Small-Conductance Ca2+-Activated K+ Channels 2 in the Hypothalamic Paraventricular Nucleus Precipitates Visceral Hypersensitivity Induced by Neonatal Colorectal Distension in Rats
In this study, we examined mechanism of SK2 in hypothalamic paraventricular nucleus (PVN) in the pathogenesis of visceral hypersensitivity induced by neonatal colorectal distension (CRD). Rats undergoing neonatal CRD presented with visceral hypersensitivity as well as downregulated membrane SK2 channel and p-PKA. Intra-PVN administration of either the membrane protein transport inhibitor dynasore or the SK2 activator 1-EBIO upregulated the expression of membrane SK2 in PVN and mitigated visceral hypersensitivity. In addition, 1-EBIO administration reversed the increase in neuronal firing rates in PVN in rats undergoing neo...
Source: Frontiers in Pharmacology - January 27, 2021 Category: Drugs & Pharmacology Source Type: research

ManoMap: an automated system for characterization of colonic propagating contractions recorded by high-resolution manometry
ConclusionsAn automated framework was developed to filter, detect, quantify, and visualize propagating contractions in cHRM recordings in an efficient manner that is reliable and consistent. (Source: Medical and Biological Engineering and Computing)
Source: Medical and Biological Engineering and Computing - January 26, 2021 Category: Biomedical Engineering Source Type: research

Erratum for: Anti-Helicobacter pylori treatment can effectively improve the clinical remission rates of irritable bowel syndrome: a controlled clinical trial meta-analysis
In this study, we aimed to evaluate the impact of PVT in LT outcomes and analyze the types of surgical techniques used for dealing with PVT during LT. A systematic review was conducted in Cochrane, MEDLINE, and EMBASE databases, selecting articles from January 1990 to December 2019. The MESH-terms used were ( “ Portal Vein ” [Mesh] AND “ Thrombosis ” [Mesh] NOT “ Neoplasms ” [Mesh]) AND ( “ Liver Transplantation ” [Mesh]). The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) recommendation was used, and meta-analysis was performed with Review Manage...
Source: Clinics - January 22, 2021 Category: General Medicine Source Type: research

A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome
Chronic pain is a serious debilitating condition that affects ∼20% of the world's population. Currently available drugs fail to produce effective pain relief in many patients and have dose-limiting side effects. Several voltage-gated sodium (NaV) and calcium (CaV) channels are implicated in the etiology of chronic pain, particularly NaV1.1, NaV1.3, NaV1.7–NaV1.9, CaV2.2, and CaV3.2. Numerous NaV and CaV modulators have been described, but with few exceptions, they display poor potency and/or selectivity for pain-related channel subtypes. Here, we report the discovery and characterization of 2 novel tarantula-veno...
Source: Pain - January 22, 2021 Category: Anesthesiology Tags: Research Paper Source Type: research

The Microbiota-Gut-Brain Axis: From Motility to Mood
The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and extrinsic factors influence signaling along this axis, modulating the function of both the enteric and central nervous systems. More recently the role of the microbiome as an important factor in modulating gut-brain signaling has emerged and the concept of a microbiota-gut-brain axis has been established. In this review, we highlight the role of this axis in modulating enteric and central nervous system function and how this may impact disorders such as Irritable Bowel Syndrome and disorders of mood and affect. (Source: Gastroenterology)
Source: Gastroenterology - January 22, 2021 Category: Gastroenterology Authors: Kara G. Margolis, John F. Cryan, Emeran A. Mayer Source Type: research

Efficacy of a curcumin extract (Curcugen ™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study
There is preliminary evidence to suggest curcumin can alleviate digestive symptoms in adults with self-reported digestive complaints and irritable bowel syndrome. However, in all these trials, curcumin was use... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - January 21, 2021 Category: Complementary Medicine Authors: Adrian L. Lopresti, Stephen J. Smith, Alethea Rea and Shavon Michel Tags: Research article Source Type: research

