Cancers, Vol. 15, Pages 5439: Ring Chromosomes in Hematological Malignancies Are Associated with TP53 Gene Mutations and Characteristic Copy Number Variants
n
Ying S. Zou
Ring chromosomes (RC) are present in <10% of patients with hematological malignancies and are associated with poor prognosis. Until now, only small cohorts of patients with hematological neoplasms and concomitant RCs have been cytogenetically characterized. Here, we performed a conventional chromosome analysis on metaphase spreads from >13,000 patients diagnosed with hematological malignancies at the Johns Hopkins University Hospital and identified 98 patients with RCs—90 with myeloid malignancies and 8 with lymphoid malignancies. We also performed a targeted Next-Gen...
Source: Cancers - November 16, 2023 Category: Cancer & Oncology Authors: Rachel J. Boyd Jaclyn B. Murry Laura A. Morsberger Melanie Klausner Suping Chen Christopher D. Gocke Andrew S. McCallion Ying S. Zou Tags: Article Source Type: research
Unclaimed Bodies in Anatomical Education: Medical Student Attitudes at One U.S. Medical Institution
. (Source: Teaching and Learning in Medicine)
Source: Teaching and Learning in Medicine - November 15, 2023 Category: Universities & Medical Training Authors: Malcolm A. MathesonJohn R. GattiLawrence D. ReidSharaya N. GallozziSiobh án B. Cookea Johns Hopkins University School of Medicine, Baltimore, Maryland, USAb Department of Family and Community Medicine, University of Maryland Medical Center, Baltimore, Ma Source Type: research
Feasibility of an abstract verb naming treatment for aphasia
. (Source: Aphasiology)
Source: Aphasiology - November 13, 2023 Category: Speech-Language Pathology Authors: Dallin J. BaileyLisa BunkerJulie L. Wambaugha Department of Communication Disorders, Brigham Young University, Provo, UT, USAb Johns Hopkins University, Baltimore, MD, USAc Department of Communication Sciences and Disorders, University of Utah, Salt Lake Source Type: research
How many in the U.S. are disabled? Proposed census changes would greatly decrease count
The U.S. Census Bureau may soon change the way one of its nationwide surveys asks about disability. But alarm bells are ringing for many researchers and activists, because the proposed change would dramatically decrease the official number of people in the United States who are considered disabled.
“Disabled people are already underserved,” says Scott Landes, a sociologist at Syracuse University who studies disability. Altering the way the Census Bureau gathers disability statistics, he argues, will generate “inaccurate information.” In
an 18 October letter
, he and other disability researchers and ...
Source: Science of Aging Knowledge Environment - November 8, 2023 Category: Geriatrics Source Type: research
A systematic review of the arts and humanities in psychiatry education
. (Source: International Review of Psychiatry)
Source: International Review of Psychiatry - November 8, 2023 Category: Psychiatry Authors: Mary E. YadenRayah T. SawayaJessica ReddyKatherine A. JongJacob WhiteTracy MonizMargaret S. Chisolma Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USAb Department of Psychiatry, Boston Source Type: research
Ophthalmologic Findings in Children with Neurofibromatosis Type 1
. (Source: Neuro-Ophthalmology)
Source: Neuro-Ophthalmology - November 7, 2023 Category: Opthalmology Authors: Caroline Maria ZimmermannShonar SinghNur CardakliCourtney Lynn Krausa Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USAb Wilmer Eye Institute, Johns Hopkins University School of Medicine, Source Type: research
Proviral location affects cognate peptide–induced virus production and immune recognition of HIV-1–infected T cell clones
CONCLUSIONS We provide direct evidence that upon activation of infected clones by cognate antigen, the lower inducibility of intact proviruses in ZNF genes can result in immune evasion and persistence.FUNDING Office of the NIH Director and National Institute of Dental & Craniofacial Research; NIAID, NIH; Johns Hopkins University Center for AIDS Research. (Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - November 1, 2023 Category: Biomedical Science Authors: Filippo Dragoni, Abena K. Kwaa, Caroline C. Traut, Rebecca T. Veenhuis, Bezawit A. Woldemeskel, Angelica Camilo-Contreras, Hayley E. Raymond, Arbor G. Dykema, Eileen P. Scully, Amanda M. Rosecrans, Kellie N. Smith, Frederic D. Bushman, Francesco R. Simone Source Type: research
Should scientists include their race, gender, or other personal details in papers?
When Genevieve Wojcik’s co-authors suggested she include details about her race and family background in a May
Nature Genetics
commentary, she was skeptical. As a genetic epidemiologist, she had always been taught “to take yourself out of the equation completely,” says Wojcik, who is at Johns Hopkins University. But Wojcik’s colleagues argued that
their paper, about the need for multiracial participants in genetics studies
, should include a “positionality statement” from each author describing how their identity might influence their work. The practice is becoming increasingly common in sci...
Source: Science of Aging Knowledge Environment - November 1, 2023 Category: Geriatrics Source Type: research
The universe ’s puzzlingly fast expansion may defy explanation, cosmologists fret
Discovered less than a century ago, the expansion of the universe causes galaxies to rush away from Earth, stretching their light to longer, redder wavelengths. That observation spawned the idea of the big bang—and decades of bickering over the rate at which the universe is expanding, the Hubble constant. After a brief rapprochement, cosmologists are arguing again. Working from our cosmic neighborhood outward to more distant galaxies, one group has measured
a rate significantly higher
than the one derived by colleagues studying the cosmos’ farthest fringe and the afterglow of the big bang, the cosmic microwav...
Source: Science of Aging Knowledge Environment - November 1, 2023 Category: Geriatrics Source Type: research
Can Predictive AI Improve Early Sepsis Detection?
In this Medical News article, Johns Hopkins University computer scientist Suchi Saria, PhD, MSc, discusses the use of AI tools in early sepsis detection and other clinical applications. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - November 1, 2023 Category: General Medicine Source Type: research
Valid and accepted novel bacterial taxa derived from human clinical specimens and taxonomic revisions published in 2022
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - October 27, 2023 Category: Microbiology Authors: Erik MunsonArianna CarellaKaren C. Carroll1Department of Medical Laboratory Science, Marquette University, Milwaukee, Wisconsin, USA2Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Mar Source Type: research
