Air Pollution Implicated as a Contributing Cause of Numerous Age-Related Conditions
A compelling range of evidence links greater particulate air pollution to a greater incidence of age-related disease and mortality. The primary mechanism is considered to be induction of chronic inflammation via the interaction of particulates with lung tissue. Constant, unresolved inflammatory signaling is disruptive to cell and tissue function throughout the body, accelerating the onset and progression of all of the most common disabling and ultimately fatal age-related conditions.
Growing evidence suggests that exposure to fine particulate matter (PM2.5) may reduce life expectancy; however, the causal pathways ...
Source: Fight Aging! - January 1, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Physical Examination as a Helpful Aid in Decision-Making in Challenging ECGs
Discussion continuedThe absence of pace spikes suggests this is not a pacemaker/ICD-related rhythm in this patient with an ICD.The presence of thinned myocardium and known large amount of scar tissue makes for a nidus for VT. Thus VT is very probable.A wide native QRS can be expected in a patient with a dilated heart and a history of heart failure, even if it is sinus rhythm. so the question of whether those are P-waves is critical.Additionally, the qR morphology, particularly in a patient with right bundle branch block (RBBB) type wide QRS complex tachycardia (WQCT), lends further support for VT.Furthermore, a pertinent p...
Source: Dr. Smith's ECG Blog - January 1, 2024 Category: Cardiology Authors: Emre Aslanger Source Type: blogs
Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
The market has been in the doldrums and it has been a tough year for fundraising, both for non-profits and biotech startups. The conferences have exhibited more of an academic focus as companies tightened belts and postponed investment rounds, while investors stayed home. Not that this halts the flow of hype for some projects, and nor has it slowed media commentary on the longevity industry as it presently stands. A few of the articles in that commmentary are even interesting to read! The field has grown and is more mature now than has ever been the case. Biotech of all forms is a challenging field with a high failure rate...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Acute OMI or " Benign " Early Repolarization?
Written by Willy FrickA man in his 50s with a history of hypertension, dyslipidemia, type 2 diabetes mellitus, and prior inferior OMI status post DES to his proximal RCA 3 years prior presented to the emergency department at around 3 AM complaining of chest pain onset around 9 PM the evening prior. He described it as severe, sharp, and substernal with associated nausea, vomiting, chills, and diaphoresis. The following ECG was obtained. Note that the machine read is" normal sinus rhythm, normal ECG. " Cardiology over read the tracing and signed the interpretation without modification.ECG 1What do you think?The Queen of Hear...
Source: Dr. Smith's ECG Blog - December 27, 2023 Category: Cardiology Authors: Willy Frick Source Type: blogs
Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies.
Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Growing Thyroid Tissue in the Spleen to Restore Function
Over the past decade or so, researchers have demonstrated that it is possible to use existing organs as bioreactors to host organoids derived from other organ tissues. Functional liver tissue can be grown in lymph nodes, as can thymus tissue. Here, researchers show that thyroid organoids can be grown in the spleen. This is intended to help patients who have undergone thyroidectomy, but will this capability also be useful in the context of the aging of the thyroid gland? Interestingly, the aging of the thyroid is poorly understood in comparison to the interaction of aging with larger organs such as liver, kidney, or heart. ...
Source: Fight Aging! - December 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Concerning EKG with a Non-obstructive angiogram. What happened?
CONCLUSION: Given resolution of severe CP in association with the above marked improvement of ST-T wave abnormalities in virtually all leads during the less than 1 hour between the recording of ECGs #1 and #2 — this strongly suggests reopening of a " culprit " vessel (whichever vessel this was) — regardless of the fact that " no obstructive lesion was seen " at the time the cardiac catheterization happened to be done.The more than doubling of Troponin (even though " normal limits " for Troponin were not surpassed) — is consistent with a brief OMI, with only...
Source: Dr. Smith's ECG Blog - December 19, 2023 Category: Cardiology Authors: Willy Frick Source Type: blogs
Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
« Back to Top
Aged Transplant Organs Cause Harm to Younger Recipients
https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/
Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An ECG with only «marginal» change
DISCUSSION: This case nicely illustrates how subtle OMI changes really can be. The Queen of Hearts AI model did not identify OMI in the initial ECG.Below is the QoH explainability for the limb leads of the ECG #2 (left part of the image) and limb leads of ECG #3 (right side of the image). The sets of six limb leads are put next to each other for comparison. I ' ve excluded the precordial leads as they didn ' t add much information in this case. You can look at each leads and compare the two ECGs. You then can appreciate the dynamic change and see what parts of the waveform the QoH identifies as ischemic findings....
Source: Dr. Smith's ECG Blog - December 15, 2023 Category: Cardiology Authors: Magnus Nossen Source Type: blogs
Lifestyle matters: What we can do in 2024 to optimize cognition and life, delaying cognitive problems even dementia
This article was originally published on The Conversation.
News in Context:
Solving the Brain Fitness Puzzle Is the Key to Self-Empowered Aging
What are cognitive abilities and how to boost them?
The post Lifestyle matters: What we can do in 2024 to optimize cognition and life, delaying cognitive problems even dementia appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - December 14, 2023 Category: Neuroscience Authors: The Conversation Tags: Brain/ Mental Health Alzheimer’s biological Brain-Fitness cognition cognitive engagement cognitive-abilities cognitive-reserve dementia depression exercise inflammation lifestyle neuroplasticity optimize cognition Stress Source Type: blogs
Top 6 Medical Trends To Watch for 2024
This study also reported a weight reduction of 4.0 kilograms and a 10.8-millimeter reduction in systolic blood pressure among patients.
This segment is becoming significant in market terms as well: the market for DTx was valued at USD 5.53 billion in 2022 and is expected to grow to USD 28.66 billion by 2030. The increased prevalence of chronic conditions, as the result of our longer lives, fuels this growth as conditions like diabetes or hypertension can be more efficiently managed with a combination of traditional medicine and DTx.
While these apps are available in a large number of medical specialties, channe...
Source: The Medical Futurist - December 14, 2023 Category: Information Technology Authors: Andrea Koncz Tags: TMF Source Type: blogs
Thoughts on Air Pollution and Accelerated Aging
A number of large epidemiological studies demonstrate that particulate air pollution correlates with mortality and incidence of age-related disease, likely via mechanisms involving increased inflammation resulting from the interaction of particulates with lung tissue. While socioeconomic status interacts with both exposure to air pollution and life expectancy, it is nonetheless possible to disentangle these effects in some population studies. While the long-term trend is towards reduced air pollution, it seems likely that chronic inflammation will be controlled and its effects on tissues reversed via novel therapeutics on ...
Source: Fight Aging! - December 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What are nitazenes? Benzimidazole opioids
Benzimidazole opioids, also commonly known as nitazenes, were first synthesised by CIBA Pharmaceuticals in the 1950s as putative alternatives to morphine and heroin for use as strong painkillers. They have never made it into use in clinical medicine because the risk of addiction, respiratory depression, and death in use is too high.
Etonitazene has hundreds of times the potency of morphine
The compounds are classified as opioid New Psychoactive Substances (opioid NPS). Their mode of action is to bind to the brain’s mu-opioid receptors, but their unique structure means that some examples are several hundred times more...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 11, 2023 Category: Science Authors: David Bradley Tags: Chemistry Health and Medicine Pharma Source Type: blogs
