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The Use of Neuromodulation in the Treatment of Cocaine Dependence
Cocaine-related disorders are currently among the most devastating mental diseases, as they impoverish all spheres of life resulting in tremendous economic, social, and moral costs. Despite multiple efforts to tackle cocaine dependence, pharmacological as well as cognitive therapies have had limited success. In this review, we discuss the use of recent neuromodulation techniques, such as conventional repetitive transcranial magnetic stimulation (rTMS), deep brain stimulation, and the use of H coils for deep rTMS for the treatment of cocaine dependence. Moreover, we discuss attempts to identify optimal brain targets underpi...
Source: Addictive Disorders and Their Treatment - February 21, 2014 Category: Addiction Tags: Original Articles Source Type: research

An Interpersonal Model of Addiction Relapse
In this article, we review the literature on interpersonal stress and rejection sensitivity and examine how these factors increase the risk of relapse in individuals with alcohol or drug dependence. We begin by considering the constructs of social pain and social threat, examining their evolutionary origins and their neuroanatomic, neuropsychological, and neurophysiological dimensions. Together, these perspectives provide insight into the role of interpersonal stress as a powerful and oftentimes destructive factor that affects individuals in recovery from substance dependence. We then review the empirical evidence showing ...
Source: Addictive Disorders and Their Treatment - November 22, 2013 Category: Addiction Tags: Original Articles Source Type: research

Factors Affecting Norbuprenorphine Level in Monitoring Clinical Outcome for Buprenorphine-maintained Patients
Conclusions and Scientific Significance: This study suggests that norbuprenorphine levels could be used to guide dosing of buprenorphine, as well as determining whether taking buprenorphine would continue to be beneficial or whether a full agonist may be needed. This study opens the door for further studies on how buprenorphine levels may be used to guide treatment in the clinical setting. (Source: Addictive Disorders and Their Treatment)
Source: Addictive Disorders and Their Treatment - November 22, 2013 Category: Addiction Tags: Original Articles Source Type: research