Functional gastrointestinal disorders in children: agreement between Rome III and Rome IV diagnoses
AbstractTo evaluate the agreement between the Rome III and Rome IV criteria in diagnosing pediatric functional gastrointestinal disorders (FGIDs), we conducted a prospective cohort study in a public school in Cali, Colombia. Children and adolescents between 11 and 18 years of age were given the Spanish version of the Questionnaire on Pediatric Functional Gastrointestinal Disorders Rome III version on day 0 and Rome IV version on day 2 (48 h later). The study protocol was completed by 135 children. Thirty-nine (28.9%) children were excluded because of not following the instructions of the questionnaire. The final analysis i...
Source: European Journal of Pediatrics - June 11, 2021 Category: Pediatrics Source Type: research

Leveraging 16S rRNA Microbiome Sequencing Data to Identify Bacterial Signatures for Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain or discomfort. Previous studies have illustrated that the gut microbiota might play a critical role in IBS, but the conclusions of these studies, based on various methods, were almost impossible to compare, and reproducible microorganism signatures were still in question. To cope with this problem, previously published 16S rRNA gene sequencing data from 439 fecal samples, including 253 IBS samples and 186 control samples, were collected and processed with a uniform bioinformatic pipeline. Although we found no significant d...
Source: Frontiers in cellular and infection microbiology - June 11, 2021 Category: Microbiology Source Type: research

Effects of Lubiprostone, an Intestinal Secretagogue, on Electrolyte Homeostasis in Chronic Idiopathic and Opioid-induced Constipation
Conclusions: Lubiprostone did not cause clinically meaningful electrolyte imbalances or affect markers of renal function in either the short-term or long-term treatment of CIC or OIC. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - June 10, 2021 Category: Gastroenterology Tags: Alimentary Tract: Original Articles Source Type: research

Trends and characteristics associated with dietary triggers and psychological distress in patients with irritable bowel syndrome: a cross-sectional study
CONCLUSIONS: Clinicians should pay more attention to self-reported food intolerance in IBS patients. A personalized therapy including dietary advice as part of treatment could be of great benefit.PMID:34109584 | DOI:10.26355/eurrev_202105_25943 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - June 10, 2021 Category: Drugs & Pharmacology Authors: T Larussa L Abenavoli A Corea A C Procopio L Giubilei R Vallelunga N Polimeni E Suraci R Marasco M Imeneo L Boccuto F Luzza Source Type: research

Trends and characteristics associated with dietary triggers and psychological distress in patients with irritable bowel syndrome: a cross-sectional study
CONCLUSIONS: Clinicians should pay more attention to self-reported food intolerance in IBS patients. A personalized therapy including dietary advice as part of treatment could be of great benefit.PMID:34109584 | DOI:10.26355/eurrev_202105_25943 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - June 10, 2021 Category: Drugs & Pharmacology Authors: T Larussa L Abenavoli A Corea A C Procopio L Giubilei R Vallelunga N Polimeni E Suraci R Marasco M Imeneo L Boccuto F Luzza Source Type: research

Otilonium Bromide treatment prevents nitrergic functional and morphological changes caused by chronic stress in the distal colon of a rat IBS model
J Cell Mol Med. 2021 Jun 9. doi: 10.1111/jcmm.16710. Online ahead of print.ABSTRACTIrritable bowel syndrome (IBS) is a highly prevalent gastrointestinal disorder characterized by periods of remission and exacerbation. Among the risk factors to develop IBS, psychosocial stress is widely acknowledged. The water avoidance stress repeatedly applied (rWAS) is considered effective to study IBS etio-pathogenesis. Otilonium bromide (OB), a drug with multiple mechanisms of action, is largely used to treat IBS patients. Orally administered, it concentrates in the large bowel and significantly ameliorates the IBS symptomatology. Pres...
Source: J Cell Mol Med - June 10, 2021 Category: Molecular Biology Authors: Chiara Traini Eglantina Idrizaj Rachele Garella Maria-Simonetta Faussone-Pellegrini Maria Caterina Baccari Maria Giuliana Vannucchi Source Type: research

