretical reason to expect evolutionary lineages to increase in complexity over time, and there is no empirical evidence that they do so. In our discussion we have assumed the hypothesis that at the origins of life, evolution had to fir...
Source: Biosystems - September 21, 2023 Category: Biotechnology Authors: Marko Vitas Andrej Dobovi šek Source Type: research
