Adverse drug events associated with nortriptyline compared with paroxetine and alternative medications in an older adult population: a retrospective cohort study in Southern California
Conclusions
Compared with therapeutic alternatives, nortriptyline was found to represent a lower risk for falls, fractures and syncope, versus comparator medications, except for a few instances that had equivalent risk. The risk for these adverse events from paroxetine was comparable to the alternative medications. (Source: BMJ Open)
Source: BMJ Open - December 28, 2023 Category: General Medicine Authors: George, M. M., Deamer, R. L., Do, D. Tags: Open access, Geriatric medicine Source Type: research
Bergenin ameliorates chemotherapy-induced neuropathic pain in rats by modulating TRPA1/TRPV1/NR2B signalling
Int Immunopharmacol. 2023 Dec;125(Pt A):111100. doi: 10.1016/j.intimp.2023.111100. Epub 2023 Oct 27.ABSTRACTChemotherapy-induced neuropathic pain (CINP) is one of the most prominent and incapacitating complication associated with chemotherapeutic regimens. The exact mechanisms underlying CINP are not fully understood yet, which hampers the development of effective therapeutics. The current study has been designed to investigate the effect of bergenin on CINP and dissect the underlying cellular and molecular mechanisms. Behavioural responsiveness assays were conducted in rats before and after CINP induction and at different...
Source: International Immunopharmacology - December 27, 2023 Category: Allergy & Immunology Authors: None Akhilesh Deepak Chouhan Obulapathi Ummadisetty Nivedita Verma Vinod Tiwari Source Type: research
Bergenin ameliorates chemotherapy-induced neuropathic pain in rats by modulating TRPA1/TRPV1/NR2B signalling
Int Immunopharmacol. 2023 Dec;125(Pt A):111100. doi: 10.1016/j.intimp.2023.111100. Epub 2023 Oct 27.ABSTRACTChemotherapy-induced neuropathic pain (CINP) is one of the most prominent and incapacitating complication associated with chemotherapeutic regimens. The exact mechanisms underlying CINP are not fully understood yet, which hampers the development of effective therapeutics. The current study has been designed to investigate the effect of bergenin on CINP and dissect the underlying cellular and molecular mechanisms. Behavioural responsiveness assays were conducted in rats before and after CINP induction and at different...
Source: International Immunopharmacology - December 27, 2023 Category: Allergy & Immunology Authors: None Akhilesh Deepak Chouhan Obulapathi Ummadisetty Nivedita Verma Vinod Tiwari Source Type: research
The impact of novel inflammation-preserving treatment towards lumbar disc herniation resorption in symptomatic patients: a prospective, multi-imaging and clinical outcomes study
ConclusionThis is the first study to note inflammation-preserving treatment, without conventional anti-inflammatory and steroid medications, as safe and effective for patients with an acute LDH. Rate of disc resorption (100%) was higher than comparative recent meta-analysis findings (66.7%) and no patient underwent surgery. (Source: European Spine Journal)
Source: European Spine Journal - December 15, 2023 Category: Orthopaedics Source Type: research
Evaluating the Effects of Probiotic Supplementation on Neuropathic Pain and Oxidative Stress Factors in an Animal Model of Chronic Constriction Injury of the Sciatic Nerve
CONCLUSION: These findings suggest that probiotics have analgesic effects on the CCI model of neuropathic pain via increasing the antioxidant capacity of the rats' sciatic nerve.HIGHLIGHTS: Oral probiotics mixture diminishes cold and mechanical allodynia in chronic constriction injury (CCI) rats.Probiotics mixture reduces thermal hyperalgesia in CCI rats as well as gabapentine.Balancing in oxidant/anti-oxidant system is key pathway in neuropathic pain reduction.PLAIN LANGUAGE SUMMARY: Currently, neuropathic pain is an underestimated socioeconomic health problem affecting millions of people worldwide. Neuropathic pain occur...
Source: Atherosclerosis - December 11, 2023 Category: Cardiology Authors: Mohammad Shabani Elham Hasanpour Mojgan Mohammadifar Fereshteh Bahmani Sayyed Alireza Talaei Fatemeh Aghighi Source Type: research
Evaluating the Effects of Probiotic Supplementation on Neuropathic Pain and Oxidative Stress Factors in an Animal Model of Chronic Constriction Injury of the Sciatic Nerve
CONCLUSION: These findings suggest that probiotics have analgesic effects on the CCI model of neuropathic pain via increasing the antioxidant capacity of the rats' sciatic nerve.HIGHLIGHTS: Oral probiotics mixture diminishes cold and mechanical allodynia in chronic constriction injury (CCI) rats.Probiotics mixture reduces thermal hyperalgesia in CCI rats as well as gabapentine.Balancing in oxidant/anti-oxidant system is key pathway in neuropathic pain reduction.PLAIN LANGUAGE SUMMARY: Currently, neuropathic pain is an underestimated socioeconomic health problem affecting millions of people worldwide. Neuropathic pain occur...
