Ervin Bauer's concept of biological thermodynamics and its different evaluations
Biosystems. 2023 Nov 24:105090. doi: 10.1016/j.biosystems.2023.105090. Online ahead of print.ABSTRACTThe development of biological concepts in the 19th century was followed by the emergence of approaches to formulate the principles of theoretical biology. Ervin Bauer in 1920, and in more detail in 1935, suggested the basic principle that can be accepted as the fundamental law of biology: "The living systems are never in equilibrium; at the expense of their free energy they constantly perform work to avoid the equilibrium required by the laws of physics and chemistry under existing external conditions." Many researchers int...
Source: Biosystems - November 26, 2023 Category: Biotechnology Authors: G ábor Elek Mikl ós Müller Source Type: research
Biological thermodynamics: Ervin Bauer and the unification of life sciences and physics
Biosystems. 2023 Nov 22:105089. doi: 10.1016/j.biosystems.2023.105089. Online ahead of print.ABSTRACTBiological systems operate toward the maximization of their self-maintenance and adaptability. This is achieved through the establishment of robust self-maintaining configurations acting as attractors resistant to external and internal perturbations. Ervin Bauer (1890-1938) was the first who formulated this essential thermodynamic constraint in the operation of biological systems, which he defined as the stable non-equilibrium state. The latter appears as the basic attractor relative to which biological organization is esta...
Source: Biosystems - November 24, 2023 Category: Biotechnology Authors: Abir U Igamberdiev Source Type: research
A new mathematical model of folate homeostasis in E. coli highlights the potential importance of the folinic acid futile cycle in cell growth
Biosystems. 2023 Nov 23;235:105088. doi: 10.1016/j.biosystems.2023.105088. Online ahead of print.ABSTRACTFolate (vitamin B9) plays a central role in one-carbon metabolism in prokaryotes and eukaryotes. This pathway mediates the transfer of one-carbon units, playing a crucial role in nucleotide synthesis, methylation, and amino acid homeostasis. The folinic acid futile cycle adds a layer of intrigue to this pathway, due to its associations with metabolism, cell growth, and dormancy. It also introduces additional complexity to folate metabolism. A logical way to deal with such complexity is to examine it by using mathematica...
Source: Biosystems - November 24, 2023 Category: Biotechnology Authors: Amy E Morgan J Enrique Salcedo-Sora Mark T Mc Auley Source Type: research
Biological thermodynamics: Ervin Bauer and the unification of life sciences and physics
Biosystems. 2023 Nov 22:105089. doi: 10.1016/j.biosystems.2023.105089. Online ahead of print.ABSTRACTBiological systems operate toward the maximization of their self-maintenance and adaptability. This is achieved through the establishment of robust self-maintaining configurations acting as attractors resistant to external and internal perturbations. Ervin Bauer (1890-1938) was the first who formulated this essential thermodynamic constraint in the operation of biological systems, which he defined as the stable non-equilibrium state. The latter appears as the basic attractor relative to which biological organization is esta...
Source: Biosystems - November 24, 2023 Category: Biotechnology Authors: Abir U Igamberdiev Source Type: research
A new mathematical model of folate homeostasis in E. coli highlights the potential importance of the futile cycle of folinic acid in cell growth
Biosystems. 2023 Nov 22:105088. doi: 10.1016/j.biosystems.2023.105088. Online ahead of print.ABSTRACTFolate (vitamin B9) plays a central role in one-carbon metabolism in prokaryotes and eukaryotes. This pathway mediates the transfer of one-carbon units, playing a crucial role in nucleotide synthesis, methylation, and amino acid homeostasis. The folinic acid futile cycle adds a layer of intrigue to this pathway, due to its associations with metabolism, cell growth, and dormancy. It also introduces additional complexity to folate metabolism. A logical way to deal with such complexity is to examine it by using mathematical mo...
Source: Biosystems - November 24, 2023 Category: Biotechnology Authors: Amy E Morgan J Enrique Salcedo-Sora Mark T Mc Auley Source Type: research
Endless forms of endless formation - Revisiting the morphogenesis of organisms and scientific objects
In conclusion, I propose a tentative mapping between each of these five connotations and the biological processes at work in their making, which are, respectively: 1) copying organic information; coding organic signs; manufacturing organic meaning 2) natural variation, natural selection, natural conventions; 3) multilevel organization, differentiation/development, complexity; 4) ambiguity, degeneracy, semiotic thresholds; 5) homeostasis, autopoiesis, codepoiesis. The processes discussed here gained salience as developments, additions, or nuances to Darwin's original theory. It must be noted that, even though the discussion...
Source: Biosystems - November 21, 2023 Category: Biotechnology Authors: Marcella Faria Source Type: research
Synthetic model ecosystem of 12 cryopreservable microbial species allowing for a noninvasive approach
Biosystems. 2023 Nov 19:105087. doi: 10.1016/j.biosystems.2023.105087. Online ahead of print.ABSTRACTSimultaneous understanding of both population and ecosystem dynamics is crucial in an era marked by the degradation of ecosystem services. Experimental ecosystems are a powerful tool for understanding these dynamics; however, they often face technical challenges, typically falling into two categories: "complex but with limited replicability microcosms" and "highly replicable but overly simplistic microcosms." Herein, we present a high-throughput synthetic microcosm system comprising 12 functionally and phylogenetically dive...
