Gut Microbiota-Derived Metabolites in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is the most common functional bowel disorder worldwide and is associated with visceral hypersensitivity, gut motility, immunomodulation, gut microbiota alterations, and dysfunction of the brain-gut axis; however, its pathophysiology remains poorly understood. Gut microbiota and its metabolites are proposed as possible etiological factors of IBS. The aim of our study was to investigate specific types of microbiota-derived metabolites, especially bile acids, short-chain fatty acids, vitamins, amino acids, serotonin and hypoxanthine, which are all implicated in the pathogenesis of IBS. Metabolit...
Source: Frontiers in cellular and infection microbiology - September 23, 2021 Category: Microbiology Source Type: research

Covering the Cover
Gut virome composition varies by irritable bowel syndrome phenotype and demonstrates stability in individuals through time, with the ability to mediate gut bacteria and host gene expression. (Source: Gastroenterology)
Source: Gastroenterology - September 22, 2021 Category: Gastroenterology Authors: Amisha Ahuja, Helenie Kefalakes Tags: Covering the Cover Source Type: research

& ldquo;Let Food Be Thy Medicine & rdquo;: Diet and Supplements in Irritable Bowel Syndrome
(Source: Clinical and Experimental Gastroenterology)
Source: Clinical and Experimental Gastroenterology - September 22, 2021 Category: Gastroenterology Tags: Clinical and Experimental Gastroenterology Source Type: research

Association Between Irritable Bowel Syndrome and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis
Background: Parkinson's disease (PD) and irritable bowel syndrome (IBS) are respectively one of the most common neurodegenerative diseases and functional bowel diseases in the world. Recent studies suggest that patients with IBS seem to have a higher risk of PD, which conflicts with the result of previous meta-analysis. Therefore, the purpose of this systematic review is to evaluate all available evidence, in order to clarify the association between PD and IBS.Methods: Two reviewers independently searched the PubMed, Embase, Web of Science, and Cochrane library on April 25, 2021 to identify all records that explore the ass...
Source: Frontiers in Neurology - September 22, 2021 Category: Neurology Source Type: research

The estimation of a preference-based single index for the IBS-QoL by mapping to the EQ-5D-5L in patients with irritable bowel syndrome
ConclusionThis study reports the development of an algorithm where the condition-specific questionnaire IBS-QoL can be used to calculate utility values for use in economic evaluations. Including a clinical measure, IBS-SSS, in the model improved the performance of the algorithm. (Source: Quality of Life Research)
Source: Quality of Life Research - September 21, 2021 Category: Health Management Source Type: research

Treatment of Irritable Bowel Syndrome by Chinese Medicine: A Review
AbstractIrritable bowel syndrome (IBS) is a common refractory disease. Chinese medicine (CM) has remarkable efficacy and advantages on the treatment of IBS. This review summarized the articles focusing on the treatment of IBS with CM to sum up the latest treatment methods for IBS and the underlying mechanisms. Literature analysis showed that prescriptions, acupuncture, and moxibustion are the primary methods of CM treatment for IBS. The potential mechanism centers on the regulation of the enteric nervous system, the alleviation of visceral hypersensitivity, the stability of intestinal flora, and the regulation of the immun...
Source: Chinese Journal of Integrative Medicine - September 21, 2021 Category: Internal Medicine Source Type: research

Examination of the Prevalence of a Positive Hydrogen Breath Test in Irritable Bowel Syndrome and the Relationship with Dietary Intake
Determine differences in dietary patterns and nutrient intake in an irritable bowel syndrome population with and without small intestinal bacterial overgrowth. (Source: Journal of the American Dietetic Association)
Source: Journal of the American Dietetic Association - September 20, 2021 Category: Nutrition Authors: C. Gales, M. Nahikian-Nelms, K. Roberts Tags: Late-breaking Research Abstracts Source Type: research

