Identification and validation of a novel necroptosis-related molecular signature to evaluate prognosis and immune features in breast cancer
This study identified a novel necroptosis-related subtype of BRCA, and a comprehensive analysis of NRGs in BRCA revealed its potential roles in prognosis, clinicopathological features, TME, chemotherapy, tumor proliferation, and tumor necroptosis. These results may improve our understanding of NRGs in BRCA and provide a reference for developing individualized therapeutic strategies. (Source: Apoptosis)
Source: Apoptosis - October 3, 2023 Category: Molecular Biology Source Type: research
Apoptosis-related prognostic biomarkers and potential targets for acute kidney injury based on machine learning algorithm and in vivo experiments
In this study, weighted gene coexpression network analysis (WGCNA), differential expression analysis, univariate and multivariate logistic regression analyses, receiver operating characteri stic (ROC) curves, and immune cell infiltration were performed to identify apoptosis-related biomarkers that can be used for AKI diagnosis. Three core apoptosis-related genes (ARGs), CBFB, EGF and COL1A1, were identified as AKI biomarkers. More importantly, an apoptosis-related signature containing three hub ARGs was validated as a diagnostic model. The hub genes exhibited good correlations with glomerular filtration rate (GFR) and seru...
Source: Apoptosis - October 3, 2023 Category: Molecular Biology Source Type: research
Identification and validation of a novel necroptosis-related molecular signature to evaluate prognosis and immune features in breast cancer
This study identified a novel necroptosis-related subtype of BRCA, and a comprehensive analysis of NRGs in BRCA revealed its potential roles in prognosis, clinicopathological features, TME, chemotherapy, tumor proliferation, and tumor necroptosis. These results may improve our understanding of NRGs in BRCA and provide a reference for developing individualized therapeutic strategies. (Source: Apoptosis)
Source: Apoptosis - October 3, 2023 Category: Molecular Biology Source Type: research
The interplay of miRNAs and ferroptosis in diseases related to iron overload
AbstractFerroptosis has been conceptualized as a novel cell death modality distinct from apoptosis, necroptosis, pyroptosis and autophagic cell death. The sensitivity of cellular ferroptosis is regulated at multiple layers, including polyunsaturated fatty acid metabolism, glutathione-GPX4 axis, iron homeostasis, mitochondria and other parallel pathways. In addition, microRNAs (miRNAs) have been implicated in modulating ferroptosis susceptibility through targeting different players involved in the execution or avoidance of ferroptosis. A growing body of evidence pinpoints the deregulation of miRNA-regulated ferroptosis as a...
Source: Apoptosis - September 27, 2023 Category: Molecular Biology Source Type: research
Rising impact of cell death research
(Source: Apoptosis)
Source: Apoptosis - September 26, 2023 Category: Molecular Biology Source Type: research
Cuprotosis clusters predict prognosis and immunotherapy response in low-grade glioma
AbstractCuprotosis, an emerging mode of cell death, has recently caught the attention of researchers worldwide. However, its impact on low-grade glioma (LGG) patients has not been fully explored. To gain a deeper insight into the relationship between cuprotosis and LGG patients ’ prognosis, we conducted this study in which LGG patients were divided into two clusters based on the expression of 18 cuprotosis-related genes. We found that LGG patients in cluster A had better prognosis than those in cluster B. The two clusters also differed in terms of immune cell infiltratio n and biological functions. Moreover, we identifie...
Source: Apoptosis - September 15, 2023 Category: Molecular Biology Source Type: research
Regulation of alveolar macrophage death in pulmonary fibrosis: a review
AbstractPulmonary fibrosis (PF) is a disease in which excessive extracellular matrix (ECM) accumulation occurs in pulmonary mesenchyme, which induces the destruction of alveolar structures and poor prognosis. Macrophage death is responsible for ECM accumulation after alveolar epithelial injury in PF. Depending on the local micro-environments, macrophages can be polarized to either classically activated (M1) or alternatively activated (M2) macrophage phenotypes. In general, M1 macrophages can promote inflammation and sterilization, stop the continuous damage process and prevent excessive repair, while M2 macrophages are ant...
Source: Apoptosis - September 14, 2023 Category: Molecular Biology Source Type: research
Triptolide induces PANoptosis in macrophages and causes organ injury in mice
In this study, we showed that triptolide exhibited significant cytotoxicity on cultured macrophages in vitro, which was associated with multiple forms of lytic cell death that could not be fully suppressed by any one specific inhibitor for a single form of RCD. Consistently, triptolide induced the simultaneous activation of pyroptotic, apoptotic and necroptotic hallmarks, which was accompanied by the co-localization of ASC specks respectively with RIPK3 or caspase-8 as well as their interaction with each other, indicating the formation of PANoptosome and thus the induction of PANoptosis. Triptolide-induced PANoptosis was a...
Source: Apoptosis - September 13, 2023 Category: Molecular Biology Source Type: research
N6-methyladenosine regulator YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in prostate cancer via m6A/PD-L1 manner
In conclusion, these findings indicate that YTHDF1 represses the CD8 + T cell-mediated antitumor immunity and ferroptosis in PCa via m6A-PD-L1 manner, which may provide novel insight for PCa immunotherapy. (Source: Apoptosis)
Source: Apoptosis - September 12, 2023 Category: Molecular Biology Source Type: research
Oncogenic and immunological roles of RACGAP1 in pan-cancer and its potential value in nasopharyngeal carcinoma
This study indicated that RACGAP1 could be a potential biomarker in pan-cancer and NPC. (Source: Apoptosis)
Source: Apoptosis - September 5, 2023 Category: Molecular Biology Source Type: research