Source: Biosystems - November 21, 2023 Category: Biotechnology Authors: Kazufumi Hosoda Shigeto Seno Naomi Murakami Hideo Matsuda Yutaka Osada Rikuto Kamiura Michio Kondoh Source Type: research
Endless forms of endless formation - Revisiting the morphogenesis of organisms and scientific objects
In conclusion, I propose a tentative mapping between each of these five connotations and the biological processes at work in their making, which are, respectively: 1) copying organic information; coding organic signs; manufacturing organic meaning 2) natural variation, natural selection, natural conventions; 3) multilevel organization, differentiation/development, complexity; 4) ambiguity, degeneracy, semiotic thresholds; 5) homeostasis, autopoiesis, codepoiesis. The processes discussed here gained salience as developments, additions, or nuances to Darwin's original theory. It must be noted that, even though the discussion...
Source: Biosystems - November 21, 2023 Category: Biotechnology Authors: Marcella Faria Source Type: research
Synthetic model ecosystem of 12 cryopreservable microbial species allowing for a noninvasive approach
Biosystems. 2023 Nov 19:105087. doi: 10.1016/j.biosystems.2023.105087. Online ahead of print.ABSTRACTSimultaneous understanding of both population and ecosystem dynamics is crucial in an era marked by the degradation of ecosystem services. Experimental ecosystems are a powerful tool for understanding these dynamics; however, they often face technical challenges, typically falling into two categories: "complex but with limited replicability microcosms" and "highly replicable but overly simplistic microcosms." Herein, we present a high-throughput synthetic microcosm system comprising 12 functionally and phylogenetically dive...
Source: Biosystems - November 21, 2023 Category: Biotechnology Authors: Kazufumi Hosoda Shigeto Seno Naomi Murakami Hideo Matsuda Yutaka Osada Rikuto Kamiura Michio Kondoh Source Type: research
Endless forms of endless formation - Revisiting the morphogenesis of organisms and scientific objects
In conclusion, I propose a tentative mapping between each of these five connotations and the biological processes at work in their making, which are, respectively: 1) copying organic information; coding organic signs; manufacturing organic meaning 2) natural variation, natural selection, natural conventions; 3) multilevel organization, differentiation/development, complexity; 4) ambiguity, degeneracy, semiotic thresholds; 5) homeostasis, autopoiesis, codepoiesis. The processes discussed here gained salience as developments, additions, or nuances to Darwin's original theory. It must be noted that, even though the discussion...
Source: Biosystems - November 21, 2023 Category: Biotechnology Authors: Marcella Faria Source Type: research
Synthetic model ecosystem of 12 cryopreservable microbial species allowing for a noninvasive approach
Biosystems. 2023 Nov 19:105087. doi: 10.1016/j.biosystems.2023.105087. Online ahead of print.ABSTRACTSimultaneous understanding of both population and ecosystem dynamics is crucial in an era marked by the degradation of ecosystem services. Experimental ecosystems are a powerful tool for understanding these dynamics; however, they often face technical challenges, typically falling into two categories: "complex but with limited replicability microcosms" and "highly replicable but overly simplistic microcosms." Herein, we present a high-throughput synthetic microcosm system comprising 12 functionally and phylogenetically dive...
Source: Biosystems - November 21, 2023 Category: Biotechnology Authors: Kazufumi Hosoda Shigeto Seno Naomi Murakami Hideo Matsuda Yutaka Osada Rikuto Kamiura Michio Kondoh Source Type: research
50 years of Metabolic Control Analysis: Its past and current influence in the biological sciences
Biosystems. 2023 Nov 16:105086. doi: 10.1016/j.biosystems.2023.105086. Online ahead of print.NO ABSTRACTPMID:37979831 | DOI:10.1016/j.biosystems.2023.105086 (Source: Biosystems)
Source: Biosystems - November 18, 2023 Category: Biotechnology Authors: David A Fell Emma Saavedra Johann Rohwer Source Type: research
50 years of Metabolic Control Analysis: Its past and current influence in the biological sciences
Biosystems. 2023 Nov 16:105086. doi: 10.1016/j.biosystems.2023.105086. Online ahead of print.NO ABSTRACTPMID:37979831 | DOI:10.1016/j.biosystems.2023.105086 (Source: Biosystems)
Source: Biosystems - November 18, 2023 Category: Biotechnology Authors: David A Fell Emma Saavedra Johann Rohwer Source Type: research
50 years of Metabolic Control Analysis: Its past and current influence in the biological sciences
Biosystems. 2023 Nov 16:105086. doi: 10.1016/j.biosystems.2023.105086. Online ahead of print.NO ABSTRACTPMID:37979831 | DOI:10.1016/j.biosystems.2023.105086 (Source: Biosystems)
Source: Biosystems - November 18, 2023 Category: Biotechnology Authors: David A Fell Emma Saavedra Johann Rohwer Source Type: research
Gaidai reliability method for high-dimensional spatio-temporal biosystems
This study presents novel methodology for pandemic risks assessment for a national health system of interest. The 2019 coronavirus disease (COVID-19) is a contagious disease with certain potential for worldwide spread and potentially significant effects on public health globally. Suggested methodology enables risks assessment of an epidemic, that may happen in the near future at any time, and in any national region of interest. Traditional spatio-temporal reliability methodologies do not have benefit of easily handling health system's high-dimensionality and complex cross-correlations between regional observations. Contrar...
Source: Biosystems - November 15, 2023 Category: Biotechnology Authors: Oleg Gaidai Vladimir Yakimov Yuhao Niu Zirui Liu Source Type: research
