American Journal of Physiology. Endocrinology and Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Relationship Between Serum β-Hydroxybutyrate and Hepatic Fatty Acid Oxidation in Individuals with Obesity and NAFLD
Am J Physiol Endocrinol Metab. 2024 Feb 21. doi: 10.1152/ajpendo.00336.2023. Online ahead of print.ABSTRACTNAFLD is characterized by excess lipid accumulation which can progress to inflammation (NASH), and fibrosis. Serum β-hydroxybutyrate (β-HB), a product of the ketogenic pathway, is commonly employed as a surrogate marker for hepatic fatty acid oxidation (FAO). However, it remains uncertain whether this relationship holds true in the context of NAFLD in humans. We compared fasting serum (β-HB) levels with direct measurement of liver mitochondrial palmitate oxidation in humans stratified based on NAFLD severity (n = 1...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 21, 2024 Category: Physiology Authors: Mary P Moore Grace Shryack Isabella Alessi Nicole Wieschhaus Grace M Meers Sarah A Johnson Andrew A Wheeler Jamal A Ibdah Elizabeth J Parks R Scott Rector Source Type: research

Larsucosterol: Endogenous Epigenetic Regulator for Treating Chronic & amp; Acute Liver Diseases
Am J Physiol Endocrinol Metab. 2024 Feb 21. doi: 10.1152/ajpendo.00406.2023. Online ahead of print.ABSTRACTLarsucosterol (25-Hydroxycholesterol 3-sulfate, 25HC3S), a potent endogenous epigenetic regulator, has been reported to play a significant role in lipid metabolism, inflammatory responses, and cell survival. Administration of 25HC3S has been shown to decrease lipid accumulation in hepatocytes, suppress LPS- and TNFα-induced inflammatory responses in macrophages, alleviate LPS- and ATMP-induced multiple organ injury, and decreases mortalities in animal models. Results from phase 1 and 2 clinical trials have shown that...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 21, 2024 Category: Physiology Authors: Yaping Wang Jenna Ren Shunlin Ren Source Type: research

Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan
This study aimed to determine whether the onset age and subsequent diabetic complications can be attributed to the polygenic architecture of T2D in the Taiwan Han population. A total of 9,627 cases with T2D and 85,606 controls from the Taiwan Biobank were enrolled. Three diabetic polygenic risk scores (PRSs)-PRS_EAS and PRS_EUR, and a trans-ancestry PRS (PRS_META)-calculated using summary statistic from East Asian and European populations. The onset age was identified by linking to the National Taiwan Insurance Research Database and the incidence of different diabetic complications during follow-up was recorded. PRS_META (...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 16, 2024 Category: Physiology Authors: Shi-Heng Wang Yu-Chuen Huang Chun-Wen Cheng Ya-Wen Chang Wen-Ling Liao Source Type: research

Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan
This study aimed to determine whether the onset age and subsequent diabetic complications can be attributed to the polygenic architecture of T2D in the Taiwan Han population. A total of 9,627 cases with T2D and 85,606 controls from the Taiwan Biobank were enrolled. Three diabetic polygenic risk scores (PRSs)-PRS_EAS and PRS_EUR, and a trans-ancestry PRS (PRS_META)-calculated using summary statistic from East Asian and European populations. The onset age was identified by linking to the National Taiwan Insurance Research Database and the incidence of different diabetic complications during follow-up was recorded. PRS_META (...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 16, 2024 Category: Physiology Authors: Shi-Heng Wang Yu-Chuen Huang Chun-Wen Cheng Ya-Wen Chang Wen-Ling Liao Source Type: research

Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan
This study aimed to determine whether the onset age and subsequent diabetic complications can be attributed to the polygenic architecture of T2D in the Taiwan Han population. A total of 9,627 cases with T2D and 85,606 controls from the Taiwan Biobank were enrolled. Three diabetic polygenic risk scores (PRSs)-PRS_EAS and PRS_EUR, and a trans-ancestry PRS (PRS_META)-calculated using summary statistic from East Asian and European populations. The onset age was identified by linking to the National Taiwan Insurance Research Database and the incidence of different diabetic complications during follow-up was recorded. PRS_META (...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 16, 2024 Category: Physiology Authors: Shi-Heng Wang Yu-Chuen Huang Chun-Wen Cheng Ya-Wen Chang Wen-Ling Liao Source Type: research

Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan
This study aimed to determine whether the onset age and subsequent diabetic complications can be attributed to the polygenic architecture of T2D in the Taiwan Han population. A total of 9,627 cases with T2D and 85,606 controls from the Taiwan Biobank were enrolled. Three diabetic polygenic risk scores (PRSs)-PRS_EAS and PRS_EUR, and a trans-ancestry PRS (PRS_META)-calculated using summary statistic from East Asian and European populations. The onset age was identified by linking to the National Taiwan Insurance Research Database and the incidence of different diabetic complications during follow-up was recorded. PRS_META (...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 16, 2024 Category: Physiology Authors: Shi-Heng Wang Yu-Chuen Huang Chun-Wen Cheng Ya-Wen Chang Wen-Ling Liao Source Type: research

Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice
Am J Physiol Endocrinol Metab. 2024 Feb 14. doi: 10.1152/ajpendo.00258.2023. Online ahead of print.ABSTRACTExercise robustly increases the glucose demands of skeletal muscle. This demand is met not only by muscle glycogenolysis, but also by accelerated liver glucose production from hepatic glycogenolysis and gluconeogenesis to fuel mechanical work and prevent hypoglycemia during exercise. Hepatic gluconeogenesis during exercise is dependent on highly coordinated responses within and between muscle and liver. Specifically, exercise increases the rate at which gluconeogenic precursors such as pyruvate/lactate or amino acids ...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 14, 2024 Category: Physiology Authors: Michael R Martino Mohammad Habibi Daniel Ferguson Rita T Brookheart John P Thyfault Gretchen A Meyer Louise Lantier Curtis C Hughey Brian N Finck Source Type: research

Increasing maternal glucose concentrations is insufficient to restore placental glucose transfer in chorionic somatomammotropin RNA interference pregnancies
Am J Physiol Endocrinol Metab. 2024 Feb 14. doi: 10.1152/ajpendo.00331.2023. Online ahead of print.ABSTRACTWe previously demonstrated impaired placental nutrient transfer in chorionic somatomammotropin (CSH) RNA interference (RNAi) pregnancies, with glucose transfer being the most impacted. Thus, we hypothesized that despite experimentally elevating maternal glucose, diminished umbilical glucose uptake would persist in CSH RNAi pregnancies, demonstrating the necessity of CSH for adequate placental glucose transfer. Trophectoderm of sheep blastocysts (9 days of gestational age; dGA) were infected with a lentivirus expressin...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 14, 2024 Category: Physiology Authors: Amelia R Tanner Victoria C Kennedy Cameron S Lynch Quinton A Winger Russell V Anthony Paul J Rozance Source Type: research

Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice
Am J Physiol Endocrinol Metab. 2024 Feb 14. doi: 10.1152/ajpendo.00258.2023. Online ahead of print.ABSTRACTExercise robustly increases the glucose demands of skeletal muscle. This demand is met not only by muscle glycogenolysis, but also by accelerated liver glucose production from hepatic glycogenolysis and gluconeogenesis to fuel mechanical work and prevent hypoglycemia during exercise. Hepatic gluconeogenesis during exercise is dependent on highly coordinated responses within and between muscle and liver. Specifically, exercise increases the rate at which gluconeogenic precursors such as pyruvate/lactate or amino acids ...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 14, 2024 Category: Physiology Authors: Michael R Martino Mohammad Habibi Daniel Ferguson Rita T Brookheart John P Thyfault Gretchen A Meyer Louise Lantier Curtis C Hughey Brian N Finck Source Type: research

