Solubility and thermodynamics of mesalazine in aqueous mixtures of poly ethylene glycol 200/600 at 293.2- 313.2 K
In this study, the solubility of mesalazine was investigated in binary solvent mixtures of poly ethylene glycols 200/600 and water at temperatures ranging from 293.2 K to 313.2 K. The solubility of mesalazine was determined using a shake-flask method, and its concentrations were measured using a UV-Vis spectrophotometer. The obtained solubility data were analyzed using mathematical models including the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, mixture response surface, and modified Wilson models. The experimental data obtained for mesalazine dissolution encompassed various thermodynamic properties, including ΔG...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Anali Ali Akbari Aynaz Zarghampour Nastaran Hashemzadeh Salar Hemmati Elaheh Rahimpour Abolghasem Jouyban Source Type: research
Exavir: implementation and evaluation of experimental pharmacology skills acquisition by pharmacy students
Ann Pharm Fr. 2024 Apr 3:S0003-4509(24)00043-9. doi: 10.1016/j.pharma.2024.03.008. Online ahead of print.ABSTRACTWith the evolution of European and French regulations on animal experimentation in higher education, taking greater account of animal welfare, the University of Angers has developed a virtual animal experimentation software named Exavir. Used for practical work (PW) in physiology, pharmacology and toxicology in the Health, Sciences, and engineering curricula, Exavir can be used to simulate various experiments for teaching purposes, in vivo or ex vivo. Thanks to an original approach integrating serious games with...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Clara Bourreau Tristan Chevrier Thomas Desserrey Nathalie Lusson Flavien Bessaguet S ébastien Faure Samuel Legeay Source Type: research
Protective effect of enicostemma axillare - swertiamarin on oxidative stress against nicotine-induced liver damage in sd rats
CONCLUSION: The results of the current study show that nicotine can seriously harm liver tissue and that Swertiamarin can prevent the harmful effects of nicotine on rat liver. Future research is necessary to delve deeply into the mechanisms behind Swertiamarin protective impact against nicotine-induced hepatotoxicity.PMID:38579927 | DOI:10.1016/j.pharma.2024.03.009 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Rajini Kolure V Nachammai Sneha Thakur Ramreddy Godela D Sherisha Bhavani S N Manjula Source Type: research
Solubility and thermodynamics of mesalazine in aqueous mixtures of poly ethylene glycol 200/600 at 293.2- 313.2 K
In this study, the solubility of mesalazine was investigated in binary solvent mixtures of poly ethylene glycols 200/600 and water at temperatures ranging from 293.2 K to 313.2 K. The solubility of mesalazine was determined using a shake-flask method, and its concentrations were measured using a UV-Vis spectrophotometer. The obtained solubility data were analyzed using mathematical models including the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, mixture response surface, and modified Wilson models. The experimental data obtained for mesalazine dissolution encompassed various thermodynamic properties, including ΔG...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Anali Ali Akbari Aynaz Zarghampour Nastaran Hashemzadeh Salar Hemmati Elaheh Rahimpour Abolghasem Jouyban Source Type: research
Exavir: implementation and evaluation of experimental pharmacology skills acquisition by pharmacy students
Ann Pharm Fr. 2024 Apr 3:S0003-4509(24)00043-9. doi: 10.1016/j.pharma.2024.03.008. Online ahead of print.ABSTRACTWith the evolution of European and French regulations on animal experimentation in higher education, taking greater account of animal welfare, the University of Angers has developed a virtual animal experimentation software named Exavir. Used for practical work (PW) in physiology, pharmacology and toxicology in the Health, Sciences, and engineering curricula, Exavir can be used to simulate various experiments for teaching purposes, in vivo or ex vivo. Thanks to an original approach integrating serious games with...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Clara Bourreau Tristan Chevrier Thomas Desserrey Nathalie Lusson Flavien Bessaguet S ébastien Faure Samuel Legeay Source Type: research
