American Journal of Physiology. Endocrinology and Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Emerging role of N6-methyladenosine (m6A) in the homeostasis of glucose metabolism
Am J Physiol Endocrinol Metab. 2023 Nov 8. doi: 10.1152/ajpendo.00225.2023. Online ahead of print.ABSTRACTN6-methyladenosine (m6A) is the most prevalent post-transcriptional internal RNA modification, which is involved in the regulation of diverse physiological processes. Dynamic and reversible m6A modification has been shown to regulate glucose metabolism, and dysregulation of m6A modification contributes to glucose metabolic disorders in multiple organs and tissues including pancreas, liver, adipose tissue, skeletal muscle, kidney, blood vessels and so forth. In this review, the role and molecular mechanism of m6A modifi...
Source: American Journal of Physiology. Endocrinology and Metabolism - November 8, 2023 Category: Physiology Authors: Yuan-Hai Sun Teng-Jiao Zhao Ling-Huan Li Zhen Wang Han-Bing Li Source Type: research

The Effect of Repeated Hot Water Immersion on Insulin Sensitivity, Heat Shock Protein 70 and Inflammation in Individuals with Type 2 Diabetes Mellitus
Conclusion: This study shows that 8-10 HWIs within a 14-day period improved fasting insulin sensitivity and plasma [insulin] in individuals with T2DM, but not when glucose tolerance is challenged. HWI also improves metabolic efficiency (i.e. reduced RMR). Together, these results could be clinically important and have implications for metabolic health outcomes and well-being in individuals with T2DM.PMID:37938179 | DOI:10.1152/ajpendo.00222.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - November 8, 2023 Category: Physiology Authors: Thomas J James Jo Corbett Michael H Cummings Sharon Allard Janis K Shute Harvey Belcher Harry Mayes Alex A M Gould Daniel D Piccolo Michael Tipton Maria Perissiou Zoe L Saynor Anthony I Shepherd Source Type: research

6-day Dry Immersion leads to downregulation of slow-fiber type and mitochondria-related genes expression
Am J Physiol Endocrinol Metab. 2023 Nov 8. doi: 10.1152/ajpendo.00284.2023. Online ahead of print.ABSTRACTThe soleus muscle in humans is responsible for maintaining an upright posture and participates in walking and running. Under muscle disuse, it undergoes molecular signaling changes that result in altered force and work capacity. The triggering mechanisms and pathways of these changes are not yet fully understood. In this article, we aimed to detect the molecular pathways that are involved in the unloading-induced alterations in the human soleus muscle under 6-days of dry immersion. A 6-day dry immersion led to the down...
Source: American Journal of Physiology. Endocrinology and Metabolism - November 8, 2023 Category: Physiology Authors: Kristina A Sharlo Natalia A Vilchinskaya Sergey A Tyganov Olga V Turtikova Irina D Lvova Ksenia V Sergeeva Ilya V Rukavishnikov Boris S Shenkman Elena S Tomilovskaya Oleg I Orlov Source Type: research

Kruppel like factor 14 ameliorated obesity and related metabolic disorders by promoting adipose tissue browning
In this study, we first found that mice with overexpression of the transcription factor Kruppel-like factor 14 (KLF14) in subcutaneous adipose tissue gained weight more slowly while consuming a high-fat diet than did control mice, and these mice also showed reduced insulin resistance and liver lipid deposition abnormalities. Mechanistically, the browning of white adipose tissue was promoted in adipose tissue with KLF14 overexpression; therefore, we preliminarily concluded that KLF14 can improve obesity by promoting the browning of white adipose tissue and energy consumption, thus amelioratingobesity and related metabolic d...
Source: American Journal of Physiology. Endocrinology and Metabolism - November 8, 2023 Category: Physiology Authors: Xiaoxiang Mao Yuanxiang Li Yi Zhong Ru Chen Kun Wang Dandan Huang Xi Luo Source Type: research

Exercise training adaptations in liver glycogen and glycerolipids require hepatic AMP-activated protein kinase in mice
In conclusion, AMPK is required for liver training adaptations that are critical to glucose and lipid metabolism.PMID:37938177 | DOI:10.1152/ajpendo.00289.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - November 8, 2023 Category: Physiology Authors: Curtis C Hughey Deanna P Bracy Ferrol I Rome Mickael Goelzer E Patrick Donahue Benoit Viollet Marc Foretz David H Wasserman Source Type: research