The Relieving Effects of a Polyherb-Based Dietary Supplement ColonVita on Gastrointestinal Quality of Life Index (GIQLI) in Older Adults with Chronic Gastrointestinal Symptoms Are Influenced by Age and Cardiovascular Disease: A 12-Week Randomized Placebo-Controlled Trial
Evid Based Complement Alternat Med. 2021 Sep 10;2021:6653550. doi: 10.1155/2021/6653550. eCollection 2021.ABSTRACTChronic gastrointestinal symptoms (CGS) negatively affect the quality of life in about 15-30% of the population without effective drugs. Recent studies suggest that dietary supplement may improve CGS, but inconsistent results exist. The goal of this study is to evaluate the effect of a polyherbal-based supplement ColonVita on the gastrointestinal quality of life index (GIQLI) in 100 old adults with CGS (63.1 ± 9.6 years) who were randomly assigned to daily ColonVita or placebo tablets (n = 50/group) for ...
Source: Evidence-based Complementary and Alternative Medicine - September 20, 2021 Category: Complementary Medicine Authors: Gang Xu Guoqiang Xing Bing Zhang Jingfen Zhu Yong Cai Tian Shen Jianyu Rao Rong Shi Zhaochun Cao Tuong Nguyen Source Type: research

When food moves from friend to foe: Why avoidant/restrictive food intake matters in irritable bowel syndrome
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 20, 2021 Category: Gastroenterology Authors: Helen Burton Murray, Kyle Staller Source Type: research

Why use nutraceutical strategies for the Irritable Bowel Syndrome
Curr Med Chem. 2021 Sep 16. doi: 10.2174/0929867328666210917115255. Online ahead of print.ABSTRACTIrritable bowel syndrome (IBS) is a chronic functional bowel disorder, often stress-related, identified by many abdominal symptoms, the most important of which is the chronic visceral abdominal pain. Therefore, IBS commonly impairs the quality of life of patients, moreover it is frequently linked to depressive and anxiety symptoms. The treatment of IBS primarily focuses on symptoms relief. Unfortunately, up to now, no efficacious therapies have been found. Therefore, it would be important to develop new anti-IBS interventions....
Source: Current Medicinal Chemistry - September 17, 2021 Category: Chemistry Authors: Flavia di Michele Source Type: research

Why use nutraceutical strategies for the Irritable Bowel Syndrome
Curr Med Chem. 2021 Sep 16. doi: 10.2174/0929867328666210917115255. Online ahead of print.ABSTRACTIrritable bowel syndrome (IBS) is a chronic functional bowel disorder, often stress-related, identified by many abdominal symptoms, the most important of which is the chronic visceral abdominal pain. Therefore, IBS commonly impairs the quality of life of patients, moreover it is frequently linked to depressive and anxiety symptoms. The treatment of IBS primarily focuses on symptoms relief. Unfortunately, up to now, no efficacious therapies have been found. Therefore, it would be important to develop new anti-IBS interventions....
Source: Current Medicinal Chemistry - September 17, 2021 Category: Chemistry Authors: Flavia di Michele Source Type: research

Prokaryotic and Eukaryotic Fecal Microbiota in Irritable Bowel Syndrome Patients and Healthy Individuals Colonized With Blastocystis
Blastocystis is the most frequently isolated protozoan from human stool. Its role in human health is still debated, and a high prevalence was reported in irritable bowel syndrome (IBS) subjects, suggesting a potential link with microbiota. In the present study, we aimed to investigate prokaryotic and eukaryotic microbiota in both IBS-C (constipated) and healthy individuals. We recruited 35 IBS-C patients and 23 healthy subjects, from which 12 and 11 carried Blastocystis, respectively. We performed 16S and 18S rRNA high-throughput sequencing on feces. Whereas we did not observe differences between infected and non-infected ...
Source: Frontiers in Microbiology - September 17, 2021 Category: Microbiology Source Type: research

