Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism
CONCLUSION: These results demonstrate the existence of a dynamic equilibrium between CSF1, the mononuclear phagocyte system and control of liver:body weight ratio, which in turn controls systemic metabolic homeostasis. This novel macrophage regulatory axis has the potential to promote fat mobilisation, without changes in appetence, which may have novel implications for managing metabolic syndrome.PMID:38117267 | DOI:10.1152/ajpendo.00347.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - December 20, 2023 Category: Physiology Authors: Sahar Keshvari Jesse J R Masson Michelle Ferrari-Cestari Liviu-Gabriel Bodea Fathima Nooru-Mohamed Brian W C Tse Kamil A Sokolowski Lena Batoon Omkar L Patkar Mitchell A Sullivan Hilmar Ebersbach Cian Stutz Robert G Parton Kim M Summers Allison R Pettit D Source Type: research

Vertical sleeve gastrectomy improves glucose-insulin homeostasis by enhancing beta cell function and survival via FGF15/19
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00218.2023. Online ahead of print.ABSTRACTVertical sleeve gastrectomy (VSG) restores glucose homeostasis in obese mice and humans. In addition, the increased fibroblast growth factor (FGF)15/19 circulating level post-surgery has been implicated in this effect. However, the impact of FGF15/19 on pancreatic islets remains unclear. Using a diet-induced obese mice model, we demonstrate that VSG attenuates insulin hypersecretion in isolated pancreatic islets, likely due to morphological alterations in the endocrine pancreas such as reduction in islet, beta cell, a...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 20, 2023 Category: Physiology Authors: Gabriela M Soares Sandra L Balbo Gabriela A Bronczek Jean F Vettorazzi Carine Marmentini Lucas Zangerolamo Licio A Velloso Everardo M Carneiro Source Type: research

Monocyte immunometabolic reprogramming in human pregnancy: contribution of trophoblast cells
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00357.2023. Online ahead of print.ABSTRACTImmunometabolism research is uncovering the relationship between metabolic features and immune cell functions in physiological and pathological conditions. Normal pregnancy entails a fine immune and metabolic regulation of the maternal-fetal interaction to assist the energetic demands of the fetus with immune homeostasis maintenance. Here, we determined the immunometabolic status of monocytes of pregnant women compared to non-pregnant controls and its impact on monocyte antiinflammatory functions such as efferocytosis...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 20, 2023 Category: Physiology Authors: F átima Merech Soledad Gori Guillermina Calo Vanesa Hauk Daniel Paparini Daiana Rios Brenda Lara Luciana Doga Luciana D'Eramo Aldo Squassi Rossana Ramhorst Rafael J Arg üello Claudia P érez Leirós Daiana Vota Source Type: research

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism
CONCLUSION: These results demonstrate the existence of a dynamic equilibrium between CSF1, the mononuclear phagocyte system and control of liver:body weight ratio, which in turn controls systemic metabolic homeostasis. This novel macrophage regulatory axis has the potential to promote fat mobilisation, without changes in appetence, which may have novel implications for managing metabolic syndrome.PMID:38117267 | DOI:10.1152/ajpendo.00347.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - December 20, 2023 Category: Physiology Authors: Sahar Keshvari Jesse J R Masson Michelle Ferrari-Cestari Liviu-Gabriel Bodea Fathima Nooru-Mohamed Brian W C Tse Kamil A Sokolowski Lena Batoon Omkar L Patkar Mitchell A Sullivan Hilmar Ebersbach Cian Stutz Robert G Parton Kim M Summers Allison R Pettit D Source Type: research

Vertical sleeve gastrectomy improves glucose-insulin homeostasis by enhancing beta cell function and survival via FGF15/19
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00218.2023. Online ahead of print.ABSTRACTVertical sleeve gastrectomy (VSG) restores glucose homeostasis in obese mice and humans. In addition, the increased fibroblast growth factor (FGF)15/19 circulating level post-surgery has been implicated in this effect. However, the impact of FGF15/19 on pancreatic islets remains unclear. Using a diet-induced obese mice model, we demonstrate that VSG attenuates insulin hypersecretion in isolated pancreatic islets, likely due to morphological alterations in the endocrine pancreas such as reduction in islet, beta cell, a...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 20, 2023 Category: Physiology Authors: Gabriela M Soares Sandra L Balbo Gabriela A Bronczek Jean F Vettorazzi Carine Marmentini Lucas Zangerolamo Licio A Velloso Everardo M Carneiro Source Type: research

