Pathological and virological findings of type I interferon receptor knockout mice upon experimental infection with Heartland virus
Virus Res. 2023 Dec 12:199301. doi: 10.1016/j.virusres.2023.199301. Online ahead of print.ABSTRACTHeartland virus (HRTV) causes generalized symptoms, severe shock, and multiple organ failure. We previously reported that interferon-α/β receptor knockout (IFNAR-/-) mice infected intraperitoneally with 1 × 107 tissue culture-infective dose (TCID50) of HRTV died, while those subcutaneously infected with the same dose of HRTV did not. The pathophysiology of IFNAR-/- mice infected with HRTV and the mechanism underlying the difference in disease severity, which depends on HRTV infection route, were analyzed in this study. The ...
Source: Virus Research - December 14, 2023 Category: Virology Authors: Hikaru Fujii Shuetsu Fukushi Tomoki Yoshikawa Noriyo Nagata Satoshi Taniguchi Masayuki Shimojima Souichi Yamada Hideki Tani Akihiko Uda Takahiro Maeki Shizuko Harada Takeshi Kurosu Chang Kweng Lim Eri Nakayama Mutsuyo Takayama-Ito Shumpei Watanabe Hideki Source Type: research

Pathological and virological findings of type I interferon receptor knockout mice upon experimental infection with Heartland virus
Virus Res. 2023 Dec 12:199301. doi: 10.1016/j.virusres.2023.199301. Online ahead of print.ABSTRACTHeartland virus (HRTV) causes generalized symptoms, severe shock, and multiple organ failure. We previously reported that interferon-α/β receptor knockout (IFNAR-/-) mice infected intraperitoneally with 1 × 107 tissue culture-infective dose (TCID50) of HRTV died, while those subcutaneously infected with the same dose of HRTV did not. The pathophysiology of IFNAR-/- mice infected with HRTV and the mechanism underlying the difference in disease severity, which depends on HRTV infection route, were analyzed in this study. The ...
Source: Virus Research - December 14, 2023 Category: Virology Authors: Hikaru Fujii Shuetsu Fukushi Tomoki Yoshikawa Noriyo Nagata Satoshi Taniguchi Masayuki Shimojima Souichi Yamada Hideki Tani Akihiko Uda Takahiro Maeki Shizuko Harada Takeshi Kurosu Chang Kweng Lim Eri Nakayama Mutsuyo Takayama-Ito Shumpei Watanabe Hideki Source Type: research

The Neutralizing Monoclonal Antibodies against SFTS Group Bandaviruses Suggest New Targets of Specific or Broad-Spectrum Antivirals
In this study, five neutralizing the mAbs against GTV and HRTV were obtained by hybridoma screening technology, four of which (14B4, 14D8, and 20D4 derived from GTV, and 27C8 derived from HRTV) showed cross reactivity and neutralization to all three viruses, and one derived from HRTV (10D6) neutralized HRTV specifically. The possible mechanisms of mAbs cross neutralization among the three viruses are discussed by analyzing their glycoprotein (GP) sequences and structures. Generating these neutralizing mAbs provides important antiviral candidates against GTV, HRTV, and SFTSV despite their differential activities, and their ...
Source: The American Journal of Tropical Medicine and Hygiene - November 6, 2023 Category: Tropical Medicine Authors: Liyan Fu Lang Xu Jin Qian Xiaoli Wu Zhiying Wang Hualin Wang Dan Liu Fei Deng Shu Shen Source Type: research

The Neutralizing Monoclonal Antibodies against SFTS Group Bandaviruses Suggest New Targets of Specific or Broad-Spectrum Antivirals
In this study, five neutralizing the mAbs against GTV and HRTV were obtained by hybridoma screening technology, four of which (14B4, 14D8, and 20D4 derived from GTV, and 27C8 derived from HRTV) showed cross reactivity and neutralization to all three viruses, and one derived from HRTV (10D6) neutralized HRTV specifically. The possible mechanisms of mAbs cross neutralization among the three viruses are discussed by analyzing their glycoprotein (GP) sequences and structures. Generating these neutralizing mAbs provides important antiviral candidates against GTV, HRTV, and SFTSV despite their differential activities, and their ...
Source: Am J Trop Med Hyg - November 6, 2023 Category: Infectious Diseases Authors: Liyan Fu Lang Xu Jin Qian Xiaoli Wu Zhiying Wang Hualin Wang Dan Liu Fei Deng Shu Shen Source Type: research

The Neutralizing Monoclonal Antibodies against SFTS Group Bandaviruses Suggest New Targets of Specific or Broad-Spectrum Antivirals
In this study, five neutralizing the mAbs against GTV and HRTV were obtained by hybridoma screening technology, four of which (14B4, 14D8, and 20D4 derived from GTV, and 27C8 derived from HRTV) showed cross reactivity and neutralization to all three viruses, and one derived from HRTV (10D6) neutralized HRTV specifically. The possible mechanisms of mAbs cross neutralization among the three viruses are discussed by analyzing their glycoprotein (GP) sequences and structures. Generating these neutralizing mAbs provides important antiviral candidates against GTV, HRTV, and SFTSV despite their differential activities, and their ...
Source: The American Journal of Tropical Medicine and Hygiene - November 6, 2023 Category: Tropical Medicine Authors: Liyan Fu Lang Xu Jin Qian Xiaoli Wu Zhiying Wang Hualin Wang Dan Liu Fei Deng Shu Shen Source Type: research