Pharmacological intervention for paediatric irritable bowel syndrome
Expert Opin Pharmacother. 2021 Sep 15. doi: 10.1080/14656566.2021.1976753. Online ahead of print.ABSTRACTINTRODUCTION: Irritable bowel syndrome is a common functional gastrointestinal disorder in children, characterized by recurrent abdominal pain associated with altered bowel habits in terms of both frequency and consistency. According to change in stool consistency it is categorized into 4 subtypes. From the etiological perspective, it is a multifactorial functional disorder with both central (psychosocial) and peripheral factors (altered bowel sensitivity, motility and microbiota) implied in the genesis of the symptoms....
Source: Expert Opinion on Pharmacotherapy - September 15, 2021 Category: Drugs & Pharmacology Authors: Marcella Pesce Maria Giovanna Puoti Anna Rybak Marta Andreozzi Eugenia Bruzzese Giovanni Sarnelli Osvaldo Borrelli Source Type: research

Electro-acupuncture for irritable bowel syndrome patients: study protocol for a single-blinded randomized sham-controlled clinical trial
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders in clinical practice. IBS diagnosis is based on symptoms defined by abdominal pain or discomfort associated with d... (Source: Trials)
Source: Trials - September 15, 2021 Category: General Medicine Authors: Linda L. D. Zhong, Tsz Fung Lam, Wei Yang, Ya Zheng, Zipan Lyu and Zhaoxiang Bian Tags: Study protocol Source Type: research

Therapeutic Effects of Berberine Hydrochloride on Stress-Induced Diarrhea-Predominant Irritable Bowel Syndrome Rats by Inhibiting Neurotransmission in Colonic Smooth Muscle
This study measured the abdominal withdrawal reflex (AWR) response to graded colorectal distention (CRD; 20, 40, 60, and 80 mmHg) and observed the fecal areas of stress-induced IBS-D model. Experiments were conducted using organ bath techniques, which were performed in vitro using strips of colonic longitudinal smooth muscle. Inhibitory and excitatory neurotransmitter agents were added to each organ bath to observe contractile responses on the strips and the treatment effect exerted by BBH. The IBS-D rat model was successfully induced by chronic restraint stress, which resulted in an increased defecation frequency and...
Source: Frontiers in Pharmacology - September 14, 2021 Category: Drugs & Pharmacology Source Type: research

Hybrid Cognitive Behavioral Therapy With Interoceptive Exposure for Irritable Bowel Syndrome: A Feasibility Study
In this study, we conducted a trial to evaluate the feasibility, efficacy, and safety of the hybrid CBT-IE program for Japanese IBS patients. The study was a single-arm, open-label pilot clinical trial. A total of 16 IBS patients were included in the study and 14 patients completed the intervention, which consisted of 10 weekly individual hybrid CBT-IE sessions. We performed an intention to treat analysis. The primary outcome measure for the efficacy of the intervention was a decrease in the severity of IBS symptoms. The feasibility and safety of the intervention were examined by the dropout rate and recording of adverse e...
Source: Frontiers in Psychiatry - September 9, 2021 Category: Psychiatry Source Type: research

Pan-Gastrointestinal Tract Mucosal Pathologies in Patients with Celiac Disease with the Demonstration of IgA Anti-Transglutaminase Mucosal Deposits: A Case –Control Study
AbstractBackgroundWhile celiac disease (CeD) is considered to affect primarily the small intestine, pathological changes in other parts of the gastrointestinal tract (GIT) are also known to occur. IgA anti-tissue transglutaminase-2 antibody (anti-TG2 Ab) deposits at the site of involvement is one of the methods to establish CeD-related tissue pathology.AimsTo explore the utility of IgA anti-TG2 Ab deposits in pan-gastrointestinal mucosal biopsies as evidence of CeD-related pathologies.MethodsForty-two treatment-naive patients with CeD and 45 patients with irritable bowel syndrome were included as cases and controls, respec...
Source: Digestive Diseases and Sciences - September 9, 2021 Category: Gastroenterology Source Type: research

