Design of a dual-mode ratiometric fluorescent probe via MOF-on-MOF strategy for Al (III) and pH detection
Anal Chim Acta. 2024 Apr 15;1298:342403. doi: 10.1016/j.aca.2024.342403. Epub 2024 Feb 24.ABSTRACTBACKGROUND: The construction of ratiometric fluorescent MOF sensors with integrated self-calibration and dual-channel detection can efficiently overcome the deficiencies of single-signal sensing. In this regard, the rational design of structurally functionalized MOFs is paramount for enhancing their performance in ratiometric fluorescent sensors. Lately, the concept of MOF-on-MOF design has garnered notable interest as a potential strategy for regulating the structural parameters of MOFs by integrating two or more distinct MOF...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Ruirui Zhao Wenjing Lu Xiaojing Chai Chuan Dong Shaomin Shuang Yujing Guo Source Type: research

Fluorometric "AND" logic gate for detection of tyramine and tyrosinase based on in-situ formation of silicon-containing nanoparticles
Anal Chim Acta. 2024 Apr 15;1298:342415. doi: 10.1016/j.aca.2024.342415. Epub 2024 Feb 26.ABSTRACTBACKGROUND: Tyramine is an important index of food freshness degree, and tyrosinase that can specifically oxidized monophenolamine to catecholamine plays a crucial part in the occurrence and development of melanin-related skin diseases. Therefore, it is crucial to develop sensitive and efficient methods for the detection of tyramine and tyrosinase.RESULTS: In this work, encouraged by tyrosinase-triggered specific oxidation of tyramine to dopamine and the unique fluorescent reaction between dopamine and amino silane, we have de...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Tingting Wang Fangning Liu Chuanxia Chen Yizhong Lu Source Type: research

An in silico scheme for optimizing the enzymatic acquisition of natural biologically active peptides based on machine learning and virtual digestion
Anal Chim Acta. 2024 Apr 15;1298:342419. doi: 10.1016/j.aca.2024.342419. Epub 2024 Feb 26.ABSTRACTBACKGROUND: As a potential natural active substance, natural biologically active peptides (NBAPs) are recently attracting increasing attention. The traditional proteolysis methods of obtaining effective NBAPs are considerably vexing, especially since multiple proteases can be used, which blocks the exploration of available NBAPs. Although the development of virtual digesting brings some degree of convenience, the activity of the obtained peptides remains unclear, which would still not allow efficient access to the NBAPs. It is...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Like Lin Cong Li Tianlong Zhang Chaoshuang Xia Qiuhong Bai Lihua Jin Yehua Shen Source Type: research

Polycarboxyl ionic liquid functionalized Yb-MOFs nanoballs based dual-wavelength responsive photoelectrochemical aptasensor for the simultaneous determination of AFB1 and OTA
Anal Chim Acta. 2024 Apr 15;1298:342383. doi: 10.1016/j.aca.2024.342383. Epub 2024 Feb 17.ABSTRACTDeveloping an accurate and precise approach for the simultaneous detection of ochratoxin A (OTA) and aflatoxin B1 (AFB1) is significant for food safety surveillance. Herein, a photoelectrochemical sensing platform was constructed based on polycarboxylic ionic liquid functionalized metal-organic framework integrated with gold nanoparticles (Yb-MOFs@AuNPs). Sulfhydryl functionalized hairpin DNA (hDNA) was immobilized on a Yb-MOFs@AuNPs modified glassy carbon electrode (GCE) surface through Au-S bond. After blocking residual acti...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Lian Xu Wei Li Yawen Hong Xiaojun Cai Xiaoyang Chen Haiping Liang XingXing Xu Yanying Wang Chunya Li Dong Sun Source Type: research

Construction of single-molecule counting-based biosensors for DNA-modifying enzymes: A review
Anal Chim Acta. 2024 Apr 15;1298:342395. doi: 10.1016/j.aca.2024.342395. Epub 2024 Feb 21.ABSTRACTDNA-modifying enzymes act as critical regulators in a wide range of genetic functions (e.g., DNA damage & repair, DNA replication), and their aberrant expression may interfere with regular genetic functions and induce various malignant diseases including cancers. DNA-modifying enzymes have emerged as the potential biomarkers in early diagnosis of diseases and new therapeutic targets in genomic research. Consequently, the development of highly specific and sensitive biosensors for the detection of DNA-modifying enzymes is o...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Qian Zhang Juan Hu Dong-Ling Li Jian-Ge Qiu Bing-Hua Jiang Chun-Yang Zhang Source Type: research