Otilonium Bromide treatment prevents nitrergic functional and morphological changes caused by chronic stress in the distal colon of a rat IBS model
J Cell Mol Med. 2021 Jun 9. doi: 10.1111/jcmm.16710. Online ahead of print.ABSTRACTIrritable bowel syndrome (IBS) is a highly prevalent gastrointestinal disorder characterized by periods of remission and exacerbation. Among the risk factors to develop IBS, psychosocial stress is widely acknowledged. The water avoidance stress repeatedly applied (rWAS) is considered effective to study IBS etio-pathogenesis. Otilonium bromide (OB), a drug with multiple mechanisms of action, is largely used to treat IBS patients. Orally administered, it concentrates in the large bowel and significantly ameliorates the IBS symptomatology. Pres...
Source: Molecular Medicine - June 10, 2021 Category: Molecular Biology Authors: Chiara Traini Eglantina Idrizaj Rachele Garella Maria-Simonetta Faussone-Pellegrini Maria Caterina Baccari Maria Giuliana Vannucchi Source Type: research

Trends and characteristics associated with dietary triggers and psychological distress in patients with irritable bowel syndrome: a cross-sectional study
CONCLUSIONS: Clinicians should pay more attention to self-reported food intolerance in IBS patients. A personalized therapy including dietary advice as part of treatment could be of great benefit.PMID:34109584 | DOI:10.26355/eurrev_202105_25943 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - June 10, 2021 Category: Drugs & Pharmacology Authors: T Larussa L Abenavoli A Corea A C Procopio L Giubilei R Vallelunga N Polimeni E Suraci R Marasco M Imeneo L Boccuto F Luzza Source Type: research

Serum Zinc and Selenium in Children with Inflammatory Bowel Disease: A Multicenter Study in Japan
AbstractBackgroundReports of zinc and selenium deficiencies accompanying inflammatory bowel disease (IBD) mostly have originated from Western countries and concerned adult patients. Whether Japanese children with IBD have similar deficiencies remained unclear.AimWe aimed to elucidate differences in serum zinc and selenium concentrations in Japanese children between types of IBD.MethodsChildren under 17  years old undergoing care at 12 Japanese pediatric centers were retrospectively enrolled between November 2016 and February 2018 to 3 groups representing Crohn’s disease (CD), ulcerative colitis (UC), and normal ...
Source: Digestive Diseases and Sciences - June 8, 2021 Category: Gastroenterology Source Type: research

Screening for Serotonin Receptor 4 Agonists Using a GPCR-Based Sensor in Yeast
Methods Mol Biol. 2021;2268:77-84. doi: 10.1007/978-1-0716-1221-7_5.ABSTRACTMore than 30% of all pharmaceuticals target G-protein-coupled receptors (GPCRs). Here, we present a GPCR-based screen in yeast to identify ligands for human serotonin receptor 4 (5-HTR4). Serotonin receptor 4 agonists are used for the treatment of irritable bowel syndrome with constipation. Specifically, the HTR4-based screen couples activation of 5-HTR4 on the yeast cell surface to luciferase reporter expression. The HTR4-based screen has a throughput of one compound per second allowing the screening of more than a thousand compounds per day.PMID:...
Source: Mol Biol Cell - June 4, 2021 Category: Molecular Biology Authors: Emily A Yasi Pamela Peralta-Yahya Source Type: research

Screening for Serotonin Receptor 4 Agonists Using a GPCR-Based Sensor in Yeast
Methods Mol Biol. 2021;2268:77-84. doi: 10.1007/978-1-0716-1221-7_5.ABSTRACTMore than 30% of all pharmaceuticals target G-protein-coupled receptors (GPCRs). Here, we present a GPCR-based screen in yeast to identify ligands for human serotonin receptor 4 (5-HTR4). Serotonin receptor 4 agonists are used for the treatment of irritable bowel syndrome with constipation. Specifically, the HTR4-based screen couples activation of 5-HTR4 on the yeast cell surface to luciferase reporter expression. The HTR4-based screen has a throughput of one compound per second allowing the screening of more than a thousand compounds per day.PMID:...
Source: Mol Biol Cell - June 4, 2021 Category: Molecular Biology Authors: Emily A Yasi Pamela Peralta-Yahya Source Type: research

