Aryl hydrocarbon receptor role in chronic inflammatory skin diseases: a narrative review
In conclusion, the AHR is a pivotal player in dermatology, with a multifaceted role in skin physiology and pathology. Understanding the intricacies of AHR signalling in the skin offers promising avenues for the development of novel therapies and preventive strategies for various dermatological conditions. Further research is warranted to elucidate the full scope of AHR's contributions to dermatology and its potential as a therapeutic target.PMID:38533374 | PMC:PMC10962376 | DOI:10.5114/ada.2023.135617 (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - March 27, 2024 Category: Dermatology Authors: Micha ł Dec Hubert Arasiewicz Source Type: research
The NLRP3 Inflammasome Gene Is Overexpressed in Hidradenitis Suppurativa Lesions: A Preliminary Study on the Role of Pyroptosis in Disease Pathogenesis
This study aimed to investigate the role of the P2X7 receptor (P2X7R) and NLRP3 inflammasome in HS pathogenesis. RNA sequencing and real-time PCR were performed to assess the gene expression levels of P2X7R and NLRP3 in the skin biopsies of HS patients and healthy controls (HC). The results of our study revealed a significantly increased expression of the NLRP3 gene in both the lesional and perilesional skin of HS patients compared to healthy controls. Moreover, the mRNA levels of NLRP3 were significantly higher in lesional skin compared to non-lesional skin in HS patients, indicating the spread of inflammation to adjacent...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Piotr K Krajewski Weronika Szuka ła Jacek C Szepietowski Source Type: research
Aryl hydrocarbon receptor role in chronic inflammatory skin diseases: a narrative review
In conclusion, the AHR is a pivotal player in dermatology, with a multifaceted role in skin physiology and pathology. Understanding the intricacies of AHR signalling in the skin offers promising avenues for the development of novel therapies and preventive strategies for various dermatological conditions. Further research is warranted to elucidate the full scope of AHR's contributions to dermatology and its potential as a therapeutic target.PMID:38533374 | PMC:PMC10962376 | DOI:10.5114/ada.2023.135617 (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - March 27, 2024 Category: Dermatology Authors: Micha ł Dec Hubert Arasiewicz Source Type: research
The NLRP3 Inflammasome Gene Is Overexpressed in Hidradenitis Suppurativa Lesions: A Preliminary Study on the Role of Pyroptosis in Disease Pathogenesis
This study aimed to investigate the role of the P2X7 receptor (P2X7R) and NLRP3 inflammasome in HS pathogenesis. RNA sequencing and real-time PCR were performed to assess the gene expression levels of P2X7R and NLRP3 in the skin biopsies of HS patients and healthy controls (HC). The results of our study revealed a significantly increased expression of the NLRP3 gene in both the lesional and perilesional skin of HS patients compared to healthy controls. Moreover, the mRNA levels of NLRP3 were significantly higher in lesional skin compared to non-lesional skin in HS patients, indicating the spread of inflammation to adjacent...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Piotr K Krajewski Weronika Szuka ła Jacek C Szepietowski Source Type: research
Aryl hydrocarbon receptor role in chronic inflammatory skin diseases: a narrative review
In conclusion, the AHR is a pivotal player in dermatology, with a multifaceted role in skin physiology and pathology. Understanding the intricacies of AHR signalling in the skin offers promising avenues for the development of novel therapies and preventive strategies for various dermatological conditions. Further research is warranted to elucidate the full scope of AHR's contributions to dermatology and its potential as a therapeutic target.PMID:38533374 | PMC:PMC10962376 | DOI:10.5114/ada.2023.135617 (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - March 27, 2024 Category: Dermatology Authors: Micha ł Dec Hubert Arasiewicz Source Type: research
The NLRP3 Inflammasome Gene Is Overexpressed in Hidradenitis Suppurativa Lesions: A Preliminary Study on the Role of Pyroptosis in Disease Pathogenesis
This study aimed to investigate the role of the P2X7 receptor (P2X7R) and NLRP3 inflammasome in HS pathogenesis. RNA sequencing and real-time PCR were performed to assess the gene expression levels of P2X7R and NLRP3 in the skin biopsies of HS patients and healthy controls (HC). The results of our study revealed a significantly increased expression of the NLRP3 gene in both the lesional and perilesional skin of HS patients compared to healthy controls. Moreover, the mRNA levels of NLRP3 were significantly higher in lesional skin compared to non-lesional skin in HS patients, indicating the spread of inflammation to adjacent...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Piotr K Krajewski Weronika Szuka ła Jacek C Szepietowski Source Type: research
Bariatric surgery reduces the incidence of hidradenitis suppurative in individuals with obesity: results of a nationwide administrative data study in France.
hidradenitis suppurativa is a systemic inflammatory condition associated to obesity, metabolic syndrome, and other environmental factors. Bariatric surgery is effective in determining weight loss and obesity-related medical problems resolution. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - March 23, 2024 Category: Surgery Authors: Andrea CHIERICI, Julie BULSEI, Mohamed ALROMAYAN, Abdelrahmane ALAMRI, Giovanna PAVONE, Eric FONTAS, Antonio IANNELLI Tags: Original articles Source Type: research
Clinical Snippets
The incomplete understanding of the pathogenesis of the chronic inflammatory disease hidradenitis suppurativa (HS) contributes to a lack of effective therapies. Recently, a proof-of-concept phase 2 clinical trial showed that fostamatinib, a spleen Y kinase inhibitor, led to clinical benefit in patients with moderate-to-severe HS. Proteomics analysis of samples from the study demonstrated that inhibition with fostamatinib downregulated T helper 17 –associated cytokines IL-12B and IL-17A; B-cell–associated chemokines CCL19 and CCL20; and IFN-γ–associated proteins CX3CL1, IL-2, and CXCL10 in the serum of patients with ...
Source: Journal of Investigative Dermatology - March 20, 2024 Category: Dermatology Tags: Clinical Snippets Source Type: research
Diseases categorized as autoinflammatory keratinization diseases (AiKDs), and their pathologies and treatments
Nagoya J Med Sci. 2024 Feb;86(1):1-15. doi: 10.18999/nagjms.86.1.1.ABSTRACTWhole-exome and whole-genome sequencing have become widespread in approximately the last 15 years, and the predisposing factors and pathomechanisms of inflammatory keratinization diseases, which have been unknown for a long time, have gradually been revealed. Hence, various inflammatory keratinization diseases are recognized to cause innate immunity hyperactivation. Therefore, we have been advocating for the clinical entity, "autoinflammatory keratinization diseases (AiKDs)" since 2017. AiKDs are inflammatory keratinization diseases caused by autoin...
Source: Nagoya Journal of Medical Science - March 20, 2024 Category: International Medicine & Public Health Authors: Masashi Akiyama Source Type: research
