Dynamic changes in renal sodium handling during sympathetic stimulation in healthy human males
CONCLUSION: Sympathetic stimulation for 90 min via LBNP at -30 mmHg LBNP compared to -15 mmHg did not result in a greater response in fractional Na+ excretion, suggesting that additional baroreceptor unloading did not cause further increases in renal sodium reabsorption. Changes in distal Na+ excretion were linear with respect to time (dose) of intervention, but seem to exhibit a saturation-like effect at a level around 4 %. The lack of recovery after 1 h is also a new finding that warrants further investigation.PMID:37984257 | DOI:10.1016/j.autneu.2023.103131 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - November 20, 2023 Category: Neuroscience Authors: J C G Petersen T E N Jonassen N-H Holstein-Rathlou L G Petersen C M Sorensen Source Type: research
Dynamic changes in renal sodium handling during sympathetic stimulation in healthy human males
CONCLUSION: Sympathetic stimulation for 90 min via LBNP at -30 mmHg LBNP compared to -15 mmHg did not result in a greater response in fractional Na+ excretion, suggesting that additional baroreceptor unloading did not cause further increases in renal sodium reabsorption. Changes in distal Na+ excretion were linear with respect to time (dose) of intervention, but seem to exhibit a saturation-like effect at a level around 4 %. The lack of recovery after 1 h is also a new finding that warrants further investigation.PMID:37984257 | DOI:10.1016/j.autneu.2023.103131 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - November 20, 2023 Category: Neuroscience Authors: J C G Petersen T E N Jonassen N-H Holstein-Rathlou L G Petersen C M Sorensen Source Type: research
Dynamic changes in renal sodium handling during sympathetic stimulation in healthy human males
CONCLUSION: Sympathetic stimulation for 90 min via LBNP at -30 mmHg LBNP compared to -15 mmHg did not result in a greater response in fractional Na+ excretion, suggesting that additional baroreceptor unloading did not cause further increases in renal sodium reabsorption. Changes in distal Na+ excretion were linear with respect to time (dose) of intervention, but seem to exhibit a saturation-like effect at a level around 4 %. The lack of recovery after 1 h is also a new finding that warrants further investigation.PMID:37984257 | DOI:10.1016/j.autneu.2023.103131 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - November 20, 2023 Category: Neuroscience Authors: J C G Petersen T E N Jonassen N-H Holstein-Rathlou L G Petersen C M Sorensen Source Type: research
Validation of symptom measures in patients under investigation for postural orthostatic tachycardia syndrome (POTS): The Orthostatic Grading Scale (OGS) and the Symptom Screen for Small-fiber Polyneuropathy (SSS)
CONCLUSIONS: Initial evidence suggests that the OGS and SSS have good psychometric properties for use in populations with suspected and confirmed POTS.PMID:37976608 | DOI:10.1016/j.autneu.2023.103130 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - November 17, 2023 Category: Neuroscience Authors: Iris Knoop Annie S K Jones Nicholas Gall Joseph Chilcot William Pascoe Rona Moss-Morris Source Type: research
Validation of symptom measures in patients under investigation for postural orthostatic tachycardia syndrome (POTS): The Orthostatic Grading Scale (OGS) and the Symptom Screen for Small-fiber Polyneuropathy (SSS)
CONCLUSIONS: Initial evidence suggests that the OGS and SSS have good psychometric properties for use in populations with suspected and confirmed POTS.PMID:37976608 | DOI:10.1016/j.autneu.2023.103130 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - November 17, 2023 Category: Neuroscience Authors: Iris Knoop Annie S K Jones Nicholas Gall Joseph Chilcot William Pascoe Rona Moss-Morris Source Type: research
Validation of symptom measures in patients under investigation for postural orthostatic tachycardia syndrome (POTS): The Orthostatic Grading Scale (OGS) and the Symptom Screen for Small-fiber Polyneuropathy (SSS)
CONCLUSIONS: Initial evidence suggests that the OGS and SSS have good psychometric properties for use in populations with suspected and confirmed POTS.PMID:37976608 | DOI:10.1016/j.autneu.2023.103130 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - November 17, 2023 Category: Neuroscience Authors: Iris Knoop Annie S K Jones Nicholas Gall Joseph Chilcot William Pascoe Rona Moss-Morris Source Type: research
Targeted stimulation of the vagus nerve reduces renal injury in female mice with systemic lupus erythematosus
Auton Neurosci. 2023 Nov 1;250:103129. doi: 10.1016/j.autneu.2023.103129. Online ahead of print.ABSTRACTPharmacological stimulation of the vagus nerve has been shown to suppress inflammation and reduce blood pressure in a murine model of systemic lupus erythematosus (SLE) that is characterized by hypertension, inflammation, renal injury and dysautonomia. The present study aims to directly stimulate vagal nerves at the level of the dorsal motor nucleus of the vagus (DMV) using designer receptors exclusively activated by designer drugs (DREADDs) to determine if there is similar protection and confirm mechanism. Female NZBWF1...
