American Journal of Physiology. Endocrinology and Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Larsucosterol: Endogenous Epigenetic Regulator for Treating Chronic & amp; Acute Liver Diseases
Am J Physiol Endocrinol Metab. 2024 Feb 21. doi: 10.1152/ajpendo.00406.2023. Online ahead of print.ABSTRACTLarsucosterol (25-Hydroxycholesterol 3-sulfate, 25HC3S), a potent endogenous epigenetic regulator, has been reported to play a significant role in lipid metabolism, inflammatory responses, and cell survival. Administration of 25HC3S has been shown to decrease lipid accumulation in hepatocytes, suppress LPS- and TNFα-induced inflammatory responses in macrophages, alleviate LPS- and ATMP-induced multiple organ injury, and decreases mortalities in animal models. Results from phase 1 and 2 clinical trials have shown that...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 21, 2024 Category: Physiology Authors: Yaping Wang Jenna Ren Shunlin Ren Source Type: research

Brain access of incretins and incretin receptor agonists to their central targets relevant for appetite suppression and weight loss
Am J Physiol Endocrinol Metab. 2024 Feb 21. doi: 10.1152/ajpendo.00250.2023. Online ahead of print.ABSTRACTIncretin-based pharmacotherapies provide novel efficient and safe therapeutic options to curb appetite and produce weight loss in obese patients. Delivered systemically, these molecules produce pleiotropic metabolic benefits, but the target sites mediating their weight-suppressive action are located within the brain. Recent research has increased our understanding of the neural circuits and behavioural mechanisms involved in the anorectic and metabolic consequences of glucagon-like peptide 1 (GLP-1)-based weight loss ...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 21, 2024 Category: Physiology Authors: Sophie Buller Clemence Blouet Source Type: research

Relationship Between Serum β-Hydroxybutyrate and Hepatic Fatty Acid Oxidation in Individuals with Obesity and NAFLD
Am J Physiol Endocrinol Metab. 2024 Feb 21. doi: 10.1152/ajpendo.00336.2023. Online ahead of print.ABSTRACTNAFLD is characterized by excess lipid accumulation which can progress to inflammation (NASH), and fibrosis. Serum β-hydroxybutyrate (β-HB), a product of the ketogenic pathway, is commonly employed as a surrogate marker for hepatic fatty acid oxidation (FAO). However, it remains uncertain whether this relationship holds true in the context of NAFLD in humans. We compared fasting serum (β-HB) levels with direct measurement of liver mitochondrial palmitate oxidation in humans stratified based on NAFLD severity (n = 1...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 21, 2024 Category: Physiology Authors: Mary P Moore Grace Shryack Isabella Alessi Nicole Wieschhaus Grace M Meers Sarah A Johnson Andrew A Wheeler Jamal A Ibdah Elizabeth J Parks R Scott Rector Source Type: research

Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan
This study aimed to determine whether the onset age and subsequent diabetic complications can be attributed to the polygenic architecture of T2D in the Taiwan Han population. A total of 9,627 cases with T2D and 85,606 controls from the Taiwan Biobank were enrolled. Three diabetic polygenic risk scores (PRSs)-PRS_EAS and PRS_EUR, and a trans-ancestry PRS (PRS_META)-calculated using summary statistic from East Asian and European populations. The onset age was identified by linking to the National Taiwan Insurance Research Database and the incidence of different diabetic complications during follow-up was recorded. PRS_META (...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 16, 2024 Category: Physiology Authors: Shi-Heng Wang Yu-Chuen Huang Chun-Wen Cheng Ya-Wen Chang Wen-Ling Liao Source Type: research

Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice
Am J Physiol Endocrinol Metab. 2024 Feb 14. doi: 10.1152/ajpendo.00258.2023. Online ahead of print.ABSTRACTExercise robustly increases the glucose demands of skeletal muscle. This demand is met not only by muscle glycogenolysis, but also by accelerated liver glucose production from hepatic glycogenolysis and gluconeogenesis to fuel mechanical work and prevent hypoglycemia during exercise. Hepatic gluconeogenesis during exercise is dependent on highly coordinated responses within and between muscle and liver. Specifically, exercise increases the rate at which gluconeogenic precursors such as pyruvate/lactate or amino acids ...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 14, 2024 Category: Physiology Authors: Michael R Martino Mohammad Habibi Daniel Ferguson Rita T Brookheart John P Thyfault Gretchen A Meyer Louise Lantier Curtis C Hughey Brian N Finck Source Type: research