Identification and molecular study on the interaction of Schisandrin C with human 5-HT < sub > 3A < /sub > receptor
In conclusion, the results demonstrate the mechanism of interaction between Sch C and 5-HT3A receptor and reveal Sch C as a novel antagonist.PMID:34081905 | DOI:10.1016/j.ejphar.2021.174220 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - June 3, 2021 Category: Drugs & Pharmacology Authors: Sanung Eom Jaeeun Lee Yeong-Bin Baek Hye Duck Yeom Shinhui Lee Chaelin Kim Youngseo Park Sang-Ik Park Chang-Min Lee Junho H Lee Source Type: research

Identification and molecular study on the interaction of Schisandrin C with human 5-HT < sub > 3A < /sub > receptor
In conclusion, the results demonstrate the mechanism of interaction between Sch C and 5-HT3A receptor and reveal Sch C as a novel antagonist.PMID:34081905 | DOI:10.1016/j.ejphar.2021.174220 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - June 3, 2021 Category: Drugs & Pharmacology Authors: Sanung Eom Jaeeun Lee Yeong-Bin Baek Hye Duck Yeom Shinhui Lee Chaelin Kim Youngseo Park Sang-Ik Park Chang-Min Lee Junho H Lee Source Type: research

Engraftment of strictly anaerobic oxygen-sensitive bacteria in irritable bowel syndrome patients following fecal microbiota transplantation does not improve symptoms
Volume 13, Issue 1, January-December 2021, Page 1-16 . (Source: Gut Microbes)
Source: Gut Microbes - June 2, 2021 Category: Microbiology Authors: Patrick Denis Browne Frederik Cold Andreas Munk Petersen Sofie Ingdam Halkj ær Alice H øjer Christensen Stig G ünther Lars Hestbjerg Hansen Source Type: research

Markers of Bile Acid Metabolism in Pediatric Diarrhea Predominant Irritable Bowel Syndrome and Healthy Controls
Objectives: Excessive fecal bile acids in adults have been associated with diarrhea-predominant irritable bowel syndrome (IBS-D), but their role in pediatric IBS-D is unknown. Serum markers including 7α-hydroxy-4-cholesten-3-one (C4) and fibroblast growth factor-19 (FGF-19) were validated in adults to detect bile acid diarrhea (BAD) compared to 48-hour fecal bile acid collection (48FBA). Our aims were to assess fasting serum C4 and FGF–19 and 48FBA in a pediatric population, to compare measurements in IBS-D patients and healthy controls (HC), and to determine the prevalence of BAD among children with IBS-D....
Source: Journal of Pediatric Gastroenterology and Nutrition - June 1, 2021 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Influence of Family History on Children With Irritable Bowel Syndrome
The influence of family history on children with irritable bowel syndrome (IBS) is unknown. We conducted a retrospective study to compare the clinical profile and management differences between children with a family history of IBS (FH-IBS) versus without. A total of 251 children were included in the study, 75 (30%) had FH-IBS and 176 (70%) did not. No significant differences were observed between the 2 groups in sex composition, age at initial visit, age of IBS diagnosis, dietary modifications, supplements, laxatives, antispasmodics, antidiarrheals, and cyproheptadine use. Children with FH-IBS were, however, more like to ...
Source: Journal of Pediatric Gastroenterology and Nutrition - June 1, 2021 Category: Gastroenterology Tags: Short Communication: Gastroenterology Source Type: research

PGI21 Quality Assessment of Systematic Literature Review and Meta-Analysis: Comparison of AMSTAR-2 and ROBIS
The objective was to compare the most commonly used quality tools AMSTAR-2 and ROBIS and determine the methodological quality of SRs/MAs published in irritable bowel syndrome with constipation (IBS-C). (Source: Value in Health)
Source: Value in Health - June 1, 2021 Category: International Medicine & Public Health Authors: V. Belekar, U.S. Lakkakula, A. Aggarwal, R. Thode, G.S. Solanki, R. Goyal Source Type: research

High disease burden in treated celiac patients - a web-based survey
Scand J Gastroenterol. 2021 May 30:1-7. doi: 10.1080/00365521.2021.1930146. Online ahead of print.ABSTRACTBACKGROUND: Strict adherence to a gluten-free diet usually leads to clinical and histological remission in celiac disease. Few studies have investigated the prevalence of persistent symptoms in a celiac population. We aimed to study the impact of gastrointestinal symptoms on general health in a large number of treated celiac patients, and describe the prevalence of persistent gastrointestinal symptoms and investigate associated factors.METHODS: Adults with celiac disease filled out background questions, the Celiac Symp...
Source: Scandinavian Journal of Gastroenterology - May 31, 2021 Category: Gastroenterology Authors: Frida van Megen Gry I Skodje Marianne Stendahl Marit B Veier ød Knut E A Lundin Christine Henriksen Source Type: research

