Synthesis of naphtho- and pyrazolo-fused systems by an intramolecular Friedel & #x2013;Crafts approach

Hassan A. K. Abd El-Aal Condensed pyrazole scaffolds form the structural core of a large number of natural products and a wide range of pharmaceuticals. Herein, we explore an efficient construction of tetracyclic pyrazolo-fused carbo- and N-heterocyclic systems, in particular, naphtho-fused cycloheptapyrazolones, azepinopyrazolones, azocinopyrazolones and azoninopyrazolones, by intramolecular Friedel–Crafts cycliacylation reactions.
Source: Australian Journal of Chemistry - Category: Chemistry Authors: Source Type: research