Recent advances in diagnosis and management of irritable bowel syndrome
Purpose of review This review summarizes recent progress in the diagnosis and management of irritable bowel syndrome, with a focus on dietary and microbiota aspects. Recent findings From a pathophysiological point of view, IBS is a multifactorial condition with both peripheral (transit) as central (visceral hypersensitivity, anxiety, depression) contribution in a cumulative fashion to the symptom pattern and severity. More recently, the focus has shifted to diet and microbiota. The number of dietary options that can be used for IBS and the understanding of determinants of their efficacy is rapidly increasing. Several ...
Source: Current Opinion in Psychiatry - August 2, 2020 Category: Psychiatry Tags: PSYCHIATRY, MEDICINE AND THE BEHAVIOURAL SCIENCES: Edited by Mohan Isaac and Igor Filipcic Source Type: research

Chinese herbal medicine versus probiotics for irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials
Publication date: Available online 28 July 2020Source: European Journal of Integrative MedicineAuthor(s): Fan Long Bu, Rui Lin Chen, Zi Yi Lin, Hui Juan Cao, Nicola Robinson, Ning Liang, Jian Ping Liu (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - July 30, 2020 Category: Complementary Medicine Source Type: research

Is there a causal link between psychological disorders and functional gastrointestinal disorders?
Authors: Koloski N, Holtmann G, Talley N Abstract INTRODUCTION: Psychological distress is associated with functional gastrointestinal disorders (FGIDs) including irritable bowel syndrome (IBS) and functional dyspepsia (FD) but only evidence from prospective longitudinal and treatment studies can indicate whether the link between FGIDs and psychological distress is causal. Emerging evidence suggests underlying biological mechanisms may explain the association of psychological distress with FGIDs. AREAS COVERED: This review critically evaluates whether anxiety and/or depression and FGIDs are causally related incl...
Source: Expert Review of Gastroenterology and Hepatology - July 28, 2020 Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research

Comprehensive assessment of patients with irritable bowel syndrome with constipation and chronic idiopathic constipation using deterministically linked administrative claims and patient-reported data: The Chronic Constipation and IBS-C Treatment and Outcomes Real-world Research Platform (CONTOR).
Conclusions: By combining administrative claims and patient-reported data over time, CONTOR afforded a deeper understanding of the IBS-C/CIC patient experience than could be achieved with 1 data source alone; for example, participants self-reported burdensome symptoms and treatment dissatisfaction despite making few treatment changes, highlighting an opportunity to improve patient management. This patient-centric approach to understanding real-world experience and management of a chronic condition could be leveraged for other conditions in which the patient experience is not adequately captured by standardized data sources...
Source: Journal of Medical Economics - July 24, 2020 Category: Health Management Tags: J Med Econ Source Type: research

The Diagnosis Performance of the TCM Syndromes of Irritable Bowel Syndrome by Gastroenterologists Based on Modified Simple Criteria Compared to TCM Practitioners: A Prospective, Multicenter Preliminary Study.
Conclusions: Gastroenterologists had good diagnostic agreement with TCM practitioners for diagnosing TCM syndrome types in IBS after learning the diagnostic criteria. This knowledge can aid gastroenterologists in selecting suitable Chinese patent medicine to treat IBS. PMID: 32695213 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 23, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The effect of immunoregulatory bacteria on the transcriptional activity of Foxp3 and RORyt genes in the gut-associated lymphoid tissue with Salmonella-induced inflammation in the presence of vancomycin and Bacteroides fragilis.
Conclusion: Our results suggest that the commensal microorganism B. fragilis may provide a protective role against the development of experimental colitis, which has to be taken into consideration for further clarification of the effective therapeutic strategy of inflammatory bowel diseases, irritable bowel syndrome and necrotising colitis. PMID: 32685120 [PubMed] (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - July 22, 2020 Category: Microbiology Tags: Iran J Microbiol Source Type: research

