Heartland Virus Transmission, Suffolk County, New York, USA
Emerg Infect Dis. 2021 Oct 14;27(12). doi: 10.3201/eid2712.211426. Online ahead of print.ABSTRACTDuring 2018, Heartland virus RNA was detected in an Amblyomma americanum tick removed from a resident of Suffolk County, New York, USA. The persons showed seroconversion. Tick surveillance and white-tailed deer (Odocoileus virginianus) serosurveys showed widespread distribution in Suffolk County, emphasizing a need for disease surveillance anywhere A. americanum ticks are established or emerging.PMID:34648421 | DOI:10.3201/eid2712.211426 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 14, 2021 Category: Infectious Diseases Authors: Alan P Dupuis Melissa A Prusinski Collin O'Connor Joseph G Maffei Kiet A Ngo Cheri A Koetzner Michael P Santoriello Christopher L Romano Guang Xu Fumiko Ribbe Scott R Campbell Stephen M Rich P Bryon Backenson Laura D Kramer Alexander T Ciota Source Type: research
Heartland Virus Transmission, Suffolk County, New York, USA
Emerg Infect Dis. 2021 Oct 14;27(12). doi: 10.3201/eid2712.211426. Online ahead of print.ABSTRACTDuring 2018, Heartland virus RNA was detected in an Amblyomma americanum tick removed from a resident of Suffolk County, New York, USA. The persons showed seroconversion. Tick surveillance and white-tailed deer (Odocoileus virginianus) serosurveys showed widespread distribution in Suffolk County, emphasizing a need for disease surveillance anywhere A. americanum ticks are established or emerging.PMID:34648421 | DOI:10.3201/eid2712.211426 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 14, 2021 Category: Infectious Diseases Authors: Alan P Dupuis Melissa A Prusinski Collin O'Connor Joseph G Maffei Kiet A Ngo Cheri A Koetzner Michael P Santoriello Christopher L Romano Guang Xu Fumiko Ribbe Scott R Campbell Stephen M Rich P Bryon Backenson Laura D Kramer Alexander T Ciota Source Type: research
Heartland Virus Transmission, Suffolk County, New York, USA
Emerg Infect Dis. 2021 Oct 14;27(12). doi: 10.3201/eid2712.211426. Online ahead of print.ABSTRACTDuring 2018, Heartland virus RNA was detected in an Amblyomma americanum tick removed from a resident of Suffolk County, New York, USA. The persons showed seroconversion. Tick surveillance and white-tailed deer (Odocoileus virginianus) serosurveys showed widespread distribution in Suffolk County, emphasizing a need for disease surveillance anywhere A. americanum ticks are established or emerging.PMID:34648421 | DOI:10.3201/eid2712.211426 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 14, 2021 Category: Infectious Diseases Authors: Alan P Dupuis Melissa A Prusinski Collin O'Connor Joseph G Maffei Kiet A Ngo Cheri A Koetzner Michael P Santoriello Christopher L Romano Guang Xu Fumiko Ribbe Scott R Campbell Stephen M Rich P Bryon Backenson Laura D Kramer Alexander T Ciota Source Type: research
Heartland Virus Transmission, Suffolk County, New York, USA
Emerg Infect Dis. 2021 Oct 14;27(12). doi: 10.3201/eid2712.211426. Online ahead of print.ABSTRACTDuring 2018, Heartland virus RNA was detected in an Amblyomma americanum tick removed from a resident of Suffolk County, New York, USA. The persons showed seroconversion. Tick surveillance and white-tailed deer (Odocoileus virginianus) serosurveys showed widespread distribution in Suffolk County, emphasizing a need for disease surveillance anywhere A. americanum ticks are established or emerging.PMID:34648421 | DOI:10.3201/eid2712.211426 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 14, 2021 Category: Infectious Diseases Authors: Alan P Dupuis Melissa A Prusinski Collin O'Connor Joseph G Maffei Kiet A Ngo Cheri A Koetzner Michael P Santoriello Christopher L Romano Guang Xu Fumiko Ribbe Scott R Campbell Stephen M Rich P Bryon Backenson Laura D Kramer Alexander T Ciota Source Type: research
Heartland Virus Transmission, Suffolk County, New York, USA
A. P. Dupuis et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - August 16, 2021 Category: Infectious Diseases Source Type: research
The NF- κB inhibitor, SC75741, is a novel antiviral against emerging tick-borne bandaviruses.
The NF-κB inhibitor, SC75741, is a novel antiviral against emerging tick-borne bandaviruses.
Antiviral Res. 2020 Dec 06;:104993
Authors: Mendoza CA, Yamaoka S, Tsuda Y, Matsuno K, Weisend CM, Ebihara H
Abstract
Severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus (HRTV) cause viral hemorrhagic fever-like illnesses in humans due to an aberrant host inflammatory response, which contributes to pathogenesis. Here, we established two separate minigenome (MG) systems based on the M-segment of SFTSV and HRTV. Following characterization of both systems for SFTSV ...
