American Journal of Physiology. Endocrinology and Metabolism 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00199.2023. Online ahead of print.ABSTRACTThe purpose of the present study was to determine the effects of obesity and biological sex on myostatin expression in humans, and to examine the direct effects of myostatin, SMAD2 and SMAD3 on insulin signaling in primary human skeletal muscle cells (HSkMCs). Cohort 1: Fifteen lean (BMI: 22.1 ± 0.5 kg/m2, n=8 males, n=7 females) and fourteen obese (BMI: 40.6 ± 1.4 kg/m2, n=7 males, n=7 females) individuals underwent skeletal muscle biopsies and an oral glucose tolerance test (OGTT). Cohort 2: Fifteen young lean (BM...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Gunjan Saxena Sean Gallagher Timothy D Law Dominic Maschari Erin Walsh Courtney Dudley Jeffrey J Brault Leslie A Consitt Source Type: research
Additive Impact of Soy Protein Dietary Intake and Exercise on Visceral Fat Mass Reduction and Mitochondrial Complex I Activation in Skeletal Muscle
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00196.2023. Online ahead of print.ABSTRACTSoy protein has shown remarkable effectiveness in reducing fat mass compared with other protein sources, and exercise has the potential to further enhance this fat loss effect. Previous studies have demonstrated that soy protein intake leads to decreased fatty acid synthesis, which contributes to its fat-loss properties. However, the exact mechanism by which these lipids are consumed remains unclear. To investigate this, we conducted a comprehensive study using C57/BL6 male mice, comparing the effects of soy and casei...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Kohei Kido Shinya Watanabe Masaki Kusano Ai Ito Kazuya Sakai Miki Kosugi Yayoi Gotoh Toshio Suzuki Kentaro Kawanaka Yasuki Higaki Source Type: research
An Extended Minimal Model of OGTT: Estimation of Alpha- and Beta-Cell Dysfunction, Insulin Resistance, and the Incretin Effect
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00278.2023. Online ahead of print.ABSTRACTLoss of insulin sensitivity, alpha- and beta-cell dysfunction, and impairment in incretin effect have all been implicated in the pathophysiology of type 2 diabetes (T2D). Parsimonious mathematical models are useful in quantifying parameters related to the pathophysiology of T2D. Here we extend the minimum model developed to describe the glucose-insulin-glucagon dynamics in the intravenous glucose infusion (IIGI) experiment to the oral glucose tolerance test (OGTT). The extended model describes glucose and hormone dyna...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Vijaya Subramanian Jonatan I Bagger Vinayak Harihar Jens J Holst Filip K Knop Tina Vilsb øll Source Type: research
Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00199.2023. Online ahead of print.ABSTRACTThe purpose of the present study was to determine the effects of obesity and biological sex on myostatin expression in humans, and to examine the direct effects of myostatin, SMAD2 and SMAD3 on insulin signaling in primary human skeletal muscle cells (HSkMCs). Cohort 1: Fifteen lean (BMI: 22.1 ± 0.5 kg/m2, n=8 males, n=7 females) and fourteen obese (BMI: 40.6 ± 1.4 kg/m2, n=7 males, n=7 females) individuals underwent skeletal muscle biopsies and an oral glucose tolerance test (OGTT). Cohort 2: Fifteen young lean (BM...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Gunjan Saxena Sean Gallagher Timothy D Law Dominic Maschari Erin Walsh Courtney Dudley Jeffrey J Brault Leslie A Consitt Source Type: research
Additive Impact of Soy Protein Dietary Intake and Exercise on Visceral Fat Mass Reduction and Mitochondrial Complex I Activation in Skeletal Muscle
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00196.2023. Online ahead of print.ABSTRACTSoy protein has shown remarkable effectiveness in reducing fat mass compared with other protein sources, and exercise has the potential to further enhance this fat loss effect. Previous studies have demonstrated that soy protein intake leads to decreased fatty acid synthesis, which contributes to its fat-loss properties. However, the exact mechanism by which these lipids are consumed remains unclear. To investigate this, we conducted a comprehensive study using C57/BL6 male mice, comparing the effects of soy and casei...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Kohei Kido Shinya Watanabe Masaki Kusano Ai Ito Kazuya Sakai Miki Kosugi Yayoi Gotoh Toshio Suzuki Kentaro Kawanaka Yasuki Higaki Source Type: research