Intestinal Mucosal Barrier Is Regulated by Intestinal Tract Neuro-Immune Interplay
Inflammatory bowel disease, irritable bowel syndrome and severe central nervous system injury can lead to intestinal mucosal barrier damage, which can cause endotoxin/enterobacteria translocation to induce infection and is closely related to the progression of metabolic diseases, cardiovascular and cerebrovascular diseases, tumors and other diseases. Hence, repairing the intestinal barrier represents a potential therapeutic target for many diseases. Enteral afferent nerves, efferent nerves and the intrinsic enteric nervous system (ENS) play key roles in regulating intestinal physiological homeostasis and coping with acute ...
Source: Frontiers in Pharmacology - May 31, 2021 Category: Drugs & Pharmacology Source Type: research

The low FODMAP diet for IBS; A multicentre UK study assessing long term follow up
This study assessed the long-term effect of the LFD on symptoms, nutritional composition and socialising. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 31, 2021 Category: Gastroenterology Authors: Anupam Rej, Christian C. Shaw, Rachel L. Buckle, Nick Trott, Anurag Agrawal, Karen Mosey, Katie Sanders, Rupert Allen, Sophie Martin, Aimee Newton, Kelly Robinson, David Elphick, William D. Chey, Imran Aziz, David S. Sanders Tags: Alimentary Tract Source Type: research

Protective effect of HCN2-induced SON sensitization on chronic visceral hypersensitivity in neonatal-CRD rat model
Brain Res. 2021 May 27:147538. doi: 10.1016/j.brainres.2021.147538. Online ahead of print.ABSTRACTAbnormal brain-gut interactions contribute to the development of chronic visceral hypersensitivity (CVH), which is the pivotal feature of irritable bowel syndrome (IBS). Despite the consensus with respect to the vital role of hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) channels in promoting painful symptoms in the peripheral nervous system, we identified that the upregulation of HCN2 in supraoptic nucleus (SON) was involved in the modulation of CVH in rat model of neonatal colorectal distention (n-CRD). Specif...
Source: Brain Research - May 30, 2021 Category: Neurology Authors: Bei Miao Guangtong Mao Jiaojiao Wu Benhuo Zhao Hengliang Shi Sujuan Fei Source Type: research

Abnormalities of intrinsic brain activity in irritable bowel syndrome (IBS): A protocol for systematic review and meta analysis of resting-state functional imaging
Conclusion This research will determine the consistent pattern of alterations in ReHo in IBS patients. (Source: Medicine)
Source: Medicine - May 28, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Faecal bile acids and colonic bile acid membrane receptor correlate with symptom severity of diarrhoea-predominant irritable bowel syndrome: A pilot study
To compare both the faecal bile acids (BAs) and the levels of two bile acid receptors, Takeda G protein-coupled receptor 5 (TGR5) and vitamin D receptor (VDR), in the colonic mucosa between patients with irritable bowel syndrome with predominant diarrhea (IBS-D) and healthy controls, and explore the correlations among clinical characteristics, bile acid receptors expression, and BAs. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - May 27, 2021 Category: Gastroenterology Authors: Wei Wei, Huifen Wang, Yanli Zhang, Yu Zhang, Bingyu Niu, Shuo Chen, Wenxue Zhang, Shukun Yao Tags: Alimentary Tract Source Type: research

Id: 3526039 food allergy sensitivity test (fast) with endomicroscopy of the duodenum enables tailored exclusion diet in patients with irritable bowel syndrome
Patients suffering from irritable bowel syndrome have an increased prevalence of typical and atypical food allergies. Endomicroscopy with food exposition during ongoing upper endoscopy (Food Allergy Sensitivity Test - FAST) is a new diagnostic method for food associates symptoms (Gastroenterology 2019 Jul;157(1):109-118). (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - May 26, 2021 Category: Gastroenterology Authors: Ralf Kiesslich, Hanan Adib-Tezer, Daniel Teubner, Thomas Frieling, Christiane Bayerl, Nina K. Wenda, Jan Gosepath Tags: Sunday, May 23, 2021 Source Type: research

