Inflammation of some visceral sensory systems and autonomic dysfunction in cardiovascular disease
Auton Neurosci. 2023 Dec 7;251:103137. doi: 10.1016/j.autneu.2023.103137. Online ahead of print.ABSTRACTThe sensitization and hypertonicity of visceral afferents are highly relevant to the development and progression of cardiovascular and respiratory disease states. In this review, we described the evidence that the inflammatory process regulates visceral afferent sensitivity and tonicity, affecting the control of the cardiovascular and respiratory system. Some inflammatory mediators like nitric oxide, angiotensin II, endothelin-1, and arginine vasopressin may inhibit baroreceptor afferents and contribute to the baroreflex...
Source: Autonomic Neuroscience - December 17, 2023 Category: Neuroscience Authors: R M Lataro F Brognara R Iturriaga J F R Paton Source Type: research

Inflammation of some visceral sensory systems and autonomic dysfunction in cardiovascular disease
Auton Neurosci. 2023 Dec 7;251:103137. doi: 10.1016/j.autneu.2023.103137. Online ahead of print.ABSTRACTThe sensitization and hypertonicity of visceral afferents are highly relevant to the development and progression of cardiovascular and respiratory disease states. In this review, we described the evidence that the inflammatory process regulates visceral afferent sensitivity and tonicity, affecting the control of the cardiovascular and respiratory system. Some inflammatory mediators like nitric oxide, angiotensin II, endothelin-1, and arginine vasopressin may inhibit baroreceptor afferents and contribute to the baroreflex...
Source: Autonomic Neuroscience - December 17, 2023 Category: Neuroscience Authors: R M Lataro F Brognara R Iturriaga J F R Paton Source Type: research

Inflammation of some visceral sensory systems and autonomic dysfunction in cardiovascular disease
Auton Neurosci. 2023 Dec 7;251:103137. doi: 10.1016/j.autneu.2023.103137. Online ahead of print.ABSTRACTThe sensitization and hypertonicity of visceral afferents are highly relevant to the development and progression of cardiovascular and respiratory disease states. In this review, we described the evidence that the inflammatory process regulates visceral afferent sensitivity and tonicity, affecting the control of the cardiovascular and respiratory system. Some inflammatory mediators like nitric oxide, angiotensin II, endothelin-1, and arginine vasopressin may inhibit baroreceptor afferents and contribute to the baroreflex...
Source: Autonomic Neuroscience - December 17, 2023 Category: Neuroscience Authors: R M Lataro F Brognara R Iturriaga J F R Paton Source Type: research

Inflammation of some visceral sensory systems and autonomic dysfunction in cardiovascular disease
Auton Neurosci. 2023 Dec 7;251:103137. doi: 10.1016/j.autneu.2023.103137. Online ahead of print.ABSTRACTThe sensitization and hypertonicity of visceral afferents are highly relevant to the development and progression of cardiovascular and respiratory disease states. In this review, we described the evidence that the inflammatory process regulates visceral afferent sensitivity and tonicity, affecting the control of the cardiovascular and respiratory system. Some inflammatory mediators like nitric oxide, angiotensin II, endothelin-1, and arginine vasopressin may inhibit baroreceptor afferents and contribute to the baroreflex...
Source: Autonomic Neuroscience - December 17, 2023 Category: Neuroscience Authors: R M Lataro F Brognara R Iturriaga J F R Paton Source Type: research

Inflammation of some visceral sensory systems and autonomic dysfunction in cardiovascular disease
Auton Neurosci. 2023 Dec 7;251:103137. doi: 10.1016/j.autneu.2023.103137. Online ahead of print.ABSTRACTThe sensitization and hypertonicity of visceral afferents are highly relevant to the development and progression of cardiovascular and respiratory disease states. In this review, we described the evidence that the inflammatory process regulates visceral afferent sensitivity and tonicity, affecting the control of the cardiovascular and respiratory system. Some inflammatory mediators like nitric oxide, angiotensin II, endothelin-1, and arginine vasopressin may inhibit baroreceptor afferents and contribute to the baroreflex...
Source: Autonomic Neuroscience - December 17, 2023 Category: Neuroscience Authors: R M Lataro F Brognara R Iturriaga J F R Paton Source Type: research

