Promptly Notifying Infectious Diseases Likely to Cause Pandemics: Individual State Responsibility, Shared Collective Burden
Md. Rizwanul Islam (North South University), Promptly Notifying Infectious Diseases Likely to Cause Pandemics: Individual State Responsibility, Shared Collective Burden, 56 Tex. Int ’l L. J. 35 (2022): In the interconnected world in which we live today, a virulent disease anywhere... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - July 29, 2022 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Teen dies when blood culture protocol botched: What can we learn from this tragedy?
It’s 4 a.m. when a 17-year-old awakens at home with severe left shoulder pain that his worried parents call 911. By the time he reaches the emergency room (ER), he has pain all the way to his wrist. “Any recent injuries?” asks the doctor. “Yeah, about three days ago, I was lifting about 200 pounds
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Teen dies when blood culture protocol botched: What can we learn from this tragedy? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 25, 2022 Category: General Medicine Authors: Charles A. Pilcher, MD Tags: Conditions Emergency Medicine Infectious Disease Malpractice Source Type: blogs
Fight Aging! Newsletter, July 18th 2022
In conclusion, we show that PVS morphology in mice is variable and that the structure and function of pia suggests a previously unrecognized role in regulating CSF transport and amyloid clearance in aging and disease.
Reversing Ovarian Fibrosis in Mice
https://www.fightaging.org/archives/2022/07/reversing-ovarian-fibrosis-in-mice/
Researchers here provide evidence for ovarian fibrosis to be an important mechanism in limiting the age at which female mammals can remain fertile. Interestingly, existing antifibrotic drugs can produce some reversal of this fibrosis, enough to restore ovulation in mice. Fibro...
Source: Fight Aging! - July 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Infection Drives Microglia Into Inflammatory Behavior that Contributes to Neurodegeneration
Correlations have been found between infectious disease and incidence of neurodegenerative conditions. The dominant hypothesis is that microglia, innate immune cells of the brain, are made more inflammatory by infection, and the resulting chronic inflammation in brain tissue produces dysfunction that contributes to neurodegeneration. The role of microglia in the onset and progression of neurodegenerative conditions is studied more generally as well, as these cells react to signs of damage in aging tissue in much the same way as they react to infection. Further, microglia also enter a state of cellular senescence in increas...
Source: Fight Aging! - July 14, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Fasting Population Exhibits Lower COVID-19 Severity and Mortality
Researchers here report that an epidemiological study population that practices long term intermittent fasting suffered a lesser severity and lower mortality rate in the early stages of the COVID-19 pandemic. The SARS-CoV-2 virus produces mortality via runaway inflammatory signaling, and people with a greater burden of chronic inflammation, such as through age or obesity, are less resilient. Intermittent fasting lowers inflammatory signaling, but it also produces a range of other benefits that improve resistance to infection. Further, it may be the case that the ability to fast on a schedule for decades selects for people ...
Source: Fight Aging! - July 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
mRNA Vaccines: From Tackling Pandemic To Treating Cancer
The story of the multi-decade uphill battle Katalin Karikó and her fellow researchers fought to prove messenger RNA can viably be used in medicine is widely known today. In just as little as two years, the world has learned about mRNA technology and how fast it can react when the need arises holding almost unlimited promises in future applications. As always is the case with “instant hits” in science, the ride was actually very long and bumpy, but more on that later.
What is mRNA?
In very simple terms: messenger ribonucleic acids (or mRNAs in short) are the body’s natural way to transport messages from o...
Source: The Medical Futurist - July 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Biotechnology Future of Medicine Nanotechnology cancer cancer research covid19 vaccine research HIV mRNA messenger RNA cancer vaccine malaria malaria vaccine HIV vaccine pancreatic cancer pancreatic cancer va Source Type: blogs
mRNA Vaccines: From Tackling A Pandemic To Treating Cancer
The story of the multi-decade uphill battle Katalin Karikó and her fellow researchers fought to prove messenger RNA can viably be used in medicine is widely known today. In just as little as two years, the world has learned about mRNA technology and how fast it can react when the need arises holding almost unlimited promises in future applications. As always is the case with “instant hits” in science, the ride was actually very long and bumpy, but more on that later.
