Studies on chitosan-g-polyethyleneimine copolymer as drug carriers for PolyI:C

Kai Zhang, Qian Sun, Peng Liu, Xiaoyu Bai, Xingtong Gao, Kai Liu, Aixiang Li, Zijian LYu, Qiuhong Li A chitosan-graft-polyethyleneimine copolymer (CS-g-PEI) was prepared by an N,N′-carbonyl diimidazole (CDI) coupling method as a drug carrier for PolyI:C and simulated antigen ovalbumin (OVA). Nanoparticles of CS-g-PEI-PolyI:C/OVA with good solution stability, coating effect, immune characteristics and suitable size were prepared through electrostatic self-assembly. CS-g-PEI protected PolyI:C from nuclease degradation and is a reliable drug carrier for the delivery of PolyI:C.
Source: Australian Journal of Chemistry - Category: Chemistry Authors: Source Type: research