Mucopolysaccharidosis (MPS IIIA) mice have increased lung compliance and airways resistance, decreased diaphragm strength and no change in alveolar structure
In conclusion, the increased storage of HS which leads to biochemical and biophysical changes in pulmonary surfactant, also affects lung and diaphragm function, but has no impact on lung or diaphragm structure at this stage of the disease.PMID:38469649 | DOI:10.1152/ajplung.00445.2022 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - March 12, 2024 Category: Respiratory Medicine Authors: Tamara L Paget Alexander N Larcombe Gavin J Pinniger Irene Tsioutsias Jan Philipp Schneider Emma J Parkinson-Lawrence Sandra Orgeig Source Type: research
< em > P. aeruginosa < /em > tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis
In conclusion, we have shown in mice and in vitro studies on CF-HBEC that tobramycin reduces inflammation by increasing 5' tRNA-fMet halves in OMVs that are delivered to CF-HBEC and reduce IL-8 and neutrophilic airway inflammation. This effect is predicted to improve lung function in pwCF receiving tobramycin for P. aeruginosa infection.PMID:38440830 | DOI:10.1152/ajplung.00018.2024 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - March 5, 2024 Category: Respiratory Medicine Authors: Zhongyou Li Roxanna Barnaby Amanda B Nymon Carolyn Roche Katja Koeppen Alix Ashare Deborah A Hogan Scott A Gerber Douglas J Taatjes Thomas H Hampton Bruce A Stanton Source Type: research
Bulk RNA Sequencing of Human Pediatric Lung Cell Populations Reveals Unique Transcriptomic Signature Associated with Post-natal Pulmonary Development
In this study we investigated gene expression patterns associated with healthy pediatric lung development in four major enriched cell populations (epithelial, endothelial, and non-endothelial mesenchymal cells, along with lung leukocytes) from one-day-old to eight-year-old organ donors with no known lung disease. For analysis, we considered the donors in 4 age groups [less than 30 days old neonates, 30 days to < 1 year old infants, toddlers (1 to < 2 years) and children 2 years and older] and assessed differentially expressed genes (DEG). We found increasing age-associated transcriptional changes in all four major ce...
Source: Am J Physiol Lung Ce... - March 5, 2024 Category: Respiratory Medicine Authors: Gautam Bandyopadhyay Matthew G Jehrio Cameron Baker Soumyaroop Bhattacharya Ravi S Misra Heidie L Huyck Chin-Yi Chu Jason R Myers John Ashton Steven Polter Matthew Cochran Timothy Bushnell Jennifer Dutra Philip J Katzman Gail H Deutsch Thomas J Mariani Gl Source Type: research
< em > P. aeruginosa < /em > tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis
In conclusion, we have shown in mice and in vitro studies on CF-HBEC that tobramycin reduces inflammation by increasing 5' tRNA-fMet halves in OMVs that are delivered to CF-HBEC and reduce IL-8 and neutrophilic airway inflammation. This effect is predicted to improve lung function in pwCF receiving tobramycin for P. aeruginosa infection.PMID:38440830 | DOI:10.1152/ajplung.00018.2024 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - March 5, 2024 Category: Respiratory Medicine Authors: Zhongyou Li Roxanna Barnaby Amanda B Nymon Carolyn Roche Katja Koeppen Alix Ashare Deborah A Hogan Scott A Gerber Douglas J Taatjes Thomas H Hampton Bruce A Stanton Source Type: research
Bulk RNA Sequencing of Human Pediatric Lung Cell Populations Reveals Unique Transcriptomic Signature Associated with Post-natal Pulmonary Development
In this study we investigated gene expression patterns associated with healthy pediatric lung development in four major enriched cell populations (epithelial, endothelial, and non-endothelial mesenchymal cells, along with lung leukocytes) from one-day-old to eight-year-old organ donors with no known lung disease. For analysis, we considered the donors in 4 age groups [less than 30 days old neonates, 30 days to < 1 year old infants, toddlers (1 to < 2 years) and children 2 years and older] and assessed differentially expressed genes (DEG). We found increasing age-associated transcriptional changes in all four major ce...
