How Technology Can Help Overcome Barriers to Getting Effective Therapies into Patients with Ultra Rare Disorders
The following is a guest article by Dr. Zach Landman, Co-Founder of Moonshots for Unicorns.
As a physician who trained at UCSF, Harvard, and Stanford, I assumed that when my youngest daughter, Lucy – at 10-months old – was diagnosed with an ultra-rare genetic disorder of glycosylation called PGAP3, the answers would reside within a hospital or academic laboratory.
Unfortunately, my pediatrician wife and I were told that our smiling, seemingly healthy babbling 10-month-old baby would likely never walk normally, never talk, and was likely to develop severe and refractory seizures at some point in her childhood. ...
Source: EMR and HIPAA - September 27, 2022 Category: Information Technology Authors: Guest Author Tags: Clinical Healthcare IT AAV9 ASO CRISPR Dr. Zach Landman epalrestat Gene Therapy Invitae Patient Stories Patients Perlara PGAP3 PMM2 PRAX-222 Rare Diseases SCN2A SMA-1 Source Type: blogs
Healthcare ’s Sustainability Problem And The Solutions Tech Can Provide
The following is a guest article by Melissa Powell, COO at Genesis HealthCare.
Healthcare’s future is smart and sustainable, led by tech-driven solutions and human ingenuity. One great success story of sustainable healthcare that combines those forces begins with a nurse who sews.
Tami Ochs, an RN at New Jersey’s Overlook Medical Center, helped the facility repurpose 15,000 pounds of surgical blue wrap that was being discarded annually. She began sewing shopping bags from the non-biodegradable material used to cover sterile equipment, a project that blossomed into a goal to replace 100,000 plastic bags patients use eve...
Source: EMR and HIPAA - September 7, 2022 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning C-Suite Leadership Healthcare IT Hospital - Health System AMA Boston Medical Center Circular Healthcare Cisco Genesis Healthcare Healthcare Facilities Healthcare Without Harm Melissa Powell Overlook Medical Cent Source Type: blogs
Weekly Australian Health IT Links – 05 September, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----There seems to be a good bit going on this week so lots to browse!The trial of AI in aged care was quite amusing in a sad sort of way ….-----https://medicalrepublic.com.au/whos-to-blame-when-the-software-gets-it-wrong/7586330 August 2022Who ’s to blame when the software gets it wrong?MedicolegalTechnologyByPursuitClinical deci...
Source: Australian Health Information Technology - September 5, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, August 29th 2022
This study demonstrates that adoptive astrocytic Mt transfer enhances neuronal Mn-SOD-mediated anti-oxidative defense and neuroplasticity in the brain, which potentiate functional recovery following ICH.
First Generation Stem Cell Therapies Remain Comparatively Poorly Understood
https://www.fightaging.org/archives/2022/08/first-generation-stem-cell-therapies-remain-comparatively-poorly-understood/
We are something like thirty years into the increasingly widespread use of first generation stem cell therapies. Cells are derived from a variety of sources, processed, and transplanted into patients. Near all...
Source: Fight Aging! - August 28, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Weekly Roundup – August 27, 2022
Welcome to our Healthcare IT Today Weekly Roundup. Each week, we’ll be providing a look back at the articles we posted and why they’re important to the healthcare IT community. We hope this gives you a chance to catch up on anything you may have missed during the week.
Rusty Yeager on EHR Standardization and Rehabilitation Hospitals. In the latest CIO Podcast, Yeager, the Senior VP and CIO at Encompass Health, talked to John Lynn about the benefits of deploying a standardized EHR across an organization. The conversation also covered some of the unique IT needs of a rehabilitation hospital. Read more…
What It Take...
Source: EMR and HIPAA - August 27, 2022 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Healthcare IT Today Weekly Roundup Source Type: blogs
Breadth and Simplicity of Accessibility in Health IT – Part 3
This article explores some important areas I haven’t yet touched on, and ends with an appeal for better web sites for all.
Other ways to make technology more usable
Bonnie Kerker, Associate Professor at the Department of Population Health at the NYU Grossman School of Medicine, discussed the difficulties of lower-income communities trying to get access to online health care and other social services. Through a community-based initiative called Together Growing Strong (TGS), she and her colleagues have collected a lot of information through intensive partnerships with community representatives in Sunset Park in Brookl...
Source: EMR and HIPAA - August 25, 2022 Category: Information Technology Authors: Andy Oram Tags: Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System Telemedicine and Remote Monitoring Accessibility Ada André Machado Rebelo Disability Dr. Paulo Pina Family Health Centers FDB First Data Source Type: blogs
Automating Accessibility in Health IT – Part 2
The first article in this series, Disabilities and Accessibility in Health IT: The Need Is Constant, introduced the importance of designing web sites and other health care tools for many different types of people. In this article, we’ll look at how far you can go with the automation of web site accessibility.
Automation and the human factor
In most endeavors, computers can provide help while leaving tasks that require human intervention, a role for the computer that user interaction pioneer Doug Engelbart called “augmentation.” In making web sites accessible, we can ask which jobs are for a computer and w...