Increasing maternal glucose concentrations is insufficient to restore placental glucose transfer in chorionic somatomammotropin RNA interference pregnancies
Am J Physiol Endocrinol Metab. 2024 Feb 14. doi: 10.1152/ajpendo.00331.2023. Online ahead of print.ABSTRACTWe previously demonstrated impaired placental nutrient transfer in chorionic somatomammotropin (CSH) RNA interference (RNAi) pregnancies, with glucose transfer being the most impacted. Thus, we hypothesized that despite experimentally elevating maternal glucose, diminished umbilical glucose uptake would persist in CSH RNAi pregnancies, demonstrating the necessity of CSH for adequate placental glucose transfer. Trophectoderm of sheep blastocysts (9 days of gestational age; dGA) were infected with a lentivirus expressin...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 14, 2024 Category: Physiology Authors: Amelia R Tanner Victoria C Kennedy Cameron S Lynch Quinton A Winger Russell V Anthony Paul J Rozance Source Type: research

Corrigendum for Stamateris et al., volume 305, 2013, p. E149-E159
Am J Physiol Endocrinol Metab. 2024 Feb 1;326(2):E148. doi: 10.1152/ajpendo.00040.2023_COR.NO ABSTRACTPMID:38329433 | DOI:10.1152/ajpendo.00040.2023_COR (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - February 8, 2024 Category: Physiology Source Type: research

Vitamin D promotes the folate transport and metabolism in zebrafish ( < em > Danio rerio < /em > )
Am J Physiol Endocrinol Metab. 2024 Feb 7. doi: 10.1152/ajpendo.00380.2023. Online ahead of print.ABSTRACTVitamin D(VD) is a fat-soluble sterol that possesses a wide range of physiological functions. The present study aimed to evaluate the effects of VD on folate metabolism in zebrafish and further investigate the underlying mechanism. Wild-type (WT) zebrafish were fed with the diet containing 0 IU/kg VD3 or 800 IU/kg VD3 for 3 weeks. Meanwhile, cyp2r1 mutant zebrafish with impaired VD metabolism served as another model of VD deficiency. Our results showed that VD deficiency in zebrafish suppressed the gene expression of f...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 7, 2024 Category: Physiology Authors: Shufei Liang Hui Zhang Lin Jiao Rui Shao Yawen Lan Xinmeng Liao Kangsen Mai QingHui Ai Min Wan Source Type: research

Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog
This study characterized the time course of glucagon-mediated molecular events and their relevance to metabolic flux in the livers of conscious dogs. Glucagon was either infused into the hepato-portal vein at a 6-fold basal rate in the presence of somatostatin and basal insulin, or it was maintained at a basal level in control studies. In one control group glucose remained at basal, while in the other, glucose was infused to match the hyperglycemia that occurred in the hyperglucagonemic group. Elevated glucagon caused a rapid (30 min) and largely sustained increase in hepatic cAMP over 4h, a continued elevation in glucose-...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 7, 2024 Category: Physiology Authors: Katie C Coate Christopher J Ramnanan Marta Smith Jason J Winnick Guillaume Kraft Jose Irimia-Dominguez Ben Farmer E Patrick Donahue Peter J Roach Alan D Cherrington Dale S Edgerton Source Type: research

Effects of exogenous lactate on lipid, protein, and glucose metabolism - a randomized cross-over trial in healthy males
Conclusion: Lactate infusion inhibited lipolysis by 30% under postabsorptive conditions but did not affect glucose metabolism or improve insulin sensitivity. In addition, whole-body phenylalanine flux was increased. Clinical trial registrations: NCT04710875.PMID:38324259 | DOI:10.1152/ajpendo.00301.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - February 7, 2024 Category: Physiology Authors: Mette Gb Pedersen Nikolaj Rittig Maj Bangshaab Kristoffer Berg-Hansen Nigopan Gopalasingam Lars C Gormsen Esben S øndergaard Niels M øller Source Type: research

Effect of resveratrol on insulin action in primary myotubes from lean and individuals with severe obesity
Conclusions. AMPK phosphorylation may play an indispensable role in improving glucose metabolism following resveratrol treatment and may be able to overcome intrinsic deficits in the insulin signaling cascade in myotubes from individuals with severe obesity.PMID:38324260 | DOI:10.1152/ajpendo.00299.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - February 7, 2024 Category: Physiology Authors: Sanghee Park Filip Jevtovic Polina M Krassovskaia Alec B Chaves Donghai Zheng Jonas T Treebak Joseph A Houmard Source Type: research