Characteristics and Risk Factors of Post-infection Irritable Bowel Syndrome Following Campylobacter Enteritis
Campylobacter is the leading cause of bacterial gastroenteritis in the United States. We investigated the prevalence of post-infection irritable bowel syndrome (PI-IBS) in a cohort with culture-confirmed Campylobacter cases; risk factors for PI-IBS based on clinical factors; and shifts in IBS patterns post-infection in patients with pre-existing IBS. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 22, 2020 Category: Gastroenterology Authors: Antonio Berumen, Ryan Lennon, Margaret Breen-Lyles, Jayne Griffith, Robin Patel, David Boxrud, Marijke Decuir, Gianrico Farrugia, Kirk Smith, Madhusudan Grover Source Type: research

PPARγ: A turning point for irritable bowel syndrome treatment
Publication date: 15 September 2020Source: Life Sciences, Volume 257Author(s): Nazanin Momeni Roudsari, Naser-Aldin Lashgari, Nadia Zandi, Benyamin Pazoki, Saeideh Momtaz, Amirhossein Sahebkar, Amir Hossein Abdolghaffari (Source: Life Sciences)
Source: Life Sciences - July 20, 2020 Category: Biology Source Type: research

Depression and Structural Factors Are Associated With Symptoms in Patients of Irritable Bowel Syndrome With Diarrhea.
Conclusions: Comorbid depression and higher scores of structural factors might aggravate GI and extra-GI symptoms other than bowel movements and stool form. Structural factors of Hamilton Depression Rating Scale correlated with efficacy of paroxetine and mirtazapine in patients with IBS-D. PMID: 32675388 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 18, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Probiotics for induction of remission in Crohn's disease.
CONCLUSIONS: The available evidence is very uncertain about the efficacy or safety of probiotics, when compared with placebo, for induction of remission in Crohn's disease. There is a lack of well-designed RCTs in this area and further research is needed. PMID: 32678465 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - July 17, 2020 Category: General Medicine Authors: Limketkai BN, Akobeng AK, Gordon M, Adepoju AA Tags: Cochrane Database Syst Rev Source Type: research

Misdiagnosis of Diverticulitis After a Prior Diagnosis of Irritable Bowel Syndrome (IBS)
Introduction: Irritable bowel syndrome (IBS) and diverticulitis share clinical features. Misdiagnosed diverticulitis can cause unnecessary antibiotic therapy. Among IBS and non-IBS patients, we compared outpatient, clinically diagnosed (no computed tomography) diverticulitis rates. Among primary-care, diverticulitis-diagnosed IBS patients, we assessed imaged diverticulosis and probable misdiagnosed diverticulitis. Methods: Among 3836-patient IBS and 67,827-patient non-IBS cohorts identified from 2000 to 2002, we retrospectively compared the frequency of outpatient, clinically diagnosed, antibiotic-treated diverticulitis f...
Source: Journal of the American Board of Family Medicine - July 16, 2020 Category: Primary Care Authors: Longstreth, G. F., Wong, C., Chen, Q. Tags: Original Research Source Type: research

Fecal Microbiota Transplantation Reduces Symptoms in Some Patients With Irritable Bowel Syndrome with Predominant Abdominal Bloating: Short- and Long-Term Results from a Placebo-Controlled Randomized Trial
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with intestinal dysbiosis. Given reported promising results of open-label fecal microbiota transplantation (FMT) therapy in patients with predominant abdominal bloating, we studied efficacy of this treatment in a randomized, placebo-controlled trial. (Source: Gastroenterology)
Source: Gastroenterology - July 15, 2020 Category: Gastroenterology Authors: Tom Holvoet, Marie Joossens, Jorge F. V ázquez-Castellanos, Evelien Christiaens, Lander Heyerick, Jerina Boelens, Bruno Verhasselt, Hans van Vlierberghe, Martine De Vos, Jeroen Raes, Danny De Looze Source Type: research

