Letter in response to: circulating von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality
(Source: Angiogenesis)
Source: Angiogenesis - August 1, 2021 Category: Molecular Biology Source Type: research
Refractory severe idiopathic systemic capillary leak syndrome successfully treated with bevacizumab: a case report
(Source: Angiogenesis)
Source: Angiogenesis - August 1, 2021 Category: Molecular Biology Source Type: research
Correction to: The role of redox system in metastasis formation
(Source: Angiogenesis)
Source: Angiogenesis - August 1, 2021 Category: Molecular Biology Source Type: research
Correction to: Phosphorylation of pericyte FAK ‑Y861 affects tumour cell apoptosis and tumour blood vessel regression
A correction to this paper has been published: https://doi.org/10.1007/s10456-021-09802-9 (Source: Angiogenesis)
Source: Angiogenesis - July 4, 2021 Category: Molecular Biology Source Type: research
COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects
AbstractCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with vascular inflammation and endothelial injury. Severe forms of SARS-CoV-2 infection induce acute respiratory distress syndrome (ARDS) and there is still an ongoing debate on whether COVID-19 ARDS and its perfusion defect differs from ARDS induced by other causes. Beside pro-inflammatory cytokines (such as interleukin-1 β [IL-1β] or IL-6), several main pathological phenomena have been seen because of endothelial cell (EC) dysfunction: hypercoagulation reflect...
Source: Angiogenesis - June 28, 2021 Category: Molecular Biology Source Type: research
Extracellular matrix stiffness controls VEGF165 secretion and neuroblastoma angiogenesis via the YAP/RUNX2/SRSF1 axis
AbstractAberrant variations in angiogenesis have been observed in tumor tissues with abnormal stiffness of extracellular matrix (ECM). However, it remains largely unclear how ECM stiffness influences tumor angiogenesis. Numerous studies have reported that vascular endothelial growth factor-A (VEGF-A) released from tumor cells plays crucial roles in angiogenesis. Hence, we demonstrated the role of ECM stiffness in VEGF-A release from neuroblastoma (NB) cells and the underlying mechanisms. Based on 17 NB clinical samples, a negative correlation was observed between the length of blood vessels and stiffness of NB tissues. In ...
Source: Angiogenesis - June 25, 2021 Category: Molecular Biology Source Type: research
Von Willebrand factor multimers during non-invasive ultrasound therapy for aortic valve stenosis
(Source: Angiogenesis)
Source: Angiogenesis - June 8, 2021 Category: Molecular Biology Source Type: research
Letter in response to: circulating von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality
(Source: Angiogenesis)
Source: Angiogenesis - June 8, 2021 Category: Molecular Biology Source Type: research
Correction to: Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking
A correction to this paper has been published: https://doi.org/10.1007/s10456-021-09801-w (Source: Angiogenesis)
Source: Angiogenesis - June 8, 2021 Category: Molecular Biology Source Type: research
The HGR motif is the antiangiogenic determinant of vasoinhibin: implications for a therapeutic orally active oligopeptide
AbstractThe hormone prolactin acquires antiangiogenic and antivasopermeability properties after undergoing proteolytic cleavage to vasoinhibin, an endogenous prolactin fragment of 123 or more amino acids that inhibits the action of multiple proangiogenic factors. Preclinical and clinical evidence supports the therapeutic potential of vasoinhibin against angiogenesis-related diseases including diabetic retinopathy, peripartum cardiomyopathy, rheumatoid arthritis, and cancer. However, the use of vasoinhibin in the clinic has been limited by difficulties in its production. Here, we removed this barrier to using vasoinhibin as...
Source: Angiogenesis - June 7, 2021 Category: Molecular Biology Source Type: research
Endothelial cell plasticity at the single-cell level
AbstractThe vascular endothelium is characterized by a remarkable level of plasticity, which is the driving force not only of physiological repair/remodeling of adult tissues but also of pathological angiogenesis. The resulting heterogeneity of endothelial cells (ECs) makes targeting the endothelium challenging, no less because many EC phenotypes are yet to be identified and functionally inventorized. Efforts to map the vasculature at the single-cell level have been instrumental to capture the diversity of EC types and states at a remarkable depth in both normal and pathological states. Here, we discuss new EC subtypes and...
Source: Angiogenesis - June 1, 2021 Category: Molecular Biology Source Type: research
Role of Notch in endothelial biology
AbstractThe Notch signalling pathway is one of the main regulators of endothelial biology. In the last 20 years the critical function of Notch has been uncovered in the context of angiogenesis, participating in tip-stalk specification, arterial-venous differentiation, vessel stabilization, and maturation processes. Importantly, pharmacological compounds targeting distinct members of the Notch signalli ng pathway have been used in the clinics for cancer therapy. However, the underlying mechanisms that support the variety of outcomes triggered by Notch in apparently opposite contexts such as angiogenesis and vascular homeo...
Source: Angiogenesis - May 29, 2021 Category: Molecular Biology Source Type: research
Angiogenesis: a year in review
(Source: Angiogenesis)
Source: Angiogenesis - May 29, 2021 Category: Molecular Biology Source Type: research
Pericyte hypoxia-inducible factor-1 (HIF-1) drives blood-brain barrier disruption and impacts acute ischemic stroke outcome
AbstractPericytes play essential roles in blood-brain barrier integrity and their dysfunction is implicated in neurological disorders such as stroke although the underlying mechanisms remain unknown. Hypoxia-inducible factor-1 (HIF-1), a master regulator of injury responses, has divergent roles in different cells especially during stress scenarios. On one hand HIF-1 is neuroprotective but on the other it induces vascular permeability. Since pericytes are critical for barrier stability, we asked if pericyte HIF-1 signaling impacts barrier integrity and injury severity in a mouse model of ischemic stroke. We show that pericy...
Source: Angiogenesis - May 27, 2021 Category: Molecular Biology Source Type: research
