Synthesis of 12-quinoline substituted andrographolide derivatives and their preliminary evaluation as anti-aggregation drugs
Xue Li, Jiafeng Yu, Xianhao Wu, Cui Hu, Xiaoqing Wang - Volume 76(2) A series of novel anti-platelet aggregation 12-quinoline substituted andrographolide derivatives 9 were designed. Among these, compound 9o had the highest anti-platelet aggregation activity induced by ADP. Compound 9q showed the highest anti-platelet aggregation activity induced by thrombin. Most of the derivatives had no significant cytotoxicity. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - February 28, 2023 Category: Chemistry Authors: Xue Li Jiafeng Yu Xianhao Wu Cui Hu Xiaoqing Wang Source Type: research
Retraction notice to 'A Biocompatible Gd III & #x2013;Organic Framework Incorporating Polar Pores for pH-Sensitive Anti-Cancer Drug Delivery and Inhibiting Human Bone Tumour Cells'
Mingliang Ren, Hui Li, Hu Liu, Lei Wang, Haibo Xiang, Xianrong Zhang, Bin Yu - Volume 76(2) Nanoscale SAPO-34 molecular sieves were synthesized by adding different types of seed into the hydrothermal synthesis system. The addition of seed into the initial gel during the synthetic process can facilitate the nucleation process and increase the crystallization rate effectively. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - February 28, 2023 Category: Chemistry Authors: Mingliang Ren Hui Li Hu Liu Lei Wang Haibo Xiang Xianrong Zhang Bin Yu Source Type: research
The effects of templates and seeds on the properties of nanosheet SAPO-34 molecular sieves and their catalytic performance in the MTO reaction
Tao Jiang, Yingzhi Bai, Lu Li, Weiwei Tai, Yujia Wang, Haiyan Wang, Na Sun - Volume 76(2) Nanoscale SAPO-34 molecular sieves were synthesized by adding different types of seed into the hydrothermal synthesis system. The addition of seed into the initial gel during the synthetic process can facilitate the nucleation process and increase the crystallization rate effectively. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - February 28, 2023 Category: Chemistry Authors: Tao Jiang Yingzhi Bai Lu Li Weiwei Tai Yujia Wang Haiyan Wang Na Sun Source Type: research
A simple 3D printed microfluidic device for point-of-care analysis of urinary uric acid
Kolsoum Dalvand, Alireza Ghiasvand, Sepideh Keshan-Balavandy, Feng Li, Michael Breadmore A microfluidic device was 3D printed for the determination of uric acid levels in urine. The device was coupled with a smartphone-based colorimetric method. Response surface methodology including central composed design was used to optimize experimental variables. This device shows promise for the evaluation of renal and kidney function. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - February 10, 2023 Category: Chemistry Authors: Kolsoum Dalvand Alireza Ghiasvand Sepideh Keshan-Balavandy Feng Li Michael Breadmore Source Type: research
Breaking down barriers: standing on the shoulders of Australia & #x2019;s early female chemists
Nicole McNamara, Anitha Kopinathan, Helen Wolff, Thomas H. Spurling, Gregory Simpson, Katherine E. S. Locock The stories of four trailblazing Australian female chemists, Isabel Joy Bear, Enid Plante, Catherine Anne Money and Annabelle Duncan, who broke barriers and paved the way for future generations. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - February 10, 2023 Category: Chemistry Authors: Nicole McNamara Anitha Kopinathan Helen Wolff Thomas H. Spurling Gregory Simpson Katherine E. S. Locock Source Type: research
Mutagenicity of N-acyloxy-N-alkoxyamides & #x2013; QSAR determination of factors controlling activity
Stephen A. Glover N-Acyloxy-N-alkoxyamides are direct-acting mutagenic anomeric amides that react with DNA. Mutagenic activities reflect how structural elements impact on this interaction with DNA. Reliable QSARs (quantitative structure–activity relationships) reveal how hydrophobicity, reactivity and steric factors affect mutagenic activity and can discern intercalative ability of polycyclic aromatics, with good predictive ability. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - January 19, 2023 Category: Chemistry Authors: Stephen A. Glover Source Type: research
Implementation of network embedding strategy on proteome datasets from multi-source cancers to demonstrate marker proteins of cancers
This study applies the representation learning method to the joint analysis of knowledge graph and omics data. The results show that our method can realize the seamless connection between omics data and knowledge graph, help to mine biological knowledge contained in omics data and provide a new perspective for further explanation of molecular mechanism. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - January 19, 2023 Category: Chemistry Authors: Dezhi Sun Ruzhen Chen Shuaikang Ma Yuqi Zhang Dong Li Source Type: research
HFIP-assisted Br & #xf8;nsted acid catalysed synthesis of furan derivatives