The impact of irritable bowel syndrome on health-related quality of life in women with polycystic ovary syndrome
The objectives of this study were to compare the prevalence and quality of life (QOL) of irritable bowel syndrome (IBS) in women with polycystic ovary syndrome (PCOS) compared with healthy women. (Source: Health and Quality of Life Outcomes)
Source: Health and Quality of Life Outcomes - July 13, 2020 Category: International Medicine & Public Health Authors: Fatemeh Bazarganipour, Seyed-Abdolvahab Taghavi, Zatollah Asemi, Helen Allan, Zahra Khashavi, Tahereh Safarzadeh, Shamsi Pourchangiz, Fatemeh Zare, Samaneh Ghasemi, Zivar Karimi and Maryam Azizi Kutenaee Tags: Research Source Type: research

Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome – An Update
Small intestinal bacterial overgrowth (SIBO) is one manifestation of gut microbiome dysbiosis and is highly prevalent in IBS (Irritable Bowel Syndrome). SIBO can be diagnosed either by a small bowel aspirate culture showing ≥103 colony-forming units (CFU) per mL of aspirate, or a positive hydrogen lactulose or glucose breath test. Numerous pathogenic organisms have been shown to be increased in subjects with SIBO and IBS, including but not limited to Enterococcus, Escherichia coli, and Klebsiella. In addition, Methanobrevibacter smithii, the causal organism in a positive methane breath test, has been linked to constipat...
Source: Frontiers in Psychiatry - July 10, 2020 Category: Psychiatry Source Type: research

Evaluation of Plecanatide for the Treatment of Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation in Patients 65  Years or Older.
Evaluation of Plecanatide for the Treatment of Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation in Patients 65 Years or Older. Clin Ther. 2020 Jul 10;: Authors: Menees SB, Franklin H, Chey WD Abstract PURPOSE: Chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) are common functional gastrointestinal disorders. The prevalence of constipation-related issues tends to increase with age. This analysis pooled data from Phase III trials in CIC and IBS-C to assess the safety and efficacy of plecanatide in patients aged ≥65 years. ...
Source: Clinical Therapeutics - July 10, 2020 Category: Drugs & Pharmacology Authors: Menees SB, Franklin H, Chey WD Tags: Clin Ther Source Type: research

High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease.
AJ Abstract The clinical spectra of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) intersect to form a scantily defined overlap syndrome, termed pre-IBD. We show that increased Enterobacteriaceae and reduced Clostridia abundance distinguish the fecal microbiota of pre-IBD patients from IBS patients. A history of antibiotics in individuals consuming a high-fat diet was associated with the greatest risk for pre-IBD. Exposing mice to these risk factors resulted in conditions resembling pre-IBD and impaired mitochondrial bioenergetics in the colonic epithelium, which triggered dysbiosis. Restorin...
Source: Cell Host and Microbe - July 9, 2020 Category: Microbiology Authors: Lee JY, Cevallos SA, Byndloss MX, Tiffany CR, Olsan EE, Butler BP, Young BM, Rogers AWL, Nguyen H, Kim K, Choi SW, Bae E, Lee JH, Min UG, Lee DC, Bäumler AJ Tags: Cell Host Microbe Source Type: research

Irritable Bowel Syndrome and lactose intolerance: the importance of differential diagnosis. A monocentric study.
Authors: Catanzaro R, Sciuto M, Singh B, Pathak S, Marotta F Abstract BACKGROUND: Nowadays Irritable Bowel Syndrome (IBS) and Lactose Intolerance (LI) are two very frequent diseases. IBS is a functional disorder, while LI is caused by the inability to digest lactose. LI is often incorrectly diagnosed as IBS. The aim of our study is to identify LI patients among IBS patients, so as to set up a correct therapy. METHODS: We enrolled 259 patients with IBS and we compared them to a control group of 108 patients. All patients underwent H2 Breath-Test (HBT) and two questionnaires regarding the symptoms associated with...
Source: Minerva Gastroenterologica e Dietologica - July 8, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Health benefits of xylitol.
und G Abstract Many diseases, including caries, chronic inflammatory diseases, diabetes, and obesity, are associated with uncontrolled sugar consumption. Artificial sweeteners are commonly used in food and pharmaceutical industries as sugar substitutes for the prevention of several dental and body diseases; they also have a favorable impact on body weight as they may help to restrict simple sugar consumption. Xylitol is a sugar alcohol that is commonly used as a sweetener. It can be found naturally or artificially prepared mainly from plant materials chemically or by fermentation of hemicelluloses from agricultura...
Source: Applied Microbiology and Biotechnology - July 7, 2020 Category: Microbiology Authors: Gasmi Benahmed A, Gasmi A, Arshad M, Shanaida M, Lysiuk R, Peana M, Pshyk-Titko I, Adamiv S, Shanaida Y, Bjørklund G Tags: Appl Microbiol Biotechnol Source Type: research

