Acupuncture for irritable bowel syndrome: study protocol for a multicenter randomized controlled trial
DiscussionThis is a multicenter randomized controlled trial for IBS in China. It may clarify the efficacy of acupuncture as an alternative therapy for IBS. This is the first time ever that the potential mechanism of IBS based on genomics has been investigated.Trial registrationChinese Clinical Trials Register, ID:ChiCTR-IOR-15006259. First registered on 14 April 2015. (Source: Trials)
Source: Trials - October 1, 2018 Category: Research Source Type: clinical trials

Low FODMAP Plus PEG 3350 for the Treatment of Patients With Irritable Bowel Syndrome-Constipation
Condition:   Irritable Bowel Syndrome Characterized by Constipation Interventions:   Other: Low FODMAP diet/PEG 3350;   Other: sham diet/PEG 3350 Sponsor:   University of Michigan Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 27, 2018 Category: Research Source Type: clinical trials

Reduced Content of Gluten Diet on Patients With Irritable Bowel Syndrome (Pro.Ali.Fun.)
Conditions:   Irritable Bowel Syndrome;   Gluten Sensitivity Intervention:   Dietary Supplement: Reduced gluten bread and Pasta compared o normal gluten bread and Pasta Sponsor:   University of Bari Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 20, 2018 Category: Research Source Type: clinical trials

The Predictive Value of Alarm Symptoms in Patients With Irritable Bowel Syndrome Based on Rome IV
Condition:   Irritable Bowel Syndrome Intervention:   Sponsor:   Second Affiliated Hospital of Xi'an Jiaotong University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 8, 2018 Category: Research Source Type: clinical trials

Fecal Microbiota Transplantation for Irritable Bowel Syndrome
Conditions:   Irritable Bowel Syndrome;   Fecal Microbiota Transplantation Interventions:   Procedure: fecal microbiota transplantation;   Procedure: Infusion of sham;   Drug: probiotics, antibiotics or antidepressants Sponsor:   Guangzhou First People's Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 3, 2018 Category: Research Source Type: clinical trials

Efficacy and Safety of Plecanatide in Children 6 to < 18 Years of Age With Irritable Bowel Syndrome With Constipation (IBS-C)
Condition:   Irritable Bowel Syndrome With Constipation Interventions:   Drug: Plecanatide;   Drug: Matching placebo Sponsor:   Synergy Pharmaceuticals Inc. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 24, 2018 Category: Research Source Type: clinical trials

Efficacy and indication optimization of Chinese medicine ( Tiao-Chang Ke-Min granules) for diarrhea-predominant irritable bowel syndrome: study protocol for a randomized controlled trial
DiscussionThis trial may provide high-quality evidence on the efficacy and safety of TCKM granules for IBS and a more accurate indication. Importantly, this trial will provide a new research method for improving the therapeutic effects of CM for clinicians and researchers. To address IBS relapse assessment, a series of special definitions of relapse incidents has been made for this trial.Trial registrationChinese Clinical Trial Registry, ID:ChiCTR-IOR-17010600. Registered on 9 February 2017. (Source: Trials)
Source: Trials - July 11, 2018 Category: Research Source Type: clinical trials

A Trial of Linaclotide 290 μg in Patients With Irritable Bowel Syndrome With Constipation
Condition:   Irritable Bowel Syndrome Characterized by Constipation Interventions:   Drug: Linaclotide;   Drug: Placebo Sponsors:   Ironwood Pharmaceuticals, Inc.;   Allergan Sales, LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 29, 2018 Category: Research Source Type: clinical trials