Monocyte immunometabolic reprogramming in human pregnancy: contribution of trophoblast cells
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00357.2023. Online ahead of print.ABSTRACTImmunometabolism research is uncovering the relationship between metabolic features and immune cell functions in physiological and pathological conditions. Normal pregnancy entails a fine immune and metabolic regulation of the maternal-fetal interaction to assist the energetic demands of the fetus with immune homeostasis maintenance. Here, we determined the immunometabolic status of monocytes of pregnant women compared to non-pregnant controls and its impact on monocyte antiinflammatory functions such as efferocytosis...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 20, 2023 Category: Physiology Authors: F átima Merech Soledad Gori Guillermina Calo Vanesa Hauk Daniel Paparini Daiana Rios Brenda Lara Luciana Doga Luciana D'Eramo Aldo Squassi Rossana Ramhorst Rafael J Arg üello Claudia P érez Leirós Daiana Vota Source Type: research

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism
CONCLUSION: These results demonstrate the existence of a dynamic equilibrium between CSF1, the mononuclear phagocyte system and control of liver:body weight ratio, which in turn controls systemic metabolic homeostasis. This novel macrophage regulatory axis has the potential to promote fat mobilisation, without changes in appetence, which may have novel implications for managing metabolic syndrome.PMID:38117267 | DOI:10.1152/ajpendo.00347.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - December 20, 2023 Category: Physiology Authors: Sahar Keshvari Jesse J R Masson Michelle Ferrari-Cestari Liviu-Gabriel Bodea Fathima Nooru-Mohamed Brian W C Tse Kamil A Sokolowski Lena Batoon Omkar L Patkar Mitchell A Sullivan Hilmar Ebersbach Cian Stutz Robert G Parton Kim M Summers Allison R Pettit D Source Type: research

Vertical sleeve gastrectomy improves glucose-insulin homeostasis by enhancing beta cell function and survival via FGF15/19
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00218.2023. Online ahead of print.ABSTRACTVertical sleeve gastrectomy (VSG) restores glucose homeostasis in obese mice and humans. In addition, the increased fibroblast growth factor (FGF)15/19 circulating level post-surgery has been implicated in this effect. However, the impact of FGF15/19 on pancreatic islets remains unclear. Using a diet-induced obese mice model, we demonstrate that VSG attenuates insulin hypersecretion in isolated pancreatic islets, likely due to morphological alterations in the endocrine pancreas such as reduction in islet, beta cell, a...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 20, 2023 Category: Physiology Authors: Gabriela M Soares Sandra L Balbo Gabriela A Bronczek Jean F Vettorazzi Carine Marmentini Lucas Zangerolamo Licio A Velloso Everardo M Carneiro Source Type: research

Monocyte immunometabolic reprogramming in human pregnancy: contribution of trophoblast cells
Am J Physiol Endocrinol Metab. 2023 Dec 20. doi: 10.1152/ajpendo.00357.2023. Online ahead of print.ABSTRACTImmunometabolism research is uncovering the relationship between metabolic features and immune cell functions in physiological and pathological conditions. Normal pregnancy entails a fine immune and metabolic regulation of the maternal-fetal interaction to assist the energetic demands of the fetus with immune homeostasis maintenance. Here, we determined the immunometabolic status of monocytes of pregnant women compared to non-pregnant controls and its impact on monocyte antiinflammatory functions such as efferocytosis...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 20, 2023 Category: Physiology Authors: F átima Merech Soledad Gori Guillermina Calo Vanesa Hauk Daniel Paparini Daiana Rios Brenda Lara Luciana Doga Luciana D'Eramo Aldo Squassi Rossana Ramhorst Rafael J Arg üello Claudia P érez Leirós Daiana Vota Source Type: research

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism
CONCLUSION: These results demonstrate the existence of a dynamic equilibrium between CSF1, the mononuclear phagocyte system and control of liver:body weight ratio, which in turn controls systemic metabolic homeostasis. This novel macrophage regulatory axis has the potential to promote fat mobilisation, without changes in appetence, which may have novel implications for managing metabolic syndrome.PMID:38117267 | DOI:10.1152/ajpendo.00347.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - December 20, 2023 Category: Physiology Authors: Sahar Keshvari Jesse J R Masson Michelle Ferrari-Cestari Liviu-Gabriel Bodea Fathima Nooru-Mohamed Brian W C Tse Kamil A Sokolowski Lena Batoon Omkar L Patkar Mitchell A Sullivan Hilmar Ebersbach Cian Stutz Robert G Parton Kim M Summers Allison R Pettit D Source Type: research