The impact of overlapping functional dyspepsia, belching disorders and functional heartburn on anxiety, depression and quality of life of Chinese patients with irritable bowel syndrome
Functional dyspepsia (FD), belching disorders (BD) and functional heartburn (FH) are the three most common upper functional gastrointestinal disorders (FGID) in IBS patients. FD is known to exert deleterious e... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - July 6, 2020 Category: Gastroenterology Authors: Xin Yao, Yunsheng Yang, Shutian Zhang, Yu Shi, Qian Zhang and Yongjun Wang Tags: Research article Source Type: research

Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex.
Conclusion: Electroacupuncture alleviates IBS visceral hypersensitivity by inhibiting the activation of astrocytes in the MT and ACC. PMID: 32617101 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 5, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Anti-irritable Bowel Syndrome Syrup Improves Constipation-Predominant Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial
ConclusionsAnti-IBS syrup significantly reduced the severity of IBS symptoms compared to placebo. However, there was a need for further investigation regarding the anxiety and depression scores. (Registration No. IRCT2017061034446N1). (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - July 4, 2020 Category: Internal Medicine Source Type: research

The Epidemiology of Migraine Headache in Arab Countries: A Systematic Review.
Conclusion: The prevalence and risk factors of migraine headache in Arab countries are comparable to reports from western countries. Longitudinal studies are still needed to investigate the prognosis and predictors of chronicity in the arab countries. PMID: 32607079 [PubMed - in process] (Source: The Scientific World Journal)
Source: The Scientific World Journal - July 3, 2020 Category: Science Tags: ScientificWorldJournal Source Type: research

Screening for functional gastrointestinal disorders in children with epilepsy.
Abstract BACKGROUND AND AIM: We aimed to examine the frequency of functional gastrointestinal disorders (FGIDs) among pediatric patients with epilepsy and the association of FGIDs with epilepsy characteristics. MATERIAL AND METHODS: Patients with epilepsy aged between 4 and 18 years old were enrolled. Age- and sex-matched healthy children were taken as the control group. Children with cerebral palsy, history of abdominal surgery, gastrointestinal disorders, medication affecting gastrointestinal system motility, recent gastrointestinal infection, and those on the ketogenic diet were excluded from the study. ...
Source: Epilepsy and Behaviour - July 2, 2020 Category: Neurology Authors: Aydemir Y, Carman KB, Yarar C Tags: Epilepsy Behav Source Type: research

Sacral Nerve Modulation Has No Effect on the Postprandial Response in Irritable Bowel Syndrome
(Source: Clinical and Experimental Gastroenterology)
Source: Clinical and Experimental Gastroenterology - June 30, 2020 Category: Gastroenterology Tags: Clinical and Experimental Gastroenterology Source Type: research

The efficacy of Bifidobacterium quadruple viable tablet in the treatment of diarrhea predominant irritable bowel syndrome: protocol for a randomized, double-blind, placebo-controlled, multicenter trial
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders characterized by recurrent abdominal pain associated with defecation or a change in bowel habits. Leading to signi... (Source: Trials)
Source: Trials - June 30, 2020 Category: General Medicine Authors: Tao Bai, Haoyu Zeng, Yanqin Long, Xiaoqing Li, Xiaohong Sun, Yu Lan, Lingling Gao, Lu Zhang, Zenghui Feng and Xiaohua Hou Tags: Study protocol Source Type: research