Source: Autonomic Neuroscience - November 11, 2023 Category: Neuroscience Authors: Caroline Gusson Shimoura Cassandra Y Stubbs Sarika Chaudhari Viet Q Dinh Keisa W Mathis Source Type: research
Targeted stimulation of the vagus nerve reduces renal injury in female mice with systemic lupus erythematosus
Auton Neurosci. 2023 Nov 1;250:103129. doi: 10.1016/j.autneu.2023.103129. Online ahead of print.ABSTRACTPharmacological stimulation of the vagus nerve has been shown to suppress inflammation and reduce blood pressure in a murine model of systemic lupus erythematosus (SLE) that is characterized by hypertension, inflammation, renal injury and dysautonomia. The present study aims to directly stimulate vagal nerves at the level of the dorsal motor nucleus of the vagus (DMV) using designer receptors exclusively activated by designer drugs (DREADDs) to determine if there is similar protection and confirm mechanism. Female NZBWF1...
Source: Autonomic Neuroscience - November 11, 2023 Category: Neuroscience Authors: Caroline Gusson Shimoura Cassandra Y Stubbs Sarika Chaudhari Viet Q Dinh Keisa W Mathis Source Type: research
Targeted stimulation of the vagus nerve reduces renal injury in female mice with systemic lupus erythematosus
Auton Neurosci. 2023 Nov 1;250:103129. doi: 10.1016/j.autneu.2023.103129. Online ahead of print.ABSTRACTPharmacological stimulation of the vagus nerve has been shown to suppress inflammation and reduce blood pressure in a murine model of systemic lupus erythematosus (SLE) that is characterized by hypertension, inflammation, renal injury and dysautonomia. The present study aims to directly stimulate vagal nerves at the level of the dorsal motor nucleus of the vagus (DMV) using designer receptors exclusively activated by designer drugs (DREADDs) to determine if there is similar protection and confirm mechanism. Female NZBWF1...
Source: Autonomic Neuroscience - November 11, 2023 Category: Neuroscience Authors: Caroline Gusson Shimoura Cassandra Y Stubbs Sarika Chaudhari Viet Q Dinh Keisa W Mathis Source Type: research
Targeted stimulation of the vagus nerve reduces renal injury in female mice with systemic lupus erythematosus
Auton Neurosci. 2023 Nov 1;250:103129. doi: 10.1016/j.autneu.2023.103129. Online ahead of print.ABSTRACTPharmacological stimulation of the vagus nerve has been shown to suppress inflammation and reduce blood pressure in a murine model of systemic lupus erythematosus (SLE) that is characterized by hypertension, inflammation, renal injury and dysautonomia. The present study aims to directly stimulate vagal nerves at the level of the dorsal motor nucleus of the vagus (DMV) using designer receptors exclusively activated by designer drugs (DREADDs) to determine if there is similar protection and confirm mechanism. Female NZBWF1...
Source: Autonomic Neuroscience - November 11, 2023 Category: Neuroscience Authors: Caroline Gusson Shimoura Cassandra Y Stubbs Sarika Chaudhari Viet Q Dinh Keisa W Mathis Source Type: research
Targeted stimulation of the vagus nerve reduces renal injury in female mice with systemic lupus erythematosus
Auton Neurosci. 2023 Nov 1;250:103129. doi: 10.1016/j.autneu.2023.103129. Online ahead of print.ABSTRACTPharmacological stimulation of the vagus nerve has been shown to suppress inflammation and reduce blood pressure in a murine model of systemic lupus erythematosus (SLE) that is characterized by hypertension, inflammation, renal injury and dysautonomia. The present study aims to directly stimulate vagal nerves at the level of the dorsal motor nucleus of the vagus (DMV) using designer receptors exclusively activated by designer drugs (DREADDs) to determine if there is similar protection and confirm mechanism. Female NZBWF1...