Single Dose Study Assessing the Pharmacokinetic and Metabolic Profile of Alverine Citrate in Healthy Volunteers
Alverine citrate is a spasmolytic commonly prescribed in conditions such as irritable bowel syndrome, painful diverticular disease of the colon, and primary dysmenorrhea. While clinical efficacy data on alverine alone or in combination with simethicone is freely available, surprisingly little information regarding the pharmacokinetics and metabolism of alverine can be found in literature. The first HPLC-MS/MS analytical protocol for determination of alverine parent, 4-hydroxy alverine, N-desethyl alverine and 4-hydroxy alverine glucuronide in human plasma was developed and validated. The two validated methods were used for...
Source: Frontiers in Pharmacology - January 20, 2021 Category: Drugs & Pharmacology Source Type: research

Do patients with central sensitivity syndromes have poor subjective outcomes despite anatomical cure from pelvic organ prolapse surgery?
AbstractIntroductionPelvic organ prolapse(POP) has an adverse impact on quality of life with lifetime risk of surgery varying from 11 to 20%. Conditions such as fibromyalgia (FMS), chronic fatigue syndrome (CFS/ME) and irritable bowel syndrome (IBS), collectively known as central sensitivity syndromes (CSS), may affect the outcome of POP surgery. The aim of this article is to compare the outcomes of vaginal POP surgery between women with and without CSS.MethodThis was a prospective cohort study. The validated Central Sensitisation Inventory (CSI) was used to identify women with CSS. Subjective and objective outcomes were c...
Source: International Urogynecology Journal - January 18, 2021 Category: OBGYN Source Type: research

Comparison of the Gut Microbiota Disturbance in Rat Models of Irritable Bowel Syndrome Induced by Maternal Separation and Multiple Early-Life Adversity
ConclusionsOur results highlight the importance in evaluating gut microbiota characteristics in IBS research while also systematically considering potential modeling procedural differences. The microbial compositional/functional differences identified in this study were suggestive to further investigation of mechanisms of early adversity induced IBS. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 14, 2021 Category: Microbiology Source Type: research

The Role of Brain-Derived Neurotrophic Factor in Irritable Bowel Syndrome
Several studies have implied a role of brain-derived neurotrophic factor (BDNF) in abdominal pain modulation in irritable bowel syndrome (IBS). The aim of this study was to establish BDNF protein expression in human colonic biopsies and to show variation in IBS compared to controls. BDNF protein and mRNA levels were correlated with IBS symptom severity based on the IBS-symptom severity score (IBS-SSS). Biopsies from the descending colon and IBS-SSS were obtained from 10 controls and 20 IBS patients. Total protein of biopsies was extracted and assessed by ELISA and Western Blot. Total mRNA was extracted and gene expression ...
Source: Frontiers in Psychiatry - January 14, 2021 Category: Psychiatry Source Type: research

Cytokines in the colon, central nervous system and serum of irritable bowel syndrome rats
AbstractObjectiveThe aim of this study was to detect the expression of interleukin (IL)-1 β and transforming growth factor (TGF)-β1 in the colonic tissue and serum of irritable bowel syndrome (IBS) rats, as well as the distribution and expression of corticotropin-releasing factor (CRF) in the spinal cord and brain of the visceral hypersensitivity rats, thus to ascertain the mechanism o f visceral hypersensitivity signal conduction pathway.MethodsThe expression of IL-1 β and TGF-β1 in the colonic tissue and serum of IBS rats was screened by the liquid chip technology and verified by RT-PCR technology. Th...
Source: European Journal of Medical Research - January 13, 2021 Category: Research Source Type: research

Local immune response to food antigens drives meal-induced abdominal pain
Nature, Published online: 13 January 2021; doi:10.1038/s41586-020-03118-2In mice, oral tolerance to food antigens can break down after enteric infection, and this leads to food-induced pain resembling irritable bowel syndrome in humans. (Source: Nature AOP)
Source: Nature AOP - January 13, 2021 Category: Research Authors: Javier Aguilera-Lizarraga Morgane V. Florens Maria Francesca Viola Piyush Jain Lisse Decraecker Iris Appeltans Maria Cuende-Estevez Naomi Fabre Kim Van Beek Eluisa Perna Dafne Balemans Nathalie Stakenborg Stavroula Theofanous Goele Bosmans St éphanie U. Source Type: research