Fecal microbiota transplantation in gastrointestinal disorders: time for precision medicine
AbstractFecal microbiota transplantation (FMT) has demonstrated efficacy in treating inflammatory bowel diseases and irritable bowel syndrome in an increasing number of randomized controlled trials. Recently published data gives striking insights into the factors associated with FMT success paving the road for the use of precision medicine in gastrointestinal disorders. (Source: Genome Medicine)
Source: Genome Medicine - June 30, 2020 Category: Genetics & Stem Cells Source Type: research

Oral Administration of S-Adenosylmethionine (SAMe) and Lactobacillus Plantarum HEAL9 Improves the Mild-To-Moderate Symptoms of Depression: A Randomized, Double-Blind, Placebo-Controlled Study.
Conclusions: Supplementation of SAMe and L. plantarum HEAL9 in adults with subthreshold or mild-to-moderate symptoms of depression resulted in fast and clinically relevant effects after 2 weeks. The combination was safe and significantly improved symptoms of depression, anxiety, and cognitive and somatic components. The effect of this novel product is independent from the severity of the symptoms unlike traditional antidepressants available on the market that have minimal benefits for subthreshold or mild-to-moderate symptoms. Trial Registration: identifier: NCT03932474. PMID: 32589828 [PubMed - ...
Source: The Primary Care Companion for CNS Disorders - June 28, 2020 Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research

TRPM8 channels: A review of distribution and clinical role.
Abstract Ion channels are important therapeutic targets due to their plethoric involvement in physiological and pathological consequences. The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation channel that controls Ca2+ homeostasis. It has been proposed to be the predominant thermoreceptor for cellular and behavioral responses to cold stimuli in the TRP channel subfamilies and exploited so far to reach the clinical-stage of drug development. TRPM8 channels can be found in multiple organs and tissues, regulating several important processes such as cell proliferation, ...
Source: European Journal of Pharmacology - June 28, 2020 Category: Drugs & Pharmacology Authors: Liu Y, Mikrani R, He Y, Faran Asraf Baig MM, Abbas M, Naveed M, Tang M, Zhang Q, Li C, Zhou X Tags: Eur J Pharmacol Source Type: research

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications.
Authors: Salehi B, Selamoglu Z, Sevindik M, Fahmy NM, Al-Sayed E, El-Shazly M, Csupor-Löffler B, Csupor D, Yazdi SE, Sharifi-Rad J, Arserim-Uçar DK, Arserim EH, Karazhan N, Jahani A, Dey A, Azadi H, Vakili SA, Sharopov F, Martins N, Büsselberg D Abstract The genus Achillea genus houses more than 100 species, a number of them are popularly used in traditional medicine for spasmodic gastrointestinal, gynecological and hepatobiliary disorders, hemorrhages, pneumonia, rheumatic pain, inflammation, wounds healing etc. Members of the genus contain a wide variety of volatile and non-volatile secondary met...
Source: Cellular and Molecular Biology - June 26, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Bifidobacterium longum alleviates irritable bowel syndrome-related visceral hypersensitivity and microbiota dysbiosis via Paneth cell regulation
. (Source: Gut Microbes)
Source: Gut Microbes - June 25, 2020 Category: Microbiology Authors: Chunhua Zhou Xue Fang Jiajia Xu Jun Gao Ling Zhang Jiulong Zhao Yuting Meng Wei Zhou Xu Han Yu Bai Zhaoshen Li Duowu Zou Source Type: research

