GSE138297 The host response of IBS patients to allogenic and autologous faecal microbiota transfer
Contributors : Savanne Holster ; Guido J Hooiveld ; Robert J Brummer ; Julia K önigSeries Type : Expression profiling by arrayOrganism : Homo sapiensIn this randomised placebo-controlled trial, irritable bowel syndrome (IBS) patients were treated with faecal material from a healthy donor (n=8, allogenic FMT) or with their own faecal microbiota (n=8, autologous FMT). The faecal transplant was administered by whole colonoscopy into the caecum (30 g of stool in 150 ml sterile saline). Two weeks before the FMT (baseline) as well as two and eight weeks after the FMT, the participants underwent a sigmoidoscopy, and biopsies...
Source: GEO: Gene Expression Omnibus - October 14, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Efficacy of Auricular Neurostimulation in Adolescents With Irritable Bowel Syndrome in a Randomized, Double-Blind Trial
Auricular neurostimulation therapy, in which a non-invasive device delivers percutaneous electrical nerve field stimulation (PENFS) to the external ear, is effective in pediatric patients with functional abdominal pain disorders. Preclinical studies showed that PENFS modulates central pain pathways and attenuates visceral hyperalgesia. We evaluated the efficacy of PENFS in adolescents with irritable bowel syndrome (IBS). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 14, 2019 Category: Gastroenterology Authors: Amornluck Krasaelap, Manu Sood, B.U.K. Li, Rachel Unteutsch, Ke Yan, Melodee Nugent, Pippa Simpson, Katja Kovacic Source Type: research

Functional gastrointestinal disorders negatively affect health-related quality of life in MS
Objective To determine the prevalence of functional gastrointestinal disorders, the demographic and clinical characteristics associated with the presence of functional gastrointestinal disorders, and the effects of these disorders with health-related quality of life (HRQOL) in a large, diverse population of persons with MS. Methods In 2014, we surveyed participants in the North American Research Committee on Multiple Sclerosis registry regarding functional gastrointestinal disorders using the Rome III questionnaire. Participants also reported their sociodemographic characteristics, disability status using Patient Determin...
Source: Neurology Clinical Practice - October 14, 2019 Category: Neurology Authors: Marrie, R. A., Leung, S., Tyry, T., Cutter, G. R., Fox, R., Salter, A. Tags: Gastrointestinal, Multiple sclerosis, All epidemiology Research Source Type: research

Durability and effectiveness of cognitive behavioral therapy for irritable bowel syndrome
(Source: Gastroenterology)
Source: Gastroenterology - October 12, 2019 Category: Gastroenterology Authors: Jordan Shapiro, Hashem B. El-Serag, Johanna Chan Source Type: research

Role of dietary fibre in older adults with asymptomatic (AS) or symptomatic uncomplicated diverticular disease (SUDD): systematic review and meta-analysis
Diverticulitis is one of the most common and costly gastrointestinal disorders, primarily presenting in older adults [1 ⿿6]. Diverticulitis is a complication of diverticulosis, a condition defined by the presence of colonic diverticula, which are mucosal herniations in the muscle layer of the colon wall [7]. Diverticulosis can present itself as asymptomatic (AS) diverticular disease or as symptomatic uncomplicated diverticular disease (SUDD). SUDD differs from AS in that the herniations are associated with persistent gastrointestinal symptoms (GIS) similar to that of irritable bowel syndrome, such as flatulence, pain, fa...
Source: Maturitas - October 12, 2019 Category: Primary Care Authors: Fiona Eberhardt, Megan Crichton, Camilla Dahl, Romina Nucera, Julie Jenkins, Wolfgang Marx, Skye Marshall Source Type: research

Effects of kampo medicine keishikashakuyakuto on large intestine disease in mice
ConclusionKeishikashakuyakuto may be effective for IBS and IBD. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - October 11, 2019 Category: Complementary Medicine Authors: Yoshiyuki Kimura Tags: ORIGINAL ARTICLE Source Type: research

Benefits and Pitfalls of Change From Rome III to Rome IV Criteria for Irritable Bowel Syndrome and Fecal Incontinence
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 10, 2019 Category: Gastroenterology Authors: Lisa Lin, Lin Chang Tags: Editorial Source Type: research