Gluten and fructan intake and their associations with gastrointestinal symptoms in irritable bowel syndrome: a food diary study
Wheat contains several components, including gluten and fructan, that may be associated with gastrointestinal symptoms (GI) in irritable bowel syndrome (IBS). The aims of the study were to determine the average daily intake of gluten, investigate the association of gluten and GI symptoms, as well as the association between fructan and GI symptoms in IBS subjects. (Source: Clinical Nutrition)
Source: Clinical Nutrition - September 8, 2021 Category: Nutrition Authors: Joost P. Algera, Stine St örsrud, Annika Lindström, Magnus Simrén, Hans Törnblom Tags: Original article Source Type: research

Psychological Interventions for Irritable Bowel Syndrome: A Meta-Analysis of Iranian Randomized Trials
CONCLUSION: The existing evidence suggests that psychological interventions can be highly effective in improving the severity of IBS symptoms, mental health, and quality of life for Iranian adults with IBS. However, some weaknesses should be considered in the interpretation of the results and future research. The risk of randomization was high or unclear in almost all of the existing trials; there was no single large trial in this area; and there was substantial inconsistency in the EFs, which might be related to methodological or clinical moderators.PMID:34488313 | DOI:10.34172/aim.2021.71 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - September 7, 2021 Category: Middle East Health Authors: Gholamreza Jandaghi Ali Zia-Tohidi Manijeh Firoozi Source Type: research

Psychological Interventions for Irritable Bowel Syndrome: A Meta-Analysis of Iranian Randomized Trials
CONCLUSION: The existing evidence suggests that psychological interventions can be highly effective in improving the severity of IBS symptoms, mental health, and quality of life for Iranian adults with IBS. However, some weaknesses should be considered in the interpretation of the results and future research. The risk of randomization was high or unclear in almost all of the existing trials; there was no single large trial in this area; and there was substantial inconsistency in the EFs, which might be related to methodological or clinical moderators.PMID:34488313 | DOI:10.34172/aim.2021.71 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - September 7, 2021 Category: Middle East Health Authors: Gholamreza Jandaghi Ali Zia-Tohidi Manijeh Firoozi Source Type: research

Psychological Interventions for Irritable Bowel Syndrome: A Meta-Analysis of Iranian Randomized Trials
CONCLUSION: The existing evidence suggests that psychological interventions can be highly effective in improving the severity of IBS symptoms, mental health, and quality of life for Iranian adults with IBS. However, some weaknesses should be considered in the interpretation of the results and future research. The risk of randomization was high or unclear in almost all of the existing trials; there was no single large trial in this area; and there was substantial inconsistency in the EFs, which might be related to methodological or clinical moderators.PMID:34488313 | DOI:10.34172/aim.2021.71 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - September 7, 2021 Category: Middle East Health Authors: Gholamreza Jandaghi Ali Zia-Tohidi Manijeh Firoozi Source Type: research

Psychological Interventions for Irritable Bowel Syndrome: A Meta-Analysis of Iranian Randomized Trials
CONCLUSION: The existing evidence suggests that psychological interventions can be highly effective in improving the severity of IBS symptoms, mental health, and quality of life for Iranian adults with IBS. However, some weaknesses should be considered in the interpretation of the results and future research. The risk of randomization was high or unclear in almost all of the existing trials; there was no single large trial in this area; and there was substantial inconsistency in the EFs, which might be related to methodological or clinical moderators.PMID:34488313 | DOI:10.34172/aim.2021.71 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - September 7, 2021 Category: Middle East Health Authors: Gholamreza Jandaghi Ali Zia-Tohidi Manijeh Firoozi Source Type: research