LncRNA H19 as a Competing Endogenous RNA to Regulate AQP Expression in the Intestinal Barrier of IBS-D Patients
ObjectiveThe study aimed to investigate the role of Long non-coding RNA (LncRNA) H19 in the pathogenesis of Diarrhea Irritable Bowel Syndrome (IBS-D), and further to the regulatory effect of LncRNA H19 on AQP1, 3 in the intestinal mucosa of IBS-D patients, so as to seek a new way to elucidate the mechanism of IBS in clinic.MethodsThe levels of LncRNA H19, AQP1, and AQP3 were detected in colonic tissues of IBS-D patients, compared with that in healthy controls. Through RNA gene interference and activation methods, small activating RNA (saRNA) and small interfering (siRNA) were transfered into Caco-2 cells in vitro experimen...
Source: Frontiers in Physiology - January 12, 2021 Category: Physiology Source Type: research

Price Is Right: Exploring Prescription Drug Coverage Barriers for Irritable Bowel Syndrome Using Threshold Pricing Analysis
ConclusionsBroader prescription drug coverage for patients failing common, inexpensive IBS treatments to which at least 30 –40% of patients would typically respond appears warranted to enable gastroenterologists to offer personalized approaches targeting specific mechanisms of this heterogeneous disease. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 12, 2021 Category: Gastroenterology Source Type: research

Surgical resection does not avoid the risk of diverticulitis recurrence —a systematic review of risk factors
AbstractPurposeFifteen percent of patients undergoing elective sigmoidectomy will present a diverticulitis recurrence, which is associated with significant costs and morbidity. We aimed to systematically review the risk factors associated with recurrence after elective sigmoidectomy.MethodsPubMed/MEDLINE, Embase, Cochrane, and Web of Science were searched for studies published until May 1, 2020. Original studies were included if (i) they included patients undergoing sigmoidectomy for diverticular disease, (ii) they reported postoperative recurrent diverticulitis, and (iii) they analyzed ≥ 1 variable associated with recu...
Source: International Journal of Colorectal Disease - January 11, 2021 Category: Gastroenterology Source Type: research

Methane and fatty acid metabolism pathways are predictive of Low-FODMAP diet efficacy for patients with Irritable Bowel Syndrome
Identification of microbiota-based biomarkers as predictors of low-FODMAP diet response and design of a diet recommendation strategy for IBS patients. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 11, 2021 Category: Nutrition Authors: Ameen Eetemadi, Ilias Tagkopoulos Tags: Original article Source Type: research

Symptoms within somatization after sexual abuse among women: a scoping review
ConclusionsThis is to our knowledge the first scoping review on sexual abuse and symptoms of somatization. The findings suggest a link between sexual abuse and somatic symptoms, but the identified association with pain and irritable bowel syndrome is inconsistent. No studies have clearly identified specific symptoms within somatization associated to sexual abuse. Qualitative research on the topic was identified as a knowledge gap. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 10, 2021 Category: OBGYN Authors: Carina Iloson, Anna M öller, Karin Sundfeldt, Susanne Bernhardsson Tags: SYSTEMATIC REVIEW Source Type: research

Differences between fixed day shift workers and rotating shift workers in gastrointestinal problems: a systematic review and meta-analysis.
This study comprised a review and compilation of literature to gain an in-depth understanding of the impact of rotating shift work on gastrointestinal health. PubMed, CINAHL, and the Cochrane Library were searched for studies published between January 1, 1985, and June 30, 2020. Fixed day shifts were defined as work shifts that began between 7:00 and 9:00 in the morning. Shifts beginning at any other time were classified as rotating shifts. A meta-analysis was performed using Comprehensive Meta-Analysis Software (CMA) version 3. In the end, 16 studies were included in the meta-analysis. An odds ratio (OR) of 1.56 (95% conf...
Source: Industrial Health - January 9, 2021 Category: Occupational Health Tags: Ind Health Source Type: research