Source: Am J Physiol Lung Ce... - March 5, 2024 Category: Respiratory Medicine Authors: Gautam Bandyopadhyay Matthew G Jehrio Cameron Baker Soumyaroop Bhattacharya Ravi S Misra Heidie L Huyck Chin-Yi Chu Jason R Myers John Ashton Steven Polter Matthew Cochran Timothy Bushnell Jennifer Dutra Philip J Katzman Gail H Deutsch Thomas J Mariani Gl Source Type: research
< em > P. aeruginosa < /em > tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis
In conclusion, we have shown in mice and in vitro studies on CF-HBEC that tobramycin reduces inflammation by increasing 5' tRNA-fMet halves in OMVs that are delivered to CF-HBEC and reduce IL-8 and neutrophilic airway inflammation. This effect is predicted to improve lung function in pwCF receiving tobramycin for P. aeruginosa infection.PMID:38440830 | DOI:10.1152/ajplung.00018.2024 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - March 5, 2024 Category: Respiratory Medicine Authors: Zhongyou Li Roxanna Barnaby Amanda B Nymon Carolyn Roche Katja Koeppen Alix Ashare Deborah A Hogan Scott A Gerber Douglas J Taatjes Thomas H Hampton Bruce A Stanton Source Type: research
Bulk RNA Sequencing of Human Pediatric Lung Cell Populations Reveals Unique Transcriptomic Signature Associated with Post-natal Pulmonary Development
In this study we investigated gene expression patterns associated with healthy pediatric lung development in four major enriched cell populations (epithelial, endothelial, and non-endothelial mesenchymal cells, along with lung leukocytes) from one-day-old to eight-year-old organ donors with no known lung disease. For analysis, we considered the donors in 4 age groups [less than 30 days old neonates, 30 days to < 1 year old infants, toddlers (1 to < 2 years) and children 2 years and older] and assessed differentially expressed genes (DEG). We found increasing age-associated transcriptional changes in all four major ce...
Source: Am J Physiol Lung Ce... - March 5, 2024 Category: Respiratory Medicine Authors: Gautam Bandyopadhyay Matthew G Jehrio Cameron Baker Soumyaroop Bhattacharya Ravi S Misra Heidie L Huyck Chin-Yi Chu Jason R Myers John Ashton Steven Polter Matthew Cochran Timothy Bushnell Jennifer Dutra Philip J Katzman Gail H Deutsch Thomas J Mariani Gl Source Type: research
< em > P. aeruginosa < /em > tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis
In conclusion, we have shown in mice and in vitro studies on CF-HBEC that tobramycin reduces inflammation by increasing 5' tRNA-fMet halves in OMVs that are delivered to CF-HBEC and reduce IL-8 and neutrophilic airway inflammation. This effect is predicted to improve lung function in pwCF receiving tobramycin for P. aeruginosa infection.PMID:38440830 | DOI:10.1152/ajplung.00018.2024 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - March 5, 2024 Category: Respiratory Medicine Authors: Zhongyou Li Roxanna Barnaby Amanda B Nymon Carolyn Roche Katja Koeppen Alix Ashare Deborah A Hogan Scott A Gerber Douglas J Taatjes Thomas H Hampton Bruce A Stanton Source Type: research
Bulk RNA Sequencing of Human Pediatric Lung Cell Populations Reveals Unique Transcriptomic Signature Associated with Post-natal Pulmonary Development
In this study we investigated gene expression patterns associated with healthy pediatric lung development in four major enriched cell populations (epithelial, endothelial, and non-endothelial mesenchymal cells, along with lung leukocytes) from one-day-old to eight-year-old organ donors with no known lung disease. For analysis, we considered the donors in 4 age groups [less than 30 days old neonates, 30 days to < 1 year old infants, toddlers (1 to < 2 years) and children 2 years and older] and assessed differentially expressed genes (DEG). We found increasing age-associated transcriptional changes in all four major ce...
Source: Am J Physiol Lung Ce... - March 5, 2024 Category: Respiratory Medicine Authors: Gautam Bandyopadhyay Matthew G Jehrio Cameron Baker Soumyaroop Bhattacharya Ravi S Misra Heidie L Huyck Chin-Yi Chu Jason R Myers John Ashton Steven Polter Matthew Cochran Timothy Bushnell Jennifer Dutra Philip J Katzman Gail H Deutsch Thomas J Mariani Gl Source Type: research
< em > P. aeruginosa < /em > tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis
In conclusion, we have shown in mice and in vitro studies on CF-HBEC that tobramycin reduces inflammation by increasing 5' tRNA-fMet halves in OMVs that are delivered to CF-HBEC and reduce IL-8 and neutrophilic airway inflammation. This effect is predicted to improve lung function in pwCF receiving tobramycin for P. aeruginosa infection.PMID:38440830 | DOI:10.1152/ajplung.00018.2024 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - March 5, 2024 Category: Respiratory Medicine Authors: Zhongyou Li Roxanna Barnaby Amanda B Nymon Carolyn Roche Katja Koeppen Alix Ashare Deborah A Hogan Scott A Gerber Douglas J Taatjes Thomas H Hampton Bruce A Stanton Source Type: research
Bulk RNA Sequencing of Human Pediatric Lung Cell Populations Reveals Unique Transcriptomic Signature Associated with Post-natal Pulmonary Development
In this study we investigated gene expression patterns associated with healthy pediatric lung development in four major enriched cell populations (epithelial, endothelial, and non-endothelial mesenchymal cells, along with lung leukocytes) from one-day-old to eight-year-old organ donors with no known lung disease. For analysis, we considered the donors in 4 age groups [less than 30 days old neonates, 30 days to < 1 year old infants, toddlers (1 to < 2 years) and children 2 years and older] and assessed differentially expressed genes (DEG). We found increasing age-associated transcriptional changes in all four major ce...
