The supramolecular chemistry of protein cages and viruses
Yu Heng Lau This Account serves to introduce the world of protein cages to a chemical audience and highlight the many similarities to concepts from supramolecular chemistry, revealing how a knowledge base in chemistry can provide the foundation for valuable insights into fundamental questions and biomolecular engineering challenges in the field of physical virology. (Image credit: Yu Heng Lau.) (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - August 22, 2023 Category: Chemistry Authors: Yu Heng Lau Source Type: research
The preparation of rod-like porous & #x3b1;-Fe 2 O 3 with large interplanar spacing for symmetric supercapacitors
Fan-Ming Yang, Xi-Da Li Rod-like porous α-Fe2O3 with large interplanar crystal spacing was prepared by static hydrothermal treatment at 160°C and used for a symmetric supercapacitor. The synthesized α-Fe2O3 exhibits good rate capability even at 20 A g–1 in 1 mol L–1 of KOH electrolyte. (Image credit: Fan-Ming Yang.) (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - August 22, 2023 Category: Chemistry Authors: Fan-Ming Yang Xi-Da Li Source Type: research
Synthesis of naphtho- and pyrazolo-fused systems by an intramolecular Friedel & #x2013;Crafts approach
Hassan A. K. Abd El-Aal Condensed pyrazole scaffolds form the structural core of a large number of natural products and a wide range of pharmaceuticals. Herein, we explore an efficient construction of tetracyclic pyrazolo-fused carbo- and N-heterocyclic systems, in particular, naphtho-fused cycloheptapyrazolones, azepinopyrazolones, azocinopyrazolones and azoninopyrazolones, by intramolecular Friedel–Crafts cycliacylation reactions. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - August 15, 2023 Category: Chemistry Authors: Hassan A. K. Abd El-Aal Source Type: research
Professor Edouard Nice
John D. Wade, Marie-Isabel Aguilar - Volume 76(8) Genetic diversity and the processes that maintain it are key considerations for translocation success. Here we compare genetic diversity, mating systems, pollination and reproductive output of a translocated population of Banksia brownii with wild populations. Genetic diversity and reproductive output were comparable or higher in the translocated population than in the reference populations indicating success, however the translocated population had the highest levels of selfing. As such we recommend incorporating both genetic monitoring and demographic assessment when eval...
Source: Australian Journal of Chemistry - August 11, 2023 Category: Chemistry Authors: John D. Wade Marie-Isabel Aguilar Source Type: research
An autoantigen profile from Jurkat T-Lymphoblasts provides a molecular guide for investigating autoimmune sequelae of COVID-19
Julia Y. Wang, Wei Zhang, Michael W. Roehrl, Victor B. Roehrl, Michael H. Roehrl Based on the unique affinity between autoantigens (autoAgs) and dermatan sulfate (DS), this paper reports 140 candidate autoAgs identified from proteome extracts of Jurkat T-cells, with at least 105 (75%) being known targets of autoantibodies in various autoimmune diseases and cancer. Comparison with currently available multi-omic COVID-19 data shows that 125 (89%) DS-affinity proteins are altered in SARS-CoV-2-infected cells or patients. AutoAgs, such as LCP1 and NACA, that are altered in the T cells of COVID-19 patients may provide insight i...
Source: Australian Journal of Chemistry - July 20, 2023 Category: Chemistry Authors: Julia Y. Wang Wei Zhang Michael W. Roehrl Victor B. Roehrl Michael H. Roehrl Source Type: research
An autoantigen-ome from HS-Sultan B-Lymphoblasts offers a molecular map for investigating autoimmune sequelae of COVID-19
Julia Y. Wang, Wei Zhang, Victor B. Roehrl, Michael W. Roehrl, Michael H. Roehrl This paper investigates the autoantigenic proteome (‘autoantigen-ome’) of human B cells and shows that a large fraction of these DS-binding autoantigens is affected during SARS-CoV-2 infection, giving rise to a diverse pool of autoAgs that may lead to infection-induced autoimmune diseases. The COVID autoantigen-ome provided in this paper may serve as a molecular map and resource for investigating autoimmune phenomena of SARS-CoV-2 infection and its long-term sequelae. Understanding immunogenic proteins of COVID ...