Does rifaximin offer any promise in Crohn's disease in remission and concurrent irritable bowel syndrome-like symptoms?
This study aimed to assess the efficacy of rifaximin in the management of irritable bowel syndrome-like symptoms (bloating, abdominal pain, stool consistency) and quality of life in patients with Crohn's disease in remission. The present study included 86 patients with Crohn's disease in remission (fecal calprotectin (Source: Medicine)
Source: Medicine - January 8, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Cognitive dysfunction in ulcerative colitis patients in remission and its comparison with patients with irritable bowel syndrome and healthy controls
ConclusionPatients with IBD-UC in remission show impairments in cognitive functioning compared to the IBS and healthy control groups as assessed on cognitive function testing on MMSE, MoCA and mean peak latency of the p300 wave. This impairment in cognitive function is  unlikely to be due to premorbid levels of intellectual functioning and is likely to have impact on health-related quality of life. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 8, 2021 Category: Gastroenterology Source Type: research

The level and prevalence of depression and anxiety among patients with different subtypes of irritable bowel syndrome: a network meta-analysis
This study a... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - January 7, 2021 Category: Gastroenterology Authors: Zhichao Hu, Meixuan Li, Liang Yao, Yinshu Wang, Enkang Wang, Jianye Yuan, Fengyun Wang, Kehu Yang, Zhaoxiang Bian and Linda L. D. Zhong Tags: Research article Source Type: research

The Brain-Gut-Microbiotal Axis: A framework for understanding functional GI illness and their therapeutic interventions.
Abstract Functional gastrointestinal disorders (FGIDs), characterized by chronic abdominal complaints without a structural or biochemical cause, are common diseases that are frequently encountered by specialists in internal medicine. Collectively, irritable bowel syndrome (IBS) and functional dyspepsia are estimated to affect up to 22% of the population, and are often associated with additional somatic and pain complaints, all without an obvious structural source [1,2]. An appreciation of the current understanding of the mechanistic basis for these disorders is key to developing treatment goals and optimization of...
Source: European Journal of Internal Medicine - January 7, 2021 Category: Internal Medicine Authors: Tait C, Sayuk GS Tags: Eur J Intern Med Source Type: research

Plasmatic and urinary 5-hydroxyindolacetic acid measurements in patients with midgut neuroendocrine tumors: a GTE study.
Abstract PURPOSE: Although 24-hour urinary 5-hydroxyindolacetic acid (24u5HIAA) is a key biomarker in midgut neuroendocrine tumors (NET), it may be inaccurate and inconvenient. We compared the diagnostic performances of 24u5HIAA, overnight urinary 5HIAA (Ou5HIAA) and plasmatic 5HIAA (p5HIAA) in midgut NET. METHODS: This prospective multicenter study included 80 patients with metastatic midgut NET and 17 control patients with irritable bowel syndrome. 24u5HIAA, Ou5HIAA and p5HIAA were measured in urine and plasma collected on two consecutive days following a specific recommended diet. Reproducibility of the bi...
Source: The Journal of Clinical Endocrinology and Metabolism - December 31, 2020 Category: Endocrinology Authors: de Mestier L, Savagner F, Brixi H, Do Cao C, Dominguez-Tinajero S, Roquin G, Goichot B, Hentic O, Dubreuil O, Hautefeuille V, Walter T, Cadiot G Tags: J Clin Endocrinol Metab Source Type: research

Lactose sensitivity and lactose malabsorption. The two faces of lactose intolerance.
Conclusions: Thirty percent of LI patients have normal lactose absorption and normal LS. In the other 70% of patients, LI could be associated with LM and/or LS. PMID: 33361550 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - December 29, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Efficacy and Safety of Acupoint Catgut Embedding for Diarrhea-Predominant Irritable Bowel Syndrome and Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.
In this study, we aim to evaluate the efficacy and safety of acupoint catgut embedding for the treatment of diarrhea-predominant irritable bowel syndrome and constipation-predominant irritable bowel syndrome. We searched seven online databases to collect studies published up to Feb 29th, 2020. Study quality of each included article was evaluated by the Cochrane Collaboration Risk of Bias Tool. Systematic reviews and meta-analyses were conducted based on the Cochrane systematic review method by using RevMan 5.3 software. Among the included trials, acupoint catgut embedding alone or plus oral western medicine or plus other a...
Source: Evidence-based Complementary and Alternative Medicine - December 29, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) affects 10% to 15% of the population and often is difficult to treat with available pharmacologic agents. Dietary therapies for IBS are of particular interest because up to 90% of IBS patients exclude certain foods to improve their gastrointestinal symptoms. Among the available dietary interventions for IBS, the low FODMAP diet has the greatest evidence for efficacy. Although dietary therapies rapidly are becoming first-line treatment of IBS, gastroenterologists need to be aware of the negative effects of prescribing restrictive diets and red flag symptoms of maladaptive eating patterns. (Sou...
Source: Gastroenterology Clinics of North America - December 27, 2020 Category: Gastroenterology Authors: Kimberly N. Harer, Shanti L. Eswaran Source Type: research