AIEgens-enhanced rapid sensitive immunofluorescent assay for SARS-CoV-2 with digital microfluidics
Anal Chim Acta. 2024 Apr 15;1298:342398. doi: 10.1016/j.aca.2024.342398. Epub 2024 Feb 20.ABSTRACTBACKGROUND: Sensitive and rapid antigen detection is critical for the diagnosis and treatment of infectious diseases, but conventional ELISAs including chemiluminescence-based assays are limited in sensitivity and require many operation steps. Fluorescence immunoassays are fast and convenient but often show limited sensitivity and dynamic range.RESULTS: To address the need, an aggregation-induced emission fluorgens (AIEgens) enhanced immunofluorescent assay with beads-based quantification on the digital microfluidic (DMF) plat...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Yuping Zeng Xiangyu Gan Zhourui Xu Xiaoxiang Hu Chenxuan Hu Hanbin Ma Hangjia Tu Bao Chai Chengbin Yang Siyi Hu Yujuan Chai Source Type: research

Determination of < sup > 90 < /sup > Sr in highly radioactive aqueous samples via conversion to a kinetically stable 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complex followed by concentration-separation-fractionation based on capillary electrophoresis-liquid scintillation
This study establishes a pathway toward safer and more practical analysis of radionuclides.PMID:38462347 | DOI:10.1016/j.aca.2024.342399 (Source: Analytica Chimica Acta)
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Kazuki Ouchi Tomoko Haraga Kazuki Hirose Yuika Kurosawa Yoshiyuki Sato Masami Shibukawa Shingo Saito Source Type: research

A microfluidic chip-based capillary zone electrophoresis-mass spectrometry method for measuring adenosine 5'-Triphosphate and its similar nucleotide analogues
Anal Chim Acta. 2024 Apr 15;1298:342400. doi: 10.1016/j.aca.2024.342400. Epub 2024 Feb 21.ABSTRACTBACKGROUND: Extracellular ATP is involved in disorders that cause inflammation of the airways and cough, thus limiting its release has therapeutic benefits. Standard luminescence-based ATP assays measure levels indirectly through enzyme degradation and do not provide a simultaneous readout for other nucleotide analogues. Conversely, mass spectrometry can provide direct ATP measurements, however, common RPLC and HILIC methods face issues because these molecules are unstable, metal-sensitive analytes which are often poorly retai...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Cristina Di Poto Xiang Tian Scott Mellors Sanna Rosengren Sabina Issop Sara J Bonvini Sonja Hess Erik L Allman Source Type: research

Copper-cobalt dual-site on N-doped carbon nanotube with dual-promoted synergy for glucose electrochemical detection
Anal Chim Acta. 2024 Apr 15;1298:342405. doi: 10.1016/j.aca.2024.342405. Epub 2024 Feb 23.ABSTRACTDoping specific active sites and accelerating the decisive step of glucose catalysis to construct highly active glucose sensing electrochemical catalysts remains a major challenge for glucose sensing. Herein, we report the detailed design of Cu-Co dual active site N-doped carbon nanotube (CuCo-NCNTs) obtained by electrodeposition modification, programmed warming and calcination for electrochemical glucose detection. In the CuCo-NCNTs material system, Cu serves as the main active site for glucose sensing. Co with good adsorptio...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Zhenlu Zhao Peihan Wang Yizhong Lu Source Type: research

Calibration transfer via filter learning
Anal Chim Acta. 2024 Apr 15;1298:342404. doi: 10.1016/j.aca.2024.342404. Epub 2024 Feb 27.ABSTRACTBACKGROUND: Calibration transfer is an essential activity in analytical chemistry in order to avoid a complete recalibration. Currently, the most popular calibration transfer methods, such as piecewise direct standardization and dynamic orthogonal projection, require a certain amount of standard or reference samples to guarantee their effectiveness. To achieve higher efficiency, it is desirable to perform the transfer with as few reference samples as possible.RESULTS: To this end, we propose a new calibration transfer method b...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Zhonghao Xie Xiaojing Chen Jean-Michel Roger Shujat Ali Guangzao Huang Wen Shi Source Type: research