Protective effect of enicostemma axillare - swertiamarin on oxidative stress against nicotine-induced liver damage in sd rats
CONCLUSION: The results of the current study show that nicotine can seriously harm liver tissue and that Swertiamarin can prevent the harmful effects of nicotine on rat liver. Future research is necessary to delve deeply into the mechanisms behind Swertiamarin protective impact against nicotine-induced hepatotoxicity.PMID:38579927 | DOI:10.1016/j.pharma.2024.03.009 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Rajini Kolure V Nachammai Sneha Thakur Ramreddy Godela D Sherisha Bhavani S N Manjula Source Type: research
Solubility and thermodynamics of mesalazine in aqueous mixtures of poly ethylene glycol 200/600 at 293.2- 313.2 K
In this study, the solubility of mesalazine was investigated in binary solvent mixtures of poly ethylene glycols 200/600 and water at temperatures ranging from 293.2 K to 313.2 K. The solubility of mesalazine was determined using a shake-flask method, and its concentrations were measured using a UV-Vis spectrophotometer. The obtained solubility data were analyzed using mathematical models including the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, mixture response surface, and modified Wilson models. The experimental data obtained for mesalazine dissolution encompassed various thermodynamic properties, including ΔG...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Anali Ali Akbari Aynaz Zarghampour Nastaran Hashemzadeh Salar Hemmati Elaheh Rahimpour Abolghasem Jouyban Source Type: research
Exavir: implementation and evaluation of experimental pharmacology skills acquisition by pharmacy students
Ann Pharm Fr. 2024 Apr 3:S0003-4509(24)00043-9. doi: 10.1016/j.pharma.2024.03.008. Online ahead of print.ABSTRACTWith the evolution of European and French regulations on animal experimentation in higher education, taking greater account of animal welfare, the University of Angers has developed a virtual animal experimentation software named Exavir. Used for practical work (PW) in physiology, pharmacology and toxicology in the Health, Sciences, and engineering curricula, Exavir can be used to simulate various experiments for teaching purposes, in vivo or ex vivo. Thanks to an original approach integrating serious games with...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Clara Bourreau Tristan Chevrier Thomas Desserrey Nathalie Lusson Flavien Bessaguet S ébastien Faure Samuel Legeay Source Type: research
Protective effect of enicostemma axillare - swertiamarin on oxidative stress against nicotine-induced liver damage in sd rats
CONCLUSION: The results of the current study show that nicotine can seriously harm liver tissue and that Swertiamarin can prevent the harmful effects of nicotine on rat liver. Future research is necessary to delve deeply into the mechanisms behind Swertiamarin protective impact against nicotine-induced hepatotoxicity.PMID:38579927 | DOI:10.1016/j.pharma.2024.03.009 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Rajini Kolure V Nachammai Sneha Thakur Ramreddy Godela D Sherisha Bhavani S N Manjula Source Type: research
Solubility and thermodynamics of mesalazine in aqueous mixtures of poly ethylene glycol 200/600 at 293.2- 313.2 K
In this study, the solubility of mesalazine was investigated in binary solvent mixtures of poly ethylene glycols 200/600 and water at temperatures ranging from 293.2 K to 313.2 K. The solubility of mesalazine was determined using a shake-flask method, and its concentrations were measured using a UV-Vis spectrophotometer. The obtained solubility data were analyzed using mathematical models including the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, mixture response surface, and modified Wilson models. The experimental data obtained for mesalazine dissolution encompassed various thermodynamic properties, including ΔG...
