Reform of early access program in France: impact on workload in a pharmacy and risk identification
Ann Pharm Fr. 2024 Feb 24:S0003-4509(24)00032-4. doi: 10.1016/j.pharma.2024.02.012. Online ahead of print.ABSTRACTThe reform of derogatory access authorisations (DAs) on 1st July 2021 has distorted the routine of the hospital pharmacists dealing with innovative medicines that are waiting for marketing authorization or approval. There are two distinct categories of DAs: Compassionate Access Authorisations (CAAs) are granted by the French National Agency for the Safety of Medicines (ANSM) while Early Access Authorisations (EAPs) are granted at the request of pharmaceutical companies by the French National Authority for Healt...
Source: Annales Pharmaceutiques Francaises - February 26, 2024 Category: Drugs & Pharmacology Authors: Oriane Jouhet Jiyan Demir Marine Sitbon Marc-Antoine Bildan Ariane Bros Esther Kim Nicolas Godron Isabelle Madelaine Laure Deville Source Type: research
Rheum Khorasanicum. L Hydroalcoholic Root Extract Induces Cell Death in Human Colorectal Adenocarcinoma: An in vitro and in silico study
In conclusion, our findings have suggested that high phenol and flavonoid contents of R. khorasanicum root extract possibly play an important role in cell cytotoxicity and apoptosis induction in HT-29 and Caco-2 colon cancer cells.PMID:38408722 | DOI:10.1016/j.pharma.2024.02.013 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - February 26, 2024 Category: Drugs & Pharmacology Authors: Arian Amirkhosravi Mehrnaz Mehrabani Saba Fooladi Mohammad Erfan Nourouzmahani Saeedeh Vasei Yousof Mir Zahra Malekoladi Sanaz Faramarz Mohammad Hadi Nematollahi Mitra Mehrabani Source Type: research
Reform of early access program in France: impact on workload in a pharmacy and risk identification
Ann Pharm Fr. 2024 Feb 24:S0003-4509(24)00032-4. doi: 10.1016/j.pharma.2024.02.012. Online ahead of print.ABSTRACTThe reform of derogatory access authorisations (DAs) on 1st July 2021 has distorted the routine of the hospital pharmacists dealing with innovative medicines that are waiting for marketing authorization or approval. There are two distinct categories of DAs: Compassionate Access Authorisations (CAAs) are granted by the French National Agency for the Safety of Medicines (ANSM) while Early Access Authorisations (EAPs) are granted at the request of pharmaceutical companies by the French National Authority for Healt...
Source: Annales Pharmaceutiques Francaises - February 26, 2024 Category: Drugs & Pharmacology Authors: Oriane Jouhet Jiyan Demir Marine Sitbon Marc-Antoine Bildan Ariane Bros Esther Kim Nicolas Godron Isabelle Madelaine Laure Deville Source Type: research
Overview of hospital city repay for paediatric preparations initiated within the marseille public university hospital system
Conclusions : The lack of clear and complete hospital prescriptions makes it difficult to carry out treatment initiated in hospital in the outpatient setting. The multiplicity of information systems between hospitals and outpatient settings are obstacles to the interoperability needed to coordinate patient treatment, particularly in paediatrics.. The quality of discharge prescriptions needs to be improved to optimise the patient care pathway.PMID:38387835 | DOI:10.1016/j.pharma.2024.02.009 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - February 22, 2024 Category: Drugs & Pharmacology Authors: Cyrielle Bouguergour Florence Peyron Christophe Curti Nathalie Bailli é S ébastien Gallice Source Type: research
Overview of hospital city repay for paediatric preparations initiated within the marseille public university hospital system
Conclusions : The lack of clear and complete hospital prescriptions makes it difficult to carry out treatment initiated in hospital in the outpatient setting. The multiplicity of information systems between hospitals and outpatient settings are obstacles to the interoperability needed to coordinate patient treatment, particularly in paediatrics.. The quality of discharge prescriptions needs to be improved to optimise the patient care pathway.PMID:38387835 | DOI:10.1016/j.pharma.2024.02.009 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - February 22, 2024 Category: Drugs & Pharmacology Authors: Cyrielle Bouguergour Florence Peyron Christophe Curti Nathalie Bailli é S ébastien Gallice Source Type: research