The Neutralizing Monoclonal Antibodies against SFTS Group Bandaviruses Suggest New Targets of Specific or Broad-Spectrum Antivirals
In this study, five neutralizing the mAbs against GTV and HRTV were obtained by hybridoma screening technology, four of which (14B4, 14D8, and 20D4 derived from GTV, and 27C8 derived from HRTV) showed cross reactivity and neutralization to all three viruses, and one derived from HRTV (10D6) neutralized HRTV specifically. The possible mechanisms of mAbs cross neutralization among the three viruses are discussed by analyzing their glycoprotein (GP) sequences and structures. Generating these neutralizing mAbs provides important antiviral candidates against GTV, HRTV, and SFTSV despite their differential activities, and their ...
Source: Am J Trop Med Hyg - November 6, 2023 Category: Infectious Diseases Authors: Liyan Fu Lang Xu Jin Qian Xiaoli Wu Zhiying Wang Hualin Wang Dan Liu Fei Deng Shu Shen Source Type: research

The Neutralizing Monoclonal Antibodies against SFTS Group Bandaviruses Suggest New Targets of Specific or Broad-Spectrum Antivirals
In this study, five neutralizing the mAbs against GTV and HRTV were obtained by hybridoma screening technology, four of which (14B4, 14D8, and 20D4 derived from GTV, and 27C8 derived from HRTV) showed cross reactivity and neutralization to all three viruses, and one derived from HRTV (10D6) neutralized HRTV specifically. The possible mechanisms of mAbs cross neutralization among the three viruses are discussed by analyzing their glycoprotein (GP) sequences and structures. Generating these neutralizing mAbs provides important antiviral candidates against GTV, HRTV, and SFTSV despite their differential activities, and their ...
Source: The American Journal of Tropical Medicine and Hygiene - November 6, 2023 Category: Tropical Medicine Authors: Liyan Fu Lang Xu Jin Qian Xiaoli Wu Zhiying Wang Hualin Wang Dan Liu Fei Deng Shu Shen Source Type: research

The Neutralizing Monoclonal Antibodies against SFTS Group Bandaviruses Suggest New Targets of Specific or Broad-Spectrum Antivirals
In this study, five neutralizing the mAbs against GTV and HRTV were obtained by hybridoma screening technology, four of which (14B4, 14D8, and 20D4 derived from GTV, and 27C8 derived from HRTV) showed cross reactivity and neutralization to all three viruses, and one derived from HRTV (10D6) neutralized HRTV specifically. The possible mechanisms of mAbs cross neutralization among the three viruses are discussed by analyzing their glycoprotein (GP) sequences and structures. Generating these neutralizing mAbs provides important antiviral candidates against GTV, HRTV, and SFTSV despite their differential activities, and their ...
Source: Am J Trop Med Hyg - November 6, 2023 Category: Infectious Diseases Authors: Liyan Fu Lang Xu Jin Qian Xiaoli Wu Zhiying Wang Hualin Wang Dan Liu Fei Deng Shu Shen Source Type: research

The Neutralizing Monoclonal Antibodies against SFTS Group Bandaviruses Suggest New Targets of Specific or Broad-Spectrum Antivirals
In this study, five neutralizing the mAbs against GTV and HRTV were obtained by hybridoma screening technology, four of which (14B4, 14D8, and 20D4 derived from GTV, and 27C8 derived from HRTV) showed cross reactivity and neutralization to all three viruses, and one derived from HRTV (10D6) neutralized HRTV specifically. The possible mechanisms of mAbs cross neutralization among the three viruses are discussed by analyzing their glycoprotein (GP) sequences and structures. Generating these neutralizing mAbs provides important antiviral candidates against GTV, HRTV, and SFTSV despite their differential activities, and their ...
Source: The American Journal of Tropical Medicine and Hygiene - November 6, 2023 Category: Tropical Medicine Authors: Liyan Fu Lang Xu Jin Qian Xiaoli Wu Zhiying Wang Hualin Wang Dan Liu Fei Deng Shu Shen Source Type: research

The Neutralizing Monoclonal Antibodies against SFTS Group Bandaviruses Suggest New Targets of Specific or Broad-Spectrum Antivirals
In this study, five neutralizing the mAbs against GTV and HRTV were obtained by hybridoma screening technology, four of which (14B4, 14D8, and 20D4 derived from GTV, and 27C8 derived from HRTV) showed cross reactivity and neutralization to all three viruses, and one derived from HRTV (10D6) neutralized HRTV specifically. The possible mechanisms of mAbs cross neutralization among the three viruses are discussed by analyzing their glycoprotein (GP) sequences and structures. Generating these neutralizing mAbs provides important antiviral candidates against GTV, HRTV, and SFTSV despite their differential activities, and their ...
Source: Am J Trop Med Hyg - November 6, 2023 Category: Infectious Diseases Authors: Liyan Fu Lang Xu Jin Qian Xiaoli Wu Zhiying Wang Hualin Wang Dan Liu Fei Deng Shu Shen Source Type: research