Psychological Interventions for Irritable Bowel Syndrome: A Meta-Analysis of Iranian Randomized Trials
CONCLUSION: The existing evidence suggests that psychological interventions can be highly effective in improving the severity of IBS symptoms, mental health, and quality of life for Iranian adults with IBS. However, some weaknesses should be considered in the interpretation of the results and future research. The risk of randomization was high or unclear in almost all of the existing trials; there was no single large trial in this area; and there was substantial inconsistency in the EFs, which might be related to methodological or clinical moderators.PMID:34488313 | DOI:10.34172/aim.2021.71 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - September 7, 2021 Category: Middle East Health Authors: Gholamreza Jandaghi Ali Zia-Tohidi Manijeh Firoozi Source Type: research

Psychological Interventions for Irritable Bowel Syndrome: A Meta-Analysis of Iranian Randomized Trials
CONCLUSION: The existing evidence suggests that psychological interventions can be highly effective in improving the severity of IBS symptoms, mental health, and quality of life for Iranian adults with IBS. However, some weaknesses should be considered in the interpretation of the results and future research. The risk of randomization was high or unclear in almost all of the existing trials; there was no single large trial in this area; and there was substantial inconsistency in the EFs, which might be related to methodological or clinical moderators.PMID:34488313 | DOI:10.34172/aim.2021.71 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - September 7, 2021 Category: Middle East Health Authors: Gholamreza Jandaghi Ali Zia-Tohidi Manijeh Firoozi Source Type: research

Psychological Interventions for Irritable Bowel Syndrome: A Meta-Analysis of Iranian Randomized Trials
CONCLUSION: The existing evidence suggests that psychological interventions can be highly effective in improving the severity of IBS symptoms, mental health, and quality of life for Iranian adults with IBS. However, some weaknesses should be considered in the interpretation of the results and future research. The risk of randomization was high or unclear in almost all of the existing trials; there was no single large trial in this area; and there was substantial inconsistency in the EFs, which might be related to methodological or clinical moderators.PMID:34488313 | DOI:10.34172/aim.2021.71 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - September 7, 2021 Category: Middle East Health Authors: Gholamreza Jandaghi Ali Zia-Tohidi Manijeh Firoozi Source Type: research

Psychological Interventions for Irritable Bowel Syndrome: A Meta-Analysis of Iranian Randomized Trials
CONCLUSION: The existing evidence suggests that psychological interventions can be highly effective in improving the severity of IBS symptoms, mental health, and quality of life for Iranian adults with IBS. However, some weaknesses should be considered in the interpretation of the results and future research. The risk of randomization was high or unclear in almost all of the existing trials; there was no single large trial in this area; and there was substantial inconsistency in the EFs, which might be related to methodological or clinical moderators.PMID:34488313 | DOI:10.34172/aim.2021.71 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - September 7, 2021 Category: Middle East Health Authors: Gholamreza Jandaghi Ali Zia-Tohidi Manijeh Firoozi Source Type: research

Psychological Interventions for Irritable Bowel Syndrome: A Meta-Analysis of Iranian Randomized Trials
CONCLUSION: The existing evidence suggests that psychological interventions can be highly effective in improving the severity of IBS symptoms, mental health, and quality of life for Iranian adults with IBS. However, some weaknesses should be considered in the interpretation of the results and future research. The risk of randomization was high or unclear in almost all of the existing trials; there was no single large trial in this area; and there was substantial inconsistency in the EFs, which might be related to methodological or clinical moderators.PMID:34488313 | DOI:10.34172/aim.2021.71 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - September 7, 2021 Category: Middle East Health Authors: Gholamreza Jandaghi Ali Zia-Tohidi Manijeh Firoozi Source Type: research