The Impact of Stool Consistency on Bowel Movement Satisfaction in Patients With IBS-C or CIC Treated With Linaclotide or Other Medications: Real-World Evidence From the CONTOR Study
This study aimed to characterize the impact of stool consistency on patient-reported bowel movement (BM) satisfaction in patients with irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation, with a focus on linaclotide. Background: As new medications for constipation become available, understanding patients’ perceptions of treatment effects may help clinicians manage patient expectations and inform clinical decision-making. Materials and Methods: Data were derived from the Chronic Constipation and IBS-C Treatment and Outcomes Real-world Research Platform (CONTOR) study from 2 pati...
Source: Journal of Clinical Gastroenterology - October 9, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Tryptophan Metabolites in Irritable Bowel Syndrome: An Overnight Time-course Study.
Conclusion: Nighttime Trp metabolites may provide clues to poor sleep and stress with IBS. Further study of the mechanism of metabolite action is warranted. PMID: 31587547 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Is there an association between Helicobacter pylori infection and irritable bowel syndrome? A meta-analysis.
CONCLUSION: Overall, current evidence does not support an association between IBS and H. pylori infection. Further rigorous and detailed studies with larger sample sizes and after H. pylori eradication therapy are warranted. PMID: 31602169 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 7, 2019 Category: Gastroenterology Authors: Ng QX, Foo NX, Loke W, Koh YQ, Seah VJM, Soh AYS, Yeo WS Tags: World J Gastroenterol Source Type: research

Relationship of Cannabis Use Disorder and Irritable Bowel Syndrome (IBS): An Analysis of 6.8 Million Hospitalizations in the United States.
Conclusions: We found that patients with CUD have 40.7% higher odds for IBS-hospitalizations with a rising trend of CUD and related psychiatric comorbidities which may further worsen IBS and health quality of life. With limited evidence of efficacy and safety of cannabis in IBS, larger, randomized controlled studies are required to examine its therapeutic efficacy. PMID: 31573379 [PubMed - as supplied by publisher] (Source: Substance Use and Misuse)
Source: Substance Use and Misuse - October 3, 2019 Category: Addiction Tags: Subst Use Misuse Source Type: research

5-HT6 receptor antagonism reduces defecation in rat: A potential treatment strategy for irritable bowel syndrome with diarrhea.
n E Abstract Whereas the potential role of serotonin for the pathophysiology of irritable bowel syndrome (IBS) has since long been discussed, the possibility that 5-hydroxytryptamine 6 (5-HT6) receptors may serve as targets for the treatment of this condition has as yet not been explored. The aim of the current study was to assess to what extent defecation in rats is influenced by manipulation of 5-HT6 receptors. Reduced defecation following SB-399885 was observed in non-stressed animals assessed for 7 h after drug administration. While not impacting context-conditioned freezing, three 5-HT6 receptor antagonists...
Source: European Journal of Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Authors: Hagsäter SM, Lisinski A, Eriksson E Tags: Eur J Pharmacol Source Type: research

Stress and a sedentary lifestyle are associated with irritable bowel syndrome in medical students from Peru: a cross-sectional study
Background Previous studies suggest that medical students may have higher rates of irritable bowel syndrome as compared to the general population. We hypothesized lifestyle characteristics may be associated to irritable bowel syndrome. Methods A cross-sectional survey was conducted in 2015 among students in their fourth, fifth, sixth and seven years of a medical school in Peru. Volunteer participants responded to questions pertaining to demographics, surveys including the Rome III criteria and the Self-reported Stress questionnaire. Regression models were performed to establish variables independently associated with ...
Source: European Journal of Gastroenterology and Hepatology - October 2, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