Inflammation of some visceral sensory systems and autonomic dysfunction in cardiovascular disease
Auton Neurosci. 2023 Dec 7;251:103137. doi: 10.1016/j.autneu.2023.103137. Online ahead of print.ABSTRACTThe sensitization and hypertonicity of visceral afferents are highly relevant to the development and progression of cardiovascular and respiratory disease states. In this review, we described the evidence that the inflammatory process regulates visceral afferent sensitivity and tonicity, affecting the control of the cardiovascular and respiratory system. Some inflammatory mediators like nitric oxide, angiotensin II, endothelin-1, and arginine vasopressin may inhibit baroreceptor afferents and contribute to the baroreflex...
Source: Autonomic Neuroscience - December 17, 2023 Category: Neuroscience Authors: R M Lataro F Brognara R Iturriaga J F R Paton Source Type: research

Inflammation of some visceral sensory systems and autonomic dysfunction in cardiovascular disease
Auton Neurosci. 2023 Dec 7;251:103137. doi: 10.1016/j.autneu.2023.103137. Online ahead of print.ABSTRACTThe sensitization and hypertonicity of visceral afferents are highly relevant to the development and progression of cardiovascular and respiratory disease states. In this review, we described the evidence that the inflammatory process regulates visceral afferent sensitivity and tonicity, affecting the control of the cardiovascular and respiratory system. Some inflammatory mediators like nitric oxide, angiotensin II, endothelin-1, and arginine vasopressin may inhibit baroreceptor afferents and contribute to the baroreflex...
Source: Autonomic Neuroscience - December 17, 2023 Category: Neuroscience Authors: R M Lataro F Brognara R Iturriaga J F R Paton Source Type: research

Sympathetic remodeling and altered angiotensin-converting enzyme 2 localization occur in patients with cardiac disease but are not exacerbated by severe COVID-19
CONCLUSIONS: Heterogeneity of sympathetic innervation, which occurs in cardiac disease and is not increased by severe COVID-19, could contribute to arrhythmogenesis. The dominant localization of ACE2 to pericytes suggests that these cells would be the primary target for potential cardiac infection by SARS-CoV-2. Regional changes in ACE2 staining by myocytes and pericytes could have complex effects on cardiac pathophysiology.PMID:38101169 | DOI:10.1016/j.autneu.2023.103134 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - December 15, 2023 Category: Neuroscience Authors: Creighton L Kellum Logan G Kirkland Tasha K Nelson Seth M Jewett Eric Rytkin Igor R Efimov Donald B Hoover Paul V Benson Brant M Wagener Source Type: research

Sympathetic remodeling and altered angiotensin-converting enzyme 2 localization occur in patients with cardiac disease but are not exacerbated by severe COVID-19
CONCLUSIONS: Heterogeneity of sympathetic innervation, which occurs in cardiac disease and is not increased by severe COVID-19, could contribute to arrhythmogenesis. The dominant localization of ACE2 to pericytes suggests that these cells would be the primary target for potential cardiac infection by SARS-CoV-2. Regional changes in ACE2 staining by myocytes and pericytes could have complex effects on cardiac pathophysiology.PMID:38101169 | DOI:10.1016/j.autneu.2023.103134 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - December 15, 2023 Category: Neuroscience Authors: Creighton L Kellum Logan G Kirkland Tasha K Nelson Seth M Jewett Eric Rytkin Igor R Efimov Donald B Hoover Paul V Benson Brant M Wagener Source Type: research

Unraveling the lost balance: Adrenergic dysfunction in cancer cachexia
Auton Neurosci. 2023 Dec 6;251:103136. doi: 10.1016/j.autneu.2023.103136. Online ahead of print.ABSTRACTCancer cachexia, characterized by muscle wasting and widespread inflammation, poses a significant challenge for patients with cancer, profoundly impacting both their quality of life and treatment management. However, existing treatment modalities remain very limited, accentuating the necessity for innovative therapeutic interventions. Many recent studies demonstrated that changes in autonomic balance is a key driver of cancer cachexia. This review consolidates research findings from investigations into autonomic dysfunct...
Source: Autonomic Neuroscience - December 10, 2023 Category: Neuroscience Authors: Parham Diba Ariana L Sattler Tetiana Korzun Beth A Habecker Daniel L Marks Source Type: research

