Aortic stiffness contributes to greater pressor responses during static hand grip exercise in healthy young and middle-aged normotensive men
Auton Neurosci. 2023 Jul 5;248:103106. doi: 10.1016/j.autneu.2023.103106. Online ahead of print.ABSTRACTCentral arterial stiffness can influence exercise blood pressure (BP) by increasing the rise in arterial pressure per unit increase in aortic inflow. Whether central arterial stiffness influences the pressor response to isometric handgrip exercise (HG) and post-exercise muscle ischemia (PEMI), two common laboratory tests to study sympathetic control of BP, is unknown. We studied 46 healthy non-hypertensive males (23 young and 23 middle-aged) during HG (which increases in cardiac output [Q̇c]) and isolated metaboreflex a...
Source: Autonomic Neuroscience - July 20, 2023 Category: Neuroscience Authors: Denis J Wakeham Rachel N Lord Jack S Talbot Freya M Lodge Bryony A Curry Tony G Dawkins Lydia L Simpson Christopher J A Pugh Rob E Shave Jonathan P Moore Source Type: research
Aortic stiffness contributes to greater pressor responses during static hand grip exercise in healthy young and middle-aged normotensive men
Auton Neurosci. 2023 Jul 5;248:103106. doi: 10.1016/j.autneu.2023.103106. Online ahead of print.ABSTRACTCentral arterial stiffness can influence exercise blood pressure (BP) by increasing the rise in arterial pressure per unit increase in aortic inflow. Whether central arterial stiffness influences the pressor response to isometric handgrip exercise (HG) and post-exercise muscle ischemia (PEMI), two common laboratory tests to study sympathetic control of BP, is unknown. We studied 46 healthy non-hypertensive males (23 young and 23 middle-aged) during HG (which increases in cardiac output [Q̇c]) and isolated metaboreflex a...
Source: Autonomic Neuroscience - July 20, 2023 Category: Neuroscience Authors: Denis J Wakeham Rachel N Lord Jack S Talbot Freya M Lodge Bryony A Curry Tony G Dawkins Lydia L Simpson Christopher J A Pugh Rob E Shave Jonathan P Moore Source Type: research
Aortic stiffness contributes to greater pressor responses during static hand grip exercise in healthy young and middle-aged normotensive men
Auton Neurosci. 2023 Jul 5;248:103106. doi: 10.1016/j.autneu.2023.103106. Online ahead of print.ABSTRACTCentral arterial stiffness can influence exercise blood pressure (BP) by increasing the rise in arterial pressure per unit increase in aortic inflow. Whether central arterial stiffness influences the pressor response to isometric handgrip exercise (HG) and post-exercise muscle ischemia (PEMI), two common laboratory tests to study sympathetic control of BP, is unknown. We studied 46 healthy non-hypertensive males (23 young and 23 middle-aged) during HG (which increases in cardiac output [Q̇c]) and isolated metaboreflex a...
Source: Autonomic Neuroscience - July 20, 2023 Category: Neuroscience Authors: Denis J Wakeham Rachel N Lord Jack S Talbot Freya M Lodge Bryony A Curry Tony G Dawkins Lydia L Simpson Christopher J A Pugh Rob E Shave Jonathan P Moore Source Type: research
Aortic stiffness contributes to greater pressor responses during static hand grip exercise in healthy young and middle-aged normotensive men
Auton Neurosci. 2023 Jul 5;248:103106. doi: 10.1016/j.autneu.2023.103106. Online ahead of print.ABSTRACTCentral arterial stiffness can influence exercise blood pressure (BP) by increasing the rise in arterial pressure per unit increase in aortic inflow. Whether central arterial stiffness influences the pressor response to isometric handgrip exercise (HG) and post-exercise muscle ischemia (PEMI), two common laboratory tests to study sympathetic control of BP, is unknown. We studied 46 healthy non-hypertensive males (23 young and 23 middle-aged) during HG (which increases in cardiac output [Q̇c]) and isolated metaboreflex a...