Effects of the Rome IV Criteria to Functional Dyspepsia Symptoms in Saudi Arabia: Epidemiology and Clinical Practice.
Conclusions: In this population-based survey, FD affected almost 1/5 of the responding adult population in SA, which was less than previously reported. PMID: 33361706 [PubMed - in process] (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - December 25, 2020 Category: Gastroenterology Authors: Zacharakis G, Al-Ghamdi S, AlZahrani J, Almasoud A, Arahmane O, AlShehri A, Alharbi MH, Alsalmi MM, Alotibi SB, Algaradi YA, Alsadiq FN, Nikolaidis P Tags: Korean J Gastroenterol Source Type: research

Study on the clinical mechanism of Tong-Xie-An-Chang Decoction in the treatment of diarrheal irritable bowel syndrome based on single-cell sequencing technology
Discussion: This trial will prove the efficacy and safety of TXACD with high-quality evidence and provide a comprehensive perspective on the molecular mechanism of IBS-D by single-cell sequencing profiling, which makes us pinpoint specific biomarkers of IBS-D and therapeutic targets of TXACD. (Source: Medicine)
Source: Medicine - December 24, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Reduced Heart Rate Variability in Patients With Medically Unexplained Physical Symptoms: A Meta-Analysis of HF-HRV and RMSSD
Objective Medically unexplained physical symptoms (MUPS) and related syndromes are common and place a substantial burden on both patients and society. Chronic psychological distress and dysregulation of the autonomic nervous system may be common factors associated with MUPS, although previous studies have reported mixed results. The aims of this meta-analysis are to provide an updated synthesis of studies investigating heart rate variability (HRV) indices associated with autonomic nervous system functioning in three common MUPS syndromes and to explain inconsistencies in previous study findings. Methods Literatu...
Source: Psychosomatic Medicine - December 22, 2020 Category: Psychiatry & Psychology Tags: SYSTEMATIC REVIEW/META-ANALYSIS Source Type: research

Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome
Beneficial Microbes, Ahead of Print. (Source: Beneficial Microbes)
Source: Beneficial Microbes - December 22, 2020 Category: Gastroenterology Authors: S. Holster D. Repsilber D. Geng T. Hy ötyläinen A. Salonen C.M. Lindqvist S.K. Rajan W.M. de Vos R.J. Brummer J. K önig Source Type: research

Sexually dimorphic response of colorectal motility to noxious stimuli in the colorectum in rats.
This study showed a remarkable sex difference in responses of colorectal motility to noxious stimuli in the colorectum in rats: colorectal motility was enhanced in response to intracolonic administration of a noxious stimulant, capsaicin, in male rats but not in female rats. The difference in descending neurons from the brain to spinal cord operating after noxious stimulation would be responsible for the sex difference. In male rats, serotoninergic and dopaminergic neurons are dominantly activated, both of which activate the spinal defaecation centre. In female rats, GABAergic neurons in addition to serotoninergic neurons ...
Source: The Journal of Physiology - December 21, 2020 Category: Physiology Authors: Horii K, Ehara Y, Shiina T, Naitou K, Nakamori H, Horii Y, Shimaoka H, Saito S, Shimizu Y Tags: J Physiol Source Type: research

