Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Auton Neurosci. 2023 Apr 29;247:103095. doi: 10.1016/j.autneu.2023.103095. Online ahead of print.ABSTRACTTransient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O2 ...
Source: Autonomic Neuroscience - May 5, 2023 Category: Neuroscience Authors: Katherine R Langen Heather A Dantzler Procopio Gama de Barcellos-Filho David D Kline Source Type: research
Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Auton Neurosci. 2023 Apr 29;247:103095. doi: 10.1016/j.autneu.2023.103095. Online ahead of print.ABSTRACTTransient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O2 ...
Source: Autonomic Neuroscience - May 5, 2023 Category: Neuroscience Authors: Katherine R Langen Heather A Dantzler Procopio Gama de Barcellos-Filho David D Kline Source Type: research
Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Auton Neurosci. 2023 Apr 29;247:103095. doi: 10.1016/j.autneu.2023.103095. Online ahead of print.ABSTRACTTransient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O2 ...
Source: Autonomic Neuroscience - May 5, 2023 Category: Neuroscience Authors: Katherine R Langen Heather A Dantzler Procopio Gama de Barcellos-Filho David D Kline Source Type: research
Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Auton Neurosci. 2023 Apr 29;247:103095. doi: 10.1016/j.autneu.2023.103095. Online ahead of print.ABSTRACTTransient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O2 ...
Source: Autonomic Neuroscience - May 5, 2023 Category: Neuroscience Authors: Katherine R Langen Heather A Dantzler Procopio Gama de Barcellos-Filho David D Kline Source Type: research
Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Auton Neurosci. 2023 Apr 29;247:103095. doi: 10.1016/j.autneu.2023.103095. Online ahead of print.ABSTRACTTransient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O2 ...
Source: Autonomic Neuroscience - May 5, 2023 Category: Neuroscience Authors: Katherine R Langen Heather A Dantzler Procopio Gama de Barcellos-Filho David D Kline Source Type: research
Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Auton Neurosci. 2023 Apr 29;247:103095. doi: 10.1016/j.autneu.2023.103095. Online ahead of print.ABSTRACTTransient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O2 ...
Source: Autonomic Neuroscience - May 5, 2023 Category: Neuroscience Authors: Katherine R Langen Heather A Dantzler Procopio Gama de Barcellos-Filho David D Kline Source Type: research
Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Auton Neurosci. 2023 Apr 29;247:103095. doi: 10.1016/j.autneu.2023.103095. Online ahead of print.ABSTRACTTransient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O2 ...
Source: Autonomic Neuroscience - May 5, 2023 Category: Neuroscience Authors: Katherine R Langen Heather A Dantzler Procopio Gama de Barcellos-Filho David D Kline Source Type: research
Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Auton Neurosci. 2023 Apr 29;247:103095. doi: 10.1016/j.autneu.2023.103095. Online ahead of print.ABSTRACTTransient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O2 ...
Source: Autonomic Neuroscience - May 5, 2023 Category: Neuroscience Authors: Katherine R Langen Heather A Dantzler Procopio Gama de Barcellos-Filho David D Kline Source Type: research
Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Auton Neurosci. 2023 Apr 29;247:103095. doi: 10.1016/j.autneu.2023.103095. Online ahead of print.ABSTRACTTransient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O2 ...
Source: Autonomic Neuroscience - May 5, 2023 Category: Neuroscience Authors: Katherine R Langen Heather A Dantzler Procopio Gama de Barcellos-Filho David D Kline Source Type: research
Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Auton Neurosci. 2023 Apr 29;247:103095. doi: 10.1016/j.autneu.2023.103095. Online ahead of print.ABSTRACTTransient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O2 ...
Source: Autonomic Neuroscience - May 5, 2023 Category: Neuroscience Authors: Katherine R Langen Heather A Dantzler Procopio Gama de Barcellos-Filho David D Kline Source Type: research
Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Auton Neurosci. 2023 Apr 29;247:103095. doi: 10.1016/j.autneu.2023.103095. Online ahead of print.ABSTRACTTransient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O2 ...
Source: Autonomic Neuroscience - May 5, 2023 Category: Neuroscience Authors: Katherine R Langen Heather A Dantzler Procopio Gama de Barcellos-Filho David D Kline Source Type: research
Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Auton Neurosci. 2023 Apr 29;247:103095. doi: 10.1016/j.autneu.2023.103095. Online ahead of print.ABSTRACTTransient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O2 ...
Source: Autonomic Neuroscience - May 5, 2023 Category: Neuroscience Authors: Katherine R Langen Heather A Dantzler Procopio Gama de Barcellos-Filho David D Kline Source Type: research
Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons
Auton Neurosci. 2023 Apr 29;247:103095. doi: 10.1016/j.autneu.2023.103095. Online ahead of print.ABSTRACTTransient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory neurons, and its influence is elevated following hypoxia. Rats were exposed to either room air (normoxia), 24-h of 10 % O2 ...
Source: Autonomic Neuroscience - May 5, 2023 Category: Neuroscience Authors: Katherine R Langen Heather A Dantzler Procopio Gama de Barcellos-Filho David D Kline Source Type: research
Exaggerated blood pressure elevation in response to orthostatic challenge, a post-acute sequelae of SARS-CoV-2 infection (PASC) after hospitalization
CONCLUSIONS: This prospective evaluation in patients with PASC revealed abnormal blood pressure rise during the orthostatic challenge, suggesting of autonomic dysfunction in a third of the studied subjects. Our findings support the hypothesis that EOPR/OHT may be a phenotype of neurogenic hypertension. Hypertension in PASC patients may adversely affect the cardiovascular burden in the world.PMID:37137186 | PMC:PMC10121145 | DOI:10.1016/j.autneu.2023.103094 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - May 3, 2023 Category: Neuroscience Authors: J Antonio Gonz ález-Hermosillo G Esteban Jorge Galarza Onasis Vicente Ferm ín Jos é Manuel Núñez González Lucia Mariel F élix Álvarez Tostado Marco Antonio Estrada Lozano Claudia Ru íz Rabasa Mar ía Del Rocio Martínez Alvarado Source Type: research
Exaggerated blood pressure elevation in response to orthostatic challenge, a post-acute sequelae of SARS-CoV-2 infection (PASC) after hospitalization
CONCLUSIONS: This prospective evaluation in patients with PASC revealed abnormal blood pressure rise during the orthostatic challenge, suggesting of autonomic dysfunction in a third of the studied subjects. Our findings support the hypothesis that EOPR/OHT may be a phenotype of neurogenic hypertension. Hypertension in PASC patients may adversely affect the cardiovascular burden in the world.PMID:37137186 | PMC:PMC10121145 | DOI:10.1016/j.autneu.2023.103094 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - May 3, 2023 Category: Neuroscience Authors: J Antonio Gonz ález-Hermosillo G Esteban Jorge Galarza Onasis Vicente Ferm ín Jos é Manuel Núñez González Lucia Mariel F élix Álvarez Tostado Marco Antonio Estrada Lozano Claudia Ru íz Rabasa Mar ía Del Rocio Martínez Alvarado Source Type: research