Source: EMR and HIPAA - August 24, 2022 Category: Information Technology Authors: Andy Oram Tags: Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System accessiBe Accessibility Ada Axe-core Brandon Cooper Deque Systems Disability Doug Engelbart Dylan Barrell Fullscript Healthcare Autom Source Type: blogs
Dysfunction in the Blood-Brain Barrier May Harm Neural Function Even Prior to Leakage
Researchers here present evidence for the proposition that the blood-brain barrier doesn't just become leaky with age, but also causes disruption of neural function in other ways yet to be fully explored. The primary function of the blood-brain barrier is to regulate passage of molecules and cells into the central nervous system, and when that breaks down the consequence is chronic inflammation in brain tissue, contributing to the onset and progression of neurodegenerative conditions. It seems that the harms may start somewhat before the blood-brain barrier is sufficiently compromised to leak, however.
The breakdo...
Source: Fight Aging! - August 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Future of 3D Printing Drugs In Pharmacies Is Closer Than You Think
3D printing drugs is not a fantasy anymore. Unbelievable shapes and any kind of drug can be fabricated with groundbreaking technology. The UK biotech company, FabRx believes it could even appear as a regular technique in hospitals and pharmacies for creating personalised drugs in specific doses within 5-10 years. In February 2022 the company announced they developed a technology allowing them to 3D print tablets in 7-17 seconds, a huge improvement from earlier.
Print out starfish-shaped drugs for your child at home
Somewhere in the 2030s: Annie was called by her daughter’s teacher that she had a high fever...
Source: The Medical Futurist - August 9, 2022 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Future of Medicine Future of Pharma Healthcare Innovation Personalized medicine GC1 pharmacies 3d printed drugs personalized drugs Source Type: blogs
Certainty is a fading flame in a failing body
“You should prepare for the future. Your son will never be independent.” I do not recall hearing those words at their source, but I was only eight when they were relayed to me by my parents. At the time my diagnosis, now characterized as juvenile myoclonic epilepsy, was poorly understood and often confused with more
Read more…
Certainty is a fading flame in a failing body originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 8, 2022 Category: General Medicine Authors: Mukund Gnanadesikan, MD Tags: Physician Psychiatry Source Type: blogs
Fight Aging! Newsletter, August 1st 2022
In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice. We observed marked differences in age-associated DNA methylation in these commonly used inbred mouse strains, indicating that epigenetic clocks for one strain cannot be simply applied to other strains without further verification. Interestingly, the CpGs with highest age-correlation were still overlapping in B6 and DBA mice and included the genes Hsf4, Prima1, Aspa, and Wnt3a. Furthermore, Hsf4, Aspa, and Wnt3a revealed highly significant age-associated DNA methyla...
Source: Fight Aging! - July 31, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing What is Known of the Longevity Gene INDY
INDY was one of the earlier longevity-related genes to be robustly identified, a discovery made 20 years ago now. Much of the exploratory work on INDY was carried out in flies, though more than enough time has now passed for mouse data to have also emerged. The authors of today's review paper characterize the benefits resulting from a reduced expression of INDY as a calorie restriction mimetic effect, more or less. That is a fair enough shorthand for any approach that improves cellular maintenance processes in a way that modestly slows the aging process, resisting the accumulation of damage, dysfunctional cells, and chroni...
Source: Fight Aging! - July 26, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Diamond Sensor for Smaller, Portable MEG Scanners
Researchers at RMIT University in Australia have developed a diamond sensor that can measure magnetic fields up to 10 times more sensitively than current sensors. The breakthrough could lead to a new generation of magnetoencephalography (MEG) scanners that are small and portable, and can function at room temperature. The researchers envisage that the new scanners could even work as a helmet that a patient could place over their head, making it useful in detecting concussions at the point of care or for routine monitoring of neurodegenerative diseases. The new sensor does not lose any of the light generated by defects in th...
Source: Medgadget - July 18, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Neurology Radiology MEG MEG scanner RMIT Source Type: blogs
Hunting Disease-Causing Genetic Variants
Dr. Miriam Meisler. Credit: University of Michigan Medical School.
“In my lab, we’ve been gene hunters—starting with visible phenotypes, or characteristics, and searching for the responsible genes,” says Miriam Meisler, Ph.D., the Myron Levine Distinguished University Professor at the University of Michigan Medical School in Ann Arbor. During her career, Dr. Meisler has identified the functions of multiple genes and has shown how genetic variants, or mutations, can impact human health.
Becoming a Scientist
Dr. Meisler had a strong interest in science as a child, which she credits to “growing up at the tim...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 29, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Genes Injury and Illness Diseases DNA Profiles Research Organisms Scientific Process Source Type: blogs
Thin Film Electrodes for Neuro Applications: Interview with Dave Rosa, CEO of NeuroOne
NeuroOne, a medtech company based in Minnesota, has developed the Evo Cortical Electrode and the sEEG electrode, both of which are thin film electrodes for neural recording and stimulation. The small profile and flexible nature of the electrodes allows for less invasive insertion, and the low resistance they offer delivers improved signal quality.
The devices can combine both diagnostic and therapeutic functions, which could potentially reduce the number of procedures a patient has to undergo, as diagnosis and treatment can occur during the same procedure.
The company has also conducted simulations of long-term neura...
Source: Medgadget - June 1, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Materials Neurology Neurosurgery epilepsy N1MTC seizures Source Type: blogs