High Rates of Non-Response Across Treatment Attempts in Chronic Irritable Bowel Syndrome: Results From a Follow-Up Study in Tertiary Care
Objective: Despite a wealth of treatment options for irritable bowel syndrome (IBS), data on the subjective experience of treatments in ongoing clinical practice are sparse. This follow-up study assessed the individual usage of treatment modalities by IBS patients over time and investigated the patients’ subjective experience of therapeutic impact.Methods: The study was conducted at the Specialty Clinic for Functional Gastrointestinal Disorders of the Heidelberg University Hospital. All patients who fulfilled the Rome III criteria for IBS and treated in our outpatient clinic between January 2012 and December 2016 wer...
Source: Frontiers in Psychiatry - October 2, 2019 Category: Psychiatry Source Type: research

Uncovering Demographic, Clinical, Triggering Factors Similarities Between Migraine and Irritable Bowel Syndrome: A Prospective Study
The objective was to uncover demographical and clinical factors associated with migraine and irritable bowel syndrome (IBS) in a group of patients experiencing both painful disorders and to identify their triggering factors. A prospective study was performed between January 2016 and June 2017. Clinical characteristics and potential generating factors for both pathologies were then assessed using validated questionnaires. Our study showed that the percentage of patients diagnosed with migraine and having IBS was 34.3%. Compared with patients with migraine alone, patients having both diseases were identified with higher prev...
Source: The Journal of Nervous and Mental Disease - October 1, 2019 Category: Psychiatry Tags: Original Articles Source Type: research

Analysis of lactose intolerance in students with suggestive symptoms of irritable bowel syndrome
ABSTRACT BACKGROUND: Irritable bowel syndrome is a clinical condition presenting pain, distension and abdominal fullness, diarrhea, constipation, and other symptoms. It generates significant impacts on the quality of life of those affected. The pathophysiology is uncertain, but the role of various food types has been established in bowel sensitivity and its clinical manifestations. Carbohydrate intolerance, particularly to lactose, generates similar and sometimes indistinguishable symptoms from irritable bowel syndrome, and in clinical practice is both a frequent and underdiagnosed condition. Carbohydrate intolerance is re...
Source: Arquivos de Gastroenterologia - October 1, 2019 Category: Gastroenterology Source Type: research

An overview of the efficacy and safety of prucalopride for the treatment of chronic idiopathic constipation.
This article is based on a PubMed and clinicaltrials.gov search for studies undertaken over the past 19 years (2000-2019) using the following keywords either alone or in combination: Prucalopride, chronic idiopathic constipation, chronic constipation, 5HT4 receptor, Resolor and Motegrity. Expert opinion: Prucalopride should be considered as one of the safe options for the treatment of CIC especially when previous treatments have failed. It can be helpful in the treatment of constipation caused by irritable bowel syndrome or spinal cord injury, opioid-induced constipation, post-operative ileus, and intestinal/colonic pseudo...
Source: Expert Opinion on Pharmacotherapy - September 28, 2019 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Clostridium butyricum alleviates intestinal low-grade inflammation in TNBS-induced irritable bowel syndrome in mice by regulating functional status of lamina propria dendritic cells.
CONCLUSION: The results suggest that C. butyricum regulates the amount and functional status of LPDCs in the intestinal mucosa of mice with IBS, and therefore modulates the local immune response in the intestine. PMID: 31576093 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 28, 2019 Category: Gastroenterology Authors: Zhao Q, Yang WR, Wang XH, Li GQ, Xu LQ, Cui X, Liu Y, Zuo XL Tags: World J Gastroenterol Source Type: research

Molecular ecology of the yet uncultured bacterial Ct85-cluster in the mammalian gut.
a A Abstract In our previous studies on irritable bowel syndrome (IBS) -associated microbiota by molecular methods, we demonstrated that a particular 16S rRNA gene amplicon was more abundant in the feces of healthy subjects or mixed type IBS (IBS-M) -sufferers than in the feces of individuals with diarrhea-type IBS (IBS-D). In the current study, we demonstrated that this, so called Ct85-amplicon, consists of a cluster of very heterogeneous 16S rRNA gene sequences, and defined six 16S rRNA gene types, a to f, within this cluster, each representing a novel species-, genus- or family level taxon. We then designed spe...
Source: Anaerobe - September 25, 2019 Category: Microbiology Authors: Hynönen U, Zoetendal EG, Virtala AK, Shetty S, Hasan S, Jakava-Viljanen M, de Vos WM, Palva A Tags: Anaerobe Source Type: research