Overview of hospital city repay for paediatric preparations initiated within the marseille public university hospital system
Conclusions : The lack of clear and complete hospital prescriptions makes it difficult to carry out treatment initiated in hospital in the outpatient setting. The multiplicity of information systems between hospitals and outpatient settings are obstacles to the interoperability needed to coordinate patient treatment, particularly in paediatrics.. The quality of discharge prescriptions needs to be improved to optimise the patient care pathway.PMID:38387835 | DOI:10.1016/j.pharma.2024.02.009 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - February 22, 2024 Category: Drugs & Pharmacology Authors: Cyrielle Bouguergour Florence Peyron Christophe Curti Nathalie Bailli é S ébastien Gallice Source Type: research
Overview of hospital city repay for paediatric preparations initiated within the marseille public university hospital system
Conclusions : The lack of clear and complete hospital prescriptions makes it difficult to carry out treatment initiated in hospital in the outpatient setting. The multiplicity of information systems between hospitals and outpatient settings are obstacles to the interoperability needed to coordinate patient treatment, particularly in paediatrics.. The quality of discharge prescriptions needs to be improved to optimise the patient care pathway.PMID:38387835 | DOI:10.1016/j.pharma.2024.02.009 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - February 22, 2024 Category: Drugs & Pharmacology Authors: Cyrielle Bouguergour Florence Peyron Christophe Curti Nathalie Bailli é S ébastien Gallice Source Type: research
Evaluation of pharmaceutical practice in hospitals: an exploratory study comparing processes in France and Quebec
CONCLUSIONS: This study highlights the evaluation processes of pharmaceutical practice in hospitals. In France as in Quebec, we recognize the importance of the drug circuit in the hospital, the development and operation of a pharmacy department and the practice of pharmacy. While there are more similarities for the assessment of the drug circuit in hospitals and pharmacy department, important differences are observed for the assessment of individuals. We believe that the publication of a comparative analysis can contribute to discussions and exchanges to benefit from the best practices of each country.PMID:38367934 | DOI:1...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Manon Marc Patrick Rambourg Jean-Fran çois Bussières Source Type: research
Implementation of an Advanced Planning and Scheduling System in a pharmaceutical context
Ann Pharm Fr. 2024 Feb 15:S0003-4509(24)00027-0. doi: 10.1016/j.pharma.2024.02.007. Online ahead of print.ABSTRACTOptimizing its supply chain has now become more than a necessity for any company seeking to expand its national and international market, so that it is able to continue its progress and fulfil its obligations towards its employees and its customers, particularly in the pharmaceutical context. The Covid-19 pandemic has shown the importance of resilience in the pharmaceutical industry to deal with unexpected disruptions and high demand from patients and authorities. Better production planning based on data manage...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Meriem Belghith Sana Bouajaja Source Type: research
Antioxidant and Anti-Arthritic Activity of Bombax buonopozense P. Beauv. Leaves
CONCLUSION: Phytochemical screening revealed the presence of flavonoids, alkaloids, and phenolics. The brine shrimp lethality assay of the crude extract and fractions gave LC50 value ≥ 1000 µg/mL, compared to Cyclophosphamide (LC50 = 224.7±0.35µg/mL). The BBME had TPC value of 19.8±0.56 mg GAE/g, while the TFC of ethyl acetate fraction was the highest (173.5±0.05 mg QE/g). The ethyl acetate fraction has the highest antioxidant activity (IC50 = 20.96±0.23 µg/mL) as compared to ascorbic acid (2.8±0.01) and rutin (20.6±9.26 µg/mL). BBME significantly reduced the paw circumference. BBME (400 mg/kg) prevented bioche...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Olusoji Aanuoluwa Fadogba Akingbolabo Daniel Ogunlakin Abayomi Mayowa Ajayi Mubo Adeola Sonibare Source Type: research
L'effet du safran et de ses extraits sur le traitement du cancer du sein: une revue narrative