Bonnie Pu, Thanh Vinh Nguyen This work describes the development of a new non‐metal Brønsted acid catalytic method for the synthesis of 2‐aryl‐3‐carboxylate ester furans and 2,3‐diaryl furans from ynone substrates. The method was shown to be efficient under very mild reaction conditions with up to 94% product yields.  (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - January 18, 2023 Category: Chemistry Authors: Bonnie Pu Thanh Vinh Nguyen Source Type: research
Thermal and magnetic dual-responsive switchable device with superhydrophilicity/underwater superoleophobicity and excellent targeted oil & #x2013;water separation performance
Congcong Li, Huixia Feng, Furong Tao, Tiantian Yang, Nali Chen, Baiyi Chen - Volume 75(12) A thermal and magnetic dual-responsive superhydrophilicity/underwater superoleophobicity switchable device (Fe3O4@PNIPAM-Cu) was fabricated through a one-step solution dipping method. The separation efficiency of this device to benzene-water mixture can reach up to 99.98% and still maintain an efficiency of more than 99.90% even after 10 separation cycles. The oil–water separation stops above ~34°C. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - December 22, 2022 Category: Chemistry Authors: Congcong Li Huixia Feng Furong Tao Tiantian Yang Nali Chen Baiyi Chen Source Type: research
Why does the synthesis of N-phenylbenzamide from benzenesulfinate and phenylisocyanate via the palladium-mediated Extrusion & #x2013;Insertion pathway not work? A mechanistic exploration
Yang Yang, Allan J. Canty, Richard A. J. O’Hair While gas-phase studies suggest that both palladium-mediated extrusion–insertion (ExIn) and condensation reactions operate for the generation of a N-phenyl-benzamide anion from the phenylsulfinate anion, a double desulfinative biaryl homocoupling reaction is favoured in the solution phase. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - December 16, 2022 Category: Chemistry Authors: Yang Yang Allan J. Canty Richard A. J. O & #x2019;Hair Source Type: research
Six-step total syntheses of ( & #x2212;)-galanthamine and ( & #x2212;)-N-norgalanthamine
Nan Hu, Yu-Tao He, Ping Lan, Martin G. Banwell, Lorenzo V. White Abbreviated total syntheses of the title alkaloids, the first of which is used in the symptomatic treatment of Alzheimer’s disease, are reported. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - December 16, 2022 Category: Chemistry Authors: Nan Hu Yu-Tao He Ping Lan Martin G. Banwell Lorenzo V. White Source Type: research
Quantum chemical and photovoltaic modeling of D- & #x3c0;-A organic dyes based on substituted arylamine electron donors in dye sensitized solar cells
Tayebeh Hosseinnejad, Marzieh Omrani-Pachin Using tunable electron donor groups on triphenylamine (TPA) based organic dyes and their positive impacts on the conjugation level of a π-spacer improves the power conversion efficiency of DSSCs from both electronic and photovoltaic viewpoints. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - December 9, 2022 Category: Chemistry Authors: Tayebeh Hosseinnejad Marzieh Omrani-Pachin Source Type: research
The ascidian Lissoclinum patella, the patellamides and copper
Philipp Baur, Peter Comba, Lawrence R. Gahan, Christian Scholz There are large quantities of cyclic peptides in Lissoclinum patella ascidians, produced by the obligate symbiont Prochloron. Ascidians accumulate copper but the generally assumed factor of 104 is much overestimated, and it is shown here that there is a significant accumulation factor >500 and up to approximately 3000. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - December 9, 2022 Category: Chemistry Authors: Philipp Baur Peter Comba Lawrence R. Gahan Christian Scholz Source Type: research
Polyphenylalanine as a self-adjuvanting delivery system for peptide-based vaccines: the role of peptide conformation
Mariusz Skwarczynski, Guangzu Zhao, Victoria Ozberk, Ashwini Kumar Giddam, Zeinab G. Khalil, Manisha Pandey, Waleed M. Hussein, Reshma J. Nevagi, Michael R. Batzloff, Robert J. Capon, Michael F. Good, Istvan Toth The peptide epitope derived from Group A Streptococcus M-protein upon conjugation with a lipidated polyphenylalanine moiety adopted a helical conformation, was able to self-assemble into nanoparticles and induced production of a high level of opsonic antibodies in immunized mice. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - December 8, 2022 Category: Chemistry Authors: Mariusz Skwarczynski Guangzu Zhao Victoria Ozberk Ashwini Kumar Giddam Zeinab G. Khalil Manisha Pandey Waleed M. Hussein Reshma J. Nevagi Michael R. Batzloff Robert J. Capon Michael F. Good Istvan Toth Source Type: research
Aryl/aryl diazoalkanes in rhodium(II)-catalyzed rearrangements of sulfur ylides
Lennard Kloene, Sripati Jana, Claire Empel, Rene M. Koenigs Detailed studies on aryl/aryl diazoalkanes are still underrepresented in organic synthesis. Herein, we report on rhodium-catalyzed [2,3]-sigmatropic rearrangement reactions of such diazoalkanes to further broaden the applicability of aryl/aryl diazoalkanes for the construction of densely functionalized small molecules. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - December 8, 2022 Category: Chemistry Authors: Lennard Kloene Sripati Jana Claire Empel Rene M. Koenigs Source Type: research