Fecal Transplant Doesn ’t Improve Symptoms of IBS
Fecal microbiota transplants (FMT) did not relieve symptoms of irritable bowel syndrome (IBS) compared with placebo, concluded a trial in The Lancet Gastroenterology& Hepatology. (Source: JAMA)
Source: JAMA - September 24, 2019 Category: General Medicine Source Type: research

Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome.
This study was carried out to investigate therapeutic potential of diet based on IgG elimination combined with probiotics on migraine plus irritable bowel syndrome. A total of 60 patients diagnosed with migraine plus IBS were recruited for the study. IgG antibodies against 266 food varieties were detected by ELISA. Then, the subjects were randomized into three groups for treatment of IgG elimination diet or probiotics or diet combined with probiotics. Migraine symptom, gut function score, medication use, and serum serotonin level were measured at baseline, 7 weeks, and 14 weeks. Improvement of migraine and gu...
Source: Pain Research and Management - September 20, 2019 Category: Anesthesiology Authors: Xie Y, Zhou G, Xu Y, He B, Wang Y, Ma R, Chang Y, He D, Xu C, Xiao Z Tags: Pain Res Manag Source Type: research

Lower socioeconomic status is associated with an increased prevalence of comorbid anxiety and depression among patients with irritable bowel syndrome: results from a multicenter cohort.
Conclusions: Among IBS patients, the presence of comorbid Generalized Anxiety Disorder and/or Major Depressive Disorder is associated with lower socioeconomic status and lower average per capita income. These findings speak to a biopsychosocial model of illness, which should be considered by clinicians in the care of IBS patients. PMID: 31530048 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - September 20, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Information- and Health-care Seeking Behaviors in Patients With Irritable Bowel Syndrome
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 20, 2019 Category: Gastroenterology Authors: Andrea Shin, Sarah Ballou, Michael Camilleri, Huiping Xu, Anthony Lembo Source Type: research

Prevalence of anti-tissue transglutaminase antibodies in patients with irritable bowel syndrome in Duhok city
ConclusionThe prevalence of anti tTG antibodies in irritable bowel syndrome is high. Patients with D-IBS should be screened for celiac disease.ResumoIntroduçãoA síndrome do intestino irritável (SII) é um distúrbio gastrointestinal comum; a doença celíaca é uma enteropatia autoimune que pode imitar qualquer distúrbio gastrointestinal funcional. O objetivo deste estudo foi estimar a prevalência de anticorpos contra a doença celíaca (antitransglutaminase tecidual - tTG) em pacientes com SII.Pacientes e MétodosEste estudo transvers...
Source: Journal of Coloproctology - September 14, 2019 Category: Gastroenterology Source Type: research

Serotonin exerts a direct modulatory role on bladder afferent firing in mice.
This article is protected by copyright. All rights reserved. PMID: 31520534 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - September 14, 2019 Category: Physiology Authors: Konthapakdee N, Grundy L, O'Donnell T, Garcia-Caraballo S, Brierley SM, Grundy D, Daly DM Tags: J Physiol Source Type: research

Effect of Tong Xie Yao Fang on endogenous metabolites in urine of irritable bowel syndrome model rats.
CONCLUSION: Tong Xie Yao Fang has pharmacological effects on IBS, and its mechanism may be related to the metabolism of the nine potential biomarkers identified above in urine. PMID: 31558862 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 14, 2019 Category: Gastroenterology Authors: Zhao XY, Wang JW, Yin Y, Li K, Zhang M, Yan FP Tags: World J Gastroenterol Source Type: research

Low FODMAP diet significantly improves IBS symptoms: an Irish retrospective cohort study
AbstractIntroductionThere is growing evidence that a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) improves symptoms in irritable bowel syndrome (IBS) patients. We aimed to retrospectively investigate the effects of this diet in Irish IBS cohort over a 12-month follow-up period, including after re-introduction of the high FODMAP foods.MethodsAll the tertiary referrals seen by an FODMAP-trained dietician were reviewed (2013 –2016). Patients were evaluated for IBS symptoms by a questionnaire (four-point Likert scale). Subsequently, advice regarding the low FODMAP diet wa...
Source: European Journal of Nutrition - September 13, 2019 Category: Nutrition Source Type: research