Controlled construction of 2D hierarchical core-shell ZnO/MnO < sub > 2 < /sub > nanosheets on Nitinol fiber with enhanced adsorption performance for selective solid-phase microextraction of trace polycyclic aromatic hydrocarbons in water samples
Anal Chim Acta. 2024 Apr 15;1298:342402. doi: 10.1016/j.aca.2024.342402. Epub 2024 Feb 22.ABSTRACTBACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) are an important class of potentially toxic persistent organic pollutants in environmental water. Their concentrations are usually too low to allow for direct determination with analytical instruments, and the preconcentration is required prior to instrumental analysis. Solid phase microextraction (SPME) is considered as a high-performance green sample preparation technique for volatile and non-volatile organic compounds due to its high enrichment factor. In fact, the nature ...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Hua Zhou Jiayu Li Huirong Li Haixia Liu Xuemei Wang Xinzhen Du Source Type: research

Magnetic photoelectrochemical sensor array utilizing addressing sensing strategy for simultaneous detection of amyloid- β 42 and microtubule-associated protein tau
This study presents the development of a magnetic photoelectrochemical (PEC) immunosensor array for the simultaneous detection of amyloid-β 42 (Aβ) and microtubule-associated protein (Tau), which are markers for neurodegenerative disorders. A metal-organic framework (MOF) derivative, Fe2O3@FeS2 magnetic composites with exceptional photoelectric and ferromagnetic properties was synthesized while preserving the original structure and advantages. Thus, the immunoassembly process of the sensor can be carried out in homogeneous solution and recovered by magnetic separation. For simultaneous detection, a chip is divided into m...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Shuo Zhang Yunfei Zhang Huan Wang Yaoguang Wang Hongmin Ma Dan Wu Zhong Feng Gao Dawei Fan Xiang Ren Qin Wei Source Type: research

GAA/(Au-Au/IrO < sub > 2 < /sub > )@Cu(PABA) reactor with cascade catalytic activity for α-glucosidase inhibitor screening
Anal Chim Acta. 2024 Apr 15;1298:342408. doi: 10.1016/j.aca.2024.342408. Epub 2024 Feb 23.ABSTRACTBACKGROUND: In vitro screening strategies based on the inhibition of α-glucosidase (GAA) activity have been widely used for the discovery of potential antidiabetic drugs, but they still face some challenges, such as poor enzyme stability, non-reusability and narrow range of applicability. To overcome these limitations, an in vitro screening method based on GAA@GOx@Cu-MOF reactor was developed in our previous study. However, the method was still not satisfactory enough in terms of construction cost, pH stability, organic solve...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Yingying Zhong Qing Wang Zi-Jian Chen Hongwu Wang Suqing Zhao Source Type: research

Golgi apparatus-targeting fluorescent probe for the imaging of superoxide anion (O < sub > 2 < /sub > < sup > •- < /sup > ) in living cells during ferroptosis
Anal Chim Acta. 2024 Apr 15;1298:342410. doi: 10.1016/j.aca.2024.342410. Epub 2024 Feb 26.ABSTRACTFerroptosis is an emerging iron-dependent oxidative cell death type, and recently has been demonstrated to show close relation with Golgi apparatus (GA). Exploring the fluctuation of superoxide anion (O2•-) level in GA during ferroptosis is of great significance to profoundly study the biological functions of GA in ferroptosis. Here, we present a GA-targeting probe (N-GA) to monitor cellular O2•- during ferroptosis. N-GA employed a triflate group and a tetradecanoic amide unit as the recognition site for O2•- and GA-targ...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Jia Chang Yan Wang Xiuqi Kong Baoli Dong Tao Yue Source Type: research

Portable photoelectrochemical immunoassay with micro-electro-mechanical-system for alpha-fetoprotein in hepatocellular carcinoma
Anal Chim Acta. 2024 Apr 15;1298:342411. doi: 10.1016/j.aca.2024.342411. Epub 2024 Feb 26.ABSTRACTEarly detection of cancer has a profound impact on patient survival and treatment outcomes considering high treatment success rates and reduced treatment complexity. Here, we developed a portable photoelectrochemical (PEC) immune platform for sensitive testing of alpha-fetoprotein (AFP) based on Pt nanocluster (Pt NCs) loaded defective-state g-C3N4 photon-electron transducers. The broad forbidden band structure of g-C3N4 was optimized by the nitrogen doping strategy and additional homogeneous porous structure was introduced to...
Source: Analytica Chimica Acta - March 10, 2024 Category: Chemistry Authors: Fangming Lou Shaojie Wang Bo Han Qunfang Li Dianping Tang Source Type: research