Source: Autonomic Neuroscience - July 20, 2023 Category: Neuroscience Authors: Denis J Wakeham Rachel N Lord Jack S Talbot Freya M Lodge Bryony A Curry Tony G Dawkins Lydia L Simpson Christopher J A Pugh Rob E Shave Jonathan P Moore Source Type: research
Enhancement of muscarinic receptor-mediated excitation in spontaneously hypertensive rat adrenal medullary chromaffin cells
Auton Neurosci. 2023 Jul 10;248:103108. doi: 10.1016/j.autneu.2023.103108. Online ahead of print.ABSTRACTOne of the mechanisms for hypertension is an increase in blood catecholamines due to increased secretion from sympathetic nerve terminals and adrenal medullary chromaffin (AMC) cells. Spontaneously hypertensive rats (SHRs) are used as an animal model of hypertension. Catecholamine secretion in AMC cells occurs in response to humoral factors and neuronal inputs from the sympathetic nerve fibres. Acetylcholine (ACh) released from the nerve terminals activates nicotinic as well as muscarinic ACh receptors. The present expe...
Source: Autonomic Neuroscience - July 19, 2023 Category: Neuroscience Authors: Masumi Inoue Keita Harada Source Type: research
Enhancement of muscarinic receptor-mediated excitation in spontaneously hypertensive rat adrenal medullary chromaffin cells
Auton Neurosci. 2023 Jul 10;248:103108. doi: 10.1016/j.autneu.2023.103108. Online ahead of print.ABSTRACTOne of the mechanisms for hypertension is an increase in blood catecholamines due to increased secretion from sympathetic nerve terminals and adrenal medullary chromaffin (AMC) cells. Spontaneously hypertensive rats (SHRs) are used as an animal model of hypertension. Catecholamine secretion in AMC cells occurs in response to humoral factors and neuronal inputs from the sympathetic nerve fibres. Acetylcholine (ACh) released from the nerve terminals activates nicotinic as well as muscarinic ACh receptors. The present expe...
Source: Autonomic Neuroscience - July 19, 2023 Category: Neuroscience Authors: Masumi Inoue Keita Harada Source Type: research
Sympathetic and angiotensinergic activity in spontaneously hypertensive rats treated with 3-amino-1,2,4-triazole
Auton Neurosci. 2023 Jul 9;248:103107. doi: 10.1016/j.autneu.2023.103107. Online ahead of print.ABSTRACTPrevious studies from our laboratory have shown that the pressor response to intracerebroventricular (icv) administered ANG II in normotensive rats or spontaneously hypertensive rats (SHRs) is attenuated by increased central H2O2 concentration, produced either by direct H2O2 icv injection or by increased endogenous H2O2 centrally in response to local catalase inhibition with 3-amino-1,2,4-triazole (ATZ). In the present study, we evaluated the effects of ATZ administered peripherally on arterial pressure and sympathetic a...
Source: Autonomic Neuroscience - July 16, 2023 Category: Neuroscience Authors: Roberto Braz Pontes D ébora S A Colombari Patr ícia M De Paula Eduardo Colombari Carina A F Andrade Laurival A De Luca Jos é V Menani Source Type: research
Sympathetic and angiotensinergic activity in spontaneously hypertensive rats treated with 3-amino-1,2,4-triazole
Auton Neurosci. 2023 Jul 9;248:103107. doi: 10.1016/j.autneu.2023.103107. Online ahead of print.ABSTRACTPrevious studies from our laboratory have shown that the pressor response to intracerebroventricular (icv) administered ANG II in normotensive rats or spontaneously hypertensive rats (SHRs) is attenuated by increased central H2O2 concentration, produced either by direct H2O2 icv injection or by increased endogenous H2O2 centrally in response to local catalase inhibition with 3-amino-1,2,4-triazole (ATZ). In the present study, we evaluated the effects of ATZ administered peripherally on arterial pressure and sympathetic a...
Source: Autonomic Neuroscience - July 16, 2023 Category: Neuroscience Authors: Roberto Braz Pontes D ébora S A Colombari Patr ícia M De Paula Eduardo Colombari Carina A F Andrade Laurival A De Luca Jos é V Menani Source Type: research
Sympathetic and angiotensinergic activity in spontaneously hypertensive rats treated with 3-amino-1,2,4-triazole
Auton Neurosci. 2023 Jul 9;248:103107. doi: 10.1016/j.autneu.2023.103107. Online ahead of print.ABSTRACTPrevious studies from our laboratory have shown that the pressor response to intracerebroventricular (icv) administered ANG II in normotensive rats or spontaneously hypertensive rats (SHRs) is attenuated by increased central H2O2 concentration, produced either by direct H2O2 icv injection or by increased endogenous H2O2 centrally in response to local catalase inhibition with 3-amino-1,2,4-triazole (ATZ). In the present study, we evaluated the effects of ATZ administered peripherally on arterial pressure and sympathetic a...
