Small fiber neuropathy in children, adolescents, and young adults with chronic orthostatic intolerance and postural orthostatic tachycardia syndrome: A retrospective study
CONCLUSION: Our data suggest a link between OI and POTS and small fiber neuropathy. Small fiber neuropathy was found by skin biopsy in over half of the patients tested. OI and Postural orthostatic tachycardia patients with small fiber neuropathy expressed multiple markers suggesting an underlying autoimmune or inflammatory process. Future research will be done to evaluate the symptomatic implication of SFN and whether immune or pharmacologic manipulation can alter patient symptoms.PMID:38537312 | DOI:10.1016/j.autneu.2024.103163 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - March 27, 2024 Category: Neuroscience Authors: Jeffrey P Moak Carolyn B Ramwell Heather Gordish-Dressman Sangeeta D Sule Elizabeth Bettini Source Type: research
Vagus nerve stimulation alleviates cardiac dysfunction and inflammatory markers during heart failure in rats
This study aimed to investigate its therapeutic effects on three main components of heart failure: cardiac function, cardiac remodeling and central neuroinflammation using a pressure overload (PO) rat model. Male Sprague-Dawley rats were divided into four groups: PO, PO + VNS, PO + VNS sham, and controls. All rats, except controls, underwent a PO surgery to constrict the thoracic aorta (~50 %) to induce HFrEF. Open loop VNS therapy was continuously administered to PO + VNS rats at 20 Hz, 1.0 mA for 60 days. Evaluation of cardiac function and structure via echocardiograms showed decreases in stroke volume and relative eject...
Source: Autonomic Neuroscience - March 21, 2024 Category: Neuroscience Authors: Misty M Owens Suman Dalal Aleksandra Radovic Luciano Fernandes Hassan Syed Mary-Katherine Herndon Coty Cooper Krishna Singh Eric Beaumont Source Type: research
Vagus nerve stimulation alleviates cardiac dysfunction and inflammatory markers during heart failure in rats
This study aimed to investigate its therapeutic effects on three main components of heart failure: cardiac function, cardiac remodeling and central neuroinflammation using a pressure overload (PO) rat model. Male Sprague-Dawley rats were divided into four groups: PO, PO + VNS, PO + VNS sham, and controls. All rats, except controls, underwent a PO surgery to constrict the thoracic aorta (~50 %) to induce HFrEF. Open loop VNS therapy was continuously administered to PO + VNS rats at 20 Hz, 1.0 mA for 60 days. Evaluation of cardiac function and structure via echocardiograms showed decreases in stroke volume and relative eject...
Source: Autonomic Neuroscience - March 21, 2024 Category: Neuroscience Authors: Misty M Owens Suman Dalal Aleksandra Radovic Luciano Fernandes Hassan Syed Mary-Katherine Herndon Coty Cooper Krishna Singh Eric Beaumont Source Type: research
Vagus nerve stimulation alleviates cardiac dysfunction and inflammatory markers during heart failure in rats
This study aimed to investigate its therapeutic effects on three main components of heart failure: cardiac function, cardiac remodeling and central neuroinflammation using a pressure overload (PO) rat model. Male Sprague-Dawley rats were divided into four groups: PO, PO + VNS, PO + VNS sham, and controls. All rats, except controls, underwent a PO surgery to constrict the thoracic aorta (~50 %) to induce HFrEF. Open loop VNS therapy was continuously administered to PO + VNS rats at 20 Hz, 1.0 mA for 60 days. Evaluation of cardiac function and structure via echocardiograms showed decreases in stroke volume and relative eject...
Source: Autonomic Neuroscience - March 21, 2024 Category: Neuroscience Authors: Misty M Owens Suman Dalal Aleksandra Radovic Luciano Fernandes Hassan Syed Mary-Katherine Herndon Coty Cooper Krishna Singh Eric Beaumont Source Type: research
Vagus nerve stimulation alleviates cardiac dysfunction and inflammatory markers during heart failure in rats
This study aimed to investigate its therapeutic effects on three main components of heart failure: cardiac function, cardiac remodeling and central neuroinflammation using a pressure overload (PO) rat model. Male Sprague-Dawley rats were divided into four groups: PO, PO + VNS, PO + VNS sham, and controls. All rats, except controls, underwent a PO surgery to constrict the thoracic aorta (~50 %) to induce HFrEF. Open loop VNS therapy was continuously administered to PO + VNS rats at 20 Hz, 1.0 mA for 60 days. Evaluation of cardiac function and structure via echocardiograms showed decreases in stroke volume and relative eject...
Source: Autonomic Neuroscience - March 21, 2024 Category: Neuroscience Authors: Misty M Owens Suman Dalal Aleksandra Radovic Luciano Fernandes Hassan Syed Mary-Katherine Herndon Coty Cooper Krishna Singh Eric Beaumont Source Type: research
Vagus nerve stimulation alleviates cardiac dysfunction and inflammatory markers during heart failure in rats
This study aimed to investigate its therapeutic effects on three main components of heart failure: cardiac function, cardiac remodeling and central neuroinflammation using a pressure overload (PO) rat model. Male Sprague-Dawley rats were divided into four groups: PO, PO + VNS, PO + VNS sham, and controls. All rats, except controls, underwent a PO surgery to constrict the thoracic aorta (~50 %) to induce HFrEF. Open loop VNS therapy was continuously administered to PO + VNS rats at 20 Hz, 1.0 mA for 60 days. Evaluation of cardiac function and structure via echocardiograms showed decreases in stroke volume and relative eject...
Source: Autonomic Neuroscience - March 21, 2024 Category: Neuroscience Authors: Misty M Owens Suman Dalal Aleksandra Radovic Luciano Fernandes Hassan Syed Mary-Katherine Herndon Coty Cooper Krishna Singh Eric Beaumont Source Type: research
Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research
Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research
Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research
Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research
Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research
Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research
Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research
Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research
Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research