Source: Autonomic Neuroscience - November 11, 2023 Category: Neuroscience Authors: Caroline Gusson Shimoura Cassandra Y Stubbs Sarika Chaudhari Viet Q Dinh Keisa W Mathis Source Type: research
Mechanosensitive channels in the mechanical component of the exercise pressor reflex
Auton Neurosci. 2023 Oct 29;250:103128. doi: 10.1016/j.autneu.2023.103128. Online ahead of print.ABSTRACTThe cardiovascular response is appropriately regulated during exercise to meet the metabolic demands of the active muscles. The exercise pressor reflex is a neural feedback mechanism through thin-fiber muscle afferents activated by mechanical and metabolic stimuli in the active skeletal muscles. The mechanical component of this reflex is referred to as skeletal muscle mechanoreflex. Its initial step requires mechanotransduction mediated by mechanosensors, which convert mechanical stimuli into biological signals. Recentl...
Source: Autonomic Neuroscience - November 5, 2023 Category: Neuroscience Authors: Amane Hori Ayumi Fukazawa Kimiaki Katanosaka Masaki Mizuno Norio Hotta Source Type: research
Mechanosensitive channels in the mechanical component of the exercise pressor reflex
Auton Neurosci. 2023 Oct 29;250:103128. doi: 10.1016/j.autneu.2023.103128. Online ahead of print.ABSTRACTThe cardiovascular response is appropriately regulated during exercise to meet the metabolic demands of the active muscles. The exercise pressor reflex is a neural feedback mechanism through thin-fiber muscle afferents activated by mechanical and metabolic stimuli in the active skeletal muscles. The mechanical component of this reflex is referred to as skeletal muscle mechanoreflex. Its initial step requires mechanotransduction mediated by mechanosensors, which convert mechanical stimuli into biological signals. Recentl...
Source: Autonomic Neuroscience - November 5, 2023 Category: Neuroscience Authors: Amane Hori Ayumi Fukazawa Kimiaki Katanosaka Masaki Mizuno Norio Hotta Source Type: research
Mechanosensitive channels in the mechanical component of the exercise pressor reflex
Auton Neurosci. 2023 Oct 29;250:103128. doi: 10.1016/j.autneu.2023.103128. Online ahead of print.ABSTRACTThe cardiovascular response is appropriately regulated during exercise to meet the metabolic demands of the active muscles. The exercise pressor reflex is a neural feedback mechanism through thin-fiber muscle afferents activated by mechanical and metabolic stimuli in the active skeletal muscles. The mechanical component of this reflex is referred to as skeletal muscle mechanoreflex. Its initial step requires mechanotransduction mediated by mechanosensors, which convert mechanical stimuli into biological signals. Recentl...
Source: Autonomic Neuroscience - November 5, 2023 Category: Neuroscience Authors: Amane Hori Ayumi Fukazawa Kimiaki Katanosaka Masaki Mizuno Norio Hotta Source Type: research
Mechanosensitive channels in the mechanical component of the exercise pressor reflex
Auton Neurosci. 2023 Oct 29;250:103128. doi: 10.1016/j.autneu.2023.103128. Online ahead of print.ABSTRACTThe cardiovascular response is appropriately regulated during exercise to meet the metabolic demands of the active muscles. The exercise pressor reflex is a neural feedback mechanism through thin-fiber muscle afferents activated by mechanical and metabolic stimuli in the active skeletal muscles. The mechanical component of this reflex is referred to as skeletal muscle mechanoreflex. Its initial step requires mechanotransduction mediated by mechanosensors, which convert mechanical stimuli into biological signals. Recentl...
Source: Autonomic Neuroscience - November 5, 2023 Category: Neuroscience Authors: Amane Hori Ayumi Fukazawa Kimiaki Katanosaka Masaki Mizuno Norio Hotta Source Type: research