Impact of Opioid Consumption in Patients With Functional Gastrointestinal Disorders
Objective: We aimed to determine the burden of opioid consumption in a cohort of patients with functional gastrointestinal disorders.Methods: All patients diagnosed with functional gastrointestinal disorders and referred to our university hospital were evaluated from 2013 to the beginning of 2019. Irritable bowel syndrome and functional dyspepsia diagnoses were determined according to Rome criteria and severity according to irritable bowel syndrome severity scoring system. Vomiting was quantified using a 5-point Likert scale, and constipation severity was measured using the Knowles-Eccersley-Scott-Symptom questionnaires. Q...
Source: Frontiers in Pharmacology - December 21, 2020 Category: Drugs & Pharmacology Source Type: research

Coronavirus disease 2019 pandemic stress and its effects on irritable bowel syndrome patients in Saudi Arabia
Coronavirus disease 2019 (COVID-19 pandemic has affected the psychological health of people, causing a higher level of stress. Stress can exaggerate the symptoms of irritable bowel syndrome (IBS). To assess the effect of the COVID-19 pandemic stress on patients with IBS in Saudi Arabia. A descriptive cross-sectional approach was used, which targeted accessible subjects with IBS from different regions of Saudi Arabia. Data were collected from participants using a structured electronic questionnaire, which captured the participants’ socio-demographic data, medical history, IBS clinical data, self-reported stress ...
Source: Medicine - December 18, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Questionnaire-Based Survey on Epidemiology of Functional Gastrointestinal Disorders and Current Status of Gastrointestinal Motility Testing in Asian Countries
Conclusions: This survey revealed epidemiology of FGIDs and current status of gastrointestinal motility testing in some East and Southeast Asian countries.Digestion (Source: Digestion)
Source: Digestion - December 16, 2020 Category: Gastroenterology Source Type: research

Upregulation of spinal ASIC1 by miR-485 mediates enterodynia in adult offspring rats with prenatal maternal stress.
CONCLUSIONS: Overall, these data suggested that miR-485 participated in enterodynia in PMS offspring, which is likely mediated by the enhanced ASIC1 activities. PMID: 33314662 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 13, 2020 Category: Neuroscience Authors: Xu X, Li YC, Wu YY, Xu YC, Weng RX, Wang CL, Zhang PA, Zhang Y, Xu GY Tags: CNS Neurosci Ther Source Type: research

Acupuncture for Adults with Diarrhea-Predominant Irritable Bowel Syndrome or Functional Diarrhea: A Systematic Review and Meta-Analysis.
Conclusion. Acupuncture treatment can improve the clinical effectiveness of IBS-D or FD, with great safety, but the above conclusions need to be further verified through the higher quality of evidence. PMID: 33299403 [PubMed - in process] (Source: Neural Plasticity)
Source: Neural Plasticity - December 12, 2020 Category: Neurology Authors: Guo J, Xing X, Wu J, Zhang H, Yun Y, Qin Z, He Q Tags: Neural Plast Source Type: research

Association between Helicobacter pylori infection and irritable bowel syndrome: A systematic review and meta-analysis
Conclusions: Our study suggests that H pylori may have a positive effect on the development of IBS. Although the differences were not statistically significant, there were significant differences among subgroups of patients. Considering the limitations and heterogeneity, high quality studies are needed to further explore the effect of H pylori on the development of IBS. (Source: Medicine)
Source: Medicine - December 11, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Network Pharmacology Identifies the Mechanisms of Action of Tongxie Anchang Decoction in the Treatment of Irritable Bowel Syndrome with Diarrhea Predominant.
Conclusions: This study revealed the possible mechanisms by which TXACD treatment alleviated IBS-D involvement in the modulation of multiple targets and multiple pathways, including the immune regulation, inflammatory response, and oxidative stress. These findings provide novel insights into the regulatory role of TXACD in the prevention and treatment of IBS-D and hold promise for herb-based complementary and alternative therapy. PMID: 33281910 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - December 9, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The patient with irritable bowel syndrome-type symptoms: when to investigate and how?
Purpose of review Irritable bowel syndrome (IBS) is a very common disorder whose clinical presentation varies considerably between patients as well as within the same individual over time. Many of its symptoms, such as pain, diarrhea, constipation and bloating, may be manifestations of a host of other gastrointestinal diseases; some accompanied by increased mortality. This presents the clinician with a real dilemma: how to sensibly investigate the patient in which one suspects IBS but there is a nagging doubt that ‘it could be something else’? Could one miss ‘something serious’? This short revie...
Source: Current Opinion in Gastroenterology - December 8, 2020 Category: Gastroenterology Tags: LARGE INTESTINE: Edited by Eamonn M.M. Quigley Source Type: research