Ann Pharm Fr. 2024 Feb 15:S0003-4509(24)00031-2. doi: 10.1016/j.pharma.2024.02.011. Online ahead of print.ABSTRACTBreast cancer (BC) is the most prevalent malignancy in women and the second most common disease worldwide, affecting approximately one million individuals annually. Despite the efficacy of conventional chemotherapy, medication resistance and adverse effects limit its effectiveness, leading researchers to explore alternative treatments, including herbal remedies. Saffron, a well-known spice derived from the Crocus sativus L. plant, has shown potential as a BC treatment. The active components of saffron exhibit a...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Roya Mokhtarian Soodeh Rajabi Setareh Zahedian Saeideh Jafarinejad-Farsangi Morteza Hadizadeh Masoumeh Sadeghinejad Source Type: research
Evaluation of pharmaceutical practice in hospitals: an exploratory study comparing processes in France and Quebec
CONCLUSIONS: This study highlights the evaluation processes of pharmaceutical practice in hospitals. In France as in Quebec, we recognize the importance of the drug circuit in the hospital, the development and operation of a pharmacy department and the practice of pharmacy. While there are more similarities for the assessment of the drug circuit in hospitals and pharmacy department, important differences are observed for the assessment of individuals. We believe that the publication of a comparative analysis can contribute to discussions and exchanges to benefit from the best practices of each country.PMID:38367934 | DOI:1...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Manon Marc Patrick Rambourg Jean-Fran çois Bussières Source Type: research
Implementation of an Advanced Planning and Scheduling System in a pharmaceutical context
Ann Pharm Fr. 2024 Feb 15:S0003-4509(24)00027-0. doi: 10.1016/j.pharma.2024.02.007. Online ahead of print.ABSTRACTOptimizing its supply chain has now become more than a necessity for any company seeking to expand its national and international market, so that it is able to continue its progress and fulfil its obligations towards its employees and its customers, particularly in the pharmaceutical context. The Covid-19 pandemic has shown the importance of resilience in the pharmaceutical industry to deal with unexpected disruptions and high demand from patients and authorities. Better production planning based on data manage...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Meriem Belghith Sana Bouajaja Source Type: research
Antioxidant and Anti-Arthritic Activity of Bombax buonopozense P. Beauv. Leaves
CONCLUSION: Phytochemical screening revealed the presence of flavonoids, alkaloids, and phenolics. The brine shrimp lethality assay of the crude extract and fractions gave LC50 value ≥ 1000 µg/mL, compared to Cyclophosphamide (LC50 = 224.7±0.35µg/mL). The BBME had TPC value of 19.8±0.56 mg GAE/g, while the TFC of ethyl acetate fraction was the highest (173.5±0.05 mg QE/g). The ethyl acetate fraction has the highest antioxidant activity (IC50 = 20.96±0.23 µg/mL) as compared to ascorbic acid (2.8±0.01) and rutin (20.6±9.26 µg/mL). BBME significantly reduced the paw circumference. BBME (400 mg/kg) prevented bioche...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Olusoji Aanuoluwa Fadogba Akingbolabo Daniel Ogunlakin Abayomi Mayowa Ajayi Mubo Adeola Sonibare Source Type: research
L'effet du safran et de ses extraits sur le traitement du cancer du sein: une revue narrative
Ann Pharm Fr. 2024 Feb 15:S0003-4509(24)00031-2. doi: 10.1016/j.pharma.2024.02.011. Online ahead of print.ABSTRACTBreast cancer (BC) is the most prevalent malignancy in women and the second most common disease worldwide, affecting approximately one million individuals annually. Despite the efficacy of conventional chemotherapy, medication resistance and adverse effects limit its effectiveness, leading researchers to explore alternative treatments, including herbal remedies. Saffron, a well-known spice derived from the Crocus sativus L. plant, has shown potential as a BC treatment. The active components of saffron exhibit a...
Source: Annales Pharmaceutiques Francaises - February 17, 2024 Category: Drugs & Pharmacology Authors: Roya Mokhtarian Soodeh Rajabi Setareh Zahedian Saeideh Jafarinejad-Farsangi Morteza Hadizadeh Masoumeh Sadeghinejad Source Type: research