An Extended Minimal Model of OGTT: Estimation of Alpha- and Beta-Cell Dysfunction, Insulin Resistance, and the Incretin Effect
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00278.2023. Online ahead of print.ABSTRACTLoss of insulin sensitivity, alpha- and beta-cell dysfunction, and impairment in incretin effect have all been implicated in the pathophysiology of type 2 diabetes (T2D). Parsimonious mathematical models are useful in quantifying parameters related to the pathophysiology of T2D. Here we extend the minimum model developed to describe the glucose-insulin-glucagon dynamics in the intravenous glucose infusion (IIGI) experiment to the oral glucose tolerance test (OGTT). The extended model describes glucose and hormone dyna...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Vijaya Subramanian Jonatan I Bagger Vinayak Harihar Jens J Holst Filip K Knop Tina Vilsb øll Source Type: research
Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00199.2023. Online ahead of print.ABSTRACTThe purpose of the present study was to determine the effects of obesity and biological sex on myostatin expression in humans, and to examine the direct effects of myostatin, SMAD2 and SMAD3 on insulin signaling in primary human skeletal muscle cells (HSkMCs). Cohort 1: Fifteen lean (BMI: 22.1 ± 0.5 kg/m2, n=8 males, n=7 females) and fourteen obese (BMI: 40.6 ± 1.4 kg/m2, n=7 males, n=7 females) individuals underwent skeletal muscle biopsies and an oral glucose tolerance test (OGTT). Cohort 2: Fifteen young lean (BM...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Gunjan Saxena Sean Gallagher Timothy D Law Dominic Maschari Erin Walsh Courtney Dudley Jeffrey J Brault Leslie A Consitt Source Type: research
Additive Impact of Soy Protein Dietary Intake and Exercise on Visceral Fat Mass Reduction and Mitochondrial Complex I Activation in Skeletal Muscle
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00196.2023. Online ahead of print.ABSTRACTSoy protein has shown remarkable effectiveness in reducing fat mass compared with other protein sources, and exercise has the potential to further enhance this fat loss effect. Previous studies have demonstrated that soy protein intake leads to decreased fatty acid synthesis, which contributes to its fat-loss properties. However, the exact mechanism by which these lipids are consumed remains unclear. To investigate this, we conducted a comprehensive study using C57/BL6 male mice, comparing the effects of soy and casei...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Kohei Kido Shinya Watanabe Masaki Kusano Ai Ito Kazuya Sakai Miki Kosugi Yayoi Gotoh Toshio Suzuki Kentaro Kawanaka Yasuki Higaki Source Type: research
An Extended Minimal Model of OGTT: Estimation of Alpha- and Beta-Cell Dysfunction, Insulin Resistance, and the Incretin Effect
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00278.2023. Online ahead of print.ABSTRACTLoss of insulin sensitivity, alpha- and beta-cell dysfunction, and impairment in incretin effect have all been implicated in the pathophysiology of type 2 diabetes (T2D). Parsimonious mathematical models are useful in quantifying parameters related to the pathophysiology of T2D. Here we extend the minimum model developed to describe the glucose-insulin-glucagon dynamics in the intravenous glucose infusion (IIGI) experiment to the oral glucose tolerance test (OGTT). The extended model describes glucose and hormone dyna...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Vijaya Subramanian Jonatan I Bagger Vinayak Harihar Jens J Holst Filip K Knop Tina Vilsb øll Source Type: research
Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00199.2023. Online ahead of print.ABSTRACTThe purpose of the present study was to determine the effects of obesity and biological sex on myostatin expression in humans, and to examine the direct effects of myostatin, SMAD2 and SMAD3 on insulin signaling in primary human skeletal muscle cells (HSkMCs). Cohort 1: Fifteen lean (BMI: 22.1 ± 0.5 kg/m2, n=8 males, n=7 females) and fourteen obese (BMI: 40.6 ± 1.4 kg/m2, n=7 males, n=7 females) individuals underwent skeletal muscle biopsies and an oral glucose tolerance test (OGTT). Cohort 2: Fifteen young lean (BM...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Gunjan Saxena Sean Gallagher Timothy D Law Dominic Maschari Erin Walsh Courtney Dudley Jeffrey J Brault Leslie A Consitt Source Type: research
Additive Impact of Soy Protein Dietary Intake and Exercise on Visceral Fat Mass Reduction and Mitochondrial Complex I Activation in Skeletal Muscle