Source: Antiviral Research - December 6, 2020 Category: Virology Authors: Mendoza CA, Yamaoka S, Tsuda Y, Matsuno K, Weisend CM, Ebihara H Tags: Antiviral Res Source Type: research
Isothermal Recombinase Polymerase Amplification-Lateral Flow Point-of-Care Diagnostic Test for Heartland Virus
Vector-Borne and Zoonotic Diseases, Ahead of Print. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - December 2, 2020 Category: Infectious Diseases Authors: Thomas R. Shelite Nathen E. Bopp Abelardo Moncayo Erin S. Reynolds Saravanan Thangamani Peter C. Melby Karen Bloch Patricia V. Aguilar Bruno L. Travi Source Type: research
Serologic Evidence of Arthropod-Borne Virus Infections in Wild and Captive Ruminants in Ontario, Canada.
Abstract
Arthropod-borne viruses (arboviruses) are globally widespread, and their transmission cycles typically involve numerous vertebrate species. Serologic testing of animal hosts can provide a routine surveillance approach to monitoring animal disease systems, can provide a surveillance alternative to arthropod testing and human case reports, and may augment knowledge of epizootiology. Wild and captive ruminants represent good candidate sentinels to track geographic distribution and prevalence of select arboviruses. They often are geographically widespread and abundant, inhabit areas shared by humans a...
Source: The American Journal of Tropical Medicine and Hygiene - August 16, 2020 Category: Tropical Medicine Authors: Allen SE, Jardine CM, Hooper-McGrevy K, Ambagala A, Bosco-Lauth AM, Kunkel MR, Mead DG, Nituch L, Ruder MG, Nemeth NM Tags: Am J Trop Med Hyg Source Type: research
Heartland Virus in Lone Star Ticks, Alabama, USA.
Abstract
We detected Heartland virus (HRTV) in lone star nymphs collected in 2018 in northern Alabama, USA. Real-time reverse transcription PCR selective for the small segment of the HRTV genome and confirmatory sequencing of positive samples showed high identity with HRTV strains sequenced from Tennessee and Missouri.
PMID: 32687045 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - July 22, 2020 Category: Infectious Diseases Authors: Newman BC, Sutton WB, Moncayo AC, Hughes HR, Taheri A, Moore TC, Schweitzer CJ, Wang Y Tags: Emerg Infect Dis Source Type: research
Heartland Virus in Lone Star Ticks, Alabama, USA
B. C. Newman et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - July 15, 2020 Category: Infectious Diseases Source Type: research
Heartland Virus in Humans and Ticks, Illinois, USA, 2018-2019.
Abstract
In 2018, Heartland disease virus infected 2 persons in Illinois, USA. In 2019, ticks were collected at potential tick bite exposure locations and tested for Heartland and Bourbon viruses. A Heartland virus-positive pool of adult male Amblyomma americanum ticks was found at 2 locations, 439 km apart, suggesting widespread distribution in Illinois.
PMID: 32568061 [PubMed - as supplied by publisher] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - June 23, 2020 Category: Infectious Diseases Authors: Tuten HC, Burkhalter KL, Noel KR, Hernandez EJ, Yates S, Wojnowski K, Hartleb J, Debosik S, Holmes A, Stone CM Tags: Emerg Infect Dis Source Type: research
Heartland Virus in Humans and Ticks, Illinois, USA, 2018 –2019
H. C. Tuten et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - June 10, 2020 Category: Infectious Diseases Source Type: research
Combinatorial Minigenome Systems for Emerging Banyangviruses Reveal Viral Reassortment Potential and Importance of a Protruding Nucleotide in Genome “Panhandle” for Promoter Activity and Reassortment
Banyangvirus is a new genus (Phenuiviridae family, Bunyavirales order) that comprises a group of emerging tick-borne viruses with severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus (HRTV) as virulent representatives. As segmented RNA viruses, bunyaviruses may have genome reassortment potential, increasing the concern about new life-threatening bunyavirus emergence. Using a series of combinatory minigenome reporter assays based on transfection and superinfection, we showed that replication machinery proteins of designated banyangviruses can recognize genomic untranslated regions (UTRs) of other ba...
Source: Frontiers in Microbiology - April 7, 2020 Category: Microbiology Source Type: research
The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target
Publication date: 7 January 2020Source: Cell Reports, Volume 30, Issue 1Author(s): Wenjie Wang, Woo-Jin Shin, Bojie Zhang, Younho Choi, Ji-Seung Yoo, Maxwell I. Zimmerman, Thomas E. Frederick, Gregory R. Bowman, Michael L. Gross, Daisy W. Leung, Jae U. Jung, Gaya K. AmarasingheSummarySevere fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%–30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States. Together, SFTSV and HRTV are emerging segmented, negative-sense RNA viral (sNSV) pathogens with potential global health impact. Here, we characteriz...
Source: Cell Reports - January 8, 2020 Category: Cytology Source Type: research
Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1 [Molecular Bases of Disease]
Heartland virus (HRTV) is a pathogenic phlebovirus recently identified in the United States and related to severe fever with thrombocytopenia syndrome virus (SFTSV) emerging in Asia. We previously reported that SFTSV disrupts host antiviral responses directed by interferons (IFNs) and their downstream regulators, signal transducer and activator of transcription (STAT) proteins. However, whether HRTV infection antagonizes the IFN–STAT signaling axis remains unclear. Here, we show that, similar to SFTSV, HRTV also inhibits IFN-α– and IFN-λ–mediated antiviral responses. As expected, the nonstructural protein (NSs) of ...
Source: Journal of Biological Chemistry - June 13, 2019 Category: Chemistry Authors: Kuan Feng, Fei Deng, Zhihong Hu, Hualin Wang, Yun-Jia Ning Tags: Immunology Source Type: research