Psychological Interventions for Irritable Bowel Syndrome: A Meta-Analysis of Iranian Randomized Trials
CONCLUSION: The existing evidence suggests that psychological interventions can be highly effective in improving the severity of IBS symptoms, mental health, and quality of life for Iranian adults with IBS. However, some weaknesses should be considered in the interpretation of the results and future research. The risk of randomization was high or unclear in almost all of the existing trials; there was no single large trial in this area; and there was substantial inconsistency in the EFs, which might be related to methodological or clinical moderators.PMID:34488313 | DOI:10.34172/aim.2021.71 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - September 7, 2021 Category: Middle East Health Authors: Gholamreza Jandaghi Ali Zia-Tohidi Manijeh Firoozi Source Type: research

Psychological Interventions for Irritable Bowel Syndrome: A Meta-Analysis of Iranian Randomized Trials
CONCLUSION: The existing evidence suggests that psychological interventions can be highly effective in improving the severity of IBS symptoms, mental health, and quality of life for Iranian adults with IBS. However, some weaknesses should be considered in the interpretation of the results and future research. The risk of randomization was high or unclear in almost all of the existing trials; there was no single large trial in this area; and there was substantial inconsistency in the EFs, which might be related to methodological or clinical moderators.PMID:34488313 | DOI:10.34172/aim.2021.71 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - September 7, 2021 Category: Middle East Health Authors: Gholamreza Jandaghi Ali Zia-Tohidi Manijeh Firoozi Source Type: research

Decreased Autonomic Reactivity and Psychiatric Comorbidities in Neurological Patients With Medically Unexplained Sensory Symptoms: A Case-Control Study
Up to 48% of patients with medically unexplained symptoms seen in neurological practice suffer from sensory symptoms, which could be of functional nature or secondary to psychiatric disorders. These patients show high medical care utilization causing elevated healthcare costs. Despite the high prevalence, little is known about clinical characteristics and pathophysiological mechanisms. For functional disorders such as irritable bowel syndrome, a reduction of heart rate variability (HRV) has been shown, suggesting a dysfunction of the autonomic nervous system (ANS). The aim of this study was to investigate psychological dat...
Source: Frontiers in Neurology - September 7, 2021 Category: Neurology Source Type: research

Investigation the Effectiveness of Duloxetine in Quality of Life and Symptoms of Patients with Irritable Bowel Syndrome
Adv Biomed Res. 2021 Jun 28;10:14. doi: 10.4103/abr.abr_247_20. eCollection 2021.ABSTRACTBACKGROUND: Selective norepinephrine-serotonin receptor inhibitors (SNRIs) such as duloxetine have already shown beneficial effects on symptoms in irritable bowel syndrome (IBS) patients. The purpose of the present investigation was to assess the efficacy of duloxetine in the symptom and quality of life improvement in diarrhea predominant-IBS (IBS-D) patients.MATERIALS AND METHODS: IN a randomized, double-blind and placebo-controlled study, sixty patients diagnosed with IBS-D (ROM-IV criteria), referred to the gastrointestinal clinic o...
Source: Biomed Res - September 3, 2021 Category: Research Authors: Razieh Salehian Marjan Mokhtare Atefeh Ghanbari Jolfaei Rouhallah Noorian Source Type: research

The Flavonoid Kurarinone Regulates Macrophage Functions via Aryl Hydrocarbon Receptor and Alleviates Intestinal Inflammation in Irritable Bowel Syndrome
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - September 3, 2021 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research

Comparison of therapeutic effects of different acupuncture and moxibustion therapies on irritable bowel syndrome: A protocol for systematic review and network meta-analysis
Conclusion: This study will provide a reliable evidence-based basis for selecting the best acupuncture and moxibustion therapy for IBS. Ethics and dissemination: Private information from individuals will not be published. This systematic review also does not involve endangering participant rights. Ethical approval will not be required. The results may be published in a peer-reviewed journal or disseminated at relevant conferences. OSF Registration number: DOI 10.17605/OSF.IO/3278Y (Source: Medicine)
Source: Medicine - September 3, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Reply
We read the letter sent by Dr Lyons in response to our recent publication showing no clinical phenotypes associated with hereditary α-tryptasemia (HαT).1 We appreciate the careful analysis and comments provided by Dr Lyons, who was the first author of the original publication claiming that HαT is associated with a “multisystem disorder” associated with common and seemingly unrelated symptoms such as irritable bowel syndro me, cutaneous complaints, connective tissue abnormalities, and dysautonomia. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - September 3, 2021 Category: Allergy & Immunology Authors: Cem Akin, Madeleine B. Chollet Tags: Correspondence Source Type: research