Source: Australian Journal of Chemistry - July 19, 2023 Category: Chemistry Authors: Julia Y. Wang Wei Zhang Victor B. Roehrl Michael W. Roehrl Michael H. Roehrl Source Type: research
Multilayer films of graphene oxide and polymeric microgels: reusable adsorbents
Shihan Xu, Dehuai Li, Yu Zhu, Jiaxiang Guo, Yuqin Ai, Qingyun Chu, Xinyu Yun, Xiaozhou Li, Lin Wang A composite film composed of poly(allylamine hydrochloride)–dextran microgels and graphene oxide can be employed repeatedly to remove cationic, anionic and non-ionic dyes in water. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 19, 2023 Category: Chemistry Authors: Shihan Xu Dehuai Li Yu Zhu Jiaxiang Guo Yuqin Ai Qingyun Chu Xinyu Yun Xiaozhou Li Lin Wang Source Type: research
Perspectives and opinions from scientific leaders on the evolution of data-independent acquisition for quantitative proteomics and novel biological applications
Christie L. Hunter, Joanna Bons, Birgit Schilling Data-independent acquisition (DIA) has developed into an important method for quantitative proteomics, to capture the depth and dynamics of biological systems, and to perform large-scale protein quantification. To celebrate the > 10 years of DIA, we interviewed some of the scientific leaders who have provided crucial improvements to the DIA workflow. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 19, 2023 Category: Chemistry Authors: Christie L. Hunter Joanna Bons Birgit Schilling Source Type: research
Polyadenine complexed to polyglutamine suggests the peptide backbone has a cis conformation
Anthony B. Bransgrove, Louise Amelia Anderson Adenine is a promiscuous base, H bonding not only to uracil and thymine, but in a radical shift from orthodoxy, also to the backbone of peptides or proteins in the cis conformation. It follows that cis peptide polar groups will resemble the geometry of uracil. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 18, 2023 Category: Chemistry Authors: Anthony B. Bransgrove Louise Amelia Anderson Source Type: research
Exploring colorimetric detection of perfluorooctane sulfonate using micelle solubilised porphyrin
Chloe M. Taylor, Michael C. Breadmore, Nathan L. Kilah A proof-of-concept method has been developed to detect perfluorooctanesulfonate (PFOS). A coloured porphyrin host molecule suspended in micelles changes colour when it encounters PFOS. Photographs of the coloured solutions were analysed allowing for the detection of PFOS in water at concentrations as low as 3 ppm. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 14, 2023 Category: Chemistry Authors: Chloe M. Taylor Michael C. Breadmore Nathan L. Kilah Source Type: research
Exploring colorimetric detection of perfluorooctane sulfonate using micelle solubilised porphyrin & #x2020;
Chloe M. Taylor, Michael C. Breadmore, Nathan L. Kilah A proof-of-concept method has been developed to detect perfluorooctanesulfonate (PFOS). A coloured porphyrin host molecule suspended in micelles changes colour when it encounters PFOS. Photographs of the coloured solutions were analysed allowing for the detection of PFOS in water at concentrations as low as 3 ppm. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 14, 2023 Category: Chemistry Authors: Chloe M. Taylor Michael C. Breadmore Nathan L. Kilah Source Type: research
Synthesis of R- and S-MDMA via nucleophilic ring-opening of homochiral N-tosylaziridines
Katie D. Lewis, Glenn A. Pullella, Han Chern Loh, Brian W. Skelton, Gavin R. Flematti, Matthew J. Piggott Homochiral R- and S-MDMA have been prepared by regioselective nucleophilic ring-opening of alanine-derived N-tosylaziridines. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 12, 2023 Category: Chemistry Authors: Katie D. Lewis Glenn A. Pullella Han Chern Loh Brian W. Skelton Gavin R. Flematti Matthew J. Piggott Source Type: research
Molecular electronics: an Australian perspective
Jeffrey R. Reimers, Paul J. Low Quantum control of electrical properties achieved through rational molecular and device design leads to functionalities useful for development of new technologies. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 12, 2023 Category: Chemistry Authors: Jeffrey R. Reimers Paul J. Low Source Type: research
The extracellular chaperone clusterin prevents primary and secondary nucleation of an amyloidogenic variant of & #x3b2;2-microglobulin
Manjeet Kumar, Cristina Cantarutti, David C. Thorn, Vittorio Bellotti, Gennaro Esposito, Mark R. Wilson, Heath Ecroyd, John A. Carver Accumulation of β2-microglobin in tissues is responsible for the disease dialysis-related amyloidosis. The D76N mutant is highly amyloidogenic. An in vitro biophysical and spectroscopic investigation of D76N β2-microglobin amyloid fibril formation and its inhibition by the common extracellular chaperone, clusterin, is described. In vivo, clusterin may play an important role in preventing β2-microglobin deposition. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 11, 2023 Category: Chemistry Authors: Manjeet Kumar Cristina Cantarutti David C. Thorn Vittorio Bellotti Gennaro Esposito Mark R. Wilson Heath Ecroyd John A. Carver Source Type: research
Chemistry, biochemistry and clinical relevance of the glutamine metabolite & #x3b1;-ketoglutaramate/2-hydroxy-5-oxoproline
Travis T. Denton, Arthur J. L. Cooper Transamination of l-glutamine yields α-ketoglutaramate (KGM), which, at neutral pH, exists mostly (99.7%) as a lactam (2-hydroxy-5-oxoproline). KGM may also be synthesized using multiple methods including oxidation with: (1a) l-amino acid oxidase, (1b) Fremy’s salt, (1c) ammonium vanadate and (2) a multistep organic synthesis procedure. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 11, 2023 Category: Chemistry Authors: Travis T. Denton Arthur J. L. Cooper Source Type: research