Source: Autonomic Neuroscience - July 16, 2023 Category: Neuroscience Authors: Roberto Braz Pontes D ébora S A Colombari Patr ícia M De Paula Eduardo Colombari Carina A F Andrade Laurival A De Luca Jos é V Menani Source Type: research
The clinical utility of the Breathing Pattern Assessment Tool (BPAT) to identify dysfunctional breathing (DB) in individuals living with postural orthostatic tachycardia syndrome (POTS)
CONCLUSION: BPAT has high sensitivity and moderate specificity for identifying DB in individuals living with POTS.PMID:37393657 | DOI:10.1016/j.autneu.2023.103104 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - July 2, 2023 Category: Neuroscience Authors: Charles C Reilly Sarah V Floyd Shehnaz Raniwalla Nicholas Gall Gerrard F Rafferty Source Type: research
Adrenal gland response to adrenocorticotropic hormone is intact in patients with postural orthostatic tachycardia syndrome
CONCLUSIONS: ACTH appropriately increased the aldosterone and cortisol levels in patients with POTS. These findings suggest that the response of the adrenal cortex to hormonal stimulation is intact in patients with POTS.PMID:37393658 | DOI:10.1016/j.autneu.2023.103105 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - July 2, 2023 Category: Neuroscience Authors: Jill K H Laurin Oyebimbola A Oyewunmi Emily M Garland Alfredo Gamboa Victor C Nwazue Sachin Y Paranjape Bonnie K Black Luis E Okamoto Cyndya A Shibao Italo Biaggioni David Robertson Andr é Diedrich William D Dupont Robert S Sheldon Satish R Raj Source Type: research
The clinical utility of the Breathing Pattern Assessment Tool (BPAT) to identify dysfunctional breathing (DB) in individuals living with postural orthostatic tachycardia syndrome (POTS)
CONCLUSION: BPAT has high sensitivity and moderate specificity for identifying DB in individuals living with POTS.PMID:37393657 | DOI:10.1016/j.autneu.2023.103104 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - July 2, 2023 Category: Neuroscience Authors: Charles C Reilly Sarah V Floyd Shehnaz Raniwalla Nicholas Gall Gerrard F Rafferty Source Type: research
Adrenal gland response to adrenocorticotropic hormone is intact in patients with postural orthostatic tachycardia syndrome
CONCLUSIONS: ACTH appropriately increased the aldosterone and cortisol levels in patients with POTS. These findings suggest that the response of the adrenal cortex to hormonal stimulation is intact in patients with POTS.PMID:37393658 | DOI:10.1016/j.autneu.2023.103105 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - July 2, 2023 Category: Neuroscience Authors: Jill K H Laurin Oyebimbola A Oyewunmi Emily M Garland Alfredo Gamboa Victor C Nwazue Sachin Y Paranjape Bonnie K Black Luis E Okamoto Cyndya A Shibao Italo Biaggioni David Robertson Andr é Diedrich William D Dupont Robert S Sheldon Satish R Raj Source Type: research
The clinical utility of the Breathing Pattern Assessment Tool (BPAT) to identify dysfunctional breathing (DB) in individuals living with postural orthostatic tachycardia syndrome (POTS)
CONCLUSION: BPAT has high sensitivity and moderate specificity for identifying DB in individuals living with POTS.PMID:37393657 | DOI:10.1016/j.autneu.2023.103104 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - July 2, 2023 Category: Neuroscience Authors: Charles C Reilly Sarah V Floyd Shehnaz Raniwalla Nicholas Gall Gerrard F Rafferty Source Type: research
Adrenal gland response to adrenocorticotropic hormone is intact in patients with postural orthostatic tachycardia syndrome
CONCLUSIONS: ACTH appropriately increased the aldosterone and cortisol levels in patients with POTS. These findings suggest that the response of the adrenal cortex to hormonal stimulation is intact in patients with POTS.PMID:37393658 | DOI:10.1016/j.autneu.2023.103105 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - July 2, 2023 Category: Neuroscience Authors: Jill K H Laurin Oyebimbola A Oyewunmi Emily M Garland Alfredo Gamboa Victor C Nwazue Sachin Y Paranjape Bonnie K Black Luis E Okamoto Cyndya A Shibao Italo Biaggioni David Robertson Andr é Diedrich William D Dupont Robert S Sheldon Satish R Raj Source Type: research