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00196.2023. Online ahead of print.ABSTRACTSoy protein has shown remarkable effectiveness in reducing fat mass compared with other protein sources, and exercise has the potential to further enhance this fat loss effect. Previous studies have demonstrated that soy protein intake leads to decreased fatty acid synthesis, which contributes to its fat-loss properties. However, the exact mechanism by which these lipids are consumed remains unclear. To investigate this, we conducted a comprehensive study using C57/BL6 male mice, comparing the effects of soy and casei...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Kohei Kido Shinya Watanabe Masaki Kusano Ai Ito Kazuya Sakai Miki Kosugi Yayoi Gotoh Toshio Suzuki Kentaro Kawanaka Yasuki Higaki Source Type: research
An Extended Minimal Model of OGTT: Estimation of Alpha- and Beta-Cell Dysfunction, Insulin Resistance, and the Incretin Effect
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00278.2023. Online ahead of print.ABSTRACTLoss of insulin sensitivity, alpha- and beta-cell dysfunction, and impairment in incretin effect have all been implicated in the pathophysiology of type 2 diabetes (T2D). Parsimonious mathematical models are useful in quantifying parameters related to the pathophysiology of T2D. Here we extend the minimum model developed to describe the glucose-insulin-glucagon dynamics in the intravenous glucose infusion (IIGI) experiment to the oral glucose tolerance test (OGTT). The extended model describes glucose and hormone dyna...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Vijaya Subramanian Jonatan I Bagger Vinayak Harihar Jens J Holst Filip K Knop Tina Vilsb øll Source Type: research
Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00199.2023. Online ahead of print.ABSTRACTThe purpose of the present study was to determine the effects of obesity and biological sex on myostatin expression in humans, and to examine the direct effects of myostatin, SMAD2 and SMAD3 on insulin signaling in primary human skeletal muscle cells (HSkMCs). Cohort 1: Fifteen lean (BMI: 22.1 ± 0.5 kg/m2, n=8 males, n=7 females) and fourteen obese (BMI: 40.6 ± 1.4 kg/m2, n=7 males, n=7 females) individuals underwent skeletal muscle biopsies and an oral glucose tolerance test (OGTT). Cohort 2: Fifteen young lean (BM...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Gunjan Saxena Sean Gallagher Timothy D Law Dominic Maschari Erin Walsh Courtney Dudley Jeffrey J Brault Leslie A Consitt Source Type: research
Additive Impact of Soy Protein Dietary Intake and Exercise on Visceral Fat Mass Reduction and Mitochondrial Complex I Activation in Skeletal Muscle
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00196.2023. Online ahead of print.ABSTRACTSoy protein has shown remarkable effectiveness in reducing fat mass compared with other protein sources, and exercise has the potential to further enhance this fat loss effect. Previous studies have demonstrated that soy protein intake leads to decreased fatty acid synthesis, which contributes to its fat-loss properties. However, the exact mechanism by which these lipids are consumed remains unclear. To investigate this, we conducted a comprehensive study using C57/BL6 male mice, comparing the effects of soy and casei...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Kohei Kido Shinya Watanabe Masaki Kusano Ai Ito Kazuya Sakai Miki Kosugi Yayoi Gotoh Toshio Suzuki Kentaro Kawanaka Yasuki Higaki Source Type: research
Estimating Insulin Sensitivity and Beta-Cell Function from the Oral Glucose Tolerance Test: Validation of a new Insulin Sensitivity and Secretion (ISS) Model
Am J Physiol Endocrinol Metab. 2023 Dec 6. doi: 10.1152/ajpendo.00189.2023. Online ahead of print.ABSTRACTEfficient and accurate methods to estimate insulin sensitivity (SI) and beta-cell function (BCF) are of great importance for studying the pathogenesis and treatment effectiveness of type 2 diabetes. Existing methods range in sensitivity, input data and technical requirements. Oral glucose tolerance tests (OGTTs) are preferred because they are simpler and more physiological than intravenous methods. However, current analytical methods for OGTT-derived SI and BCF also range in complexity; the oral minimal models require ...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 6, 2023 Category: Physiology Authors: Joon Ha Stephanie T Chung Max Springer Joon Young Kim Phil Chen Aaryan Chhabra Melanie G Cree Cecilia Diniz Behn Anne E Sumner Silva A Arslanian Arthur S Sherman Source Type: research