What is mRNA?
In very simple terms: messenger ribonucleic acids (or mRNAs in short) are the body’s natural way to transport messages from o...
Source: The Medical Futurist - July 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Biotechnology Future of Medicine Nanotechnology cancer cancer research covid19 vaccine research HIV mRNA messenger RNA cancer vaccine malaria malaria vaccine HIV vaccine pancreatic cancer pancreatic cancer va Source Type: blogs
Celebrating Hospice and Palliative Medicine as the Fifth Largest Medical Subspecialty
by Christian Sinclair (@ctsinclair)We have entered a new age! Spread the word!Hospice and palliative medicine (HPM) is the fifth largest medical subspecialty!You may have sensed we have been climbing the ranks, but I bet you are still surprised. A close look at the fellowship match data from Dec 2021, shows that HPM has the fifth highest number of matched applicants, behind the big 4: Cardiovascular, Pulmonary and Critical Care, Hematology and Oncology, and Gastroenterology.When I share this good news with HPM colleagues, few put us anywhere near fifth.I did an informal poll on Twitter and less than half of respondents ran...
Source: Pallimed: A Hospice and Palliative Medicine Blog - July 11, 2022 Category: Palliative Care Tags: fellowship sinclair The profession Source Type: blogs
Monkeypox: Have we learned anything?
Perhaps I am being pessimistic, with a“glass half full attitude,” but please hear me out. I am optimistic, but I am also realistic, and I pay attention to trends and behaviors in people. When monkeypox was first mentioned in the Canadian media, it was seen as low risk for spread. I laughed and groanedRead more …Monkeypox: Have we learned anything? originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 10, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/tomi-mitchell" rel="tag" data-wpel-link="internal" > Tomi Mitchell, MD < /a > < /span > Tags: Conditions Infectious Disease Source Type: blogs
Fight Aging! Newsletter, July 11th 2022
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Myths and facts in antibiotic stewardship
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - July 9, 2022 Category: Internal Medicine Tags: hospital medicine infectious disease pharmacology Source Type: blogs
Innate Immune Activation as a Contributing Cause of Inflammaging, Reduced by Calorie Restriction
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 4, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Get ready for a COVID culture shock
A friend called me for medical advice two weeks ago. He’s single, in his 30s and generally healthy, but he’d developed a dry cough with mild congestion. After a self-administered COVID-19 test turned up negative results, he remained suspicious he could be infected. He was set to fly west in a couple of days forRead more …Get ready for a COVID culture shock originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 27, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/robert-pearl" rel="tag" data-wpel-link="internal" > Robert Pearl, MD < /a > < /span > Tags: Physician COVID Infectious Disease Source Type: blogs
Notes on monkeypox
If you remember the right wing freakout over Ebola virus -- of which IIRC there were fewer than 5 cases in the U.S., none of which was fatal -- you may wonder why the deafening silence about monkeypox. Ha ha! You don ' t have to wonder. So far, he monkeypox outbreak in the U.S. and Europe seems to be largely if not entirely limited to men who have sex with men. This will likely change, of course.Here are the basics about monkeypox. Unfortunately it ' s behind the NYT paywall but it ' s the best summary I could find. Anyway I ' ll review the situation for you. Monkeypox is indigenous to sub-Saharan Africa, but among th...
Source: Stayin' Alive - June 27, 2022 Category: American Health Source Type: blogs
My experience as a teenage health care worker during the COVID-19 pandemic [PODCAST]
“We owe it to our patients to do better. Every time I picture the couple leaving the pharmacy unvaccinated, I am reminded that true health care requires accountability and a willingness to challenge the status quo. That means challenging a “no” or “that’s too much work” rather than accepting it passively. If I could doRead more …My experience as a teenage health care worker during the COVID-19 pandemic [PODCAST] originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 24, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/the-podcast-by-kevinmd" rel="tag" data-wpel-link="internal" > The Podcast by KevinMD < /a > < /span > Tags: Podcast COVID Infectious Disease Source Type: blogs
