Mesenchymal stromal cell extracellular vesicles improve lung development in mechanically ventilated preterm lambs
CONCLUSIONS: MSC-sEVs improved respiratory system physiology and alveolar formation in mechanically ventilated preterm lambs. MSC-sEVs may be an effective and safe therapy for appropriate functional and structural development of the lung in preterm infants who require mechanical ventilation and are at-risk of developing BPD.PMID:38563994 | DOI:10.1152/ajplung.00349.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 2, 2024 Category: Respiratory Medicine Authors: Kurt H Albertine Andrew Rebentisch Elaine Dawson Jakob Van Boerum Emily Major Juraj Štipka Hannah Foreman David Headden Zo ë Vordos Emily Beck Zhengming Wang Haixia Yang Baifeng Yu Mar Janna Dahl Donald M Null Davide Bizzotto Chiara Veneroni Anna Lavizz Source Type: research
Endothelial Knockdown of the Tumor Suppressor, WWOX, Increases Inflammation in Ventilator-Induced Lung Injury
CONCLUSION: Loss of WWOX function in ECs is associated with a heightened inflammatory response during mechanical stretch that is associated with increased MAPK phosphorylation and appears to be dependent on upregulation of zyxin.PMID:38563965 | DOI:10.1152/ajplung.00277.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 2, 2024 Category: Respiratory Medicine Authors: Zhenguo Zeng Eltyeb Abdelwahid Weiguo Chen Christian Ascoli Trinh Pham Jeffrey R Jacobson Steven M Dudek Viswanathan Natarajan C Marcelo Aldaz Roberto F Machado Sunit Singla Source Type: research
Mesenchymal stromal cell extracellular vesicles improve lung development in mechanically ventilated preterm lambs
CONCLUSIONS: MSC-sEVs improved respiratory system physiology and alveolar formation in mechanically ventilated preterm lambs. MSC-sEVs may be an effective and safe therapy for appropriate functional and structural development of the lung in preterm infants who require mechanical ventilation and are at-risk of developing BPD.PMID:38563994 | DOI:10.1152/ajplung.00349.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 2, 2024 Category: Respiratory Medicine Authors: Kurt H Albertine Andrew Rebentisch Elaine Dawson Jakob Van Boerum Emily Major Juraj Štipka Hannah Foreman David Headden Zo ë Vordos Emily Beck Zhengming Wang Haixia Yang Baifeng Yu Mar Janna Dahl Donald M Null Davide Bizzotto Chiara Veneroni Anna Lavizz Source Type: research
Endothelial Knockdown of the Tumor Suppressor, WWOX, Increases Inflammation in Ventilator-Induced Lung Injury
CONCLUSION: Loss of WWOX function in ECs is associated with a heightened inflammatory response during mechanical stretch that is associated with increased MAPK phosphorylation and appears to be dependent on upregulation of zyxin.PMID:38563965 | DOI:10.1152/ajplung.00277.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 2, 2024 Category: Respiratory Medicine Authors: Zhenguo Zeng Eltyeb Abdelwahid Weiguo Chen Christian Ascoli Trinh Pham Jeffrey R Jacobson Steven M Dudek Viswanathan Natarajan C Marcelo Aldaz Roberto F Machado Sunit Singla Source Type: research
Mesenchymal stromal cell extracellular vesicles improve lung development in mechanically ventilated preterm lambs
CONCLUSIONS: MSC-sEVs improved respiratory system physiology and alveolar formation in mechanically ventilated preterm lambs. MSC-sEVs may be an effective and safe therapy for appropriate functional and structural development of the lung in preterm infants who require mechanical ventilation and are at-risk of developing BPD.PMID:38563994 | DOI:10.1152/ajplung.00349.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 2, 2024 Category: Respiratory Medicine Authors: Kurt H Albertine Andrew Rebentisch Elaine Dawson Jakob Van Boerum Emily Major Juraj Štipka Hannah Foreman David Headden Zo ë Vordos Emily Beck Zhengming Wang Haixia Yang Baifeng Yu Mar Janna Dahl Donald M Null Davide Bizzotto Chiara Veneroni Anna Lavizz Source Type: research
Endothelial Knockdown of the Tumor Suppressor, WWOX, Increases Inflammation in Ventilator-Induced Lung Injury
CONCLUSION: Loss of WWOX function in ECs is associated with a heightened inflammatory response during mechanical stretch that is associated with increased MAPK phosphorylation and appears to be dependent on upregulation of zyxin.PMID:38563965 | DOI:10.1152/ajplung.00277.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 2, 2024 Category: Respiratory Medicine Authors: Zhenguo Zeng Eltyeb Abdelwahid Weiguo Chen Christian Ascoli Trinh Pham Jeffrey R Jacobson Steven M Dudek Viswanathan Natarajan C Marcelo Aldaz Roberto F Machado Sunit Singla Source Type: research
