Australian chemistry and drug discovery towards the development of antimalarials & #x2020;
Brad E. Sleebs Malaria is a devasting disease that causes significant morbidity and mortality worldwide. New therapies are urgently needed, because of the emergent resistance against current frontline therapies. This perspective highlights the contributions of Australian chemists and drug discovery experts to the field of antimalarial development. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - September 2, 2022 Category: Chemistry Authors: Brad E. Sleebs Source Type: research
Photochemical generation of the 2-azabicyclo[4.2.0]octa-4,7-diene skeleton
Tyler Fahrenhorst-Jones, G. Paul Savage, Craig M. Williams Herein disclosed is the isolation of the 2-azabicyclo[4.2.0]octa-4,7-diene skeleton derived from the photochemical irradiation of 2-vinyl-1,2-dihydropyridine. A cascading 6π–8π–4π electrocyclic rearrangement is proposed as the mechanistic rationale. This is the first observation of this ring system. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - August 31, 2022 Category: Chemistry Authors: Tyler Fahrenhorst-Jones G. Paul Savage Craig M. Williams Source Type: research
Stable organic radicals and their untapped potential in ionic liquids
Theo A. Ellingsen, Natasha Hoffmann, Wesley J. Olivier, Stuart C. Thickett, Debbie S. Silvester, Rebecca O. Fuller The next generation of energy storage with stable organic radicals offers flexibility and lower costs compared to current lithium battery systems. This highlight showcases the recent developments of using ionic liquids to improve the stability and reversibility of the redox process. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - August 19, 2022 Category: Chemistry Authors: Theo A. Ellingsen Natasha Hoffmann Wesley J. Olivier Stuart C. Thickett Debbie S. Silvester Rebecca O. Fuller Source Type: research
Development and patent synthesis of nirmatrelvir & #x2013; the main component of the first oral drug against SARS-CoV-2 Paxlovid & #xae;
Bruno A. Cotrim, José C. Barros A highlight of the development and patent synthesis of nirmatrelvir – the main component of the first oral drug against SARS-CoV-2 Paxlovid® is presented. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - August 18, 2022 Category: Chemistry Authors: Bruno A. Cotrim Jos & #xe9; C. Barros Source Type: research
Preparation and oil absorption performance of ATP/P(MMA-BMA-St)/Fe 3 O 4 composite porous materials by double Pickering emulsion
Yongchun Tong, Min Feng, Yun Liu, Hao Li, Qingyun Wang Oil-in-water-in-oil (O/W/O) double Pickering emulsions were prepared using purified and modified attapulgite (ATP) and modified nano-Fe3O4 as stable particles and then used as templates to form ATP/P(MMA-BMA-St)/Fe3O4 composite porous resins. The experiment provides a simple, economic and environmentally friendly method for the preparation of inorganic–organic composite porous materials, which are expected to have great application potential in the field of oil treatment. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - August 16, 2022 Category: Chemistry Authors: Yongchun Tong Min Feng Yun Liu Hao Li Qingyun Wang Source Type: research
Reduction of phosphine sulfides and selenides by samarium(ii) formamidinate as an approach to binuclear mono- and dichalcogenide complexes & #x2020;
Boris Yu. Savkov, Taisiya S. Sukhikh, Sergey N. Konchenko, Nikolay A. Pushkarevsky Samarium(ii) formamidinates are promising candidates for studying reductive transformations. As opposed to samarocenes(ii), they provide a flexible coordination sphere that can fit the steric demands of a reduced substrate. Reduction of phosphine(arsine) chalcogenides has resulted in mono- and dichalcogenide complexes capable of co-crystallization. Long-lived S-centered radicals are expected to be the key reactive species in these processes. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - August 16, 2022 Category: Chemistry Authors: Boris Yu. Savkov Taisiya S. Sukhikh Sergey N. Konchenko Nikolay A. Pushkarevsky Source Type: research
Studies on chitosan-g-polyethyleneimine copolymer as drug carriers for PolyI:C
Kai Zhang, Qian Sun, Peng Liu, Xiaoyu Bai, Xingtong Gao, Kai Liu, Aixiang Li, Zijian LYu, Qiuhong Li A chitosan-graft-polyethyleneimine copolymer (CS-g-PEI) was prepared by an N,N′-carbonyl diimidazole (CDI) coupling method as a drug carrier for PolyI:C and simulated antigen ovalbumin (OVA). Nanoparticles of CS-g-PEI-PolyI:C/OVA with good solution stability, coating effect, immune characteristics and suitable size were prepared through electrostatic self-assembly. CS-g-PEI protected PolyI:C from nuclease degradation and is a reliable drug carrier for the delivery of PolyI:C. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - August 11, 2022 Category: Chemistry Authors: Kai Zhang Qian Sun Peng Liu Xiaoyu Bai Xingtong Gao Kai Liu Aixiang Li Zijian LYu Qiuhong Li Source Type: research
Compounds of amine-substituted cyclic amines: synthesis and structures
Neil F. Curtis Reactions of [M(en)2]2+ and [M(3,7-diaza-nonane-1,9-diamine)]2+, M = Cu2+, Ni2+, with nitroethane and formaldehyde in basic solution to form (nitro, methyl)-substituted cyclic tetraamine cations, and reduction of the nitro-group(s) to form (amine, methyl)-substituted cyclic tetraamine cations are reviewed. This Review covers the preparations and properties of compounds of amine‐substituted cyclic amines formed via nitroalkane‐aldehyde ...