Risk for Post-Colonoscopy Irritable Bowel Syndrome in Patients with and without Antibiotic Exposure: A Retrospective Cohort Study
Laboratory studies have demonstrated that antibiotic use in conjunction with bowel purgatives causes alterations to the gut microbiota. Because gut microbiota changes may be a trigger for the development of irritable bowel syndrome (IBS), we sought to assess whether individuals who undergo bowel cleansing for colonoscopy and have concurrent antibiotic exposure develop IBS at higher rates than individuals who undergo colonoscopy without antibiotic exposure. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 2, 2021 Category: Gastroenterology Authors: Ravy K. Vajravelu, Jordan M. Shapiro, Josephine Ni, Shivani U. Thanawala, James D. Lewis, Hashem B. El-Serag Source Type: research

Association between abuse and neglect with functional constipation and irritable bowel syndrome in adolescents
Scand J Gastroenterol. 2021 Sep 1:1-6. doi: 10.1080/00365521.2021.1923059. Online ahead of print.ABSTRACTOBJECTIVES: To evaluate the association between violence exposure, abuse, and neglect victimization with functional constipation and irritable bowel syndrome in adolescents.METHODS: Observational cross-sectional case-control study conducted with adolescents from two public schools in the municipality of Osasco, metropolitan region of São Paulo, Brazil. A self-administered questionnaire validated for Brazilian Portuguese Child Abuse Screening Tools - Children's version (ICAST-C) was used to screen the different ty...
Source: Scandinavian Journal of Gastroenterology - September 1, 2021 Category: Gastroenterology Authors: Camila Nunes Thomaz de Almeida Soraia Tahan Kelsy Nema Areco Mauro Batista de Morais Source Type: research

Open-label placebo vs double-blind placebo for irritable bowel syndrome: a randomized clinical trial
This study had 2 objectives: first, to determine whether OLP treatment is superior to no-pill control (NPC) in irritable bowel syndrome (IBS) and, second, to compare the efficacy of OLP against double-blind placebo (DBP). In a 6-week, 3-arm, randomized clinical trial, participants were randomized in equal proportions to 3 arms: OLP, DBP, or NPC. Two hundred sixty-two adults (72.9% women), with a mean age of 42.0 (SD = 18.1) years, participated in the primary study. The mean improvement on the IBS Severity Scoring System from baseline to the 6-week end point was significantly greater in OLP compared with that in NPC (90.6 v...
Source: Pain - September 1, 2021 Category: Anesthesiology Tags: Research Paper Source Type: research

Recent advances in the treatment of irritable bowel syndrome
Pol Arch Intern Med. 2021 Aug 30;131(7-8):709-715. doi: 10.20452/pamw.16067. Epub 2021 Aug 30.ABSTRACTIrritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder which presents with abdominal pain and altered bowel habits. It affects about 20% of the general population, mainly women, and has a considerable impact on the quality of life and health care costs. Four different entities of IBS have been identified: IBS with constipation (IBS‑ C), IBS with diarrhea (IBS D), IBS with a mixed pattern of constipation and diarrhea, and unclassified IBS. Although the precise pathogenesis of IBS remains unclear,...
Source: Pain Physician - August 31, 2021 Category: Anesthesiology Authors: Silvia Bonetto Sharmila Fagoonee Edda Battaglia Mario Grassini Giorgio Maria Saracco Rinaldo Pellicano Source Type: research