Efficacy and Safety of a Novel Herbal Medicine in the Treatment of Irritable Bowel Syndrome: A Randomized Double-Blinded Clinical Trial.
Authors: Bordbar G, Miri MB, Omidi M, Shoja S, Akhavan M Abstract Background: The unresponsiveness to conventional pharmacological treatments and their side effects have led patients with irritable bowel syndrome (IBS) to use complementary and alternative medicine such as herbal remedies. Beside, Zataria multiflora Boiss (ZM), Trachyspermum ammi L. (TA), and Anethum graveolens L. (AG) are being used as an antiseptic, carminative, and antispasmodic in traditional medicine. This trial investigated the efficacy and safety of a combination of ZM, AG, and TA essential oils in the treatment of IBS. Method: The presen...
Source: Gastroenterology Research and Practice - June 24, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Abdominal Massage Reduces Visceral Hypersensitivity via Regulating GDNF and PI3K/AKT Signal Pathway in a Rat Model of Irritable Bowel Syndrome.
In this study, a rat model of IBS with diarrhea (IBS-D) was established by instillation of acetic acid from the colon. The effects of abdominal massage on changes in gut motility, visceral hypersensitivity, and the possible mechanism were investigated. Continuous abdominal massage could decrease the stool consistency score and increase the efflux time of glass beads compared with model groups, while also decreasing mast cell counts in IBS-D rats. The mRNA and protein expressions of neuronal nitric oxide synthase (nNOS), choline acetyl transferase (CHAT), and protein gene product 9.5 (PGP9.5) were significantly upregulated ...
Source: Evidence-based Complementary and Alternative Medicine - June 24, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Fusobacterium nucleatum Causes Microbial Dysbiosis and Exacerbates Visceral Hypersensitivity in a Colonization-Independent Manner
Conclusion:Fusobacterium increased significantly in IBS-D patients, and F. nucleatum was involved in the pathogenesis of IBS by causing microbial dysbiosis and exacerbating visceral hypersensitivity in a colonization-independent manner. Meanwhile, F. nucleatum was found to induce an increase in specific secretory IgA through FomA. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - June 24, 2020 Category: Microbiology Source Type: research

Non-bladder centric interstitial cystitis/bladder pain syndrome phenotype is significantly associated with co-occurring endometriosis.
Authors: Overholt TL, Evans RJ, Lessey BA, Matthews CA, Hines KN, Badlani G, Walker SJ Abstract INTRODUCTION: Interstitial cystitis/bladder pain syndrome (IC/BPS) and endometriosis are coexistent diagnoses in 48%-65% of women with chronic pelvic pain (CPP), suggesting that dual screening may be warranted. To further investigate the clinical relationship and risk factors between these two conditions, we performed a retrospective review of our large IC/BPS patient data registry. MATERIALS AND METHODS: We evaluated IC/BPS patients who were prospectively enrolled into our registry who completed validated questionna...
Source: Canadian Journal of Urology - June 18, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

Clinical effects of Lactobacillus strains as probiotics in the treatment of irritable bowel syndrome. Results from the LAPIBSS trial: Future objectives.
The objective of this communication is to present and analyze the recent results from the LAPIBSS study in order to improve future clinical trials on the effects of Lactobacillus strains in the treatment of irritable bowel syndrome (IBS). Using a tightly-controlled clinical trial protocol with the highest Jadad score of 5/5, the current trial aimed to demonstrate the efficacy of a 2-strain mixture of Lactobacillus acidophilus (L. acidophilus) to improve IBS symptoms. Eighty patients diagnosed with IBS according to Rome III criteria were recruited to a multicentric, double-blind, in parallel groups, placebo-controlled, rand...
Source: Cellular and Molecular Biology - June 18, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

An update on efficacy and safety considerations for the latest drugs used to treat irritable bowel syndrome
. (Source: Expert Opinion on Drug Metabolism and Toxicology)
Source: Expert Opinion on Drug Metabolism and Toxicology - June 18, 2020 Category: Drugs & Pharmacology Authors: Taraneh Mousavi Shekoufeh Nikfar Mohammad Abdollahi Source Type: research

Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients
Psychological co-morbidities in irritable bowel syndrome (IBS) have been widely recognized, whereas less is known regarding the role of gut microbial and host metabolic changes in clinical and psychological sy... (Source: BMC Microbiology)
Source: BMC Microbiology - June 17, 2020 Category: Microbiology Authors: Tong Liu, Xiang Gu, Li-Xiang Li, Ming Li, Bing Li, Xiao Cui and Xiu-li Zuo Tags: Research article Source Type: research

Predictors of new onsets of irritable bowel syndrome, chronic fatigue syndrome and fibromyalgia: the lifelines study.
CONCLUSIONS: Syndrome-specific predictors were more common than shared ones and these predictors might form a better starting point to unravel the heterogeneous etiologies of these syndromes than the current approach based on symptom patterns. The close relationship between IBS and FM is striking and requires further research. PMID: 32546287 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - June 17, 2020 Category: Psychiatry Authors: Monden R, Rosmalen JGM, Wardenaar KJ, Creed F Tags: Psychol Med Source Type: research

