Virtualized clinical studies to assess the natural history and impact of gut microbiome modulation in non-hospitalized patients with mild to moderate COVID-19 a randomized, open-label, prospective study with a parallel group study evaluating the physiologic effects of KB109 on gut microbiota structure and function: a structured summary of a study protocol for a randomized controlled study
AbstractObjectivesThese 2 parallel studies (K031 and K032) aim to evaluate the safety of KB109 in addition to supportive self-care (SSC) compared with SSC alone in outpatients with mild to moderate coronavirus disease 2019 (COVID-19). KB109 is a novel synthetic glycan that was formulated to modulate the gut microbiome composition and metabolic output in order to increase beneficial short-chain fatty acid (SCFA) production in the gut. The K031 study is designed to evaluate the safety of KB109 and characterize its impact on the natural progression of COVID-19 in patients with mild to moderate disease. The K032 study is evalu...
Source: Trials - April 2, 2021 Category: Research Source Type: clinical trials

The Effects of Bifidobacterium Breve Bif195 for Diarrhea-predominant Irritable Bowel Syndrome
Condition:   Irritable Bowel Syndrome Interventions:   Dietary Supplement: Bifidobacterium breve Bif195;   Dietary Supplement: Placebo Sponsors:   Hvidovre University Hospital;   Chr Hansen Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 22, 2021 Category: Research Source Type: clinical trials

Role of Parasitic Infection in Inflammatory Bowel Disease and Irritable Bowel Syndrome
Condition:   Parasite IBS IBD Intervention:   Sponsor:   Assiut University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 18, 2021 Category: Research Source Type: clinical trials

The Effects of Prucalopride in Patients With Constipation Predominant Irritable Bowel Syndrome
Condition:   Irritable Bowel Syndrome Intervention:   Drug: Prucalopride 2mg Sponsor:   Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 17, 2021 Category: Research Source Type: clinical trials

Zemedy Application for Irritable Bowel Syndrome
Condition:   IBS - Irritable Bowel Syndrome Intervention:   Device: Use of Zemedy Application Sponsors:   Stanford University;   Bold Health Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2021 Category: Research Source Type: clinical trials

GI Effects of Iron in Healthy Volunteers
Conditions:   Iron Deficiency Anemia Treatment;   Microbial Colonization;   Iron-deficiency;   Iron Deficiency Anemia Interventions:   Diagnostic Test: Lactulose breath test;   Other: Stool sample;   Other: Daily Diary;   Other: Irritable Bowel syndrome severity scoring system (IBS-SSS) questionnaire;   Dietary Supplement: Ferrous Sulphate Sponsors:   Dr Anthony Hobson;   Anglia Ruskin University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 12, 2021 Category: Research Source Type: clinical trials