Executive summary of the 14th HHT international scientific conference
AbstractHereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder characterized by small, dilated clustered vessels (telangiectasias) and by larger visceral arteriovenous malformations (AVMs), which directly connect the feeding arteries with the draining veins. These lesions are fragile, prone to rupture, and lead to recurrent epistaxis and/or internal hemorrhage among other complications. Germline heterozygous loss-of-function (LOF) mutations in Bone Morphogenic Protein 9 (BMP9) and BMP10 signaling pathway genes (endoglin-ENG, activin like kinase 1ACVRL1 akaALK1, andSMAD4) cause different subt...
Source: Angiogenesis - September 11, 2023 Category: Molecular Biology Source Type: research
2022 14th HHT International Scientific Conference Abstracts
(Source: Angiogenesis)
Source: Angiogenesis - September 8, 2023 Category: Molecular Biology Source Type: research
Reply to “Embracing imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19”
(Source: Angiogenesis)
Source: Angiogenesis - September 2, 2023 Category: Molecular Biology Source Type: research
The modes of angiogenesis: an updated perspective
AbstractFollowing the process of vasculogenesis during development, angiogenesis generates new vascular structures through a variety of different mechanisms or modes. These different modes of angiogenesis involve, for example, increasing microvasculature density by sprouting of endothelial cells, splitting of vessels to increase vascular surface area by intussusceptive angiogenesis, fusion of capillaries to increase blood flow by coalescent angiogenesis, and the recruitment of non-endothelial cells by vasculogenic mimicry. The recent reporting on coalescent angiogenesis as a new mode of vessel formation warrants a brief ov...
Source: Angiogenesis - August 28, 2023 Category: Molecular Biology Source Type: research
Correction: Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
(Source: Angiogenesis)
Source: Angiogenesis - August 23, 2023 Category: Molecular Biology Source Type: research
Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice
AbstractTissue-resident vascular endothelial stem cells (VESCs), marked by expression of CD157, possess long-term repopulating potential and contribute to vascular regeneration and homeostasis in mice. Stem cell exhaustion is regarded as one of the hallmarks of aging and is being extensively studied in several types of tissue-resident stem cells; however, how aging affects VESCs has not been clarified yet. In the present study, we isolated VESCs from young and aged mice to compare their potential to differentiate into endothelial cells in vitro and in vivo. Here, we report that the number of liver endothelial cells (ECs) i...
Source: Angiogenesis - August 10, 2023 Category: Molecular Biology Source Type: research
Embracing Imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19
AbstractImatinib, an ABL tyrosine-kinase inhibitor, shows promise in restoring endothelial barrier function in patients with COVID-19, thus, preventing cytokine leakage from the alveolar compartment to the systemic compartment. COVID-19 is characterized by an alveolar cytokine storm, and imatinib has been shown to strengthen the endothelial barrier and mitigate alveolar inflammatory responses by modulating NF- κB signaling. Incorporating imatinib into COVID-19 treatment strategies offers a novel approach to safeguard the endothelial barrier and address the complex pathophysiology of the disease, including its potential im...
Source: Angiogenesis - August 2, 2023 Category: Molecular Biology Source Type: research
VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients
ConclusionVEGF-A is a relevant predictive factor for DLCO impairment and radiological sequelae in PASC. Beyond being a biomarker, we hypothesize that the persistence of angiogenic disorders may contribute to long COVID symptoms. (Source: Angiogenesis)
Source: Angiogenesis - August 1, 2023 Category: Molecular Biology Source Type: research
