Preliminary Investigation of a Novel 18 F Radiopharmaceutical for Imaging CB2 Receptors in a SOD Mouse Model
Giancarlo Pascali, Daniele Panetta, Mariarosaria De Simone, Silvia Burchielli, Valentina Lucchesi, Elena Sanguinetti, Simone Zanoni, Patricia Iozzo, Giuseppe Saccomanni, Clementina Manera, Piero A. Salvadori
A novel prospective CB2 receptor ligand has been labelled with 18F and tested in microPET imaging of SOD1 mouse models. Image analysis revealed a fast washout from brain regions. A significant increase of distribution volume was noticed between symptomatic and asymptomatic subjects. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - February 1, 2021 Category: Chemistry Authors: Giancarlo Pascali Daniele Panetta Mariarosaria De Simone Silvia Burchielli Valentina Lucchesi Elena Sanguinetti Simone Zanoni Patricia Iozzo Giuseppe Saccomanni Clementina Manera Piero A. Salvadori Source Type: research
Synthetic Cannabinomimetics: A Brief History and the Challenges They Pose for the Forensic Chemist
Michael Collins
The emergence of synthetic cannabinoids during the last decade has created problems for the forensic chemist tasked with identification. This paper gives a brief history of the synthetic cannabinoids and discusses the analytical and legal challenges faced by the forensic community. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - January 29, 2021 Category: Chemistry Authors: Michael Collins Source Type: research
Spectroelectrochemistry: A Powerful Tool for Studying Fundamental Properties and Emerging Applications of Solid-State Materials Including Metal & #x2013;Organic Frameworks
Deanna M. D'Alessandro, Pavel M. Usov
This review article highlights the state of the art in solid-state SEC (ultraviolet–visible–near-infrared (UV-Vis-NIR), infrared (IR), Raman, photoluminescence, electron paramagnetic resonance (EPR), and X-ray absorption (XAS) spectroscopy) relevant to interrogating solid-state materials, particularly those in the burgeoning field of metal–organic frameworks (MOFs). (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - January 22, 2021 Category: Chemistry Authors: Deanna M. D & #39;Alessandro Pavel M. Usov Source Type: research
DNA Binding and DNA Cleavage Activities of Newly Synthesized Co II and Cu II Complexes of a & #x3b2;-Cyclodextrin Based Azo-Functionalized Schiff Base
Ananya Das, Dipu Kumar Mishra, Pritika Gurung, Vikas Kumar Dakua, Biswajit Sinha
A novel β-cyclodextrin based azo functionalized Schiff base with high aqueous solubility was synthesized. It induced high aqueous solubility in its CoII and CuII complexes. These complexes with enhanced bio-availability showed good DNA binding and DNA cleavage activities. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - January 19, 2021 Category: Chemistry Authors: Ananya Das Dipu Kumar Mishra Pritika Gurung Vikas Kumar Dakua Biswajit Sinha Source Type: research
4-(Dimethylamino)pyridine as Multivalent Catalyst in Organic Synthesis
Rosana Helena C. N. Freitas, David Rodrigues da Rocha
4-(Dimethylamino)pyridine (DMAP) is a common catalyst in organic synthesis, able to promote different types of reactions with an emphasis on heterocycle synthesis, multicomponent reactions (MCRs), esterification reactions, cycloadditions, and even stereoselective reactions. In this focus article, some recent and relevant uses of this catalyst have been selected to demonstrate its importance and versatility in organic chemistry. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - January 5, 2021 Category: Chemistry Authors: Rosana Helena C. N. Freitas David Rodrigues da Rocha Source Type: research
A Novel Imidazophenazine-Based Stimuli Responsive Chemosensor for Highly Selective and Sensitive Fluorescence Detection of CN & #x2013;
Haixiong Shi, Juanjuan Hou, Pengwei Jiang, Quanlu Yang, Qi Lin, Taibao Wei, Hong Yao, Youming Zhang, Shang Wu
A stimuli responsive chemosensor S based on imidazophenazine was synthesised. It displayed colourimetric–fluorescence dual channel detection properties for CN– based on an obvious change of colour and fluorescence. The fluorescence responding cycle could be repeated three times by the sequential addition of CN– and CH3COO– or CN– and HSO4–. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - December 30, 2020 Category: Chemistry Authors: Haixiong Shi Juanjuan Hou Pengwei Jiang Quanlu Yang Qi Lin Taibao Wei Hong Yao Youming Zhang Shang Wu Source Type: research
Self-Assembly of CDs@NH 2 -MOF(Ni)/n-Bu 4 NBr and its Catalytic Performance for CO 2 Fixation with Epoxides
Kai Huang, Xiaomeng Zhang
By a one-pot method, the metal–organic frameworks (CDs@NH2-MOF(Ni)) with carbon dots as the core were synthesised successfully. The synthesised CDs@NH2-MOF(Ni) were characterised by FT-IR, SEM, TEM, EDX, XRD, TG, and BET. The synthesised CDs@NH2-MOF(Ni)/TBAB and NH2-MOF(Ni)/TBAB have good catalytic performance for the cycloaddition reaction of PO and CO2. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - December 24, 2020 Category: Chemistry Authors: Kai Huang Xiaomeng Zhang Source Type: research
Gamma Radiation-Induced Unsaturated P(VDF-CTFE) Membranes with Improved Mechanical Properties
Huazhao Wang, Yu Liu, Yaoxin Xiao, Jiafu Chen, Jinjiang Xu, Haobin Zhang, Jie Sun, Jie Li, Chunhua Zhu, Jihu Su, Feng Liu