The Neutralizing Monoclonal Antibodies against SFTS Group Bandaviruses Suggest New Targets of Specific or Broad-Spectrum Antivirals
In this study, five neutralizing the mAbs against GTV and HRTV were obtained by hybridoma screening technology, four of which (14B4, 14D8, and 20D4 derived from GTV, and 27C8 derived from HRTV) showed cross reactivity and neutralization to all three viruses, and one derived from HRTV (10D6) neutralized HRTV specifically. The possible mechanisms of mAbs cross neutralization among the three viruses are discussed by analyzing their glycoprotein (GP) sequences and structures. Generating these neutralizing mAbs provides important antiviral candidates against GTV, HRTV, and SFTSV despite their differential activities, and their ...
Source: The American Journal of Tropical Medicine and Hygiene - November 6, 2023 Category: Tropical Medicine Authors: Liyan Fu Lang Xu Jin Qian Xiaoli Wu Zhiying Wang Hualin Wang Dan Liu Fei Deng Shu Shen Source Type: research

The Neutralizing Monoclonal Antibodies against SFTS Group Bandaviruses Suggest New Targets of Specific or Broad-Spectrum Antivirals
In this study, five neutralizing the mAbs against GTV and HRTV were obtained by hybridoma screening technology, four of which (14B4, 14D8, and 20D4 derived from GTV, and 27C8 derived from HRTV) showed cross reactivity and neutralization to all three viruses, and one derived from HRTV (10D6) neutralized HRTV specifically. The possible mechanisms of mAbs cross neutralization among the three viruses are discussed by analyzing their glycoprotein (GP) sequences and structures. Generating these neutralizing mAbs provides important antiviral candidates against GTV, HRTV, and SFTSV despite their differential activities, and their ...
Source: Am J Trop Med Hyg - November 6, 2023 Category: Infectious Diseases Authors: Liyan Fu Lang Xu Jin Qian Xiaoli Wu Zhiying Wang Hualin Wang Dan Liu Fei Deng Shu Shen Source Type: research

The Neutralizing Monoclonal Antibodies against SFTS Group Bandaviruses Suggest New Targets of Specific or Broad-Spectrum Antivirals
In this study, five neutralizing the mAbs against GTV and HRTV were obtained by hybridoma screening technology, four of which (14B4, 14D8, and 20D4 derived from GTV, and 27C8 derived from HRTV) showed cross reactivity and neutralization to all three viruses, and one derived from HRTV (10D6) neutralized HRTV specifically. The possible mechanisms of mAbs cross neutralization among the three viruses are discussed by analyzing their glycoprotein (GP) sequences and structures. Generating these neutralizing mAbs provides important antiviral candidates against GTV, HRTV, and SFTSV despite their differential activities, and their ...
Source: The American Journal of Tropical Medicine and Hygiene - November 6, 2023 Category: Tropical Medicine Authors: Liyan Fu Lang Xu Jin Qian Xiaoli Wu Zhiying Wang Hualin Wang Dan Liu Fei Deng Shu Shen Source Type: research

The Neutralizing Monoclonal Antibodies against SFTS Group Bandaviruses Suggest New Targets of Specific or Broad-Spectrum Antivirals
In this study, five neutralizing the mAbs against GTV and HRTV were obtained by hybridoma screening technology, four of which (14B4, 14D8, and 20D4 derived from GTV, and 27C8 derived from HRTV) showed cross reactivity and neutralization to all three viruses, and one derived from HRTV (10D6) neutralized HRTV specifically. The possible mechanisms of mAbs cross neutralization among the three viruses are discussed by analyzing their glycoprotein (GP) sequences and structures. Generating these neutralizing mAbs provides important antiviral candidates against GTV, HRTV, and SFTSV despite their differential activities, and their ...
Source: Am J Trop Med Hyg - November 6, 2023 Category: Infectious Diseases Authors: Liyan Fu Lang Xu Jin Qian Xiaoli Wu Zhiying Wang Hualin Wang Dan Liu Fei Deng Shu Shen Source Type: research

Geographical distribution and pathogenesis of ticks and tick-borne viral diseases
Ticks are obligatory hematophagous arthropods that harbor and transmit infectious pathogens to humans and animals. Tick species belonging to Amblyomma, Ixodes, Dermacentor, and Hyalomma genera may transmit certain viruses such as Bourbon virus (BRBV), Dhori virus (DHOV), Powassan virus (POWV), Omsk hemorrhagic fever virus (OHFV), Colorado tick fever virus (CTFV), Crimean-Congo hemorrhagic fever virus (CCHFV), Heartland virus (HRTV), Kyasanur forest disease virus (KFDV), etc. that affect humans and certain wildlife. The tick vectors may become infected through feeding on viraemic hosts before transmitting the pathogen to hu...
Source: Frontiers in Microbiology - May 24, 2023 Category: Microbiology Source Type: research