Irritable Bowel Disease
It has been said that one can be judged by the company that one keeps. It has also been said that one cannot be judged guilty by association. So once again, aphorisms don ’t clarify matters too much for us. Still, both of those ideas can be true simultaneously under the correct circumstances. With whom we choose to associate does say much, though not all, about us. In the field of medicine, some of the same logic prevails. Once upon a time, there were surgeons and physicians, and their paths did not intersect much. (Source: Surgical Clinics of North America)
Source: Surgical Clinics of North America - September 10, 2019 Category: Surgery Authors: Ronald F. Martin Tags: Foreword Source Type: research

Corrigendum to "The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome" [Eur. J. Pharmacol. (2018), 836 34-43].
Corrigendum to "The novel peripherally active cannabinoid type 1 and serotonin type 3 receptor agonist AM9405 inhibits gastrointestinal motility and reduces abdominal pain in mouse models mimicking irritable bowel syndrome" [Eur. J. Pharmacol. (2018), 836 34-43]. Eur J Pharmacol. 2019 Sep 10;:172656 Authors: Salaga M, Binienda A, Tichkule RB, Thakur GA, Makriyannis A, Storr M, Fichna J PMID: 31519354 [PubMed - as supplied by publisher] (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - September 10, 2019 Category: Drugs & Pharmacology Authors: Salaga M, Binienda A, Tichkule RB, Thakur GA, Makriyannis A, Storr M, Fichna J Tags: Eur J Pharmacol Source Type: research

Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially.
Abstract Effects of the microbiome associated with diarrhea-predominant irritable bowel syndrome (IBS-D) on the gut have been reported, but no study has reported the effects of the IBS-D gut microbiome on the liver. We transplanted the fecal microbiota from an IBS-D patient and from a healthy volunteer to GF rats. The hepatic inflammation, serum biochemical parameters and metabolome, fecal microbiota profile, fecal short-chain fatty acids (SCFAs), and correlations among them before and after berberine intervention were assessed. Compared with the healthy control fecal microbiome transplantation (FMT) rats, the fec...
Source: Biomed Res - September 6, 2019 Category: Research Authors: Jia Q, Zhang L, Zhang J, Pei F, Zhu S, Sun Q, Duan L Tags: Biomed Res Int Source Type: research

Prebiotics: Trends in food, health and technological applications
Publication date: Available online 5 September 2019Source: Trends in Food Science & TechnologyAuthor(s): David de Paulo Farias, Fábio Fernandes de Araújo, Iramaia Angélica Neri-Numa, Glaucia Maria PastoreAbstractBackgroundCurrently, there is a growing interest in the identification of new molecules that promote health and exhibit potential for technological applications. Prebiotics are functional ingredients naturally occurring in some plant and animal foods that have received considerable attention from the pharmaceutical and food industries due to their positive health effects. With an increasing...
Source: Trends in Food Science and Technology - September 6, 2019 Category: Food Science Source Type: research

The good bugs: the use of probiotics in pediatrics
Purpose of review There is growing evidence encouraging the use of probiotics in many conditions in children. However, given the wide number of probiotics available and contradictory data in the literature, the health-care provider is often faced with uncertainness about whether or not to use probiotics and which one(s) to choose. We here review current hypotheses regarding the efficacy and safety of probiotics and evaluate the available data on the use of probiotics in most common diseases in children. Considering that probiotics have strain-specific effects, we will focus on individual probiotic strains rather than on ...
Source: Current Opinion in Pediatrics - September 6, 2019 Category: Pediatrics Tags: GASTROENTEROLOGY AND NUTRITION: Edited by Bradley Barth Source Type: research

Sucrase-Isomaltase Deficiency as a Potential Masquerader in Irritable Bowel Syndrome
ConclusionSID was found in 35% of patients with presumed IBS-D/M and should be considered in the differential diagnosis of patients presenting with abdominal pain, diarrhea, or bloating. Further studies should better characterize the clinical features of SID and investigate the effects of dietary modification in this group of patients. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - September 6, 2019 Category: Gastroenterology Source Type: research