Source: Atherosclerosis - December 11, 2023 Category: Cardiology Authors: Mohammad Shabani Elham Hasanpour Mojgan Mohammadifar Fereshteh Bahmani Sayyed Alireza Talaei Fatemeh Aghighi Source Type: research
Priapism associated with anti-seizure medications: a pharmacovigilance study and a review of published cases
CONCLUSIONS: Our study identified signals for priapism for several anti-seizure medications, but these results need to be confirmed in well-designed pharmacoepidemiological studies.PMID:38062555 | DOI:10.1080/14740338.2023.2293208 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - December 8, 2023 Category: Drugs & Pharmacology Authors: Nemanja Z Petrovi ć Ana V Pej čić Ivan R Milovanovi ć Source Type: research
Characterizing Opioid Prescribing Trends of Medical Oncologists From 2013 to 2019: Analysis From the Centers for Medicare & amp; Medicaid Services Medicare Part D Prescribers Database
CONCLUSION: Opioid prescriptions by medical oncologists decreased significantly from 2013 to 2019, but this decrease was most substantial from 2017 to 2019. These results may imply that the 2016 CDC guidelines influenced medical oncologists, particularly more junior physicians in urban settings, to manage chronic cancer pain with alternative therapies.PMID:38061003 | DOI:10.1200/OP.23.00285 (Source: Pain Physician)
Source: Pain Physician - December 7, 2023 Category: Anesthesiology Authors: Mark R Korst Marco Santos Teles Hassaam S Choudhry Joseph G Santitoro Daniel J Garcia Sophia Marie T Schwab Joshua A Kra Source Type: research
A Hidden Pandemic? Abuse of Gabapentinoids: A Brief Review of Recent Studies
CONCLUSION: Gabapentinoids are highly abused molecules worldwide. Physicians should be aware of their abuse potential.PMID:38031769 | DOI:10.2174/0125899775268780231002064605 (Source: Epilepsy Curr)
Source: Epilepsy Curr - November 30, 2023 Category: Neurology Authors: Gamze Zengin İspir Mustafa Dan ışman K übra Sezer Katar Source Type: research
A rare case of vestibular schwannoma manifesting as trigeminal neuralgia
J Am Dent Assoc. 2023 Nov 29:S0002-8177(23)00621-9. doi: 10.1016/j.adaj.2023.10.004. Online ahead of print.ABSTRACTBACKGROUND: In this case report, the authors reviewed a rare case of a vestibular schwannoma manifesting as trigeminal neuralgia (TN). Intracranial tumors can have a variety of orofacial pain symptoms. Among benign cerebellopontine angle tumors, vestibular schwannoma is the most common cause of a TN-like manifestation. Although the most common symptoms of a vestibular schwannoma are hearing loss and vestibulopathy, the unique feature of this case was the manifestation of symptoms consistent with TN.CASE DESCRI...
Source: Journal of the American Dental Association - November 30, 2023 Category: Dentistry Authors: Sowmya Ananthan Upasana Kumar Stephen Johnson Source Type: research
A Hidden Pandemic? Abuse of Gabapentinoids: A Brief Review of Recent Studies
CONCLUSION: Gabapentinoids are highly abused molecules worldwide. Physicians should be aware of their abuse potential.PMID:38031769 | DOI:10.2174/0125899775268780231002064605 (Source: Epilepsy Curr)
Source: Epilepsy Curr - November 30, 2023 Category: Neurology Authors: Gamze Zengin İspir Mustafa Dan ışman K übra Sezer Katar Source Type: research
A rare case of vestibular schwannoma manifesting as trigeminal neuralgia
J Am Dent Assoc. 2023 Nov 29:S0002-8177(23)00621-9. doi: 10.1016/j.adaj.2023.10.004. Online ahead of print.ABSTRACTBACKGROUND: In this case report, the authors reviewed a rare case of a vestibular schwannoma manifesting as trigeminal neuralgia (TN). Intracranial tumors can have a variety of orofacial pain symptoms. Among benign cerebellopontine angle tumors, vestibular schwannoma is the most common cause of a TN-like manifestation. Although the most common symptoms of a vestibular schwannoma are hearing loss and vestibulopathy, the unique feature of this case was the manifestation of symptoms consistent with TN.CASE DESCRI...
Source: Journal of the American Dental Association - November 30, 2023 Category: Dentistry Authors: Sowmya Ananthan Upasana Kumar Stephen Johnson Source Type: research
A Hidden Pandemic? Abuse of Gabapentinoids: A Brief Review of Recent Studies
CONCLUSION: Gabapentinoids are highly abused molecules worldwide. Physicians should be aware of their abuse potential.PMID:38031769 | DOI:10.2174/0125899775268780231002064605 (Source: Epilepsy Curr)
Source: Epilepsy Curr - November 30, 2023 Category: Neurology Authors: Gamze Zengin İspir Mustafa Dan ışman K übra Sezer Katar Source Type: research