Treating Chronic Abdominal Pain in Patients with Chronic Abdominal Pain and/or Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is probably the most common diagnosis in gastroenterology involving the brain-gut axis. By definition, pain is the most frequent symptom experienced by patients. It is important to understand the biopsychosocial and physiologic aspects of the disease when discussing treatment of IBS. Such therapies as lifestyle modifications, changes in diet, and cognitive behavioral therapy should be used in conjunction with pharmacotherapy rather than pharmacotherapy alone. The pathophysiologic mechanisms are reviewed in this article along with the current treatments available, in the era of growing demand ...
Source: Gastroenterology Clinics of North America - June 16, 2020 Category: Gastroenterology Authors: Lauren Stemboroski, Ron Schey Source Type: research

Quality of life and psychometric evaluation of patients diagnosed with irritable bowel syndrome: an observational cohort study.
CONCLUSION: Our study showed that IBS had a very high impact on these patients, regarding their anxiety and depression levels, alongside very poor results relating to quality of life. PMID: 32556060 [PubMed - as supplied by publisher] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - June 15, 2020 Category: General Medicine Authors: Yildiz A, Kizil E, Yildiz A Tags: Sao Paulo Med J Source Type: research

IJERPH, Vol. 17, Pages 4230: The Impact of an Individual Educational Program on the Quality of Life and Severity of Symptoms of Patients with Irritable Bowel Syndrome
Conclusion: An educational program combined with elements of behavioral therapy, individualized for patients with IBS, is an important part of therapy for these patients. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - June 13, 2020 Category: Environmental Health Authors: Regina Sier żantowicz Jolanta Lewko Gra żyna Jurkowska Tags: Article Source Type: research

Short-course Rifaximin therapy efficacy and lactulose hydrogen breath test in Chinese patients with diarrhea-predominant irritable bowel syndrome
Gut microbiota alterations including small intestinal bacterial overgrowth (SIBO) might play a role in pathogenesis of irritable bowel syndrome (IBS). Rifaximin could effectively and safely improve IBS symptom... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 12, 2020 Category: Gastroenterology Authors: Xiaojun Zhuang, Zhenyi Tian, Mei Luo and Lishou Xiong Tags: Research article Source Type: research

Significance of G Protein-Coupled Estrogen Receptor in the Pathophysiology of Irritable Bowel Syndrome, Inflammatory Bowel Diseases and Colorectal Cancer
The regulatory role of estrogens and nuclear estrogen receptors, i. e., estrogen receptor α and β has been reported in gastrointestinal diseases. However, the contribution of G protein-coupled estrogen receptor, the membrane-bound estrogen receptor, is still poorly understood. Unlike nuclear estrogen receptors, which are responsible for the genomic activity of estrogens, the G protein-coupled estrogen receptor affects the “rapid” non-genomic activity of estrogens, leading to modulation of many signaling pathways and ultimately changing gene expression. Recently, the crucial role of G protein-coupled ...
Source: Frontiers in Endocrinology - June 12, 2020 Category: Endocrinology Source Type: research

Tadalafil versus linaclotide in gastrointestinal dysfunction and depressive behavior in constipation–predominant irritable bowel syndrome
Publication date: Available online 10 June 2020Source: Life SciencesAuthor(s): Amina Ahmed Sedky, Yosra Magdy (Source: Life Sciences)
Source: Life Sciences - June 11, 2020 Category: Biology Source Type: research

Skills over pills? A clinical gastroenterologist's primer in cognitive behavioral therapy for irritable bowel syndrome.
Authors: Lackner JM Abstract INTRODUCTION: Irritable bowel syndrome is a common, painful and often disabling GI disorder for which there is no satisfactory medical or dietary treatment. The past 10 years has seen the development and validation of a number of psychological treatments of which CBT is arguably the most effective based on two recently conducted multiple site trials from two investigative teams in the UK and USA. AREAS COVERED: The purpose of this review is to describe the principles, processes, procedures, and empirical basis supporting CBT and distinguish it from other psychological treatments ava...
Source: Expert Review of Gastroenterology and Hepatology - June 10, 2020 Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research