Risk Factors for Gastrointestinal Symptoms Following Successful Eradication of Clostridium difficile by Fecal Microbiota Transplantation (FMT)
Conclusions: Altered bowel habits are a consequence of CDI and are common after FMT. This study suggests that donor type and FMT delivery modality are not related to the presence of irregular gastrointestinal symptoms after FMT. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - September 5, 2019 Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research

Prevalence of Functional GI Diseases and Pelvic Floor Symptoms in Marfan Syndrome and Ehlers-Danlos Syndrome: A National Cohort Study
This study evaluates the prevalence of and compares FGIDs and pelvic floor symptoms in a national cohort of EDS and MFS patients. Methods: A questionnaire was sent to members of local and national MFS and EDS societies. The questionnaire evaluated the presence of GI and pelvic floor symptoms and diagnoses. The presence of FGIDs was confirmed using Rome III criteria. Quality of life was evaluated and scored with the CDC quality of life. Key Results: Overall, 3934 patients completed the questionnaire, from which 1804 reported that they had some form of EDS and 600 had MFS. In total, 93% of patients with EDS complained ...
Source: Journal of Clinical Gastroenterology - September 5, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Distinct Microbial Populations Exist in the Mucosa-associated Microbiota of Diarrhea Predominant Irritable Bowel Syndrome and Ulcerative Colitis
Goals: The goal of this study was to observe the bacterial colonization in the intestinal mucosa in the patients with diarrhea predominant irritable bowel syndrome (IBS-D) and ulcerative colitis (UC), and compare the mucosa-associated microbiota among the IBS-D patients, UC patients and the healthy control, and explore the correlation of the mucosa-associated microbiota with clinical manifestations. Study: A total of 20 IBS-D patients, 28 patients with UC (16 active, 12 inactive) and 16 healthy subjects were enrolled in the study. They all underwent colonoscopies in the Gastrointestinal Endoscopy Center in the Second ...
Source: Journal of Clinical Gastroenterology - September 5, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Atopic dermatitis in adults and irritable bowel syndrome: A cross-sectional study
Conclusions: This is a rather uncultivated area in the field of AD. We observed that IBS was more common in AD group. Also, supporting findings like abnormal stool form, abdominal distension, feeling of incomplete evacuation, and straining were found more frequently in AD patients. These results may indicate the association between AD and IBS. In our opinion, patients with atopic dermatitis should be questioned in terms of IBS. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - September 5, 2019 Category: Dermatology Authors: Z Gizem Kaya & #304;slamo & #487;lu Mehmet Unal Adem K & #252; & #231; & #252;k Source Type: research

Homeopathy for treatment of irritable bowel syndrome.
CONCLUSIONS: The results for the outcomes assessed in this review are uncertain. Thus no firm conclusions regarding the effectiveness and safety of homeopathy for the treatment of IBS can be drawn. Further high quality, adequately powered RCTs are required to assess the efficacy and safety of clinical and individualised homeopathy for IBS compared to placebo or usual care. PMID: 31483486 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - September 4, 2019 Category: General Medicine Authors: Peckham EJ, Cooper K, Roberts ER, Agrawal A, Brabyn S, Tew G Tags: Cochrane Database Syst Rev Source Type: research

[TECHNIQUES] Use of Bioelectronics in the Gastrointestinal Tract
Gastrointestinal (GI) motility disorders are major contributing factors to functional GI diseases that account for>40% of patients seen in gastroenterology clinics and affect>20% of the general population. The autonomic and enteric nervous systems and the muscles within the luminal GI tract have key roles in motility. In health, this complex integrated system works seamlessly to transport liquid, solid, and gas through the GI tract. However, major and minor motility disorders occur when these systems fail. Common functional GI motility disorders include dysphagia, gastroesophageal reflux disease, functional dyspepsia...
Source: Cold Spring Harbor perspectives in medicine - September 3, 2019 Category: Research Authors: Miller, L., Farajidavar, A., Vegesna, A. Tags: Bioelectronic Medicine TECHNIQUES Source Type: research