The relationship between gut microbiota and proteolytic activity in irritable bowel syndrome
Publication date: Available online 25 May 2021Source: Microbial PathogenesisAuthor(s): Jun-Jie Hou, Xin Wang, Ying Li, Shuai Su, Yu-Ming Wang, Bang-Mao Wang, Jun-Jie Hou (Source: Microbial Pathogenesis)
Source: Microbial Pathogenesis - May 26, 2021 Category: Infectious Diseases Source Type: research

Greater overlap of rome iv disorders of gut-brain interactions leads to increased disease severity and poorer quality of life
This study aimed to assess the degree and consequences of overlapping DGBI in a large population-based global scale. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 26, 2021 Category: Gastroenterology Authors: Ami D. Sperber, Tamar Freud, Imran Aziz, Olafur S. Palsson, Douglas A. Drossman, Dan L. Dumitrascu, Xuicai Fang, Shin Fukudo, Uday C. Ghoshal, John Kellow, Rutaba Khatun, Edith Okeke, Eamonn MM. Quigley, Max Schmulson, Magnus Simren, Jan Tack, William E. Source Type: research

Standardizing and optimizing acupuncture treatment for irritable bowel syndrome: A Delphi expert consensus study
Publication date: September 2021Source: Integrative Medicine Research, Volume 10, Issue 3Author(s): Xin-Tong Su, Li-Qiong Wang, Na Zhang, Jin-Ling Li, Ling-Yu Qi, Yu Wang, Jing-Wen Yang, Guang-Xia Shi, Cun-Zhi Liu (Source: Integrative Medicine Research)
Source: Integrative Medicine Research - May 24, 2021 Category: Complementary Medicine Source Type: research

Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome
CONCLUSION: There was no sex difference in the response to FMT among IBS patients with moderate-to-severe symptoms who had previously not responded to NICE-modified diet. However, female patients with IBS-D respond better and have higher reduction of symptoms than males after FMT.PMID:34025075 | PMC:PMC8117742 | DOI:10.3748/wjg.v27.i18.2219 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 24, 2021 Category: Gastroenterology Authors: Magdy El-Salhy Christina Casen J ørgen Valeur Trygve Hausken Jan Gunnar Hatlebakk Source Type: research

Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome
CONCLUSION: There was no sex difference in the response to FMT among IBS patients with moderate-to-severe symptoms who had previously not responded to NICE-modified diet. However, female patients with IBS-D respond better and have higher reduction of symptoms than males after FMT.PMID:34025075 | PMC:PMC8117742 | DOI:10.3748/wjg.v27.i18.2219 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - May 24, 2021 Category: Gastroenterology Authors: Magdy El-Salhy Christina Casen J ørgen Valeur Trygve Hausken Jan Gunnar Hatlebakk Source Type: research

Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome
CONCLUSION: There was no sex difference in the response to FMT among IBS patients with moderate-to-severe symptoms who had previously not responded to NICE-modified diet. However, female patients with IBS-D respond better and have higher reduction of symptoms than males after FMT.PMID:34025075 | PMC:PMC8117742 | DOI:10.3748/wjg.v27.i18.2219 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 24, 2021 Category: Gastroenterology Authors: Magdy El-Salhy Christina Casen J ørgen Valeur Trygve Hausken Jan Gunnar Hatlebakk Source Type: research

Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome
CONCLUSION: There was no sex difference in the response to FMT among IBS patients with moderate-to-severe symptoms who had previously not responded to NICE-modified diet. However, female patients with IBS-D respond better and have higher reduction of symptoms than males after FMT.PMID:34025075 | PMC:PMC8117742 | DOI:10.3748/wjg.v27.i18.2219 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - May 24, 2021 Category: Gastroenterology Authors: Magdy El-Salhy Christina Casen J ørgen Valeur Trygve Hausken Jan Gunnar Hatlebakk Source Type: research

Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome
CONCLUSION: There was no sex difference in the response to FMT among IBS patients with moderate-to-severe symptoms who had previously not responded to NICE-modified diet. However, female patients with IBS-D respond better and have higher reduction of symptoms than males after FMT.PMID:34025075 | PMC:PMC8117742 | DOI:10.3748/wjg.v27.i18.2219 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 24, 2021 Category: Gastroenterology Authors: Magdy El-Salhy Christina Casen J ørgen Valeur Trygve Hausken Jan Gunnar Hatlebakk Source Type: research

Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome
CONCLUSION: There was no sex difference in the response to FMT among IBS patients with moderate-to-severe symptoms who had previously not responded to NICE-modified diet. However, female patients with IBS-D respond better and have higher reduction of symptoms than males after FMT.PMID:34025075 | PMC:PMC8117742 | DOI:10.3748/wjg.v27.i18.2219 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - May 24, 2021 Category: Gastroenterology Authors: Magdy El-Salhy Christina Casen J ørgen Valeur Trygve Hausken Jan Gunnar Hatlebakk Source Type: research

Reevaluation of the Cardiovascular Safety Profile of Tegaserod: A Review of the Clinical Data
Tegaserod is a 5-HT4 receptor agonist approved for irritable bowel syndrome with constipation in females (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 24, 2021 Category: Gastroenterology Authors: Brian E. Lacy, Darren M. Brenner, William D. Chey Source Type: research

Re-evaluation of the Cardiovascular Safety Profile of Tegaserod: A Review of the Clinical Data
Tegaserod is a 5-HT4 receptor agonist approved for irritable bowel syndrome with constipation in women (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 24, 2021 Category: Gastroenterology Authors: Brian E. Lacy, Darren M. Brenner, William D. Chey Source Type: research

Frequency of Irritable Bowel Syndrome in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Pattern
Irritable bowel syndrome (IBS) is one of the most widely recognized functional bowel disorders (FBDs) with a genetic component. SCN5A gene and SCN1B loci have been identified in population-based IBS cohorts and proposed to have a mechanistic role in the pathophysiology of IBS. These same genes have been associated with Brugada syndrome (BrS). The present study examines the hypothesis that these two inherited syndromes are linked. Prevalence of FBDs over a 12 months period were compared between probands with BrS/drug-induced type 1 Brugada pattern (DI-Type 1 BrP) (n  = 148) and a control group (n = 124) matched for ...
Source: The American Journal of Cardiology - May 23, 2021 Category: Cardiology Authors: Anil S. Sarica, Serhat Bor, Mehmet N. Orman, Hector Barajas-Martinez, Jyh-Ming Jimmy Juang, Charles Antzelevitch, Can Hasdemir Source Type: research

Somatization in patients with predominant diarrhoea irritable bowel syndrome: the role of the intestinal barrier function and integrity
Irritable bowel syndrome (IBS) is characterised by gastrointestinal (GI) and psychological symptoms (e.g., depression, anxiety, and somatization). Depression and anxiety, but not somatization, have already bee... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - May 22, 2021 Category: Gastroenterology Authors: Laura Prospero, Giuseppe Riezzo, Michele Linsalata, Antonella Orlando, Benedetta D ’Attoma, Marta Di Masi, Manuela Martulli and Francesco Russo Tags: Research Source Type: research

The impact of the intestinal microbiota and the mucosal permeability on three different antibiotic drugs
ConclusionsThe study provides interesting data since in literature there are not yet mathematical models with these features, in which the importance of intestinal microbiota, the "forgotten organ", is considered both for the subject health state and in the nutrients and drugs metabolism.PMID:34020000 | DOI:10.1016/j.ejps.2021.105869 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - May 21, 2021 Category: Drugs & Pharmacology Authors: Giovanni Palombo Mario Merone Annamaria Altomare Manuele Gori Carlotta Terradura Luca Bacco Federica Del Chierico Lorenza Putignani Michele Cicala Michele Pier Luca Guarino Vincenzo Piemonte Source Type: research

Forthcoming Issues
Irritable Bowel Syndrome (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - May 21, 2021 Category: Gastroenterology Source Type: research

