Development of Chromenopyrazole-Based Selective Cannabinoid 2 Receptor Agonists

Sameek Singh, Ian Liddle, Christa Macdonald, Joel D. A. Tyndall, Michelle Glass, Andrea J. Vernall Compounds that bind to and activate cannabinoid receptors are typically very lipophilic. We have developed a series of more polar ligands that are high-affinity, selective cannabinoid type 2 receptor activators. These ligands will be useful tools to probe cannabinoid receptor function and location.
Source: Australian Journal of Chemistry - Category: Chemistry Authors: Source Type: research