Efficacy and safety of lactulose for the treatment of irritable bowel syndrome
Conclusions: This study will provide the evidence for the clinical efficacy and safety of lactulose for the treatment of IBS. PROSPERO registration number: PROSPERO CRD42019140639. (Source: Medicine)
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Are There Potential Applications of Fecal Microbiota Transplantation beyond Intestinal Disorders?
Abstract Intestinal microbial dysbiosis is associated with various intestinal and extraintestinal disorders. Fecal microbiota transplantation (FMT), a type of fecal bacteriotherapy, is considered an effective therapeutic option for recurrent Clostridium difficile infection (rCDI) and also has important value in other intestinal diseases including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). The purpose of this review is to discuss promising therapeutic value in extraintestinal diseases associated with gut microbial dysbiosis, including liver, metabolic, chronic kidney, neuropsychiatric, all...
Source: Biomed Res - September 1, 2019 Category: Research Authors: Zhou Y, Xu H, Huang H, Li Y, Chen H, He J, Du Y, Chen Y, Zhou Y, Nie Y Tags: Biomed Res Int Source Type: research

Predisposing Risk Factors for Functional Limb Weakness: A Case-Control Study.
Authors: Stone J, Warlow C, Deary I, Sharpe M Abstract OBJECTIVE: Functional limb weakness is a common symptom of functional neurological disorder. Few controlled studies have examined possible predisposing factors to determine their specificity for this symptom. METHODS: In this prospective case-control study, patients with functional limb weakness (
Source: Journal of Neuropsychiatry and Clinical Neurosciences - August 31, 2019 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Gut Microbial Dysbiosis in the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies
Publication date: Available online 28 August 2019Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Lin Wang, Nuha Alammar, Rajdeep Singh, Julie Nanavati, Yiran Song, Rahul Chaudhary, Gerard E. MullinAbstractBackgroundIrritable bowel syndrome (IBS) is the most common functional digestive condition in the industrialized world. The gut microbiota plays a key role in disease pathogenesis.ObjectiveA systematic review and meta-analysis on case–control studies was conducted to determine whether there is gut microbial dysbiosis in participants with IBS in comparison with healthy controls and, if so, whether...
Source: Journal of the Academy of Nutrition and Dietetics - August 30, 2019 Category: Nutrition Source Type: research

Larger regional volume of the thalamus in diarrhea-predominant irritable bowel syndrome: a cross-sectional study
AbstractAs a relay center between the cerebral cortex and various subcortical brain areas, the thalamus is repeatedly associated with the dysfunction of brain-gut interaction in patients with irritable bowel syndrome (IBS). However, the regional morphological alterations of the thalamus in IBS are not well defined. We acquired structural magnetic resonance data from 34 patients with IBS and 34 demographically similar healthy subjects. Data processing was performed using FMRIB ’s Integrated Registration and Segmentation Tool (FIRST). Volumetric analysis and surface-based vertex analysis were both carried out to charac...
Source: Brain Imaging and Behavior - August 29, 2019 Category: Neurology Source Type: research

Gut Microbial Dysbiosis in the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Case-Control Studies
Irritable bowel syndrome (IBS) is the most common functional digestive condition in the industrialized world. The gut microbiota plays a key role in disease pathogenesis. (Source: Journal of the American Dietetic Association)
Source: Journal of the American Dietetic Association - August 28, 2019 Category: Nutrition Authors: Lin Wang, Nuha Alammar, Rajdeep Singh, Julie Nanavati, Yiran Song, Rahul Chaudhary, Gerard E. Mullin Tags: Research Source Type: research