A case of repeated drug-induced lung diseases due to multiple herbal medicines containing common ingredients
We present a rare case of repetitive lung disease caused by various herbal medicines containing common ingredients. In June 201X-2, an 81-year-old man with chronic sinusitis was treated with Shini-seihai-to. One month later, the patient experienced liver dysfunction, and pulmonary opacity was observed on a chest radiograph; this condition improved following the discontinuation of Shini-seihai-to. In October 201X-2, the patient developed fever and dyspnea after treatment with Saiko-keishi-to, which was administered to treat irritable bowel syndrome, and was diagnosed with pneumonia. His condition did not improve with antimi...
Source: Arerugi - May 20, 2021 Category: Allergy & Immunology Authors: Rie Mori Yoshiyuki Oyama Meiko Morita Shogo Nakamura Sho Takuma Masaki Ikeda Hideki Kusagaya Source Type: research

A case of repeated drug-induced lung diseases due to multiple herbal medicines containing common ingredients
We present a rare case of repetitive lung disease caused by various herbal medicines containing common ingredients. In June 201X-2, an 81-year-old man with chronic sinusitis was treated with Shini-seihai-to. One month later, the patient experienced liver dysfunction, and pulmonary opacity was observed on a chest radiograph; this condition improved following the discontinuation of Shini-seihai-to. In October 201X-2, the patient developed fever and dyspnea after treatment with Saiko-keishi-to, which was administered to treat irritable bowel syndrome, and was diagnosed with pneumonia. His condition did not improve with antimi...
Source: Allergology International - May 20, 2021 Category: Allergy & Immunology Authors: Rie Mori Yoshiyuki Oyama Meiko Morita Shogo Nakamura Sho Takuma Masaki Ikeda Hideki Kusagaya Source Type: research

A case of repeated drug-induced lung diseases due to multiple herbal medicines containing common ingredients
We present a rare case of repetitive lung disease caused by various herbal medicines containing common ingredients. In June 201X-2, an 81-year-old man with chronic sinusitis was treated with Shini-seihai-to. One month later, the patient experienced liver dysfunction, and pulmonary opacity was observed on a chest radiograph; this condition improved following the discontinuation of Shini-seihai-to. In October 201X-2, the patient developed fever and dyspnea after treatment with Saiko-keishi-to, which was administered to treat irritable bowel syndrome, and was diagnosed with pneumonia. His condition did not improve with antimi...
Source: Arerugi - May 20, 2021 Category: Allergy & Immunology Authors: Rie Mori Yoshiyuki Oyama Meiko Morita Shogo Nakamura Sho Takuma Masaki Ikeda Hideki Kusagaya Source Type: research

A case of repeated drug-induced lung diseases due to multiple herbal medicines containing common ingredients
We present a rare case of repetitive lung disease caused by various herbal medicines containing common ingredients. In June 201X-2, an 81-year-old man with chronic sinusitis was treated with Shini-seihai-to. One month later, the patient experienced liver dysfunction, and pulmonary opacity was observed on a chest radiograph; this condition improved following the discontinuation of Shini-seihai-to. In October 201X-2, the patient developed fever and dyspnea after treatment with Saiko-keishi-to, which was administered to treat irritable bowel syndrome, and was diagnosed with pneumonia. His condition did not improve with antimi...
Source: Allergology International - May 20, 2021 Category: Allergy & Immunology Authors: Rie Mori Yoshiyuki Oyama Meiko Morita Shogo Nakamura Sho Takuma Masaki Ikeda Hideki Kusagaya Source Type: research

A case of repeated drug-induced lung diseases due to multiple herbal medicines containing common ingredients
We present a rare case of repetitive lung disease caused by various herbal medicines containing common ingredients. In June 201X-2, an 81-year-old man with chronic sinusitis was treated with Shini-seihai-to. One month later, the patient experienced liver dysfunction, and pulmonary opacity was observed on a chest radiograph; this condition improved following the discontinuation of Shini-seihai-to. In October 201X-2, the patient developed fever and dyspnea after treatment with Saiko-keishi-to, which was administered to treat irritable bowel syndrome, and was diagnosed with pneumonia. His condition did not improve with antimi...
Source: Arerugi - May 20, 2021 Category: Allergy & Immunology Authors: Rie Mori Yoshiyuki Oyama Meiko Morita Shogo Nakamura Sho Takuma Masaki Ikeda Hideki Kusagaya Source Type: research