Monocyte chemotactic protein-1 and nitrotyrosine in irritable bowel syndrome.
Authors: Chira A, Braicu C, Budisan L, Ioan Chira R, Berindan-Neagoe I, Lucian Dumitrascu D Abstract Irritable bowel syndrome (IBS) is one the most frequent and common functional gastrointestinal disorders that has a multifactorial etiopathogenesis. Multiple biomarkers have been tested in search for a reliable and specific biomarker, but there is not yet a specific biomarker for IBS. The aim of this study was to evaluate two biomarkers of different putative pathways of the pathogenesis of IBS: the monocyte chemotactic protein-1 (MCP-1) and nitrotyrosine, in order to establish their role as potential biomarkers. We ...
Source: Experimental and Therapeutic Medicine - June 9, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

The relationship between dectin-1 and mast cells in patients with diarrhea-predominant irritable bowel syndrome.
Authors: Chi Y, Li C, Wu LH, Wang HH Abstract Background/Aims: Currently, the role of the microbiome GBA is being widely studied in the pathogenesis of visceral hypersensitivity in IBS. To investigate the role of fungus, the current study aimed to i) investigate the expression of Syk/CARD9-coupled Dectin-1 receptors in the ileocecal mucosa in D-IBS patients and (ii) explore the relationships between Dectin-1 and plasma MCT levels as well as anorectal sensory function in patients with D-IBS.Methods: Thirty-eight D-IBS patients who met the Rome III criteria and 2 groups of age- and sex-matched asymptomatic healthy co...
Source: Scandinavian Journal of Gastroenterology - June 5, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Metabolic syndrome, depression, and fibromyalgia syndrome prevalence in patients with irritable bowel syndrome: A case-control study
Although both metabolic syndrome (MetS) and irritable bowel syndrome (IBS) have been linked with altered gut microbiota, only a few studies investigated the association between them. Hence, we aimed to evaluate the prevalence of MetS along with depression and fibromyalgia syndrome (FMS) in IBS patients. This was a case-control study in which 3808 consecutive patients who attended outpatient clinics of Erzurum Regional Training and Research Hospital between May 2019 and August 2019 were evaluated in terms of IBS with Rome-IV criteria. Out of 486 patients who were diagnosed as IBS, 176 patients were excluded for various rea...
Source: Medicine - June 5, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Psychological and clinical characteristics of female patients with spontaneous coronary artery dissection.
Abstract AIMS: Spontaneous coronary artery dissection (SCAD) is increasingly recognised as a cause of myocardial infarction, but psychological characteristics of patients with SCAD have not yet been extensively investigated. We assessed the prevalence of a broad range of psychological and clinical factors, and their inter-relationships in patients with a history of SCAD. Furthermore, we investigated whether specific clusters of patients with SCAD can be identified. METHODS: Participants were recruited between March and May 2019 from a Dutch SCAD database and completed online questionnaires...
Source: Netherlands Heart Journal - June 4, 2020 Category: Cardiology Authors: Smaardijk VR, Mommersteeg PMC, Kop WJ, Adlam D, Maas AHEM Tags: Neth Heart J Source Type: research

Tenapanor for the treatment of irritable bowel syndrome with constipation.
Authors: Sinagra E, Rossi F, Raimondo D, Conoscenti G, Anderloni A, Guarnotta V, Maida M Abstract INTRODUCTION: Irritable bowel syndrome with constipation is associated with higher rates of functional impairment, as compared to other subtypes of the syndrome. Conventional laxative-based pharmacologic therapy of IBS-C, which is mostly symptom-based, is often unsatisfactory. Tenapanor represents a first-in-class orally available inhibitor of NHE3, which is minimally absorbed in the GI tract, what constitutes a significant therapeutic benefit, as it may act on the drug target. AREAS COVERED: Aim of this article is...
Source: Expert Review of Clinical Pharmacology - June 2, 2020 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research