Human endothelial colony-forming cells provide trophic support for pluripotent stem cell-derived cardiomyocytes via distinctively high expression of neuregulin-1
AbstractThe search for a source of endothelial cells (ECs) with translational therapeutic potential remains crucial in regenerative medicine. Human blood-derived endothelial colony-forming cells (ECFCs) represent a promising source of autologous ECs due to their robust capacity to form vascular networks in vivo and their easy accessibility from peripheral blood. However, whether ECFCs have distinct characteristics with translational value compared to other ECs remains unclear. Here, we show that vascular networks generated with human ECFCs exhibited robust paracrine support for human pluripotent stem cell-derived cardiomyo...
Source: Angiogenesis - January 17, 2021 Category: Molecular Biology Source Type: research
Circulating Von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality
ConclusionVWF:Ag is a relevant predictive factor for in-hospital mortality in COVID-19 patients. More than a biomarker, we hypothesize that VWF, including excess of HMWM forms, drives microthrombosis in COVID-19. (Source: Angiogenesis)
Source: Angiogenesis - January 15, 2021 Category: Molecular Biology Source Type: research
To be or not to be: endothelial cell plasticity in development, repair, and disease
AbstractEndothelial cells display an extraordinary plasticity both during development and throughout adult life. During early development, endothelial cells assume arterial, venous, or lymphatic identity, while selected endothelial cells undergo additional fate changes to become hematopoietic progenitor, cardiac valve, and other cell types. Adult endothelial cells are some of the longest-lived cells in the body and their participation as stable components of the vascular wall is critical for the proper function of both the circulatory and lymphatic systems, yet these cells also display a remarkable capacity to undergo chan...
Source: Angiogenesis - January 15, 2021 Category: Molecular Biology Source Type: research
RIPK3 modulates growth factor receptor expression in endothelial cells to support angiogenesis
AbstractReceptor-interacting protein kinase 3 (RIPK3) is a multifunctional intracellular protein that was first recognized as an important component of the necroptosis programmed cell death pathway. RIPK3 is also highly expressed in non-necroptotic murine embryonic endothelial cells (ECs) during vascular development, indicating its potential contribution to angiogenesis. To test this hypothesis, we generated mice lacking endothelial RIPK3 and found non-lethal embryonic and perinatal angiogenesis defects in multiple vascular beds. Our in vitro data indicate that RIPK3 supports angiogenesis by regulating growth factor recept...
Source: Angiogenesis - January 15, 2021 Category: Molecular Biology Source Type: research
Protection of capillaries may be critical in delaying aging around the eyes and prevention of facial plastic surgery
(Source: Angiogenesis)
Source: Angiogenesis - January 15, 2021 Category: Molecular Biology Source Type: research