A case of repeated drug-induced lung diseases due to multiple herbal medicines containing common ingredients
We present a rare case of repetitive lung disease caused by various herbal medicines containing common ingredients. In June 201X-2, an 81-year-old man with chronic sinusitis was treated with Shini-seihai-to. One month later, the patient experienced liver dysfunction, and pulmonary opacity was observed on a chest radiograph; this condition improved following the discontinuation of Shini-seihai-to. In October 201X-2, the patient developed fever and dyspnea after treatment with Saiko-keishi-to, which was administered to treat irritable bowel syndrome, and was diagnosed with pneumonia. His condition did not improve with antimi...
Source: Allergology International - May 20, 2021 Category: Allergy & Immunology Authors: Rie Mori Yoshiyuki Oyama Meiko Morita Shogo Nakamura Sho Takuma Masaki Ikeda Hideki Kusagaya Source Type: research

A case of repeated drug-induced lung diseases due to multiple herbal medicines containing common ingredients
We present a rare case of repetitive lung disease caused by various herbal medicines containing common ingredients. In June 201X-2, an 81-year-old man with chronic sinusitis was treated with Shini-seihai-to. One month later, the patient experienced liver dysfunction, and pulmonary opacity was observed on a chest radiograph; this condition improved following the discontinuation of Shini-seihai-to. In October 201X-2, the patient developed fever and dyspnea after treatment with Saiko-keishi-to, which was administered to treat irritable bowel syndrome, and was diagnosed with pneumonia. His condition did not improve with antimi...
Source: Arerugi - May 20, 2021 Category: Allergy & Immunology Authors: Rie Mori Yoshiyuki Oyama Meiko Morita Shogo Nakamura Sho Takuma Masaki Ikeda Hideki Kusagaya Source Type: research

A case of repeated drug-induced lung diseases due to multiple herbal medicines containing common ingredients
We present a rare case of repetitive lung disease caused by various herbal medicines containing common ingredients. In June 201X-2, an 81-year-old man with chronic sinusitis was treated with Shini-seihai-to. One month later, the patient experienced liver dysfunction, and pulmonary opacity was observed on a chest radiograph; this condition improved following the discontinuation of Shini-seihai-to. In October 201X-2, the patient developed fever and dyspnea after treatment with Saiko-keishi-to, which was administered to treat irritable bowel syndrome, and was diagnosed with pneumonia. His condition did not improve with antimi...
Source: Allergology International - May 20, 2021 Category: Allergy & Immunology Authors: Rie Mori Yoshiyuki Oyama Meiko Morita Shogo Nakamura Sho Takuma Masaki Ikeda Hideki Kusagaya Source Type: research

A case of repeated drug-induced lung diseases due to multiple herbal medicines containing common ingredients
We present a rare case of repetitive lung disease caused by various herbal medicines containing common ingredients. In June 201X-2, an 81-year-old man with chronic sinusitis was treated with Shini-seihai-to. One month later, the patient experienced liver dysfunction, and pulmonary opacity was observed on a chest radiograph; this condition improved following the discontinuation of Shini-seihai-to. In October 201X-2, the patient developed fever and dyspnea after treatment with Saiko-keishi-to, which was administered to treat irritable bowel syndrome, and was diagnosed with pneumonia. His condition did not improve with antimi...
Source: Arerugi - May 20, 2021 Category: Allergy & Immunology Authors: Rie Mori Yoshiyuki Oyama Meiko Morita Shogo Nakamura Sho Takuma Masaki Ikeda Hideki Kusagaya Source Type: research

A case of repeated drug-induced lung diseases due to multiple herbal medicines containing common ingredients
We present a rare case of repetitive lung disease caused by various herbal medicines containing common ingredients. In June 201X-2, an 81-year-old man with chronic sinusitis was treated with Shini-seihai-to. One month later, the patient experienced liver dysfunction, and pulmonary opacity was observed on a chest radiograph; this condition improved following the discontinuation of Shini-seihai-to. In October 201X-2, the patient developed fever and dyspnea after treatment with Saiko-keishi-to, which was administered to treat irritable bowel syndrome, and was diagnosed with pneumonia. His condition did not improve with antimi...
Source: Allergology International - May 20, 2021 Category: Allergy & Immunology Authors: Rie Mori Yoshiyuki Oyama Meiko Morita Shogo Nakamura Sho Takuma Masaki Ikeda Hideki Kusagaya Source Type: research