Correction: Celecoxib and octreotide synergistically ameliorate portal hypertension via inhibition of angiogenesis in cirrhotic rats
(Source: Angiogenesis)
Source: Angiogenesis - September 10, 2022 Category: Molecular Biology Source Type: research
Correction: A novel lymphatic pattern promotes metastasis of cervical cancer in a hypoxic tumour-associated macrophage-dependent manner
(Source: Angiogenesis)
Source: Angiogenesis - September 10, 2022 Category: Molecular Biology Source Type: research
MicroRNA-375 repression of Kruppel-like factor 5 improves angiogenesis in diabetic critical limb ischemia
AbstractPeripheral artery disease (PAD) is an occlusive disease of limb arteries. Critical limb ischemia (CLI) is an advanced form of PAD that is prognostically worse in subjects with diabetes and can result in limb loss, gangrene, and death, although the underlying signaling mechanisms that contribute to its development remain poorly understood. By comparing plasma samples from diabetic humans with PAD and mouse models of PAD, we identified miR-375 to be significantly downregulated in humans and mice during progression to CLI. Overexpression of miR-375 was pro-angiogenic in endothelial cells in vitro and induced endotheli...
Source: Angiogenesis - September 8, 2022 Category: Molecular Biology Source Type: research
Protein disulfide isomerase A1 as a novel redox sensor in VEGFR2 signaling and angiogenesis
AbstractVEGFR2 signaling in endothelial cells (ECs) is regulated by reactive oxygen species (ROS) derived from NADPH oxidases (NOXs) and mitochondria, which plays an important role in postnatal angiogenesis. However, it remains unclear how highly diffusible ROS signal enhances VEGFR2 signaling and reparative angiogenesis. Protein disulfide isomerase A1 (PDIA1) functions as an oxidoreductase depending on the redox environment. We hypothesized that PDIA1 functions as a redox sensor to enhance angiogenesis. Here we showed that PDIA1 co-immunoprecipitated with VEGFR2 or colocalized with either VEGFR2 or an early endosome marke...
Source: Angiogenesis - August 19, 2022 Category: Molecular Biology Source Type: research
Endothelial cell expression of mutant Map2k1 causes vascular malformations in mice
In conclusion, expression of MAP2K1 p.K57N is sufficient to cause vascular malformations in mice. This model can be used to study the malformation process and for pre-clinical pharmacologic studies. (Source: Angiogenesis)
Source: Angiogenesis - August 16, 2022 Category: Molecular Biology Source Type: research
Persistent capillary rarefication in long COVID syndrome
ConclusionsOur current data strongly suggest that COVID-19 leaves a persistent capillary rarefication even 18 months after infection. Whether, to what extent, and when the observed damage might be reversible remains unclear. (Source: Angiogenesis)
Source: Angiogenesis - August 11, 2022 Category: Molecular Biology Source Type: research
Tissue oxygenation stabilizes neovessels and mitigates hemorrhages in human atherosclerosis-induced angiogenesis
AbstractProgression of atherosclerosis is associated with a maladaptive form of angiogenesis which contributes to intraplaque hemorrhage and plaque disruption. Hypoxia has been implicated in mechanisms of angiogenic neovessel fragility and atherosclerotic plaque destabilization. We used ex vivo and in vivo models to characterize the effect of oxygen (O2) on the formation, stability and tendency to bleed of human plaque-induced neovessels. Plaque explants potently stimulated the ex vivo angiogenic response of rat aortic rings at atmospheric O2 levels. Severe hypoxia (1% O2) inhibited plaque-induced angiogenesis and pericyte...
Source: Angiogenesis - August 10, 2022 Category: Molecular Biology Source Type: research
Somatic GJA4 gain-of-function mutation in orbital cavernous venous malformations
AbstractOrbital cavernous venous malformation (OCVM) is a sporadic vascular anomaly of uncertain etiology characterized by abnormally dilated vascular channels. Here, we identify a somatic missense mutation, c.121G > T (p.Gly41Cys) inGJA4, which encodes a transmembrane protein that is a component of gap junctions and hemichannels in the vascular system, in OCVM tissues from 25/26 (96.2%) individuals with OCVM. GJA4 expression was detected in OCVM tissue including endothelial cells and the stroma, through immunohistochemistry. Within OCVM tissue, the mutation allele frequency was higher in endothelial cell-enriched...
Source: Angiogenesis - July 29, 2022 Category: Molecular Biology Source Type: research
The rising impact of angiogenesis research
AbstractWhile inhibiting pathological angiogenesis has been long associated with the field of oncology, recent advances in angiogenesis research have impacted the progress of disease treatment for additional non-malignant diseases or chronic conditions in the fields of ophthalmology, cardiology, and gynecology. Moreover, stimulators of angiogenesis find application in ischemic diseases, while inhibitors of angiogenesis are being used to limit blood vessel formation, but in judicious ways that modify or “reprogram” the vasculature as a reinforcement for immunotherapy. We have noticed an increasing impact, as evidenced b...
Source: Angiogenesis - July 26, 2022 Category: Molecular Biology Source Type: research