Mesenchymal stromal cell extracellular vesicles improve lung development in mechanically ventilated preterm lambs
CONCLUSIONS: MSC-sEVs improved respiratory system physiology and alveolar formation in mechanically ventilated preterm lambs. MSC-sEVs may be an effective and safe therapy for appropriate functional and structural development of the lung in preterm infants who require mechanical ventilation and are at-risk of developing BPD.PMID:38563994 | DOI:10.1152/ajplung.00349.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 2, 2024 Category: Respiratory Medicine Authors: Kurt H Albertine Andrew Rebentisch Elaine Dawson Jakob Van Boerum Emily Major Juraj Štipka Hannah Foreman David Headden Zo ë Vordos Emily Beck Zhengming Wang Haixia Yang Baifeng Yu Mar Janna Dahl Donald M Null Davide Bizzotto Chiara Veneroni Anna Lavizz Source Type: research
Red Blood Cells Function as Reservoirs of Tumor DNA
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 26. doi: 10.1152/ajplung.00049.2024. Online ahead of print.ABSTRACTNovel screening techniques for early detection of lung cancer are urgently needed. Profiling circulating tumor cell-free DNA (ctDNA) has emerged as a promising tool for biopsy-free tumor genotyping. However, both the scarcity and short half-life of ctDNA substantially limit the sensitivity and clinical utility of ctDNA detection methodologies. Our discovery that Red Blood Cells (RBCs) sequester mitochondrial DNA opens a new avenue for detecting circulating nucleic acids, as RBCs represent an unrecognized reservoi...
Source: Am J Physiol Lung Ce... - March 26, 2024 Category: Respiratory Medicine Authors: Jeffrey C Thompson Sue Li Joshua S Jose Jarrod Predina Aasha Gupta Evgeniy Eruslanov Sunil Singhal Steven M Albelda Nilam S Mangalmurti Source Type: research
Downregulation of protein phosphatase 2A α in asthmatic airway smooth muscle
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 26. doi: 10.1152/ajplung.00050.2024. Online ahead of print.ABSTRACTAirway smooth muscle cell (ASM) is renowned for its involvement in airway hyperresponsiveness through impaired ASM relaxation and bronchoconstriction in asthma which poses a significant challenge in the field. Recent studies have explored different targets in ASM to alleviate airway hyperresponsiveness, however, a sizeable portion of asthmatics still experience poor control. In our study, we explored protein phosphatase 2A (PP2A) in ASM as it has been reported to regulate cellular contractility by controlling int...
Source: Am J Physiol Lung Ce... - March 26, 2024 Category: Respiratory Medicine Authors: Mohammad Irshad Reza Ashish Kumar Christina M Pabelick Rodney D Britt Y S Prakash Venkatachalem Sathish Source Type: research
Identification of Siglec-1-negative alveolar macrophages with pro-inflammatory phenotypes in chronic obstructive pulmonary disease
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 26. doi: 10.1152/ajplung.00303.2023. Online ahead of print.ABSTRACTAlveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD) orchestrate persistent inflammation in the airway. However, sub-populations of AMs participating in the chronic inflammation have been poorly characterized. We previously reported that Siglec-1 expression on AMs, which is important for bacteria engulfment, was decreased in COPD. Here, we show that Siglec-1-negative AMs isolated from COPD lung tissues exhibit a pro-inflammatory phenotype and is associated with poor clinical ou...
Source: Am J Physiol Lung Ce... - March 26, 2024 Category: Respiratory Medicine Authors: Takuya Saito Naoya Fujino Yorihiko Kyogoku Mitsuhiro Yamada Koji Okutomo Yoshinao Ono Shuichi Konno Takuto Endo Koji Itakura Shuichiro Matsumoto Hirohito Sano Hiroyuki Aizawa Tadahisa Numakura Katsuhiro Onodera Yoshinori Okada Tracy Hussell Masakazu Ichin Source Type: research
Red Blood Cells Function as Reservoirs of Tumor DNA
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 26. doi: 10.1152/ajplung.00049.2024. Online ahead of print.ABSTRACTNovel screening techniques for early detection of lung cancer are urgently needed. Profiling circulating tumor cell-free DNA (ctDNA) has emerged as a promising tool for biopsy-free tumor genotyping. However, both the scarcity and short half-life of ctDNA substantially limit the sensitivity and clinical utility of ctDNA detection methodologies. Our discovery that Red Blood Cells (RBCs) sequester mitochondrial DNA opens a new avenue for detecting circulating nucleic acids, as RBCs represent an unrecognized reservoi...