Unraveling the lost balance: Adrenergic dysfunction in cancer cachexia
Auton Neurosci. 2023 Dec 6;251:103136. doi: 10.1016/j.autneu.2023.103136. Online ahead of print.ABSTRACTCancer cachexia, characterized by muscle wasting and widespread inflammation, poses a significant challenge for patients with cancer, profoundly impacting both their quality of life and treatment management. However, existing treatment modalities remain very limited, accentuating the necessity for innovative therapeutic interventions. Many recent studies demonstrated that changes in autonomic balance is a key driver of cancer cachexia. This review consolidates research findings from investigations into autonomic dysfunct...
Source: Autonomic Neuroscience - December 10, 2023 Category: Neuroscience Authors: Parham Diba Ariana L Sattler Tetiana Korzun Beth A Habecker Daniel L Marks Source Type: research

Unraveling the lost balance: Adrenergic dysfunction in cancer cachexia
Auton Neurosci. 2023 Dec 6;251:103136. doi: 10.1016/j.autneu.2023.103136. Online ahead of print.ABSTRACTCancer cachexia, characterized by muscle wasting and widespread inflammation, poses a significant challenge for patients with cancer, profoundly impacting both their quality of life and treatment management. However, existing treatment modalities remain very limited, accentuating the necessity for innovative therapeutic interventions. Many recent studies demonstrated that changes in autonomic balance is a key driver of cancer cachexia. This review consolidates research findings from investigations into autonomic dysfunct...
Source: Autonomic Neuroscience - December 10, 2023 Category: Neuroscience Authors: Parham Diba Ariana L Sattler Tetiana Korzun Beth A Habecker Daniel L Marks Source Type: research

Unraveling the lost balance: Adrenergic dysfunction in cancer cachexia
Auton Neurosci. 2023 Dec 6;251:103136. doi: 10.1016/j.autneu.2023.103136. Online ahead of print.ABSTRACTCancer cachexia, characterized by muscle wasting and widespread inflammation, poses a significant challenge for patients with cancer, profoundly impacting both their quality of life and treatment management. However, existing treatment modalities remain very limited, accentuating the necessity for innovative therapeutic interventions. Many recent studies demonstrated that changes in autonomic balance is a key driver of cancer cachexia. This review consolidates research findings from investigations into autonomic dysfunct...
Source: Autonomic Neuroscience - December 10, 2023 Category: Neuroscience Authors: Parham Diba Ariana L Sattler Tetiana Korzun Beth A Habecker Daniel L Marks Source Type: research

Unraveling the lost balance: Adrenergic dysfunction in cancer cachexia
Auton Neurosci. 2023 Dec 6;251:103136. doi: 10.1016/j.autneu.2023.103136. Online ahead of print.ABSTRACTCancer cachexia, characterized by muscle wasting and widespread inflammation, poses a significant challenge for patients with cancer, profoundly impacting both their quality of life and treatment management. However, existing treatment modalities remain very limited, accentuating the necessity for innovative therapeutic interventions. Many recent studies demonstrated that changes in autonomic balance is a key driver of cancer cachexia. This review consolidates research findings from investigations into autonomic dysfunct...
Source: Autonomic Neuroscience - December 10, 2023 Category: Neuroscience Authors: Parham Diba Ariana L Sattler Tetiana Korzun Beth A Habecker Daniel L Marks Source Type: research

A retrospective analysis of neurogenic orthostatic hypotension in long-term care facility residents with recurrent falls
CONCLUSION: Older adults with recurrent falls at a long-term care facility meet criteria for neurogenic orthostatic hypotension diagnosis far more often than is documented. Common comorbidities associated with neurogenic orthostatic hypotension in this population include Parkinson's disease.PMID:38065033 | DOI:10.1016/j.autneu.2023.103135 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - December 8, 2023 Category: Neuroscience Authors: Mehdi Shadmand Brian Elliott Jacob Lautze Ali Mehdirad Source Type: research