An Extended Minimal Model of OGTT: Estimation of Alpha- and Beta-Cell Dysfunction, Insulin Resistance, and the Incretin Effect
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00278.2023. Online ahead of print.ABSTRACTLoss of insulin sensitivity, alpha- and beta-cell dysfunction, and impairment in incretin effect have all been implicated in the pathophysiology of type 2 diabetes (T2D). Parsimonious mathematical models are useful in quantifying parameters related to the pathophysiology of T2D. Here we extend the minimum model developed to describe the glucose-insulin-glucagon dynamics in the intravenous glucose infusion (IIGI) experiment to the oral glucose tolerance test (OGTT). The extended model describes glucose and hormone dyna...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Vijaya Subramanian Jonatan I Bagger Vinayak Harihar Jens J Holst Filip K Knop Tina Vilsb øll Source Type: research

Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00199.2023. Online ahead of print.ABSTRACTThe purpose of the present study was to determine the effects of obesity and biological sex on myostatin expression in humans, and to examine the direct effects of myostatin, SMAD2 and SMAD3 on insulin signaling in primary human skeletal muscle cells (HSkMCs). Cohort 1: Fifteen lean (BMI: 22.1 ± 0.5 kg/m2, n=8 males, n=7 females) and fourteen obese (BMI: 40.6 ± 1.4 kg/m2, n=7 males, n=7 females) individuals underwent skeletal muscle biopsies and an oral glucose tolerance test (OGTT). Cohort 2: Fifteen young lean (BM...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Gunjan Saxena Sean Gallagher Timothy D Law Dominic Maschari Erin Walsh Courtney Dudley Jeffrey J Brault Leslie A Consitt Source Type: research

Additive Impact of Soy Protein Dietary Intake and Exercise on Visceral Fat Mass Reduction and Mitochondrial Complex I Activation in Skeletal Muscle
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00196.2023. Online ahead of print.ABSTRACTSoy protein has shown remarkable effectiveness in reducing fat mass compared with other protein sources, and exercise has the potential to further enhance this fat loss effect. Previous studies have demonstrated that soy protein intake leads to decreased fatty acid synthesis, which contributes to its fat-loss properties. However, the exact mechanism by which these lipids are consumed remains unclear. To investigate this, we conducted a comprehensive study using C57/BL6 male mice, comparing the effects of soy and casei...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Kohei Kido Shinya Watanabe Masaki Kusano Ai Ito Kazuya Sakai Miki Kosugi Yayoi Gotoh Toshio Suzuki Kentaro Kawanaka Yasuki Higaki Source Type: research

An Extended Minimal Model of OGTT: Estimation of Alpha- and Beta-Cell Dysfunction, Insulin Resistance, and the Incretin Effect
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00278.2023. Online ahead of print.ABSTRACTLoss of insulin sensitivity, alpha- and beta-cell dysfunction, and impairment in incretin effect have all been implicated in the pathophysiology of type 2 diabetes (T2D). Parsimonious mathematical models are useful in quantifying parameters related to the pathophysiology of T2D. Here we extend the minimum model developed to describe the glucose-insulin-glucagon dynamics in the intravenous glucose infusion (IIGI) experiment to the oral glucose tolerance test (OGTT). The extended model describes glucose and hormone dyna...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Vijaya Subramanian Jonatan I Bagger Vinayak Harihar Jens J Holst Filip K Knop Tina Vilsb øll Source Type: research

Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes
Am J Physiol Endocrinol Metab. 2023 Dec 13. doi: 10.1152/ajpendo.00199.2023. Online ahead of print.ABSTRACTThe purpose of the present study was to determine the effects of obesity and biological sex on myostatin expression in humans, and to examine the direct effects of myostatin, SMAD2 and SMAD3 on insulin signaling in primary human skeletal muscle cells (HSkMCs). Cohort 1: Fifteen lean (BMI: 22.1 ± 0.5 kg/m2, n=8 males, n=7 females) and fourteen obese (BMI: 40.6 ± 1.4 kg/m2, n=7 males, n=7 females) individuals underwent skeletal muscle biopsies and an oral glucose tolerance test (OGTT). Cohort 2: Fifteen young lean (BM...
Source: American Journal of Physiology. Endocrinology and Metabolism - December 13, 2023 Category: Physiology Authors: Gunjan Saxena Sean Gallagher Timothy D Law Dominic Maschari Erin Walsh Courtney Dudley Jeffrey J Brault Leslie A Consitt Source Type: research