Effects of Perilla frutescens var. crispa herb extract, the essential oil perillaldehyde, and the caffeetannin rosmarinic acid on gastric emptying and gastrointestinal motility in mice
ConclusionIn this study, rosmarinic acid in Perilla herb may be effective for functional dyspepsia. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - August 26, 2021 Category: Complementary Medicine Authors: Yoshiyuki Kimura, Masahiko Taniguchi Tags: ORIGINAL ARTICLE Source Type: research

Irritable bowel syndrome and risk of glaucoma: An analysis of two independent population-based cohort studies
CONCLUSIONS: In two large European cohort studies, IBS is a risk factor for glaucoma.PMID:34431591 | DOI:10.1002/ueg2.12136 (Source: Australian Family Physician)
Source: Australian Family Physician - August 25, 2021 Category: Primary Care Authors: Zachary E McPherson Henrik T S ørensen Erzs ébet Horváth-Puhó Ashish Agar Minas T Coroneo Andrew White Ian C Francis Louis R Pasquale Jae H Kang Sven Pettersson Nicholas J Talley Mark A McEvoy Source Type: research

Irritable bowel syndrome and risk of glaucoma: An analysis of two independent population-based cohort studies
CONCLUSIONS: In two large European cohort studies, IBS is a risk factor for glaucoma.PMID:34431591 | DOI:10.1002/ueg2.12136 (Source: Australian Family Physician)
Source: Australian Family Physician - August 25, 2021 Category: Primary Care Authors: Zachary E McPherson Henrik T S ørensen Erzs ébet Horváth-Puhó Ashish Agar Minas T Coroneo Andrew White Ian C Francis Louis R Pasquale Jae H Kang Sven Pettersson Nicholas J Talley Mark A McEvoy Source Type: research

Diagnostic yield of endoscopy in irritable bowel syndrome: A nationwide prevalence study 1987-2016
We examined the yield of colonoscopy and upper endoscopy in IBS for several organic diseases.METHODS: Matched population-based prevalence study in Sweden. We identified 21,944 participants diagnosed with IBS from 1987 to 2016 undergoing colonoscopy with a biopsy from all of Sweden's 28 pathology departments within 6 months of diagnosis. We compared prevalence of histopathology-proven diagnoses of inflammatory bowel disease (IBD), colorectal cancer, precancerous polyps, and microscopic colitis between patients recently diagnosed with IBS and matched controls without IBS (n = 81,101) undergoing colonoscopy. We also compared ...
Source: European Journal of Internal Medicine - August 23, 2021 Category: Internal Medicine Authors: Kyle Staller Ola Ol én Jonas S öderling Bjorn Roelstraete Hans T örnblom Hamed Khalili Mingyang Song Jonas F Ludvigsson Source Type: research

Correction to: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis
(Source: European Journal of Nutrition)
Source: European Journal of Nutrition - August 22, 2021 Category: Nutrition Source Type: research

Theories behind the effect of starch ‑ and sucrose‑reduced diets on gastrointestinal symptoms in irritable bowel syndrome (Review)
In conclusion, further studies are needed to investigate the pathophysiology behind development of symptoms after starch and sucrose intake, and the mechanisms behind symptom relief after reduced intake.PMID:34414452 | DOI:10.3892/mmr.2021.12372 (Source: Molecular Medicine)
Source: Molecular Medicine - August 20, 2021 Category: Molecular Biology Authors: Bodil Ohlsson Source Type: research

Theories behind the effect of starch ‑ and sucrose‑reduced diets on gastrointestinal symptoms in irritable bowel syndrome (Review)
In conclusion, further studies are needed to investigate the pathophysiology behind development of symptoms after starch and sucrose intake, and the mechanisms behind symptom relief after reduced intake.PMID:34414452 | DOI:10.3892/mmr.2021.12372 (Source: Molecular Medicine)
Source: Molecular Medicine - August 20, 2021 Category: Molecular Biology Authors: Bodil Ohlsson Source Type: research