Source: Australian Journal of Chemistry - August 8, 2022 Category: Chemistry Authors: Neil F. Curtis Source Type: research
Natural products isolation studies of native Australian fern species
Thinley Gyeltshen, Jason A. Smith, Alex C. Bissember This work reports natural products isolation studies of 16 native Australian fern species, 14 of which have not been the subject of such research previously. In total, 14 different compounds were isolated from 12 of these 16 different fern species. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 26, 2022 Category: Chemistry Authors: Thinley Gyeltshen Jason A. Smith Alex C. Bissember Source Type: research
Photovoltaic properties of hole transport materials for organic solar cell (OSC) applications: physiochemical insight and in silico designing
Muhammad Haroon, Saba Jamil, Muhammad Bilal Zeshan, Nargis Sultana, Muhammad Ilyas Tariq, Muhammad Ramzan Saeed Ashraf Janjua Our results indicate that the designed and reported molecules are superior to the Y3N molecule; thus, we recommend these molecules to experimentalists for future development of highly efficient solar cells. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 26, 2022 Category: Chemistry Authors: Muhammad Haroon Saba Jamil Muhammad Bilal Zeshan Nargis Sultana Muhammad Ilyas Tariq Muhammad Ramzan Saeed Ashraf Janjua Source Type: research
Tuning the photoreactivity of photocycloaddition by halochromism & #x2020;
Vinh X. Truong, Christopher Barner-Kowollik The photochemical reaction pathways of heterocylic N-containing stilbene functions under visible light irradiation can be controlled by pH and the proximity of the reacting moieties. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 25, 2022 Category: Chemistry Authors: Vinh X. Truong Christopher Barner-Kowollik Source Type: research
In situ fabrication of AgVO 3 /BiVO 4 graphene aerogels with enhanced photocatalytic activity
Ying Wang, Maoli Chen, Qin Xie, Bolin Wang, Li Lin, Yuanyuan Jiang, Li Zhang, Ying Zhao, Yunsong Zhang, Maojun Zhao A 3D porous AgVO3/BiVO4@GA was fabricated by an in situ ion exchange method. In the as-prepared AgVO3/BiVO4@GA photocatalyst, GA with a 3D macrostructure, porous channels and excellent electrical conductivity can efficiently support AgVO3 and facilitate cyclic regeneration, improve the mass transfer of reactants/products and promote the photogenerated charge separation rate in the photocatalytic process. Furthermore, benefitting from the ion exchange between Ag+ and Bi3+, the B...
Source: Australian Journal of Chemistry - July 22, 2022 Category: Chemistry Authors: Ying Wang Maoli Chen Qin Xie Bolin Wang Li Lin Yuanyuan Jiang Li Zhang Ying Zhao Yunsong Zhang Maojun Zhao Source Type: research
New red-emitting phosphor of Eu 3+ -doped Ba 2 Gd 0.67 W 1 & #x2212;x Mo x O 6 for solid state lighting
Yitong Jiang, Wenhao Liu, Jie Liu, Xibin Yu A new red emission phosphor Ba2Gd0.67WO6 was synthesized. The introduction of Mo extends the excitation peak from 370 to 425 nm, which is more suitable for solid-state lighting applications. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 15, 2022 Category: Chemistry Authors: Yitong Jiang Wenhao Liu Jie Liu Xibin Yu Source Type: research
Simple and modestly scalable synthesis of iso-Cyrene from levoglucosenone and its comparison to the bio-derived and polar aprotic solvent Cyrene & #xae;
Xin Liu, Brett Pollard, Martin G. Banwell, Li-Juan Yu, Michelle L. Coote, Michael G. Gardiner, Barbara M. A. van Vugt-Lussenburg, Bart van der Burg, Fabien L. Grasset, Elisabeth Campillo, James Sherwood, Fergal P. Byrne, Thomas J. Farmer Cyrene® (2), a commercially available solvent, is obtained by hydrogenation of levoglucosenone (LGO, 1), itself the product of pyrolysis of acid-treated cellulose. iso-Cyrene (4) has now been prepared from iso-LGO (3) and shown to display certain complementary solvent properties. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 7, 2022 Category: Chemistry Authors: Xin Liu Brett Pollard Martin G. Banwell Li-Juan Yu Michelle L. Coote Michael G. Gardiner Barbara M. A. van Vugt-Lussenburg Bart van der Burg Fabien L. Grasset Elisabeth Campillo James Sherwood Fergal P. Byrne Thomas J. Farmer Source Type: research
Properties tuning of supramolecular discotics by non-mesogenic triazines and acids
Chunming He, Kunlun Wang, Yue Wang, Shengang Xu, Yingliang Liu, Shaokui Cao Hydrogen-bonded supramolecules Tx-Ay were prepared by solution blending of triazine derivatives (Tx) and aromatic acids (Ay). 1H NMR and FT-IR results showed that hydrogen-bonded supramolecules were formed in all triazine-aromatic acid groups except T3-A1. DSC and POM analysis indicated that T1-A4, T2-A4 and T4-A4 in A4 series showed columnar liquid crystal behavior in a certain temperature range, while T3-A4 was nematic liquid crystal; WAXS confirmed that T1-A1, T2-A1 and T1-A4 were room temperature columnar liquid crystals. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - June 10, 2022 Category: Chemistry Authors: Chunming He Kunlun Wang Yue Wang Shengang Xu Yingliang Liu Shaokui Cao Source Type: research