Fluoropolymer P(VDF-CTFE) membranes prepared by solution casting with tetrahydrofuran (THF) were radiated by a low gamma radiation dose without any other reagents, which introduced C=C bonds into the polymeric chains and resulted in a change of membrane colour and mechanical properties. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - December 22, 2020 Category: Chemistry Authors: Huazhao Wang Yu Liu Yaoxin Xiao Jiafu Chen Jinjiang Xu Haobin Zhang Jie Sun Jie Li Chunhua Zhu Jihu Su Feng Liu Source Type: research
In-Cell Solid-State NMR Analysis of Membrane Proteins
Shiying Zhu, Marc-Antoine Sani, Frances Separovic
In-cell solid-state NMR is a potential technique to probe site-specific structural arrangements of membrane proteins in the native cellular environment. The benefits of this technique are increased sensitivity and prolonged cell lifetime, which allow the determination of complex membrane proteins within a time frame suitable for cell survival. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - December 15, 2020 Category: Chemistry Authors: Shiying Zhu Marc-Antoine Sani Frances Separovic Source Type: research
Reduction Chemistry of Natural Pyrethrins and Preliminary Insecticidal Activity of Reduced Pyrethrins
Todd E. Markham, Andrew C. Kotze, Peter J. Duggan, Martin R. Johnston
The reduction chemistry of the natural insecticides the pyrethrins was investigated and a method to convert them into their more stable jasmolin counterparts, as a mixture with the over-reduced tetrahydropyrethrins, was developed. Reduced products resulting from other chemical treatments lacked insecticidal activity, whereas some isomerised analogues showed comparable potency with the individual natural pyrethrin esters. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - December 11, 2020 Category: Chemistry Authors: Todd E. Markham Andrew C. Kotze Peter J. Duggan Martin R. Johnston Source Type: research
Colorimetric Aptasensor for Testosterone Detection Based on Aggregation of Gold Nanoparticles Induced by Cationic Surfactant
Chaoqiang Pan, Jianmin Qiu, Lumei Wang, Zhiyu Yan, Weiwen Huang, Dongwei Zhang, Xuejia Zhan, Guoqing Shen
This paper proposes a colorimetric aptasensor for detecting testosterone (TES) based on competition between TES and CTAB for apT5. The results show the aptasensor has a wide linear range from 1.91–800 nM and a good limit of detection of 1.91 nM. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - December 9, 2020 Category: Chemistry Authors: Chaoqiang Pan Jianmin Qiu Lumei Wang Zhiyu Yan Weiwen Huang Dongwei Zhang Xuejia Zhan Guoqing Shen Source Type: research
Development of Chromenopyrazole-Based Selective Cannabinoid 2 Receptor Agonists
Sameek Singh, Ian Liddle, Christa Macdonald, Joel D. A. Tyndall, Michelle Glass, Andrea J. Vernall
Compounds that bind to and activate cannabinoid receptors are typically very lipophilic. We have developed a series of more polar ligands that are high-affinity, selective cannabinoid type 2 receptor activators. These ligands will be useful tools to probe cannabinoid receptor function and location. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - November 18, 2020 Category: Chemistry Authors: Sameek Singh Ian Liddle Christa Macdonald Joel D. A. Tyndall Michelle Glass Andrea J. Vernall Source Type: research
Fluorescence Study of the Influence of the Structure and Hydrophobicity of Fluorescent Dyes and Cationic Surfactants on their Association in Aqueous Solutions
Viktoriia Klovak, Sergey Kulichenko, Serhii Lelyushok
The influence of structure and hydrophobicity parameters of reagents and cationic surfactants during their association on the fluorescent analytical signal has been investigated. Rational bases of search and design of analytical systems for the determination of hydrophobic organic cations by fluorescent method have been formulated. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - November 12, 2020 Category: Chemistry Authors: Viktoriia Klovak Sergey Kulichenko Serhii Lelyushok Source Type: research
Immobilisation of Homogeneous Pd Catalysts within a Type I Porous Liquid
Ellen B. Hemming, Anthony F. Masters, Thomas Maschmeyer
An NHC–Pd-based complex was successfully built and immobilised within the cavities of a Type I porous liquid. The catalytic ability of the resulting porous liquid system was investigated, using the Heck reaction as a model reaction, to confirm the successful immobilisation. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - November 10, 2020 Category: Chemistry Authors: Ellen B. Hemming Anthony F. Masters Thomas Maschmeyer Source Type: research
A New Strategy for the Synthesis of Organosilicon Compounds of Cyclopropane Derivatives
Saeed Gholizadeh, Kazem D. Safa, Nader Noroozi Pesyan
A new strategy to synthesise new cyclopropane compounds with organosilicon functional groups at different temperatures and under different conditions leads to various new compounds. A discussion about the different reaction mechanisms and obtained products (characterised by IR, 1H NMR, and 13C NMR spectroscopies) is given. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - November 3, 2020 Category: Chemistry Authors: Saeed Gholizadeh Kazem D. Safa Nader Noroozi Pesyan Source Type: research