A 3 ‐Part Phase 1 Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DSP‐6952 in Healthy Japanese Subjects and Those With ≤3 Spontaneous Bowel Movements per Week
AbstractWe hypothesized that DSP ‐6952, a partial agonist of the 5‐hydroxytryptamine type‐4 receptor and a gastrointestinal prokinetic agent, can induce natural bowel movements by enhancing gastrointestinal motility and colonic transit in patients with chronic constipation and irritable bowel syndrome with constipation. This 3‐part phase 1 study evaluated the safety, tolerability, and pharmacokinetic and pharmacodynamic profiles of DSP‐6952. Eighty‐eight Japanese subjects (64 healthy volunteers and 24 subjects with spontaneous bowel movements ≤3 times/wk) were randomized to DSP‐6952 or placebo. The overall...
Source: Clinical Pharmacology in Drug Development - August 28, 2019 Category: Drugs & Pharmacology Authors: Takuya Yumizaki, Mika Maeda, Tomoe Fujita, Hiroyoshi Kakuyama, Yuji Kumagai Tags: Original Manuscript Source Type: research

Are Viruses and Parasites linked to Celiac Disease? A question that still has no definite answer.
Abstract Celiac disease is a complex autoimmune enteropathy of the small intestine that commonly occurs in genetically predisposed individuals due to intake of gluten and related proteins. Gluten consumption, duration of breast-feeding, various infections, especially frequent intestine infections, vaccinations and use of antibiotics can be linked to celiac disease. It is predicted that it affects 1% of the global population and its incidence rate is increasing. Celiac disease is closely related to Turner's syndrome, type I diabetes mellitus, Down's syndrome, and other autoimmune conditions and most people with the...
Source: Current Pharmaceutical Biotechnology - August 28, 2019 Category: Biotechnology Authors: Shariati A, Aslani HR, Shayesteh MRH, Taghipour A, Nasser A, Safari H, Alizade-Sani M, Dehghan A, Azimi T Tags: Curr Pharm Biotechnol Source Type: research

A 3 ‐Part Phase 1 Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DSP‐6952 in Healthy Japanese Subjects and Those With ≤3 Spontaneous Bowel Movements per Week
AbstractWe hypothesized that DSP ‐6952, a partial agonist of the 5‐hydroxytryptamine type‐4 receptor and a gastrointestinal prokinetic agent, can induce natural bowel movements by enhancing gastrointestinal motility and colonic transit in patients with chronic constipation and irritable bowel syndrome with constipation. This 3‐part phase 1 study evaluated the safety, tolerability, and pharmacokinetic and pharmacodynamic profiles of DSP‐6952. Eighty‐eight Japanese subjects (64 healthy volunteers and 24 subjects with spontaneous bowel movements ≤3 times/wk) were randomized to DSP‐6952 or placebo. The overall...
Source: Clinical Pharmacology in Drug Development - August 28, 2019 Category: Drugs & Pharmacology Authors: Takuya Yumizaki, Mika Maeda, Tomoe Fujita, Hiroyoshi Kakuyama, Yuji Kumagai Tags: Original Manuscript Source Type: research

Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome.
CONCLUSION: These findings indicated that mild moxibustion can relieve low-grade GI inflammation and alleviate visceral hypersensitivity in PI-IBS by regulating intestinal microbes and controlling NLRP6 inflammasome signaling. PMID: 31528095 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 28, 2019 Category: Gastroenterology Authors: Bao CH, Wang CY, Li GN, Yan YL, Wang D, Jin XM, Wu LY, Liu HR, Wang XM, Shi Z, Wu HG Tags: World J Gastroenterol Source Type: research

Efficacy and Safety of Peppermint Oil in a Randomized Double-blind Trial of Patients With Irritable Bowel Syndrome
Peppermint oil is frequently used to treat irritable bowel syndrome (IBS), despite a lack of evidence for efficacy from high-quality controlled trials. We studied the efficacy and safety of small intestinal-release peppermint oil in patients with IBS and explored the effects of targeted ileocolonic-release peppermint oil. (Source: Gastroenterology)
Source: Gastroenterology - August 27, 2019 Category: Gastroenterology Authors: Z.Z.R.M. Weerts, A.A.M. Masclee, B.J.M. Witteman, C.H.M. Clemens, B. Winkens, J.R.B.J. Brouwers, H.W. Frijlink, J.W.M. Muris, N.J. De Wit, B.A.B. Essers, J. Tack, J.W.T. Snijkers, A.M.H. Bours, A.S. de Ruiter-van der Ploeg, D.M.A.E. Jonkers, D. Keszthelyi Source Type: research