Role of Diet in Diarrhea-predominant Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a chronic condition characterized by abdominal pain associated with altered bowel habits. Patients with IBS often complain of food-related gastrointestinal symptoms. Specifically, those with diarrhea-predominant IBS report a significantly higher effect on quality on life because of food avoidance compared with those with other IBS subtypes. Physicians and patients often use dietary therapies to mitigate IBS symptoms. In the last 10 years, several dietary interventions such as a gluten-free diet, a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols diets h...
Source: Journal of Clinical Gastroenterology - December 8, 2020 Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research

Long-Term Outcomes Following Multiply Recurrent Clostridioides Difficile Infection and Fecal Microbiota Transplantation
Fecal microbiota transplantation (FMT) is a commonly used therapy for multiply recurrent Clostridioides difficile (mrCDI). By altering the gut microbiota, there is the potential for FMT to impact the risk for cardiometabolic, intestinal or immune-mediated conditions. Likewise, the microbiota disturbance associated with mrCDI could potentially lead to these conditions. We aimed to assess the associations of mrCDI and FMT with cardiometabolic, immune-mediated diseases, and irritable bowel syndrome. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 8, 2020 Category: Gastroenterology Authors: Ghadeer Dawwas, Colleen M. Brensinger, Ravy K. Vajravelu, Qufei Wu, Colleen R. Kelly, Loren Laine, Gary D. Wu, James D. Lewis Source Type: research

The gut –brain axis in irritable bowel syndrome and inflammatory bowel disease
Research increasingly demonstrates the bidirectional communication between gut microbiota and the brain, enhancing the role of gut microbiota modulation in the treatment of central nervous system (CNS) disorders. The first five years of life are extremely important as it affects the development of gut microbiota, immune system and, consequently, the onset of psychometric alterations, particularly in genetically predisposed individuals.In this review, we focus on the link between specific microbial genera, gastrointestinal (GI) disorders, anxiety and depression and on the effects of different therapeutic strategies for mood...
Source: Digestive and Liver Disease - December 7, 2020 Category: Gastroenterology Authors: Angela Ancona, Claudia Petito, Irene Iavarone, Valentina Petito, Linda Galasso, Alessia Leonetti, Laura Turchini, Daniela Belella, Daniele Ferrarrese, Giovanni Addolorato, Alessandro Armuzzi, Antonio Gasbarrini, Franco Scaldaferri Tags: Review Article Source Type: research

Altered metabolism of bile acids correlates with clinical parameters and the gut microbiota in patients with diarrhea-predominant irritable bowel syndrome.
Abstract BACKGROUND: Bile acids (BAs) have attracted attention in the research of irritable bowel syndrome with predominant diarrhea (IBS-D) due to their ability to modulate bowel function and their tight connection with the gut microbiota. The composition of the fecal BA pool in IBS-D patients is reportedly different from that in healthy populations. We hypothesized that BAs may participate in the pathogenesis of IBS-D and the altered BA profile may be correlated with the gut microbiome. AIM: To investigate the role of BAs in the pathogenesis of IBS-D and the correlation between fecal BAs and gut microbiota....
Source: World Journal of Gastroenterology : WJG - December 7, 2020 Category: Gastroenterology Authors: Wei W, Wang HF, Zhang Y, Zhang YL, Niu BY, Yao SK Tags: World J Gastroenterol Source Type: research

Mucosa-Associated Microbiota in Patients with Irritable Bowel Syndrome: A Comparison of Subtypes
Conclusion: Dysbiosis pattern and the function of the microbiome seem to be different among subtypes of IBS, and MAM may play a crucial role in IBS symptom generation.Digestion (Source: Digestion)
Source: Digestion - December 3, 2020 Category: Gastroenterology Source Type: research

