American Journal of Physiology. Endocrinology and Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Functional hypothalamic amenorrhea: gut microbiota composition and the effects of exogenous estrogen administration
Am J Physiol Endocrinol Metab. 2023 Nov 29. doi: 10.1152/ajpendo.00281.2023. Online ahead of print.ABSTRACTFunctional hypothalamic amenorrhea (FHA) is characterized by estrogen deficiency that significantly impacts on metabolic, bone, cardiovascular, mental, and reproductive health. Given the importance of environmental factors such as stress, and body composition, and particularly considering the importance of estrogens in regulating the gut microbiota, some changes in the intestinal microenvironment are expected when all of these factors occur simultaneously. We aimed to assess whether the gut microbiota composition is a...
Source: American Journal of Physiology. Endocrinology and Metabolism - November 29, 2023 Category: Physiology Authors: Giovanna Notaristefano Francesca Romana Ponziani Monia Ranalli Alice Diterlizzi Martina Asia Policriti Leonardo Stella Fabio Del Zompo Francesca Fianchi Anna Picca Valentina Petito Federica Del Chierico Matteo Scanu Francesca Toto Lorenza Putignani Emanue Source Type: research

Skeletal muscle-specific inducible AMPK α1/α2 knockout mice develop muscle weakness, glycogen depletion, and fibrosis that persists during disuse atrophy
Am J Physiol Endocrinol Metab. 2023 Nov 29. doi: 10.1152/ajpendo.00261.2023. Online ahead of print.ABSTRACTThe 5' adenosine monophosphate-activated protein kinase (AMPK) is an important skeletal muscle regulator implicated as a possible therapeutic target to ameliorate the local undesired deconditioning of disuse atrophy. However, the muscle-specific role of AMPK in regulating muscle function, fibrosis, and transcriptional reprogramming during physical disuse are unknown. The purpose of this study was to determine how the absence of both catalytic subunits of AMPK in skeletal muscle influence muscle force production, colla...
Source: American Journal of Physiology. Endocrinology and Metabolism - November 29, 2023 Category: Physiology Authors: Jonathan J Petrocelli Jingtong Liu Elena M Yee Patrick J Ferrara Paul-Emile Bourrant Naomi M M P de Hart Sean M Tatum William J Holland Katsuhiko Funai Micah J Drummond Source Type: research

Absence of < em > Slc39a14/Zip14 < /em > in mouse pancreatic beta cells results in hyperinsulinemia
Conclusion This study provided new insights into the contribution of metal transporter ZIP14-mediated intracellular zinc trafficking in glucose-stimulated insulin secretion and subsequent metabolic responses.PMID:38019082 | DOI:10.1152/ajpendo.00117.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - November 29, 2023 Category: Physiology Authors: Yu-Han Hung Yongeun Kim Samuel Blake Mitchell Trista Lee Thorn Tolunay Beker Aydemir Source Type: research

The effect of acute and 14-day exogenous ketone supplementation on glycaemic control in adults with type 2 diabetes: two randomized controlled trials
Am J Physiol Endocrinol Metab. 2023 Nov 22. doi: 10.1152/ajpendo.00332.2023. Online ahead of print.ABSTRACTAcute ingestion of the exogenous ketone monoester supplement [(R)-3-hydroxybutyl-(R)-3-hydroxybutyrate] lowers blood glucose, suggesting therapeutic potential in individuals with impaired glucose metabolism. However, it is unknown how acute or repeated ingestion of exogenous ketones affect blood glucose control in individuals with type 2 diabetes (T2D). We conducted two randomized, counter-balanced, double-blind, placebo-controlled crossover trials to determine if (1) acute exogenous ketone monoester (0.3 g/kg body ma...
Source: American Journal of Physiology. Endocrinology and Metabolism - November 22, 2023 Category: Physiology Authors: Kaja Falkenhain Barbara F Oliveira Hashim Islam Helena Neudorf Haoning H Cen James D Johnson Kenneth Madden Joel Singer Jeremy J Walsh Jonathan P Little Source Type: research

Content of stress granules reveals a sex difference at the early phase of cold exposure in mice
Am J Physiol Endocrinol Metab. 2023 Nov 22. doi: 10.1152/ajpendo.00317.2023. Online ahead of print.ABSTRACTAdaptive thermogenesis is a vital physiological process for small endotherms. Female animals usually are more sensitive to cold temperature due to anatomical differences. Whether there is sex difference at molecular level is unclear. Stress granules (SGs) are dynamic organelles in which untranslated mRNAs reside during cellular stress. We hypothesize that the prompt response of SGs to cold stress can reveal the molecular difference between sexes. By analyzing the content in SGs of BAT at the early phase of cold stress...
Source: American Journal of Physiology. Endocrinology and Metabolism - November 22, 2023 Category: Physiology Authors: Samson W M Cheung Jensen H C Yiu Karie T C Chin Jieling Cai Aimin Xu Chi Ming Wong Connie W Woo Source Type: research

Effects of circulating endothelial microvesicles isolated from adults with obesity on endothelial cell inflammation, apoptosis and nitric oxide production
Am J Physiol Endocrinol Metab. 2023 Nov 22. doi: 10.1152/ajpendo.00139.2023. Online ahead of print.ABSTRACTCirculating endothelial-cell derived microvesicles (EMVs) have been shown to be elevated with obesity and associated with endothelial dysfunction; however, their direct effect on endothelial cells is unknown. The experimental aim of this study was to determine the effect of EMVs isolated from adults with obesity on endothelial cell inflammation, apoptosis, and nitric oxide (NO) production. EMVs (CD144+ microvesicles) were identified, enumerated and isolated from plasma by flow cytometry from 24 sedentary adults: 12 no...
Source: American Journal of Physiology. Endocrinology and Metabolism - November 22, 2023 Category: Physiology Authors: Vinicius P Garcia Hannah K Fandl Jamie G Hijmans Auburn R Berry Hannah L Cardenas Kelly A Stockelman Noah M DeSouza John W Treuth Jared J Greiner Andrew Joon Park Brian L Stauffer Christopher A DeSouza Source Type: research

Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling
Am J Physiol Endocrinol Metab. 2023 Nov 22. doi: 10.1152/ajpendo.00151.2023. Online ahead of print.ABSTRACTCells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes that limit protein synthesis, myotube size, and proliferation in skeletal muscle cells. We inhibited key enzymes of glycolysis, the pentose phosphate pathway, and serine synthesis pathway to evaluate their importance in C2C12 myo...
Source: American Journal of Physiology. Endocrinology and Metabolism - November 22, 2023 Category: Physiology Authors: Sakari M äntyselkä Kalle Kolari Philipp Baumert Laura Yl ä-Outinen Lauri Kuikka Suvi Lahtonen Perttu Permi Henning Wackerhage Elina Kalenius Riikka Kivel ä Juha J Hulmi Source Type: research