Method development and validation for the quantitative determination of total flavonoids through the complexation of iron (III) and its application in real sample
Anal Chim Acta. 2024 May 1;1301:342443. doi: 10.1016/j.aca.2024.342443. Epub 2024 Mar 13.ABSTRACTBACKGROUND: The determination of flavonoids in real sample using UV-Vis spectrophotometer commonly uses quercetin and catechin with Al+3 complexing agent as reference materials for the calibration of the instrument. However, getting these standard materials is challenging due to its expense and unavailability in the chemical reserve of the country. Moreover, the Al+3 - quercetin complexation standard method demands high amount of quercetin in spite of its high cost. Hence, developing alternative method that can solve this probl...
Source: Analytica Chimica Acta - March 29, 2024 Category: Chemistry Authors: Sayge Sate Shanko Tolera Seda Badessa Alemu Mekonnen Tura Source Type: research
Nanocluster/metal-organic framework nanosheet-based confined ECL enhancement biosensor for the extracellular vesicle detection
Anal Chim Acta. 2024 May 1;1301:342488. doi: 10.1016/j.aca.2024.342488. Epub 2024 Mar 16.ABSTRACTGastric cancer (GC) was one of the most common cancers with high mortality. The detection of GC peritoneal metastasis had important significance. In this work, we have developed the novel electrochemiluminescence (ECL) biosensor to detect microRNA in GC extracellular vesicle (EV). Firstly, in situ growth of Cu nanocluster (Cu NC) on the metal-organic frameworks (MOFs) nanosheet was achieved successfully. Due to the confinement effect, Cu NCs in the porous structure of Zn MOF possessed the high quantum yield and good stability. ...
Source: Analytica Chimica Acta - March 29, 2024 Category: Chemistry Authors: Fuzhe Ma Wenyan Li Peilin Wang Qiang Ma Source Type: research
A SERS nanocellulose-paper-based analytical device for ultrasensitive detection of Alzheimer's disease
Anal Chim Acta. 2024 May 1;1301:342447. doi: 10.1016/j.aca.2024.342447. Epub 2024 Mar 4.ABSTRACTBACKGROUND: Alzheimer's disease (AD), one of the most prevalent neurodegenerative diseases, results in severe cognitive decline and irreversible memory loss. Early detection of AD is significant to patients for personalized intervention since effective cure and treatment methods for AD are still lacking. Despite the severity of the disease, existing highly sensitive AD detection methods, including neuroimaging and brain deposit-positive lesion tests, are not suitable for screening purposes due to their high cost and complicated ...
Source: Analytica Chimica Acta - March 29, 2024 Category: Chemistry Authors: Wenwen Yuan Hang Yuan Ruibing Li Ruiqi Yong Ivona Mitrovic Eng Gee Lim Sixuan Duan Pengfei Song Source Type: research
Exploring a new generation of bimetallic magnetic ionic liquids with ultra-low viscosity in microextraction that enable direct coupling with high-performance liquid-chromatography
This study represents the first liquid-phase microextraction method using the new generation of low-viscous bimetallic MILs. The proposed MIL-DLLME approach represents 2 important advances with respect to previous methods employing bimetallic MILs: 1) no dispersive solvent is required, and 2) direct injection of the MIL in the HPLC is possible after minor dilution (no back extraction steps are required). Therefore, the microextraction strategy is simple, rapid, and consumes very small amounts of energy.PMID:38553120 | DOI:10.1016/j.aca.2024.342448 (Source: Analytica Chimica Acta)
Source: Analytica Chimica Acta - March 29, 2024 Category: Chemistry Authors: Ra úl González-Martín Sirintorn Jullakan Mar ía J Trujillo-Rodríguez Nabeel Mujtaba Abbasi Shashini De Silva Jared L Anderson Ver ónica Pino Source Type: research
Oriented docking of the template for improved imprinting efficiency toward peptide with modifications
In this report, a facile and one-pot strategy by integrating the in-situ growth of magnetic nanoparticles and reversed phase microemulsion oriented molecularly imprinting strategy to develop magnetic molecular imprinted nanocomposites was proposed. Through self-assembling of the template, it brought up highly ordered and uniform arrangement of the imprinting structure, which offered faster adsorption kinetic as adsorption equilibrium was achived within 15 min, higher adsorption capacity (Qmax = 48.78 ± 1.54 μmol/g) and high affinity (Kd = 127.63 ± 9.66 μM) toward paradigm molecule-adenosine monophosphate (AMP) compared...
Source: Analytica Chimica Acta - March 29, 2024 Category: Chemistry Authors: Juntao Zhou Muhammad Mujahid Ali Wenjing Yu Xianhui Cheng Yujun Gao Lianghai Hu Source Type: research