Medicinal Applications of Cannabinoids Extracted from Cannabis sativa (L.): A new Route to Fight against COVID-19?
Abstract Cannabis sativa is a well-known plant which has been of benefit since ancient times in several medicinal systems, including Chinese, Indian, Greek and Egyptian ones. Although C. sativa is one of the most investigated medicinal plants in the world, it faces the most controversial of issues for its legalization as a medication. C. sativa contains several hundreds of phytoconstituents including the infamous «cannabinoid." It is necessary to properly understand the medicinal importance of these phytochemicals and spread awareness among the countries where it's still facing legal complexities. The c...
Source: Current Pharmaceutical Design - December 2, 2020 Category: Drugs & Pharmacology Authors: Khalid S, Almalki FA, Ben Hadda T, Bader A, Abu-Izneid T, Berredjem M, Elsharkawy ER, Alqahtani AM Tags: Curr Pharm Des Source Type: research

Food-specific serum IgG and symptom reduction with a personalized, unrestricted-calorie diet of six weeks in Irritable Bowel Syndrome (IBS)
Irritable Bowel Syndrome (IBS) is a widespread disease with variable symptoms that have an important impact on the quality of life. Despite the prevalence of IBS, its etiology and pathophysiology are still to ... (Source: Nutrition and Metabolism)
Source: Nutrition and Metabolism - December 1, 2020 Category: Nutrition Authors: Mattia Cappelletti, Emiliana Tognon, Linda Vona, Katia Basello, Andrea Costanzi, Michela Carola Speciani and Attilio Francesco Speciani Tags: Research Source Type: research

Efficacy of Shenlingbaizhu formula on irritable bowel syndrome: a systematic review.
CONCLUSION: Based on the 13 trials reviewed here, the SLBZ formula with or without conventional treatment appeared to be safe and more effective in improving the cure rate and reducing the severity of diarrhea, abdominal pain, and abdominal distention compared to conventional treatment alone. However, these trials only generated a moderate quality of evidence, and well-designed and high-quality random controlled trials of the SLBZ formula for the treatment of IBS are required to confirm the efficacy of this treatment option. PMID: 33258340 [PubMed - in process] (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - December 1, 2020 Category: Complementary Medicine Authors: Wang Y, Zhang S, Zhou Q, Meng M, Chen W Tags: J Tradit Chin Med Source Type: research

Effects of intradermal needle therapy plus pinaverium bromide on gastrointestinal hormone levels in irritable bowel syndrome-diarrhea patients
AbstractObjectiveTo observe the clinical efficacy difference in treating irritable bowel syndrome-diarrhea (IBS-D) of liver-qi stagnation and spleen-deficiency pattern with different treatment protocols, and the effects on serum levels of 5-hydroxytryptamine (5-HT), substance P (SP) and vasoactive intestinal peptide (VIP), for unveiling the mechanism of intradermal needle therapy plus pinaverium bromide in treating IBS-D.MethodsA total of 123 IBS-D patients were divided into an observation group, a Western medication group and an integrated Western and Chinese medication group using the random number table method, with 41 ...
Source: Journal of Acupuncture and Tuina Science - December 1, 2020 Category: Complementary Medicine Source Type: research

Irritable Bowel Syndrome: Psychological Disorder or Poverty? Results of a Large Cross-sectional Study in Iran.
This study aims to report the prevalence and possible determinants of IBS in southwestern Iran, an area with a notable history of war. METHODS: We randomly enrolled 1849 permanent residents in 29 cities aged 20 to 65 years. A validated for Farsi version Rome III criteria and a questionnaire, including demographic data and health history, were administered to each subject. Participants who fulfilled the Rome III criteria were categorized into three groups: Diarrhea dominant (IBS-D), Constipation dominant (IBS-C), and Mixed type (IBS-M). RESULTS: The total prevalence of IBS was 3.2%, with 70% of subjects being of A...
Source: Archives of Iranian Medicine - December 1, 2020 Category: Middle East Health Authors: Alvand S, Mohammadi Z, Rashidian L, Cheraghian B, Rahimi Z, Danehchin L, Paridar Y, Abolnezhadian F, Noori M, Mard SA, Masoudi S, Shayesteh AA, Poustchi H Tags: Arch Iran Med Source Type: research