Source: Am J Physiol Lung Ce... - March 5, 2024 Category: Respiratory Medicine Authors: Gautam Bandyopadhyay Matthew G Jehrio Cameron Baker Soumyaroop Bhattacharya Ravi S Misra Heidie L Huyck Chin-Yi Chu Jason R Myers John Ashton Steven Polter Matthew Cochran Timothy Bushnell Jennifer Dutra Philip J Katzman Gail H Deutsch Thomas J Mariani Gl Source Type: research
< em > P. aeruginosa < /em > tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis
In conclusion, we have shown in mice and in vitro studies on CF-HBEC that tobramycin reduces inflammation by increasing 5' tRNA-fMet halves in OMVs that are delivered to CF-HBEC and reduce IL-8 and neutrophilic airway inflammation. This effect is predicted to improve lung function in pwCF receiving tobramycin for P. aeruginosa infection.PMID:38440830 | DOI:10.1152/ajplung.00018.2024 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - March 5, 2024 Category: Respiratory Medicine Authors: Zhongyou Li Roxanna Barnaby Amanda B Nymon Carolyn Roche Katja Koeppen Alix Ashare Deborah A Hogan Scott A Gerber Douglas J Taatjes Thomas H Hampton Bruce A Stanton Source Type: research
Repetitive Sulfur Dioxide Exposure in Mice Models Post-Deployment Respiratory Syndrome
Am J Physiol Lung Cell Mol Physiol. 2024 Feb 27. doi: 10.1152/ajplung.00239.2023. Online ahead of print.ABSTRACTSoldiers deployed to Iraq and Afghanistan have a higher prevalence of respiratory symptoms than non-deployed military personnel and some have been shown to have a constellation of findings on lung biopsy termed post-deployment respiratory syndrome (PDRS). Since many of the subjects in this cohort reported exposure to sulfur dioxide (SO2), we developed a model of repetitive exposure to SO2 in mice that phenocopies many aspects of PDRS, including adaptive immune activation, airway wall remodeling, and pulmonary vas...
Source: Am J Physiol Lung Ce... - February 27, 2024 Category: Respiratory Medicine Authors: Sergey S Gutor Rodrigo I Salinas David S Nichols Julia M R Bazzano Wei Han Jason J Gokey Georgii Vasiukov James D West Dawn C Newcomb Anna E Dikalova Bradley W Richmond Sergey I Dikalov Timothy S Blackwell Vasiliy V Polosukhin Source Type: research
Repetitive Sulfur Dioxide Exposure in Mice Models Post-Deployment Respiratory Syndrome
Am J Physiol Lung Cell Mol Physiol. 2024 Feb 27. doi: 10.1152/ajplung.00239.2023. Online ahead of print.ABSTRACTSoldiers deployed to Iraq and Afghanistan have a higher prevalence of respiratory symptoms than non-deployed military personnel and some have been shown to have a constellation of findings on lung biopsy termed post-deployment respiratory syndrome (PDRS). Since many of the subjects in this cohort reported exposure to sulfur dioxide (SO2), we developed a model of repetitive exposure to SO2 in mice that phenocopies many aspects of PDRS, including adaptive immune activation, airway wall remodeling, and pulmonary vas...
Source: Am J Physiol Lung Ce... - February 27, 2024 Category: Respiratory Medicine Authors: Sergey S Gutor Rodrigo I Salinas David S Nichols Julia M R Bazzano Wei Han Jason J Gokey Georgii Vasiukov James D West Dawn C Newcomb Anna E Dikalova Bradley W Richmond Sergey I Dikalov Timothy S Blackwell Vasiliy V Polosukhin Source Type: research
Repetitive Sulfur Dioxide Exposure in Mice Models Post-Deployment Respiratory Syndrome
Am J Physiol Lung Cell Mol Physiol. 2024 Feb 27. doi: 10.1152/ajplung.00239.2023. Online ahead of print.ABSTRACTSoldiers deployed to Iraq and Afghanistan have a higher prevalence of respiratory symptoms than non-deployed military personnel and some have been shown to have a constellation of findings on lung biopsy termed post-deployment respiratory syndrome (PDRS). Since many of the subjects in this cohort reported exposure to sulfur dioxide (SO2), we developed a model of repetitive exposure to SO2 in mice that phenocopies many aspects of PDRS, including adaptive immune activation, airway wall remodeling, and pulmonary vas...
Source: Am J Physiol Lung Ce... - February 27, 2024 Category: Respiratory Medicine Authors: Sergey S Gutor Rodrigo I Salinas David S Nichols Julia M R Bazzano Wei Han Jason J Gokey Georgii Vasiukov James D West Dawn C Newcomb Anna E Dikalova Bradley W Richmond Sergey I Dikalov Timothy S Blackwell Vasiliy V Polosukhin Source Type: research