Source: Am J Physiol Lung Ce... - March 26, 2024 Category: Respiratory Medicine Authors: Jeffrey C Thompson Sue Li Joshua S Jose Jarrod Predina Aasha Gupta Evgeniy Eruslanov Sunil Singhal Steven M Albelda Nilam S Mangalmurti Source Type: research
Downregulation of protein phosphatase 2A α in asthmatic airway smooth muscle
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 26. doi: 10.1152/ajplung.00050.2024. Online ahead of print.ABSTRACTAirway smooth muscle cell (ASM) is renowned for its involvement in airway hyperresponsiveness through impaired ASM relaxation and bronchoconstriction in asthma which poses a significant challenge in the field. Recent studies have explored different targets in ASM to alleviate airway hyperresponsiveness, however, a sizeable portion of asthmatics still experience poor control. In our study, we explored protein phosphatase 2A (PP2A) in ASM as it has been reported to regulate cellular contractility by controlling int...
Source: Am J Physiol Lung Ce... - March 26, 2024 Category: Respiratory Medicine Authors: Mohammad Irshad Reza Ashish Kumar Christina M Pabelick Rodney D Britt Y S Prakash Venkatachalem Sathish Source Type: research
Identification of Siglec-1-negative alveolar macrophages with pro-inflammatory phenotypes in chronic obstructive pulmonary disease
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 26. doi: 10.1152/ajplung.00303.2023. Online ahead of print.ABSTRACTAlveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD) orchestrate persistent inflammation in the airway. However, sub-populations of AMs participating in the chronic inflammation have been poorly characterized. We previously reported that Siglec-1 expression on AMs, which is important for bacteria engulfment, was decreased in COPD. Here, we show that Siglec-1-negative AMs isolated from COPD lung tissues exhibit a pro-inflammatory phenotype and is associated with poor clinical ou...
Source: Am J Physiol Lung Ce... - March 26, 2024 Category: Respiratory Medicine Authors: Takuya Saito Naoya Fujino Yorihiko Kyogoku Mitsuhiro Yamada Koji Okutomo Yoshinao Ono Shuichi Konno Takuto Endo Koji Itakura Shuichiro Matsumoto Hirohito Sano Hiroyuki Aizawa Tadahisa Numakura Katsuhiro Onodera Yoshinori Okada Tracy Hussell Masakazu Ichin Source Type: research
Red Blood Cells Function as Reservoirs of Tumor DNA
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 26. doi: 10.1152/ajplung.00049.2024. Online ahead of print.ABSTRACTNovel screening techniques for early detection of lung cancer are urgently needed. Profiling circulating tumor cell-free DNA (ctDNA) has emerged as a promising tool for biopsy-free tumor genotyping. However, both the scarcity and short half-life of ctDNA substantially limit the sensitivity and clinical utility of ctDNA detection methodologies. Our discovery that Red Blood Cells (RBCs) sequester mitochondrial DNA opens a new avenue for detecting circulating nucleic acids, as RBCs represent an unrecognized reservoi...
Source: Am J Physiol Lung Ce... - March 26, 2024 Category: Respiratory Medicine Authors: Jeffrey C Thompson Sue Li Joshua S Jose Jarrod Predina Aasha Gupta Evgeniy Eruslanov Sunil Singhal Steven M Albelda Nilam S Mangalmurti Source Type: research
Downregulation of protein phosphatase 2A α in asthmatic airway smooth muscle
Am J Physiol Lung Cell Mol Physiol. 2024 Mar 26. doi: 10.1152/ajplung.00050.2024. Online ahead of print.ABSTRACTAirway smooth muscle cell (ASM) is renowned for its involvement in airway hyperresponsiveness through impaired ASM relaxation and bronchoconstriction in asthma which poses a significant challenge in the field. Recent studies have explored different targets in ASM to alleviate airway hyperresponsiveness, however, a sizeable portion of asthmatics still experience poor control. In our study, we explored protein phosphatase 2A (PP2A) in ASM as it has been reported to regulate cellular contractility by controlling int...
Source: Am J Physiol Lung Ce... - March 26, 2024 Category: Respiratory Medicine Authors: Mohammad Irshad Reza Ashish Kumar Christina M Pabelick Rodney D Britt Y S Prakash Venkatachalem Sathish Source Type: research