Source: Annales Pharmaceutiques Francaises - April 5, 2024 Category: Drugs & Pharmacology Authors: Anali Ali Akbari Aynaz Zarghampour Nastaran Hashemzadeh Salar Hemmati Elaheh Rahimpour Abolghasem Jouyban Source Type: research
A UPLC method development and validation study of Upadacitinib and its impurities in extended - release oral tablet dosage forms
CONCLUSION: A fast, isocratic, specific, and reproducible ultra - performance liquid chromatographic method was developed and validated for various parameters according to the ICH Q2 (R1) guidelines studies. Stress studies were conducted exposing the sample dilution to various treatments (acid, alkali, peroxide, HPLC water, heat, and UV light). The degradants were well - separated apart from the peaks of the active substance. The stability indicating nature was observed during the degradation. The optimized method can be applied for the separation and estimation of Upadacitinib and its process - related impurities in pharm...
Source: Annales Pharmaceutiques Francaises - March 30, 2024 Category: Drugs & Pharmacology Authors: Rajya Lakshmi Nimmagadda Sowjanya Gummadi Source Type: research
A UPLC method development and validation study of Upadacitinib and its impurities in extended - release oral tablet dosage forms
CONCLUSION: A fast, isocratic, specific, and reproducible ultra - performance liquid chromatographic method was developed and validated for various parameters according to the ICH Q2 (R1) guidelines studies. Stress studies were conducted exposing the sample dilution to various treatments (acid, alkali, peroxide, HPLC water, heat, and UV light). The degradants were well - separated apart from the peaks of the active substance. The stability indicating nature was observed during the degradation. The optimized method can be applied for the separation and estimation of Upadacitinib and its process - related impurities in pharm...
Source: Annales Pharmaceutiques Francaises - March 30, 2024 Category: Drugs & Pharmacology Authors: Rajya Lakshmi Nimmagadda Sowjanya Gummadi Source Type: research
A UPLC method development and validation study of Upadacitinib and its impurities in extended - release oral tablet dosage forms
CONCLUSION: A fast, isocratic, specific, and reproducible ultra - performance liquid chromatographic method was developed and validated for various parameters according to the ICH Q2 (R1) guidelines studies. Stress studies were conducted exposing the sample dilution to various treatments (acid, alkali, peroxide, HPLC water, heat, and UV light). The degradants were well - separated apart from the peaks of the active substance. The stability indicating nature was observed during the degradation. The optimized method can be applied for the separation and estimation of Upadacitinib and its process - related impurities in pharm...
Source: Annales Pharmaceutiques Francaises - March 30, 2024 Category: Drugs & Pharmacology Authors: Rajya Lakshmi Nimmagadda Sowjanya Gummadi Source Type: research
A UPLC method development and validation study of Upadacitinib and its impurities in extended - release oral tablet dosage forms
CONCLUSION: A fast, isocratic, specific, and reproducible ultra - performance liquid chromatographic method was developed and validated for various parameters according to the ICH Q2 (R1) guidelines studies. Stress studies were conducted exposing the sample dilution to various treatments (acid, alkali, peroxide, HPLC water, heat, and UV light). The degradants were well - separated apart from the peaks of the active substance. The stability indicating nature was observed during the degradation. The optimized method can be applied for the separation and estimation of Upadacitinib and its process - related impurities in pharm...
Source: Annales Pharmaceutiques Francaises - March 30, 2024 Category: Drugs & Pharmacology Authors: Rajya Lakshmi Nimmagadda Sowjanya Gummadi Source Type: research
A UPLC method development and validation study of Upadacitinib and its impurities in extended - release oral tablet dosage forms
CONCLUSION: A fast, isocratic, specific, and reproducible ultra - performance liquid chromatographic method was developed and validated for various parameters according to the ICH Q2 (R1) guidelines studies. Stress studies were conducted exposing the sample dilution to various treatments (acid, alkali, peroxide, HPLC water, heat, and UV light). The degradants were well - separated apart from the peaks of the active substance. The stability indicating nature was observed during the degradation. The optimized method can be applied for the separation and estimation of Upadacitinib and its process - related impurities in pharm...
Source: Annales Pharmaceutiques Francaises - March 30, 2024 Category: Drugs & Pharmacology Authors: Rajya Lakshmi Nimmagadda Sowjanya Gummadi Source Type: research
